The NSD Family of Protein Methyltransferases in Human Cancer

References

• Wagner EJ , CarpenterPB . Understanding the language of Lys36 methylation at histone H3 . Nat. Rev. Mol. Cell Biol.13 , 115 – 126 ( 2012 ).
   PubMed Web of Science ®Google Scholar
• Rice JC , NishiokaK , SarmaK , StewardR , ReinbergD , AllisCD . Mitoticspecific methylation of histone H4 Lys 20 follows increased PR-Set7 expression and its localization to mitotic chromosomes . Genes Dev.16 , 2225 – 2230 ( 2002 ).
   PubMed Web of Science ®Google Scholar
• Hamamoto R , SalouraV , NakamuraY . Critical roles of non-histone protein lysine methylation in human tumorigenesis . Nat. Rev. Cancer15 , 110 – 124 ( 2015 ).
   PubMed Web of Science ®Google Scholar
• Lucio-Eterovic AK , SinghMM , GardnerJE , VeerappanCS , RiceJC , CarpenterPB . Role for the nuclear receptor-binding SET domain protein 1 (NSD1) methyltransferase in coordinating lysine 36 methylation at histone 3 with RNA polymerase II function . Proc. Natl Acad. Sci. USA107 , 16952 – 16957 ( 2010 ).
   PubMed Web of Science ®Google Scholar
• Barski A , CuddapahS , CuiKet al. High-resolution profiling of histone methylations in the human genome . Cell129 , 823 – 837 ( 2007 ).
   PubMed Web of Science ®Google Scholar
• Lee YF , NimuraK , LoWN , SagaK , KanedaY . Histone H3 lysine 36 methyltransferase Whsc1 promotes the association of Runx2 and p300 in the activation of bone-related genes . PLoS ONE9 , e106661 ( 2014 ).
   PubMed Web of Science ®Google Scholar
• Mikkelsen TS , KuM , JaffeDBet al. Genome-wide maps of chromatin state in pluripotent and lineage-committed cells . Nature448 , 553 – 560 ( 2007 ).
   PubMed Web of Science ®Google Scholar
• Rayasam GV , WendlingO , AngrandPOet al. NSD1 is essential for early postimplantation development and has a catalytically active SET domain . EMBO J.22 , 3153 – 3163 ( 2003 ).
   PubMed Web of Science ®Google Scholar
• Nimura K , UraK , ShiratoriHet al. A histone H3 lysine 36 trimethyltransferase links Nkx2–5 to Wolf-Hirschhorn syndrome . Nature460 , 287 – 291 ( 2009 ).
   PubMed Web of Science ®Google Scholar
• Kudithipudi S , LunguC , RathertP , HappelN , JeltschA . Substrate specificity analysis and novel substrates of the protein lysine methyltransferase NSD1 . Chem. Biol.21 , 226 – 237 ( 2014 ).
   PubMedGoogle Scholar
• Lu T , JacksonMW , WangBet al. Regulation of NF-kappaB by NSD1/FBXL11dependent reversible lysine methylation of p65 . Proc. Natl Acad. Sci. USA107 , 46 – 51 ( 2010 ).
   PubMed Web of Science ®Google Scholar
• Li Y , TrojerP , XuCFet al. The target of the NSD family of histone lysine methyltransferases depends on the nature of the substrate . J. Chem. Biol.284 , 34283 – 34295 ( 2009 ).
   PubMed Web of Science ®Google Scholar
• Huang N , vom BaurE , GarnierJMet al. Two distinct nuclear receptor interaction domains in NSD1, a novel SET protein that exhibits characteristics of both corepressors and coactivators . EMBO J.17 , 3398 – 3412 ( 1998 ).
   PubMed Web of Science ®Google Scholar
• Jaju RJ , FidlerC , HaasOAet al. A novel gene, NSD1, is fused to NUP98 in the t(5;11)(q35;p15.5) in de novo childhood acute myeloid leukemia . Blood98 , 1264 – 1267 ( 2001 ).
   PubMed Web of Science ®Google Scholar
• Wang X , YehS , WuGet al. Identification and characterization of a novel androgen receptor coregulator ARA267-alpha in prostate cancer cells . J. Chem. Biol.276 , 40417 – 40423 ( 2001 ).
   PubMed Web of Science ®Google Scholar
• Leventopoulos G , Kitsiou-TzeliS , KritikosKet al. A clinical study of Sotos syndrome patients with review of the literature . Pediatr. Neurol.40 , 357 – 364 ( 2009 ).
