Advanced search
Publication Cover
Epigenomics Volume 6, 2014 - Issue 1
Submit an article Journal homepage
162
Views
0
CrossRef citations to date
0
Altmetric
Editorial

Epigenetic dysregulation in Alzheimer’s disease: cause or consequence?

Daniel LA van den Hove1 Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience (MHeNS), Maastricht University, Maastricht, The Netherlands;2 Laboratory of Translational Neuroscience, Department of Psychiatry, Psychosomatics & Psychotherapy, University of Wuerzburg, Wuerzburg, GermanyCorrespondence[email protected]
View further author information
,
Gunter Kenis1 Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience (MHeNS), Maastricht University, Maastricht, The NetherlandsView further author information
&
Bart PF Rutten1 Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience (MHeNS), Maastricht University, Maastricht, The NetherlandsView further author information
Pages 9-11 | Published online: 28 Feb 2014

References

  • Ferri CP , PrinceM , BrayneCet al. Global prevalence of dementia: a Delphi consensus study . Lancet366 ( 9503 ), 2112 – 2117 ( 2005 ).
  • Budson AE , SolomonPR . New diagnostic criteria for Alzheimer’s disease and mild cognitive impairment for the practical neurologist . Pract. Neurol.12 ( 2 ), 88 – 96 ( 2013 ).
  • Chouliaras L , MastroeniD , DelvauxEet al. Consistent decrease in global DNA methylation and hydroxymethylation in the hippocampus of Alzheimer’s disease patients . Neurobiol. Aging34 ( 9 ), 2091 – 2099 ( 2013 ).
  • Iwata A , NagataK , HatsutaHet al. Altered CpG methylation in sporadic Alzheimer’s disease is associated with APP and MAPT dysregulation . Hum. Mol. Genet. doi: https://doi.org/10.1093/hmg/ddt451 ( 2013 ).
  • Mastroeni D , GroverA , DelvauxE , WhitesideC , ColemanPD , RogersJ . Epigenetic changes in Alzheimer’s disease: decrements in DNA methylation . Neurobiol Aging31 ( 12 ), 2025 – 2037 ( 2010 ).
  • Lunnon K , MillJ . Epigenetic studies in Alzheimer’s disease: Current findings, caveats, and considerations for future studies . Am. J. Med. Genet. B Neuropsychiatr. Genet. doi:10.1002/ajmg.b.322012013 ) ( Epub ahead of print ).
  • Day JJ , SweattJD . Epigenetic mechanisms in cognition . Neuron70 ( 5 ), 813 – 829 ( 2011 ).
  • Taher N , MckenzieC , GarrettR , BakerM , FoxN , IsaacsGD . Amyloid-beta alters the DNA methylation status of cell-fate genes in an Alzheimer’s disease model . J. Alzheimers Dis.38 ( 4 ), 831 – 844 ( 2013 ).
  • Veerappan CS , SleimanS , CoppolaG . Epigenetics of Alzheimer’s disease and frontotemporal dementia . Neurotherapeutics10 ( 4 ), 709 – 721 ( 2013 ).
  • Bradley-Whitman MA , LovellMA . Epigenetic changes in the progression of Alzheimer’s disease . Mech. Ageing Dev.134 ( 10 ), 486 – 495 ( 2013 ).
  • Barnes DE , YaffeK , ByersAL , MccormickM , SchaeferC , WhitmerRA . Midlife vs late-life depressive symptoms and risk of dementia: differential effects for Alzheimer disease and vascular dementia . Arch. Gen. Psychiatry69 ( 5 ), 493 – 498 ( 2012 ).
  • Simic G , StanicG , MladinovM , Jovanov-MilosevicN , KostovicI , HofPR . Does Alzheimer’s disease begin in the brainstem?Neuropathol. Appl. Neurobiol.35 ( 6 ), 532 – 554 ( 2009 ).
  • Rodriguez JJ , NoristaniHN , VerkhratskyA . The serotonergic system in ageing and Alzheimer’s disease . Prog. Neurobiol.99 ( 1 ), 15 – 41 ( 2012 ).
  • Braak H , DelTredici K . The pathological process underlying Alzheimer’s disease in individuals under thirty . Acta Neuropathol.121 ( 2 ), 171 – 181 ( 2011 ).
  • Davies MN , VoltaM , PidsleyRet al. Functional annotation of the human brain methylome identifies tissue-specific epigenetic variation across brain and blood . Genome Biol.13 ( 6 ), R43 ( 2012 ).
  • Adwan L , ZawiaNH . Epigenetics: a novel therapeutic approach for the treatment of Alzheimer’s disease . Pharmacol. Ther.139 ( 1 ), 41 – 50 ( 2013 ).
  • Van Den Hove Dl , ChouliarasL , RuttenBP . The role of 5-hydroxymethylcytosine in aging and Alzheimer’s disease: current status and prospects for future studies . Curr. Alzheimer Res.9 ( 5 ), 545 – 549 ( 2012 ).
  • Van Den Hove Dl ,  KompotisK ,  LardenoijeR , Epigenetically regulated microRNAs in Alzheimer’s disease .  Neurobiol. Aging   35 ( 4 ),  731 – 745  ( 2013 ).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.