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Epigenomics Volume 6, 2014 - Issue 4
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Editorial

Does Epigenetic Drift Contribute To Age-Related Increases In Breast Cancer Risk?

Scott M LangevinDepartment of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, OH, USACorrespondence[email protected]
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,
Susan M PinneyDepartment of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, OH, USAView further author information
,
Yuet-Kin LeungDepartment of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, OH, USAView further author information
&
Shuk-Mei HoDepartment of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, OH, USAView further author information
Pages 367-369 | Published online: 21 Oct 2014

References

  • Siegel R , MaJ , ZouZ , JemalA . Cancer statistics, 2014 . CA Cancer J. Clin.64 ( 1 ), 9 – 29 ( 2014 ).
  • Desantis C , MaJ , BryanL , JemalA . Breast cancer statistics, 2013 . CA Cancer J. Clin.64 ( 1 ), 52 – 62 ( 2014 ).
  • Stefansson OA , EstellerM . Epigenetic modifications in breast cancer and their role in personalized medicine . Am. J. Pathol.183 ( 4 ), 1052 – 1063 ( 2013 ).
  • Issa JP . Aging and epigenetic drift: a vicious cycle . J. Clin. Invest.124 ( 1 ), 24 – 29 ( 2014 ).
  • Bell JT , SpectorTD . A twin approach to unraveling epigenetics . Trends Genet.27 ( 3 ), 116 – 125 ( 2011 ).
  • Martin GM . Stochastic modulations of the pace and patterns of ageing: impacts on quasi-stochastic distributions of multiple geriatric pathologies . Mech. Ageing Dev.133 ( 4 ), 107 – 111 ( 2012 ).
  • Huidobro C , FernandezAF , FragaMF . Aging epigenetics: causes and consequences . Mol. Aspects Med.34 ( 4 ), 765 – 781 ( 2013 ).
  • Fraga MF , BallestarE , PazMFet al. Epigenetic differences arise during the lifetime of monozygotic twins . Proc. Natl Acad. Sci. USA102 ( 30 ), 10604 – 10609 ( 2005 ).
  • Hervouet E , CartronPF , JouvenotM , Delage-MourrouxR . Epigenetic regulation of estrogen signaling in breast cancer . Epigenetics8 ( 3 ), 237 – 245 ( 2013 ).
  • Christensen BC , HousemanEA , MarsitCJet al. Aging and environmental exposures alter tissue-specific DNA methylation dependent upon CpG island context . PLoS Genet.5 ( 8 ), e1000602 ( 2009 ).
  • Langevin SM , HousemanEA , ChristensenBCet al. The influence of aging, environmental exposures and local sequence features on the variation of DNA methylation in blood . Epigenetics6 ( 7 ), 908 – 919 ( 2011 ).
  • Bjornsson HT , SigurdssonMI , FallinMDet al. Intra-individual change over time in DNA methylation with familial clustering . JAMA299 ( 24 ), 2877 – 2883 ( 2008 ).
  • Damaschke NA , YangB , BhusariS , SvarenJP , JarrardDF . Epigenetic susceptibility factors for prostate cancer with aging . Prostate73 ( 16 ), 1721 – 1730 ( 2013 ).
  • Horvath S . DNA methylation age of human tissues and cell types . Genome Biol.14 ( 10 ), R115 ( 2013 ).
  • Hannum G , GuinneyJ , ZhaoLet al. Genome-wide methylation profiles reveal quantitative views of human aging rates . Mol. Cell49 ( 2 ), 359 – 367 ( 2013 ).
  • Euhus DM , BuD , MilchgrubSet al. DNA methylation in benign breast epithelium in relation to age and breast cancer risk . Cancer Epidemiol. Biomarkers Prev.17 ( 5 ), 1051 – 1059 ( 2008 ).
  • Toyota M , AhujaN , Ohe-ToyotaM , HermanJG , BaylinSB , IssaJP . CpG island methylator phenotype in colorectal cancer . Proc. Natl Acad. Sci. USA96 ( 15 ), 8681 – 8686 ( 1999 ).
  • Johnson KC , KoestlerDC , ChengC , ChristensenBC . Age-related DNA methylation in normal breast tissue and its relationship with invasive breast tumor methylation . Epigenetics9 ( 2 ), 268 – 275 ( 2014 ).
  • Rakyan VK , DownTA , MaslauSet al. Human aging-associated DNA hypermethylation occurs preferentially at bivalent chromatin domains . Genome Res.20 ( 4 ), 434 – 439 ( 2010 ).
  • Bean GR , Ibarra DrendallC , GoldenbergVKet al. Hypermethylation of the breast cancer-associated gene 1 promoter does not predict cytologic atypia or correlate with surrogate end points of breast cancer risk . Cancer Epidemiol. Biomarkers Prev.16 ( 1 ), 50 – 56 ( 2007 ).

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