240
Views
0
CrossRef citations to date
0
Altmetric
Research Article

Variability of Response to Methadone: Genome-Wide DNA Methylation Analysis in Two Independent Cohorts

, , , , , , , , & show all
Pages 181-195 | Received 20 Jul 2015, Accepted 13 Nov 2015, Published online: 21 Jan 2016

References

  • Gibson A , DegenhardtL , MattickRP , AliR , WhiteJ , O’BrienS . Exposure to opioid maintenance treatment reduces long-term mortality . Addiction103 ( 3 ), 502 – 468 ( 2008 ).
  • Mattick RP , BreenC , KimberJ , DavoliM . Methadone maintenance therapy versus no opioid replacement therapy for opioid dependence . Cochrane Database Syst. Rev. ( 3 ), CD002209 ( 2009 ).
  • Fucci N , De GiovanniN . Methadone in hair and sweat from patients in long-term maintenance therapy . Ther. Drug Monitor.29 ( 4 ), 452 – 454 ( 2007 ).
  • Dennis BB , NajiL , BaworMet al. The effectiveness of opioid substitution treatments for patients with opioid dependence: a systematic review and multiple treatment comparison protocol . Syst. Rev.3 , 105 ( 2014 ).
  • Somogyi AA , BarrattDT , AliRL , CollerJK . Pharmacogenomics of methadone maintenance treatment . Pharmacogenomics15 ( 7 ), 1007 – 1027 ( 2014 ).
  • Bell J , MutchC . Treatment retention in adolescent patients treated with methadone or buprenorphine for opioid dependence: a file review . Drug Alcohol Rev.25 ( 2 ), 167 – 171 ( 2006 ).
  • Mattick RP , KimberJ , BreenC , DavoliM . Buprenorphine maintenance versus placebo or methadone maintenance for opioid dependence . Cochrane Database Syst. Rev. ( 2 ), CD002207 ( 2008 ).
  • Winstock AR , LintzerisN , LeaT . “Should I stay or should I go?” Coming off methadone and buprenorphine treatment . Int. J. Drug Policy22 ( 1 ), 77 – 81 ( 2010 ).
  • Epstein DH , SchmittnerJ , UmbrichtA , SchroederJR , MoolchanET , PrestonKL . Promoting abstinence from cocaine and heroin with a methadone dose increase and a novel contingency . Drug Alcohol Depend.101 ( 1–2 ), 92 – 100 ( 2009 ).
  • Farre M , MasA , TorrensM , MorenoV , CamiJ . Retention rate and illicit opioid use during methadone maintenance interventions: a meta-analysis . Drug Alcohol Depend.65 ( 3 ), 283 – 290 ( 2002 ).
  • Kreek MJ , BorgL , DucatE , RayB . Pharmacotherapy in the treatment of addiction: methadone . J. Addict. Dis.29 ( 2 ), 200 – 216 ( 2010 ).
  • Mullen L , BarryJ , LongJet al. A national study of the retention of irish opiate users in methadone substitution treatment . Am. J. Drug Alcohol Abuse38 ( 6 ), 551 – 558 ( 2012 ).
  • Faggiano F , Vigna-TagliantiF , VersinoE , LemmaP . Methadone maintenance at different dosages for opioid dependence . Cochrane Database Syst. Rev. ( 3 ), CD002208 ( 2003 ).
  • Strain EC , BigelowGE , LiebsonIA , StitzerML . Moderate- vs high-dose methadone in the treatment of opioid dependence: A randomized trial . J. Am. Med. Assoc.281 ( 11 ), 1000 – 1005 ( 1999 ).
  • Fareed A , CasarellaJ , RobertsMet al. High dose versus moderate dose methadone maintenance: Is there a better outcome? J. Addict. Dis. 28 ( 4 ), 399 – 405 ( 2009 ).
  • Hanna J , FosterDJ , SalterA , SomogyiAA , WhiteJM , BochnerF . Within- and between- subject variability in methadone pharmacokinetics and pharmacodynamics in methadone maintenance subjects . Br. J. Clin. Pharmacol.60 ( 4 ), 404 – 413 ( 2005 ).
