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DNMT3A Moderates Cognitive Decline in Subjects with Mild Cognitive Impairment: Replicated Evidence from Two Mild Cognitive Impairment Cohorts

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Pages 533-537 | Published online: 25 Jun 2015

References

  • Chouliaras L , RuttenBP , KenisGet al. Epigenetic regulation in the pathophysiology of Alzheimer’s disease . Prog. Neurobiol.90 ( 4 ), 498 – 510 ( 2010 ).
  • Day JJ , SweattJD . DNA methylation and memory formation . Nat. Neurosci.13 ( 11 ), 1319 – 1323 ( 2010 ).
  • Chouliaras L , MastroeniD , DelvauxEet al. Consistent decrease in global DNA methylation and hydroxymethylation in the hippocampus of Alzheimer’s disease patients . Neurobiol. Aging34 ( 9 ), 2091 – 2099 ( 2013 ).
  • Daniilidou M , KoutroumaniM , TsolakiM . Epigenetic mechanisms in Alzheimer’s disease . Curr. Med. Chem.18 ( 12 ), 1751 – 1756 ( 2011 ).
  • Horvath S . DNA methylation age of human tissues and cell types . Genome Biol.14 ( 10 ), R115 ( 2013 ).
  • Bi XH , ZhaoHL , ZhangZX , ZhangJW . Association of RFC1 A80G and MTHFR C677T polymorphisms with Alzheimer’s disease . Neurobiol. Aging30 ( 10 ), 1601 – 1607 ( 2009 ).
  • Coppede F , ZitarosaMT , MigheliFet al. DNMT3B promoter polymorphisms and risk of late onset Alzheimer’s disease . Curr. Alzheimer Res.9 ( 5 ), 550 – 554 ( 2012 ).
  • Pezzi JC , EnsCM , BorbaEMet al. DNA methyltransferase haplotype is associated with Alzheimer’s disease . Neurosci. Lett.579 , 70 – 74 ( 2014 ).
  • Morgan AR , HamiltonG , TuricDet al. Association analysis of 528 intra-genic SNPs in a region of chromosome 10 linked to late onset Alzheimer’s disease . Am. J. Med. Genet. B Neuropsychiatr. Genet.147B ( 6 ), 727 – 731 ( 2008 ).
  • Visser PJ , KesterA , JollesJ , VerheyF . Ten-year risk of dementia in subjects with mild cognitive impairment . Neurology67 ( 7 ), 1201 – 1207 ( 2006 ).
  • Lettre G , LangeC , HirschhornJN . Genetic model testing and statistical power in population-based association studies of quantitative traits . Genet. Epidemiol.31 ( 4 ), 358 – 362 ( 2007 ).
  • Pishva E , DrukkerM , ViechtbauerWet al. Epigenetic genes and emotional reactivity to daily life events: a multi-step gene-environment interaction study . PLoS ONE9 ( 6 ), e100935 ( 2014 ).
  • Sherry ST , WardMH , KholodovMet al. dbSNP: the NCBI database of genetic variation . Nucleic Acids Res.29 ( 1 ), 308 – 311 ( 2001 ).
  • Chen T , UedaY , XieS , LiE . A novel Dnmt3a isoform produced from an alternative promoter localizes to euchromatin and its expression correlates with active de novo methylation . J. Biol. Chem.277 ( 41 ), 38746 – 38754 ( 2002 ).
  • Oliveira AM , HemstedtTJ , BadingH . Rescue of aging-associated decline in Dnmt3a2 expression restores cognitive abilities . Nat. Neurosci.15 ( 8 ), 1111 – 1113 ( 2012 ).
  • Feng J , ZhouY , CampbellSLet al. Dnmt1 and Dnmt3a maintain DNA methylation and regulate synaptic function in adult forebrain neurons . Nat. Neurosci.13 ( 4 ), 423 – 430 ( 2010 ).
  • Wu H , CoskunV , TaoJet al. Dnmt3a-dependent nonpromoter DNA methylation facilitates transcription of neurogenic genes . Science329 ( 5990 ), 444 – 448 ( 2010 ).
  • Guo JU , SuY , ShinJHet al. Distribution, recognition and regulation of non-CpG methylation in the adult mammalian brain . Nat. Neurosci.17 ( 2 ), 215 – 222 ( 2013 ).
  • Chouliaras L , Van Den HoveDL , KenisGet al. Caloric restriction attenuates age-related changes of DNA methyltransferase 3a in mouse hippocampus . Brain Behav. Immun.25 ( 4 ), 616 – 623 ( 2011 ).
  • Haggarty P , HoadG , HarrisSEet al. Human intelligence and polymorphisms in the DNA methyltransferase genes involved in epigenetic marking . PLoS ONE5 ( 6 ), e11329 ( 2010 ).

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