147
Views
0
CrossRef citations to date
0
Altmetric
Commentary

Candidate gene methylation studies are at high risk of erroneous conclusions

, &
Pages 13-15 | Published online: 17 Feb 2015

References

  • Bell JT , PaiAA , PickrellJKet al. DNA methylation patterns associate with genetic and gene expression variation in HapMap cell lines . Genome Biol.12 ( 1 ), R10 ( 2011 ).
  • Aberg KA , McClayJL , NerellaSet al. Methylome-wide association study of schizophrenia: identifying blood biomarker signatures of environmental insults . JAMA Psychiatry71 ( 3 ), 255 – 264 ( 2014 ).
  • Hsiung DT , MarsitCJ , HousemanEAet al. Global DNA methylation level in whole blood as a biomarker in head and neck squamous cell carcinoma . Cancer Epidemiol. Biomarkers Prev.16 ( 1 ), 108 – 114 ( 2007 ).
  • Lim U , SongMA . Dietary and lifestyle factors of DNA methylation . Methods Mol. Biol.863 , 359 – 376 ( 2012 ).
  • van den Oord EJ , SullivanPF . False discoveries and models for gene discovery . Trends Genet.19 ( 10 ), 537 – 542 ( 2003 ).
  • Wacholder S , ChanockS , Garcia-ClosasM , El GhormliL , RothmanN . Assessing the probability that a positive report is false: an approach for molecular epidemiology studies . J. Natl Cancer Inst.96 ( 6 ), 434 – 442 ( 2004 ).
  • Benjamini Y , HochbergY . Controlling the false discovery rate: a practical and powerful approach to multiple testing . J. Royal Stat. Soc. B57 , 289 – 300 ( 1995 ).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.