893
Views
0
CrossRef citations to date
0
Altmetric
News

Conference Scene: 2nd Cancer Epigenetics Conference

Pages 123-130 | Published online: 08 Apr 2013

References

  • Filippakopoulos P , PicaudS, MangosM et al. Histone recognition and large-scale structural analysis of the human bromodomain family. Cell 149(1) , 214–231 (2012).
  • Muller S , FilippakopoulosP, KnappS. Bromodomains as therapeutic targets. Expert Rev. Mol. Med.13 , e29 (2011).
  • Hewings DS , WangM, PhilpottM et al. 3,5-dimethylisoxazoles act as acetyl-lysine-mimetic bromodomain ligands. J. Med. Chem. 54(19) , 6761–6770 (2011).
  • Hewings DS , RooneyTP, JenningsLE et al. Progress in the development and application of small molecule inhibitors of bromodomain–acetyl–lysine interactions. J. Med. Chem. 55(22) , 9393–9413 (2012).
  • Bryant B . Chromatin computation. PLoS ONE7(5) , e35703 (2012).
  • Prinjha RK , WitheringtonJ, LeeK. Place your BETs: the therapeutic potential of bromodomains. Trends Pharmacol. Sci.33(3) , 146–153 (2012).
  • Chung CW , CosteH, WhiteJH et al. Discovery and characterization of small molecule inhibitors of the BET family bromodomains. J. Med. Chem. 54(11) , 3827–3838 (2011).
  • Dawson MA , PrinjhaRK, DittmannA et al. Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia. Nature 478(7370) , 529–533 (2011).
  • Zuber J , ShiJ, WangE et al. RNAi screen identifies BRD4 as a therapeutic target in acute myeloid leukaemia. Nature 478(7370) , 524–528 (2011).
  • Nicodeme E , JeffreyKL, SchaeferU et al. Suppression of inflammation by a synthetic histone mimic. Nature 468(7327) , 1119–1123 (2010).
  • Bisgrove DA , MahmoudiT, HenkleinP, VerdinE. Conserved P-TEFb-interacting domain of BRD4 inhibits HIV transcription. Proc. Natl Acad. Sci. USA104(34) , 13690–13695 (2007).
  • Marazzi I , HoJS, KimJ et al. Suppression of the antiviral response by an influenza histone mimic. Nature 483(7390) , 428–433 (2012).
  • Delmore JE , IssaGC, LemieuxME et al. BET bromodomain inhibition as a therapeutic strategy to target c-Myc. Cell 146(6) , 904–917 (2011).
  • Schwartz BE , HoferMD, LemieuxME et al. Differentiation of nut midline carcinoma by epigenomic reprogramming. Cancer Res. 71(7) , 2686–2696 (2011).
  • Herrmann H , BlattK, ShiJ et al. Small-molecule inhibition of BRD4 as a new potent approach to eliminate leukemic stem- and progenitor cells in acute myeloid leukemia AML. Oncotarget 3(12) , 1588–1599 (2012).
  • Matzuk MM , MckeownMR, FilippakopoulosP et al. Small-molecule inhibition of BRDT for male contraception. Cell 150(4) , 673–684 (2012).
  • Sharma SV , LeeDY, LiB et al. A chromatin-mediated reversible drug-tolerant state in cancer cell subpopulations. Cell 141(1) , 69–80 (2010).
  • Mertz JA , ConeryAR, BryantBM et al. Targeting myc dependence in cancer by inhibiting bet bromodomains. Proc. Natl Acad. Sci. USA 108(40) , 16669–16674 (2011).
  • Munteanu B , Von Reitzenstein C, Hansch GM, Meyer B, Hopf C. Sensitive, robust and automated protein analysis of cell differentiation and of primary human blood cells by intact cell MALDI mass spectrometry biotyping. Anal. Bioanal. Chem.404(8) , 2277–2286 (2012).
  • Heltweg B , GatbontonT, SchulerAD et al. Antitumor activity of a small-molecule inhibitor of human silent information regulator 2 enzymes. Cancer Res. 66(8) , 4368–4377 (2006).
  • Copeland RA , OlhavaEJ, ScottMP. Targeting epigenetic enzymes for drug discovery. Curr. Opin Chem. Biol.14(4) , 505–510 (2010).
  • Copeland RA , MoyerMP, RichonVM. Targeting genetic alterations in protein methyltransferases for personalized cancer therapeutics. Oncogene32(8) , 939–946 (2012).
  • Majer CR , JinL, ScottMP et al. A687V EZH2 is a gain-of-function mutation found in lymphoma patients. FEBS Lett. 586(19) , 3448–3451 (2012).
  • Cosgrove MS , PatelA. Mixed lineage leukemia: a structure–function perspective of the MLL1 protein. FEBS J.277(8) , 1832–1842 (2010).