  • Fonseca F , De La TorreR , DiazLet al. Contribution of cytochrome P450 and ABCB1 genetic variability on methadone pharmacokinetics, dose requirements, and response . PLoS ONE6 ( 5 ), e19527 ( 2011 ).
  • Moolchan ET , HoffmanJA . Phases of treatment: a practical approach to methadone maintenance treatment . Int. J. Addict.29 ( 2 ), 135 – 160 ( 1994 ).
  • Kleber HD . Methadone maintenance 4 decades later: Thousands of lives saved but still controversial . J. Am. Med. Assoc.300 ( 19 ), 2303 – 2305 ( 2008 ).
  • Crettol S , DeglonJJ , BessonJet al. ABCB1 and cytochrome P450 genotypes and phenotypes: influence on methadone plasma levels and response to treatment . Clin. Pharmacol. Ther.80 ( 6 ), 668 – 681 ( 2006 ).
  • Perez De Los Cobos J , SinolN , TrujolsJet al. Association of CYP2D6 ultrarapid metabolizer genotype with deficient patient satisfaction regarding methadone maintenance treatment . Drug Alcohol Depend.89 ( 2–3 ), 190 – 194 ( 2007 ).
  • Wang SC , HoIK , TsouHHet al. CYP2B6 polymorphisms influence the plasma concentration and clearance of the methadone S-enantiomer . J. Clin. Psychopharmacol.31 ( 4 ), 463 – 469 ( 2011 ).
  • Wang JS , RuanY , TaylorRM , DonovanJL , MarkowitzJS , DevaneCL . Brain penetration of methadone (R)- and (S)-enantiomers is greatly increased by P-glycoprotein deficiency in the blood-brain barrier of Abcb1a gene knockout mice . Psychopharmacology (Berl.)173 ( 1–2 ), 132 – 138 ( 2004 ).
  • Tournier N , ChevillardL , MegarbaneB , PirnayS , ScherrmannJM , DeclevesX . Interaction of drugs of abuse and maintenance treatments with human P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) . Int. J. Neuropsychopharmacol.13 ( 7 ), 905 – 915 ( 2010 ).
  • Coller JK , BarrattDT , DahlenK , LoennechenMH , SomogyiAA . ABCB1 genetic variability and methadone dosage requirements in opioid-dependent individuals . Clin. Pharmacol. Ther.80 ( 6 ), 682 – 690 ( 2006 ).
  • Levran O , O’HaraK , PelesEet al. ABCB1 (MDR1) genetic variants are associated with methadone doses required for effective treatment of heroin dependence . Hum. Mol. Genet.17 ( 14 ), 2219 – 2227 ( 2008 ).
  • Dennis BB , BaworM , ThabaneL , SohaniZ , SamaanZ . Impact of ABCB1 and CYP2B6 genetic polymorphisms on methadone metabolism, dose and treatment response in patients with opioid addiction: A systematic review and meta-analysis . PLoS ONE9 ( 1 ), e86114 ( 2014 ).
  • Mouly S , BlochV , Peoc’hKet al. Methadone dose in heroin-dependent patients: role of clinical factors, comedications, genetic polymorphisms and enzyme activity . Brit. J. Clin. Pharmacol.79 ( 6 ), 967 – 977 ( 2015 ).
  • Levran O , PelesE , RandesiMet al. Association of genetic variation in pharmacodynamic factors with methadone dose required for effective treatment of opioid addiction . Pharmacogenomics14 ( 7 ), 755 – 768 ( 2013 ).
  • Barratt DT , CollerJK , HallinanRet al. ABCB1 haplotype and OPRM1 118A >G genotype interaction in methadone maintenance treatment pharmacogenetics . Pharmacogenomics Pers. Med.5 , 53 – 62 ( 2012 ).
  • Crettol S , BessonJ , Croquette-KrokarMet al. Association of dopamine and opioid receptor genetic polymorphisms with response to methadone maintenance treatment . Prog. Neuropsychopharmacol. Biol. Psychiatry32 ( 7 ), 1722 – 1727 ( 2008 ).