   PubMed Web of Science ®Google Scholar
• Visser R , LandmanEB , GoemanJ , WitJM , KarperienM . Sotos syndrome is associated with deregulation of the MAPK/ERK-signaling pathway . PLoS ONE7 , e49229 ( 2012 ).
   PubMed Web of Science ®Google Scholar
• Wang GG , CaiL , PasillasMP , KampsMP . NUP98-NSD1 links H3K36 methylation to Hox-A gene activation and leukaemogenesis . Nat. Cell Biol.9 , 804 – 812 ( 2007 ).
   PubMed Web of Science ®Google Scholar
• Hollink IH , Van Den Heuvel-EibrinkMM , Arentsen-PetersSTet al. NUP98/NSD1 characterizes a novel poor prognostic group in acute myeloid leukemia with a distinct HOX gene expression pattern . Blood118 , 3645 – 3656 ( 2011 ).
   PubMed Web of Science ®Google Scholar
• Thol F , KolkingB , HollinkIHet al. Analysis of NUP98/NSD1 translocations in adult AML and MDS patients . Leukemia27 , 750 – 754 ( 2013 ).
   PubMed Web of Science ®Google Scholar
• Fasan A , HaferlachC , AlpermannT , KernW , HaferlachT , SchnittgerS . A rare but specific subset of adult AML patients can be defined by the cytogenetically cryptic NUP98-NSD1 fusion gene . Leukemia27 , 245 – 248 ( 2013 ).
   PubMed Web of Science ®Google Scholar
• Berdasco M , RoperoS , SetienFet al. Epigenetic inactivation of the Sotos overgrowth syndrome gene histone methyltransferase NSD1 in human neuroblastoma and glioma . Proc. Natl Acad. Sci. USA106 , 21830 – 21835 ( 2009 ).
   PubMed Web of Science ®Google Scholar
• Cancer Genome Atlas N . Comprehensive genomic characterization of head and neck squamous cell carcinomas . Nature517 , 576 – 582 ( 2015 ).
   PubMed Web of Science ®Google Scholar
• Keck MK , ZuoZ , KhattriAet al. Integrative analysis of head and neck cancer identifies two biologically distinct HPV and three non-HPV subtypes . Clin. Cancer Res.21 , 870 – 881 ( 2015 ).
   PubMed Web of Science ®Google Scholar
• Cerami E , GaoJ , DogrusozUet al. The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data . Cancer Discov.2 , 401 – 404 ( 2012 ).
   PubMed Web of Science ®Google Scholar
• Stec I , WrightTJ , Van OmmenGJet al. WHSC1, a 90kb SET domain-containing gene, expressed in early development and homologous to a Drosophila dysmorphy gene maps in the Wolf-Hirschhorn syndrome critical region and is fused to IgH in t(4;14) multiple myeloma . Hum. Mol. Genet.7 , 1071 – 1082 ( 1998 ).
   PubMed Web of Science ®Google Scholar
• Paradowska-Stolarz AM . Wolf-Hirschhorn syndrome (WHS) - literature review on the features of the syndrome . Adv. Clin. Exp. Med.23 , 485 – 489 ( 2014 ).
   PubMed Web of Science ®Google Scholar
• Toyokawa G , ChoHS , MasudaKet al. Histone lysine methyltransferase WolfHirschhorn syndrome candidate 1 is involved in human carcinogenesis through regulation of the Wnt pathway . Neoplasia13 , 887 – 898 ( 2011 ).
   PubMed Web of Science ®Google Scholar
• Hudlebusch HR , SkotteJ , Santoni-RugiuEet al. MMSET is highly expressed and associated with aggressiveness in neuroblastoma . Cancer Res.71 , 4226 – 4235 ( 2011 ).
   PubMed Web of Science ®Google Scholar
• Saloura V , ChoHS , KyiotaniKet al. WHSC1 promotes oncogenesis through regulation of NIMA-related-kinase-7 in squamous cell carcinoma of the head and neck . Mol. Cancer Res.13 , 293 – 304 ( 2015 ).
   PubMed Web of Science ®Google Scholar
• Xiao M , YangS , ChenJet al. Overexpression of MMSET in endometrial cancer: a clinicopathologic study . J. Surg. Oncol.107 , 428 – 432 ( 2013 ).
   PubMed Web of Science ®Google Scholar
• Zhou P , WuLL , WuKMet al. Overexpression of MMSET is correlation with poor prognosis in hepatocellular carcinoma . Pathol. Oncol. Res.19 , 303 – 309 ( 2013 ).