  • Dharmarajan V , LeeJH, PatelA, SkalnikDG, CosgroveMS. Structural basis for WDR5 interaction (win) motif recognition in human SET1 family histone methyltransferases. J. Biol. Chem.287(33) , 27275–27289 (2012).
  • Kawamura A , TumberA, RoseNR et al. Development of homogeneous luminescence assays for histone demethylase catalysis and binding. Anal. Biochem. 404(1) , 86–93 (2010).
  • King ON , LiXS, SakuraiM et al. Quantitative high-throughput screening identifies 8-hydroxyquinolines as cell-active histone demethylase inhibitors. PLoS ONE 5(11) , e15535 (2010).
  • Kar S , DebM, SenguptaD et al. An insight into the various regulatory mechanisms modulating human DNA methyltransferase 1 stability and function. Epigenetics 7(9) , 994–1007 (2012).
  • Schenk T , ChenWC, GollnerS et al. Inhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia. Nature Med. 18(4) , 605–611 (2012).
  • Sinha SH , OwensEA, FengY et al. Synthesis and evaluation of carbocyanine dyes as PRMT inhibitors and imaging agents. Eur. J. Med. Chem. 54 , 647–659 (2012).
  • Al-Dhaheri M , WuJ, SklirisGP et al. CARM1 is an important determinant of ERα-dependent breast cancer cell differentiation and proliferation in breast cancer cells. Cancer Res. 71(6) , 2118–2128 (2011).
  • Masch A , ZerweckJ, ReimerU, WenschuhH, SchutkowskiM. Antibody signatures defined by high-content peptide microarray analysis. Methods Mol. Biol.669 , 161–172 (2010).
  • Houseman EA , AccomandoWP, KoestlerDC et al. DNA methylation arrays as surrogate measures of cell mixture distribution. BMC Bioinformatics 13 , 86 (2012).
  • Wiencke JK , AccomandoWP, ZhengS et al. Epigenetic biomarkers of T-cells in human glioma. Epigenetics 7(12) , 1391–1402 (2012).
  • Accomando WP , WienckeJK, HousemanEA et al. Decreased nk cells in patients with head and neck cancer determined in archival DNA. Clin. Cancer Res. 18(22) , 6147–6154 (2012).
  • Devos T , TetznerR, ModelF et al. Circulating methylated SEPT9 DNA in plasma is a biomarker for colorectal cancer. Clin. Chem. 55(7) , 1337–1346 (2009).
  • Kinney SM , ChinHG, VaisvilaR et al. Tissue-specific distribution and dynamic changes of 5-hydroxymethylcytosine in mammalian genomes. J. Biol. Chem. 286(28) , 24685–24693 (2011).
  • Kinney SR , PradhanS. Ten eleven translocation enzymes and 5-hydroxymethylation in mammalian development and cancer. Adv. Exp. Med. Biol.754 , 57–79 (2013).
  • Esteve PO , ChangY, SamaranayakeM et al. A methylation and phosphorylation switch between an adjacent lysine and serine determines human DNMT1 stability. Nat. Struct. Mol. Biol. 18(1) , 42–48 (2011).
  • Kinney SR , PradhanS. Regulation of expression and activity of DNA (cytosine-5) methyltransferases in mammalian cells. Prog. Mol. Biol. Transl Sci.101 , 311–333 (2011).
  • Cohen-Karni D , XuD, AponeL et al. The mspji family of modification-dependent restriction endonucleases for epigenetic studies. Proc. Natl Acad. Sci. USA 108(27) , 11040–11045 (2011).
  • Ferraiuolo MA , SanyalA, NaumovaN, DekkerJ, DostieJ. From cells to chromatin: capturing snapshots of genome organization with 5c technology. Methods58(3) , 255–267 (2012).
  • Naumova N , SmithEM, ZhanY, DekkerJ. Analysis of long-range chromatin interactions using chromosome conformation capture. Methods58(3) , 192–203 (2012).
  • Magistri M , FaghihiMA, St Laurent G 3rd, Wahlestedt C. Regulation of chromatin structure by long noncoding RNAs: focus on natural antisense transcripts. Trends Genet.28(8) , 389–396 (2012).
  • Smith CL , BoltonA, NguyenG. Genomic and epigenomic instability, fragile sites, schizophrenia and autism. Curr. Genomics11(6) , 447–469 (2010).

▪ Websites

▪ Patent

  • Miyoshi S, Ooike S, Iwata K, Hikawa H, Sugaraha K. Antitumor agents. International patent No. PCT/JP2008/073864 (WO/2009/084693) (2009).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.