  • Oneda B , CrettolS , BochudMet al. Beta-arrestin2 influences the response to methadone in opioid-dependent patients . Pharmacogenomics J.11 ( 4 ), 258 – 266 ( 2011 ).
  • Barratt DT , CollerJK , SomogyiAA . Association between the DRD2 A1 allele and response to methadone and buprenorphine maintenance treatments . Am. J. Med. Genet. B Neuropsychiatr. Genet.141B ( 4 ), 323 – 331 ( 2006 ).
  • Doehring A , OertelBG , SittlR , LotschJ . Chronic opioid use is associated with increased DNA methylation correlating with increased clinical pain . Pain154 ( 1 ), 15 – 23 ( 2013 ).
  • Nielsen DA , YuferovV , HamonSet al. Increased OPRM1 DNA methylation in lymphocytes of methadone-maintained former heroin addicts . Neuropsychopharmacol.34 ( 4 ), 867 – 873 ( 2009 ).
  • Nielsen DA , HamonS , YuferovVet al. Ethnic diversity of DNA methylation in the oprm1 promoter region in lymphocytes of heroin addicts . Hum. Genet.127 ( 6 ), 639 – 649 ( 2010 ).
  • Toskulkao T , PornchaiR , AkkarapatumwongV , VatanatunyakumS , GovitrapongP . Alteration of lymphocyte opioid receptors in methadone maintenance subjects . Neurochem. Int.56 ( 2 ), 285 – 290 ( 2010 ).
  • Crettol S , DeglonJJ , BessonJet al. Methadone enantiomer plasma levels, CYP2B6, CYP2C19, and CYP2C9 genotypes, and response to treatment . Clin. Pharmacol. Ther.78 ( 6 ), 593 – 604 ( 2005 ).
  • Dunning MJ , Barbosa-MoraisNL , LynchAG , TavareS , RitchieME . Statistical issues in the analysis of illumina data . BMC Bioinformatics9 , 85 ( 2008 ).
  • Wong WC , LohM , EisenhaberF . On the necessity of different statistical treatment for illumina beadchip and affymetrix genechip data and its significance for biological interpretation . Biol. Direct3 , 23 ( 2008 ).
  • R Core Team. R: A language and environment for statistical computing. R Foundation for Statistical Computing. Vienna, Austria ISBN 3-900051-07-0 . www.R-project.org/ .
  • Pidsley R , CcYW , VoltaM , LunnonK , MillJ , SchalkwykLC . A data-driven approach to preprocessing illumina 450k methylation array data . BMC Genomics14 , 293 ( 2013 ).
  • Teschendorff AE , MarabitaF , LechnerMet al. A beta-mixture quantile normalization method for correcting probe design bias in illumina infinium 450 k DNA methylation data . Bioinformatics29 ( 2 ), 189 – 196 ( 2013 ).
  • Benaglia T , ChauveauD , HunterDR , YoungDS . Mixtools: an R package for analyzing mixture models . J. Stat. Softw.32 ( 6 ), 29 ( 2009 ).
  • Li D , XieZ , PapeML , DyeT . An evaluation of statistical methods for DNA methylation microarray data analysis . BMC Bioinformatics16 , 217 ( 2015 ).
  • WEB-based GEne SeT AnaLysis Toolkit . http://bioinfo.vanderbilt.edu/webgestalt/ .
  • King VL , BroonerRK , KidorfMS , StollerKB , MirskyAF . Attention deficit hyperactivity disorder and treatment outcome in opioid abusers entering treatment . J. Nerv. Ment. Dis.187 ( 8 ), 487 – 495 ( 1999 ).
  • Carpentier PJ , Van GoghMT , KnapenLJ , BuitelaarJK , De JongCA . Influence of attention deficit hyperactivity disorder and conduct disorder on opioid dependence severity and psychiatric comorbidity in chronic methadone-maintained patients . Eur. Addict. Res.17 ( 1 ), 10 – 20 ( 2011 ).
  • Peles E , PotikD , SchreiberS , BlochM , AdelsonM . Psychiatric comorbidity of patients on methadone maintenance treatment with a history of sexual abuse . Eur. Neuropsychopharmacol.22 ( 12 ), 883 – 891 ( 2012 ).
