Epigenetic Signatures as Prognostic Tools in Acute Myeloid Leukemia and Myelodysplastic Syndromes

References

• Patel JP , GonenM , FigueroaMEet al. Prognostic relevance of integrated genetic profiling in acute myeloid leukemia . N. Engl. J. Med.366 ( 12 ), 1079 – 1089 ( 2012 ).
   PubMed Web of Science ®Google Scholar
• Figueroa ME , Abdel-WahabO , LuCet al. Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation . Cancer Cell18 ( 6 ), 553 – 567 ( 2010 ).
   PubMed Web of Science ®Google Scholar
• Delhommeau F , DupontS , Della ValleVet al. Mutation in TET2 in myeloid cancers . N. Engl. J. Med.360 ( 22 ), 2289 – 2301 ( 2009 ).
   PubMed Web of Science ®Google Scholar
• Ley TJ , DingL , WalterMJet al. DNMT3A mutations in acute myeloid leukemia . N. Engl. J. Med.363 ( 25 ), 2424 – 2433 ( 2010 ).
   PubMed Web of Science ®Google Scholar
• Shih AH , Abdel-WahabO , PatelJP , LevineRL . The role of mutations in epigenetic regulators in myeloid malignancies . Nat. Rev. Cancer12 ( 9 ), 599 – 612 ( 2012 ).
   PubMed Web of Science ®Google Scholar
• Lübbert M , SuciuS , BailaLet al. Low-dose decitabine versus best supportive care in elderly patients with intermediate- or high-risk myelodysplastic syndrome (MDS) ineligible for intensive chemotherapy: final results of the randomized phase III study of the European Organisation for Research and Treatment of Cancer Leukemia Group and the German MDS Study Group . J. Clin. Oncol.29 ( 15 ), 1987 – 1996 ( 2011 ).
   PubMed Web of Science ®Google Scholar
• Fenaux P , MuftiGJ , Hellstrom-LindbergEet al. Azacitidine prolongs overall survival compared with conventional care regimens in elderly patients with low bone marrow blast count acute myeloid leukemia . J. Clin. Oncol.28 ( 4 ), 562 – 569 ( 2010 ).
   PubMed Web of Science ®Google Scholar
• Golub TR , SlonimDK , TamayoPet al. Molecular classification of cancer: class discovery and class prediction by gene expression monitoring . Science286 ( 5439 ), 531 – 537 ( 1999 ).
   PubMed Web of Science ®Google Scholar
• Alizadeh AA , EisenMB , DavisREet al. Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling . Nature403 ( 6769 ), 503 – 511 ( 2000 ).
   PubMed Web of Science ®Google Scholar
• Eppert K , TakenakaK , LechmanERet al. Stem cell gene expression programs influence clinical outcome in human leukemia . Nat. Med.17 ( 9 ), 1086 – 1093 ( 2011 ).
   PubMed Web of Science ®Google Scholar
• Schoch C , KohlmannA , SchnittgerSet al. Acute myeloid leukemias with reciprocal rearrangements can be distinguished by specific gene expression profiles . Proc. Natl Acad. Sci. USA99 ( 15 ), 10008 – 10013 ( 2002 ).
   PubMed Web of Science ®Google Scholar
• Gentles AJ , PlevritisSK , MajetiR , AlizadehAA . Association of a leukemic stem cell gene expression signature with clinical outcomes in acute myeloid leukemia . JAMA304 ( 24 ), 2706 – 2715 ( 2010 ).
   PubMed Web of Science ®Google Scholar
• Christopeit M , KrögerN , HaferlachT , BacherU . Relapse assessment following allogeneic SCT in patients with MDS and AML . Ann. Hematol.93 ( 7 ), 1097 – 110 ( 2014 ).
   PubMed Web of Science ®Google Scholar
• Shearstone JR , PopR , BockC , BoyleP , MeissnerA , SocolovskyM . Global DNA demethylation during mouse erythropoiesis in vivo . Science334 ( 6057 ), 799 – 802 ( 2011 ).
   PubMed Web of Science ®Google Scholar
• Bartholdy B , ChristopeitM , WillBet al. HSC commitment-associated epigenetic signature is prognostic in acute myeloid leukemia . J. Clin. Invest.124 ( 3 ), 1158 – 1167 ( 2014 ).
   PubMed Web of Science ®Google Scholar
• Agrawal S , HofmannWK , TidowNet al. The C/EBPdelta tumor suppressor is silenced by hypermethylation in acute myeloid leukemia . Blood109 ( 9 ), 3895 – 3905 ( 2007 ).