   PubMed Web of Science ®Google Scholar
• Keats JJ , ReimanT , MaxwellCAet al. In multiple myeloma, t(4;14)(p16;q32) is an adverse prognostic factor irrespective of FGFR3 expression . Blood101 , 1520 – 1529 ( 2003 ).
   PubMed Web of Science ®Google Scholar
• Keats JJ , MaxwellCA , TaylorBJet al. Overexpression of transcripts originating from the MMSET locus characterizes all t(4;14)(p16;q32)-positive multiple myeloma patients . Blood105 , 4060 – 4069 ( 2005 ).
   PubMed Web of Science ®Google Scholar
• Santra M , ZhanF , TianE , BarlogieB , ShaughnessyJJr . A subset of multiple myeloma harboring the t(4;14)(p16;q32) translocation lacks FGFR3 expression but maintains an IGH/MMSET fusion transcript . Blood101 , 2374 – 2376 ( 2003 ).
   PubMed Web of Science ®Google Scholar
• Martinez-Garcia E , PopovicR , MinDJet al. The MMSET histone methyl transferase switches global histone methylation and alters gene expression in t(4;14) multiple myeloma cells . Blood117 , 211 – 220 ( 2011 ).
   PubMed Web of Science ®Google Scholar
• Kuo AJ , CheungP , ChenKet al. NSD2 links dimethylation of histone H3 at lysine 36 to oncogenic programming . Mol. Cell44 , 609 – 620 ( 2011 ).
   PubMed Web of Science ®Google Scholar
• Oyer JA , HuangX , ZhengYet al. Point mutation E1099K in MMSET/NSD2 enhances its methyltranferase activity and leads to altered global chromatin methylation in lymphoid malignancies . Leukemia28 , 198 – 201 ( 2014 ).
   PubMed Web of Science ®Google Scholar
• Jaffe JD , WangY , ChanHMet al. Global chromatin profiling reveals NSD2 mutations in pediatric acute lymphoblastic leukemia . Nat. Genet.45 , 1386 – 1391 ( 2013 ).
   PubMed Web of Science ®Google Scholar
• Ezponda T , PopovicR , ShahMYet al. The histone methyltransferase MMSET/WHSC1 activates TWIST1 to promote an epithelial-mesenchymal transition and invasive properties of prostate cancer . Oncogene32 , 2882 – 2890 ( 2013 ).
   PubMed Web of Science ®Google Scholar
• Asangani IA , AteeqB , CaoQet al. Characterization of the EZH2-MMSET histone methyltransferase regulatory axis in cancer . Mol. Cell49 , 80 – 93 ( 2013 ).
   PubMed Web of Science ®Google Scholar
• Popovic R , Martinez-GarciaE , GiannopoulouEGet al. Histone methyltransferase MMSET/NSD2 alters EZH2 binding and reprograms the myeloma epigenome through global and focal changes in H3K36 and H3K27 methylation . PLoS Genet.10 , e1004566 ( 2014 ).
   PubMed Web of Science ®Google Scholar
• Min DJ , EzpondaT , KimMKet al. MMSET stimulates myeloma cell growth through microRNA-mediated modulation of c-MYC . Leukemia27 , 686 – 694 ( 2013 ).
   PubMed Web of Science ®Google Scholar
• Yang P , GuoL , DuanZJet al. Histone methyltransferase NSD2/MMSET mediates constitutive NF-kappaB signaling for cancer cell proliferation, survival, and tumor growth via a feed-forward loop . Mol. Cell Biol.32 , 3121 – 3131 ( 2012 ).
   PubMed Web of Science ®Google Scholar
• Pei H , ZhangL , LuoKet al. MMSET regulates histone H4K20 methylation and 53BP1 accumulation at DNA damage sites . Nature470 , 124 – 128 ( 2011 ).
   PubMed Web of Science ®Google Scholar
• Hajdu I , CicciaA , LewisSM , ElledgeSJ . Wolf-Hirschhorn syndrome candidate 1 is involved in the cellular response to DNA damage . Proc. Natl Acad. Sci. USA108 , 13130 – 13134 ( 2011 ).
   PubMed Web of Science ®Google Scholar
• Angrand PO , ApiouF , StewartAF , DutrillauxB , LossonR , ChambonP . NSD3, a new SET domain-containing gene, maps to 8p12 and is amplified in human breast cancer cell lines . Genomics74 , 79 – 88 ( 2001 ).