  • Mehta D , KlengelT , ConneelyKNet al. Childhood maltreatment is associated with distinct genomic and epigenetic profiles in posttraumatic stress disorder . Proc. Natl Acad. Sci. USA110 ( 20 ), 8302 – 8307 ( 2013 ).
  • Perroud N , Paoloni-GiacobinoA , PradaPet al. Increased methylation of glucocorticoid receptor gene (NR3C1) in adults with a history of childhood maltreatment: A link with the severity and type of trauma . Transl. Psychiatr.1 , e59 ( 2011 ).
  • Van Mil NH , Steegers-TheunissenRP , Bouwland-BothMIet al. DNA methylation profiles at birth and childADHD symptoms . J. Psychiatr. Res.49 , 51 – 59 ( 2014 ).
  • Moser D , EkawardhaniS , KumstaRet al. Functional analysis of a potassium-chloride co-transporter 3 (SLC12A6) promoter polymorphism leading to an additional DNA methylation site . Neuropsychopharmacology34 ( 2 ), 458 – 467 ( 2009 ).
  • Reimer J , BoniakowskiE , BachnerCet al. When higher doses in opioid replacement treatment are still inadequate – association to multidimensional illness severity: a cohort study . Subst. Abus. Treatment Prev. Pol.9 , 13 ( 2014 ).
  • Lechner M , FentonT , WestJet al. Identification and functional validation of hpv-mediated hypermethylation in head and neck squamous cell carcinoma . Genome Med.5 ( 2 ), 15 ( 2013 ).
  • Reinius LE , AcevedoN , JoerinkMet al. Differential DNA methylation in purified human blood cells: Implications for cell lineage and studies on disease susceptibility . PLoS ONE7 ( 7 ), e41361 ( 2012 ).
  • Davies MN , VoltaM , PidsleyRet al. Functional annotation of the human brain methylome identifies tissue-specific epigenetic variation across brain and blood . Genome Biol.13 ( 6 ), R43 ( 2012 ).
  • Dobrinas M , CrettolS , OnedaBet al. Contribution of CYP2B6 alleles in explaining extreme (S)-methadone plasma levels: a CYP2B6 gene resequencing study . Pharmacogenet. Genomics23 ( 2 ), 84 – 93 ( 2013 ).
  • Oneda B , CrettolS , Jaquenoud SirotE , BochudM , AnsermotN , EapCB . The P450 oxidoreductase genotype is associated with CYP3A activity in vivo as measured by the midazolam phenotyping test . Pharmacogenet. Genomics19 ( 11 ), 877 – 883 ( 2009 ).
  • Icick R , Peoc’hK , KsoudaKet al. OPRM1 polymorphism and lifetime suicide attempts among stabilized, methadone-maintained outpatients . Psychiatry Res.218 ( 1–2 ), 259 – 260 ( 2014 ).
  • Hajj A , KsoudaK , Peoc’hKet al. KCNH2 polymorphism and methadone dosage interact to enhance QT duration . Drug Alcohol Depend.141 , 34 – 38 ( 2014 ).
  • Icick R , Peoc’hK , KarsintiEet al. A cannabinoid receptor 1 polymorphism is protective against major depressive disorder in methadone-maintained outpatients . Am. J. Addict.24 ( 7 ), 613 – 620 ( 2015 ).
  • Sakae DY , MartiF , LeccaSet al. The absence of VGLUT3 predisposes to cocaine abuse by increasing dopamine and glutamate signaling in the nucleus accumbens . Mol. Psychiatry20 ( 11 ), 1448 – 1459 ( 2015 ).
  • Eap CB , CrettolS , RougierJSet al. Stereoselective block of herg channel by (S)-methadone and QT interval prolongation in CYP2B6 slow metabolizers . Clin. Pharmacol. Ther.81 ( 5 ), 719 – 728 ( 2007 ).
  • Uehlinger C , CrettolS , ChassotPet al. Increased (R)-methadone plasma concentrations by quetiapine in cytochrome P450s and ABCB1 genotyped patients . J. Clin. Psychopharmacol.27 ( 3 ), 273 – 278 ( 2007 ).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.