Advanced search
Publication Cover
Epigenomics Volume 5, 2013 - Issue 5
Submit an article Journal homepage
1,196
Views
0
CrossRef citations to date
0
Altmetric
Editorial

Neurodevelopmental Epigenetic Etiologies: Insights from Studies on Mouse Models of Fetal Alcohol Spectrum Disorders

Benjamin I LauferMolecular Genetics Unit, Department of Biology, Western University, London, ON, N6A 5B7, Canada. [email protected]
,
Eric J DiehlMolecular Genetics Unit, Department of Biology, Western University, London, ON, N6A 5B7, Canada. [email protected]
&
Shiva M SinghMolecular Genetics Unit, Department of Biology, Western University, London, ON, N6A 5B7, Canada. [email protected]
Pages 465-468 | Published online: 24 Sep 2013

References

  • Jirikowic T , OlsonHC, KartinD. Sensory processing, school performance, and adaptive behavior of young school-age children with fetal alcohol spectrum disorders. Phys. Occup. Ther. Pediatr.28(2) , 117–136 (2008).
  • Herman LE , AcostaMC, ChangPN. Gender and attention deficits in children diagnosed with a fetal alcohol spectrum disorder. Can. J. Clin. Pharmacol.15(3) , e411–e419 (2008).
  • Kleiber ML , ManthaK, StringerRL, SinghSM. Neurodevelopmental alcohol exposure elicits long-term changes to gene expression that alter distinct molecular pathways dependent on timing of exposure. J. Neurodev. Disord.5(1) , 6 (2013).
  • Mantha K , KleiberM, SinghS. Neurodevelopmental timing of ethanol exposure may contribute to observed heterogeneity of behavioral deficits in a mouse model of fetal alcohol spectrum disorder (FASD). Behav. Brain Sci.3 , 85–99 (2013).
  • May PA , GossageJP, KalbergWO et al. Prevalence and epidemiologic characteristics of FASD from various research methods with an emphasis on recent in-school studies. Dev. Disabil. Res. Rev. 15(3) , 176–192 (2009).
  • Popova S , StadeB, BekmuradovD, LangeS, RehmJ. What do we know about the economic impact of fetal alcohol spectrum disorder? A systematic literature review. Alcohol Alcohol.46(4) , 490–497 (2011).
  • Garro AJ , McBethDL, LimaV, LieberCS. Ethanol-consumption inhibits fetal DNA methylation in mice: implications for the fetal alcohol syndrome. Alcohol Clin. Exp. Res.15(3) , 395–398 (1991).
  • Liu Y , BalaramanY, WangG, NephewKP, ZhouFC. Alcohol exposure alters DNA methylation profiles in mouse embryos at early neurulation. Epigenetics4(7) , 500–511 (2009).
  • Kaminen-Ahola N , AholaA, MagaM et al. Maternal ethanol consumption alters the epigenotype and the phenotype of offspring in a mouse model. PLoS Genet. 6(1) , e1000811 (2010).
  • Bekdash RA , ZhangC, SarkarDK. Gestational choline supplementation normalized fetal alcohol-induced alterations in histone modifications, DNA methylation, and proopiomelanocortin (POMC) gene expression in β-endorphin-producing pomc neurons of the hypothalamus. Alcohol. Clin. Exp. Res.37(7) , 1132–1142 (2013).
  • Kleiber ML , WrightE, SinghSM. Maternal voluntary drinking in C57BL/6J mice: advancing a model for fetal alcohol spectrum disorders. Behav. Brain Res.223(2) , 376–387 (2011).
  • Kleiber ML , LauferBI, WrightE, DiehlEJ, SinghSM. Long-term alterations to the brain transcriptome in a maternal voluntary consumption model of fetal alcohol spectrum disorders. Brain Res.1458 , 18–33 (2012).
  • Laufer BI , ManthaK, KleiberML, DiehlEJ, AddisonSM, SinghSM. Long lasting alterations to DNA methylation and ncRNAs may underlie the effects of fetal alcohol exposure. Dis. Model. Mech.6(4) , 977–992 (2013).
  • May PA , GossageJP. Estimating the prevalence of fetal alcohol syndrome – a summary. Alcohol Res. Health25(3) , 159–167 (2001).
  • Lin S , Ferguson-SmithAC, SchultzRM, BartolomeiMS. Nonallelic transcriptional roles of ctcf and cohesins at imprinted loci. Mol. Cell. Biol.31(15) , 3094–3104 (2011).
  • Lim WA , LeeCM, TangC. Design principles of regulatory networks: searching for the molecular algorithms of the cell. Mol. Cell49(2) , 202–212 (2013).
  • Sauer U , HeinemannM, ZamboniN. Getting closer to the whole picture. Science316(5824) , 550–551 (2007).
  • Silverman EK , LoscalzoJ. Network medicine approaches to the genetics of complex diseases. Discov. Med.14(75) , 143–152 (2012).
  • Sathyan P , GoldenHB, MirandaRC. Competing interactions between micro-RNAs determine neural progenitor survival and proliferation after ethanol exposure: evidence from an ex vivo model of the fetal cerebral cortical neuroepithelium. J. Neurosci.27(32) , 8546–8557 (2007).
  • Haycock PC , RamsayM. Exposure of mouse embryos to ethanol during preimplantation development: effect on DNA methylation in the H19 imprinting control region. Biol. Reprod.81(4) , 618–627 (2009).
  • Wang LL , ZhangZ, LiQ et al. Ethanol exposure induces differential microRNA and target gene expression and teratogenic effects which can be suppressed by folic acid supplementation. Hum. Reprod. 24(3) , 562–579 (2009).
  • Kaminen-Ahola N , AholaA, Flatscher-BaderT et al. Postnatal growth restriction and gene expression changes in a mouse model of fetal alcohol syndrome. Birth Defects Res. Part A Clin. Mol. Teratol. 88(10) , 818–826 (2010).
  • Subramanian A , TamayoP, MoothaVK et al. Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc. Natl Acad. Sci. USA 102(43) , 15545–15550 (2005).
  • Lee SI , BatzoglouS. Application of independent component analysis to microarrays. Genome Biol.4(11) , R76 (2003).
  • Barabasi AL , OltvaiZN. Network biology: understanding the cell‘s functional organization. Nat. Rev. Genet.5(2) , 101–113 (2004).
  • Amiri A , ChoW, ZhouJ et al. PTEN deletion in adult hippocampal neural stem/progenitor cells causes cellular abnormalities and alters neurogenesis. J. Neurosci.32(17) , 5880–5890 (2012).
  • Ostrakhovitch EA , SemenikhinOA. The role of redox environment in neurogenic development. Arch. Biochem. Biophys.534(1–2) , 44–54 (2013).
  • Laufer B , SinghS. A macro role for imprinted clusters of microRNAs in the brain. MicroRNA1 , 59–64 (2012).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.