   PubMed Web of Science ®Google Scholar
• Liu L , KimballS , LiuH , HolowatyjA , YangZQ . Genetic alterations of histone lysine methyltransferases and their significance in breast cancer . Oncotarget6 , 2466 – 2482 ( 2014 ).
   Google Scholar
• Gelsi-Boyer V , OrsettiB , CerveraNet al. Comprehensive profiling of 8p11–12 amplification in breast cancer . Mol. Cancer Res.3 , 655 – 667 ( 2005 ).
   PubMed Web of Science ®Google Scholar
• Ray ME , YangZQ , AlbertsonDet al. Genomic and expression analysis of the 8p11–12 amplicon in human breast cancer cell lines . Cancer Res.64 , 40 – 47 ( 2004 ).
   PubMed Web of Science ®Google Scholar
• Yang ZQ , StreicherKL , RayME , AbramsJ , EthierSP . Multiple interacting oncogenes on the 8p11-p12 amplicon in human breast cancer . Cancer Res.66 , 11632 – 11643 ( 2006 ).
   PubMed Web of Science ®Google Scholar
• Chen Y , McgeeJ , ChenXet al. Identification of druggable cancer driver genes amplified across TCGA datasets . PLoS ONE9 , e98293 ( 2014 ).
   PubMed Web of Science ®Google Scholar
• Rosati R , La StarzaR , VeroneseAet al. NUP98 is fused to the NSD3 gene in acute myeloid leukemia associated with t(8;11)(p11.2;p15) . Blood99 , 3857 – 3860 ( 2002 ).
   PubMed Web of Science ®Google Scholar
• Taketani T , TakiT , NakamuraH , TaniwakiM , MasudaJ , HayashiY . NUP98-NSD3 fusion gene in radiation-associated myelodysplastic syndrome with t(8;11)(p11;p15) and expression pattern of NSD family genes . Cancer Genet. Cytogenet.190 , 108 – 112 ( 2009 ).
   PubMedGoogle Scholar
• Yang ZQ , LiuG , Bollig-FischerA , GirouxCN , EthierSP . Transforming properties of 8p11–12 amplified genes in human breast cancer . Cancer Res.70 , 8487 – 8497 ( 2010 ).
   PubMed Web of Science ®Google Scholar
• Kang D , ChoHS , ToyokawaGet al. The histone methyltransferase Wolf-Hirschhorn syndrome candidate 1-like 1 (WHSC1L1) is involved in human carcinogenesis . Genes Chromosomes Cancer52 , 126 – 139 ( 2013 ).
   PubMed Web of Science ®Google Scholar
• Rahman S , SowaME , OttingerMet al. The Brd4 extraterminal domain confers transcription activation independent of pTEFb by recruiting multiple proteins, including NSD3 . Mol. Cell Biol.31 , 2641 – 2652 ( 2011 ).
   PubMed Web of Science ®Google Scholar
• French CA , RahmanS , WalshEMet al. NSD3-NUT fusion oncoprotein in NUT midline carcinoma: implications for a novel oncogenic mechanism . Cancer Discov.4 , 928 – 941 ( 2014 ).
   PubMed Web of Science ®Google Scholar
• Cho HS , HayamiS , ToyokawaGet al. RB1 methylation by SMYD2 enhances cell cycle progression through an increase of RB1 phosphorylation . Neoplasia14 , 476 – 486 ( 2012 ).
   PubMed Web of Science ®Google Scholar
• Cho HS , ShimazuT , ToyokawaGet al. Enhanced HSP70 lysine methylation promotes proliferation of cancer cells through activation of Aurora kinase B . Nat. Commun.3 , 1072 ( 2012 ).
   PubMed Web of Science ®Google Scholar
• Cho HS , SuzukiT , DohmaeNet al. Demethylation of RB regulator MYPT1 by histone demethylase LSD1 promotes cell cycle progression in cancer cells . Cancer Res.71 , 1 – 6 ( 2011 ).
   Web of Science ®Google Scholar
• Hamamoto R , ToyokawaG , NakakidoM , UedaK , NakamuraY . SMYD2-dependent HSP90 methylation promotes cancer cell proliferation by regulating the chaperone complex formation . Cancer Lett.351 , 126 – 133 ( 2014 ).
   PubMed Web of Science ®Google Scholar
• Takawa M , ChoHS , HayamiSet al. Histone lysine methyltransferase SETD8 promotes carcinogenesis by deregulating PCNA expression . Cancer Res.72 , 3217 – 3227 ( 2012 ).
   PubMed Web of Science ®Google Scholar