   PubMed Web of Science ®Google Scholar
• Jan M , SnyderTM , Corces-ZimmermanMRet al. Clonal evolution of preleukemic hematopoietic stem cells precedes human acute myeloid leukemia . Sci. Transl. Med.4 ( 149 ), 149ra118 ( 2012 ).
   PubMed Web of Science ®Google Scholar
• Schoofs T , RohdeC , HebestreitKet al. DNA methylation changes are a late event in acute promyelocytic leukemia and coincide with loss of transcription factor binding . Blood121 ( 1 ), 178 – 187 ( 2013 ).
   PubMed Web of Science ®Google Scholar
• Hnisz D , AbrahamBJ , LeeTIet al. Super-enhancers in the control of cell identity and disease . Cell155 ( 4 ), 934 – 947 ( 2013 ).
   PubMed Web of Science ®Google Scholar
• Figueroa ME , SkrabanekL , LiYet al. MDS and secondary AML display unique patterns and abundance of aberrant DNA methylation . Blood114 ( 16 ), 3448 – 3458 ( 2009 ).
   PubMed Web of Science ®Google Scholar
• Bullinger L , EhrichM , DohnerKet al. Quantitative DNA methylation predicts survival in adult acute myeloid leukemia . Blood115 ( 3 ), 636 – 642 ( 2010 ).
   PubMed Web of Science ®Google Scholar
• Figueroa ME , LugthartS , LiYet al. DNA methylation signatures identify biologically distinct subtypes in acute myeloid leukemia . Cancer Cell17 ( 1 ), 13 – 27 ( 2010 ).
   PubMed Web of Science ®Google Scholar
• Cancer Genome Atlas Research N . Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia . N. Engl. J. Med.368 ( 22 ), 2059 – 2074 ( 2013 ).
   PubMed Web of Science ®Google Scholar
• Alvarez S , SuelaJ , ValenciaAet al. DNA methylation profiles and their relationship with cytogenetic status in adult acute myeloid leukemia . PLoS One5 ( 8 ): e12197 ( 2010 ).
   PubMed Web of Science ®Google Scholar
• Marcucci G , YanP , MaharryKet al. Epigenetics meets genetics in acute myeloid leukemia: clinical impact of a novel seven-gene score . J. Clin. Oncol.32 ( 6 ), 548 – 556 ( 2014 ).
   PubMed Web of Science ®Google Scholar
• Deneberg S , GuardiolaP , LennartssonAet al. Prognostic DNA methylation patterns in cytogenetically normal acute myeloid leukemia are predefined by stem cell chromatin marks . Blood118 ( 20 ), 5573 – 5582 ( 2011 ).
   PubMed Web of Science ®Google Scholar
• Cross M , BachE , TranTet al. Pretreatment long interspersed element (LINE)-1 methylation levels, not early hypomethylation under treatment, predict hematological response to azacitidine in elderly patients with acute myeloid leukemia . Onco. Targets Ther.6 , 741 – 748 ( 2013 ).
   PubMed Web of Science ®Google Scholar
• Shen L , KantarjianH , GuoYet al. DNA methylation predicts survival and response to therapy in patients with myelodysplastic syndromes . J. Clin. Oncol.28 ( 4 ), 605 – 613 ( 2010 ).
   PubMed Web of Science ®Google Scholar
• Akalin A , Garrett-BakelmanFE , KormakssonMet al. Base-pair resolution DNA methylation sequencing reveals profoundly divergent epigenetic landscapes in acute myeloid leukemia . PLoS Genet.8 ( 6 ): e1002781 ( 2012 ).
   PubMed Web of Science ®Google Scholar
• Bhattacharyya S , YuY , SuzukiMet al. Genome-wide hydroxymethylation tested using the HELP-GT assay shows redistribution in cancer . Nucleic Acids Res.41 ( 16 ): e157 ( 2013 ).
   PubMed Web of Science ®Google Scholar
• Sun D , LuoM , JeongMet al. Epigenomic profiling of young and aged HSCs reveals concerted changes during aging that reinforce self-renewal . Cell Stem Cell14 ( 5 ), 673 – 688 ( 2014 ).
   PubMed Web of Science ®Google Scholar
• Krug U , KoschmiederA , SchwammbachDet al. Feasibility of azacitidine added to standard chemotherapy in older patients with acute myeloid leukemia—a randomised SAL pilot study . PLoS One7 ( 12 ): e52695 ( 2012 ).
   PubMed Web of Science ®Google Scholar