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Editorial

Does DNA Methylation Influence the Effects of Psychiatric Drugs?

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Pages 309-312 | Received 02 Dec 2015, Accepted 08 Dec 2015, Published online: 26 Feb 2016

References

  • Xu Z , ZhangZ , ShiYet al. Influence and interaction of genetic polymorphisms in the serotonin system and life stress on antidepressant drug response . J. Psychopharmacol.26 ( 3 ), 349 – 359 ( 2012 ).
  • Vijayendran M , BeachSRH , PlumeJM , BrodyGH , PhilibertRA . Effects of genotype and child abuse on DNA methylation and gene expression at the serotonin transporter . Front. Psychiatry3 , 55 ( 2012 ).
  • Domschke K , TidowN , SchwarteKet al. Serotonin transporter gene hypomethylation predicts impaired antidepressant treatment response . Int. J. Neuropsychopharmacol.17 ( 8 ), 1167 – 1176 ( 2014 ).
  • Kang H-J , KimJ-M , StewartRet al. Association of SLC6A4 methylation with early adversity, characteristics and outcomes in depression . Prog. Neuropsychopharmacol. Biol. Psychiatry44 , 23 – 28 ( 2013 ).
  • Sales AJ , BiojoneC , TercetiMS , GuimarãesFS , GomesMVM , JocaSRL . Antidepressant-like effect induced by systemic and intra-hippocampal administration of DNA methylation inhibitors . Br. J. Pharmacol.164 ( 6 ), 1711 – 1721 ( 2011 ).
  • Melas PA , RogdakiM , LennartssonAet al. Antidepressant treatment is associated with epigenetic alterations in the promoter of P11 in a genetic model of depression . Int. J. Neuropsychopharmacol.15 ( 05 ), 669 – 679 ( 2012 ).
  • Melka MG , CastellaniCA , LauferBI , RajakumarRN , O’ReillyR , SinghSM . Olanzapine induced DNA methylation changes support the dopamine hypothesis of psychosis . J. Mol. Psychiatry1 ( 1 ), 19 ( 2013 ).
  • Reynolds GP . The impact of pharmacogenetics on the development and use of antipsychotic drugs . Drug Discov. Today12 ( 21–22 ), 953 – 959 ( 2007 ).
  • Reynolds GP , ArranzB , TemplemanLA , FertuzinhosS , SanL . Effect of a 5-HT1A receptor gene polymorphism on negative and depressive symptom response to antipsychotic treatment of drug-naïve psychotic patients . Am. J. Psychiatry163 , 1826 – 1829 ( 2006 ).
  • Tang H , DaltonCF , SrisawatU , ZhangZJ , ReynoldsGP . Methylation at a transcription factor-binding site on the 5-HT1A receptor gene correlates with negative symptom treatment response in first episode schizophrenia . Int. J. Neuropsychopharmacol.17 ( 4 ), 645 – 649 ( 2014 ).
  • Sugawara H , BundoM , IshigookaJ , IwamotoK , KatoT . Epigenetic regulation of serotonin transporter in psychiatric disorders . J. Genet. Genomics40 ( 7 ), 325 – 329 ( 2013 ).
  • D’Addario C , Dell’OssoB , PalazzoMCet al. Selective DNA methylation of BDNF promoter in bipolar disorder: differences among patients with BDI and BDII . Neuropsychopharmacology37 ( 7 ), 1647 – 1655 ( 2012 ).
  • Dong E , ChenY , GavinDP , GraysonDR , GuidottiA . Valproate induces DNA demethylation in nuclear extracts from adult mouse brain . Epigenetics5 ( 8 ), 730 – 735 ( 2010 ).
  • Phiel CJ , ZhangF , HuangEY , GuentherMG , LazarMA , KleinPS . Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen . J. Biol. Chem.276 ( 39 ), 36734 – 36741 ( 2001 ).
  • Xu Y , ChenX-T , LuoMet al. Multiple epigenetic factors predict the attention deficit/hyperactivity disorder among the Chinese Han children . J. Psychiatr. Res.64 , 40 – 50 ( 2015 ).
  • Wilmot B , FryR , SmeesterL , MusserED , MillJ , NiggJT . Methylomic analysis of salivary DNA in childhood ADHD identifies altered DNA methylation in VIPR2 . J. Child. Psychol. Psychiatry57 ( 2 ), 152 – 160 ( 2016 ).
  • Masliah E , DumaopW , GalaskoD , DesplatsP . Distinctive patterns of DNA methylation associated with Parkinson disease: identification of concordant epigenetic changes in brain and peripheral blood leukocytes . Epigenetics8 ( 10 ), 1030 – 1038 ( 2013 ).
  • Smith AK , KilaruV , KlengelT , MercerKB , BradleyB , ConneelyKNet al. DNA extracted from saliva for methylation studies of psychiatric traits: evidence tissue specificity and relatedness to brain . Am. J. Med. Genet. B Neuropsychiatr. Genet.168B ( 1 ), 36 – 44 ( 2015 ).
  • Ghadirivasfi M , NohesaraS , AhmadkhanihaH-Ret al. Hypomethylation of the serotonin receptor type-2A gene (HTR2A) at T102C polymorphic site in DNA derived from the saliva of patients with schizophrenia and bipolar disorder . Am. J. Med. Genet. B Neuropsychiatr. Genet.156B ( 5 ), 536 – 545 ( 2011 ).

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