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Research Article

DNA 5-Hydroxymethylation in Human Adipose Tissue Differs Between Subcutaneous and Visceral Adipose Tissue Depots

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Pages 911-920 | Published online: 29 Sep 2015

References

  • Jimenez-Useche I , KeJ , TianYet al. DNA methylation regulated nucleosome dynamics . Sci. Rep.3 ( 2121 ), 1 – 5 ( 2013 ).
  • Koukoura O , SifakisS , SpandidosD . DNA methylation in the human placenta and fetal growth (review) . Mol. Med. Report5 ( 4 ), 883 – 889 ( 2012 ).
  • Horsthemke B . In brief: genomic imprinting and imprinting diseases . J. Pathol.232 ( 5 ), 485 – 487 ( 2014 ).
  • Boland MJ , NazorKL , LoringJF . Epigenetic regulation of pluripotency and differentiation . Circ. Res.115 ( 2 ), 311 – 324 ( 2014 ).
  • Jeltsch A , JurkowskaRZ . New concepts in DNA methylation . Trends. Bioch. Sci.39 ( 7 ), 310 – 318 ( 2014 ).
  • Tahiliani M , KohKP , ShenYet al. Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1 . Science324 ( 5929 ), 930 – 935 ( 2009 ).
  • Nestor CE , OttavianoR , ReddingtonJet al. Tissue type is a major modifier of the 5-hydroxymethylcytosine content of human genes . Genome. Res.22 ( 3 ), 467 – 477 ( 2012 ).
  • Yildirim O , LiR , HungJet al. Mbd3/NURD complex regulates expression of 5-hydroxymethylcytosine marked genes in embryonic stem cells . Cell147 ( 7 ), 1498 – 1510 ( 2011 ).
  • Kriaucionis S , HeintzN . The nuclear DNA base, 5-hydroxymethylcytosine is present in brain and enriched in Purkinje neurons . Science324 ( 5929 ), 929 – 930 ( 2009 ).
  • Pastor WA , PapeUJ , HuangYet al. Genome-wide mapping of 5-hydroxymethylcytosine in embryonic stem cells . Nature473 ( 7347 ), 394 – 397 ( 2011 ).
  • Li W , LiuM . Distribution of 5-hydroxymethylcytosine in different human tissues . J. Nucleic Acids2011 ( 3 ), 1 – 5 ( 2011 ).
  • Globisch D , MünzelM , MüllerMet al. Tissue distribution of 5-hydroxymethylcytosine and search for active demethylation intermediates . PLoS ONE5 ( 12 ), e15367 ( 2010 ).
  • Yu M , HonGC , SzulwachKEet al. Base-resolution analysis of 5-hydroxymethylcytosine in the mammalian genome . Cell149 ( 6 ), 1368 – 1380 ( 2012 ).
  • Stroud H , FengS , Morey KinneyS , PradhanS , JacobsenSE . 5-hydroxymethylcytosine is associated with enhancers and gene bodies in human embryonic stem cells . Genome Biol.12 ( 6 ), R54 ( 2011 ).
  • Ficz G , BrancoMR , SeisenbergerSet al. Dynamic regulation of 5-hydroxmethylcytosine in mouse ES cells and during differentiation . Nature473 ( 7347 ), 398 – 402 ( 2011 ).
  • Wu H , D’AlessioAC , ItoSet al. Genome-wide analysis of 5-hydroxymethylcytosine distribution reveals its dual function in transcriptional regulation in mouse embryonic stem cells . Genes. Dev.25 ( 7 ), 679 – 684 ( 2011 ).
  • Robertson J , RobertsonAB , KlunglandA . The presence of 5-hydroxymethylcytosine at the gene promoter and not in the gene body negatively regulates gene expression . Biochem. Biophys. Res. Commun.411 ( 1 ), 40 – 43 ( 2011 ).
  • Pfeifer GP , XiongW , HahnMA , JinS . The role of 5-hydroxymethylcytosine in human cancer . Cell. Tissue Res.356 ( 3 ), 631 – 641 ( 2014 ).
  • Haffner M , ChauxA , MeekerAet al. Global 5-hydroxymethylcytosine content is significantly reduced in tissue stem/progenitor cell compartments and in human global 5-hydroxymethylcytosine content is significantly reduced in tissue stem/progenitor cell compartments and in human cancers . Oncotraget2 ( 8 ), 627 – 637 ( 2011 ).
  • Yang H , LiuY , BaiFet al. Tumor development is associated with decrease of TET gene expression and 5-methylcytosine hydroxylation . Oncogene32 ( 5 ), 663 – 669 ( 2012 ).
  • Kudo Y , TateishiK , YamamotoKet al. Loss of 5-hydroxymethylcytosine is accompanied with malignant cellular transformation . Cancer Sci.103 ( 4 ), 670 – 676 ( 2012 ).
  • Sérandour AA , AvnerS , OgerFet al. Dynamic hydroxymethylation of deoxyribonucleic acid marks differentiation-associated enhancers . Nucleic Acids Res.40 ( 17 ), 8255 – 8265 ( 2012 ).
  • Wanunu M , Cohen-KarniD , JohnsonRRet al. Discrimination of methylcytosine from hydroxymethylcytosine in DNA molecules . J. Am. Chem. Soc.133 ( 3 ), 486 – 492 ( 2011 ).
  • Dao T , ChengRYS , ReveloMP , MitznerW , TangWY . Hydroxymethylation as a novel environmental biosensor . Curr. Envir. Health Rpt1 ( 1 ), 1 – 10 ( 2014 ).
  • Mahaira LG , KatsaraO , PappouEet al. IGF2BP1 expression in human mesenchymal stem cells significantly affects their proliferation and is under the epigenetic control of TET1/2 demethylases . Stem Cells Dev.23 ( 20 ), 2501 – 2512 ( 2014 ).
  • Schleinitz D , BöttcherY , BlüherM , KovacsP . The genetics of fat distribution . Diabetologia57 ( 7 ), 1276 – 1286 ( 2014 ).
  • Keller M , KralischS , RohdeKet al. Global DNA methylation levels in human adipose tissue are related to fat distribution and glucose homeostasis . Diabetologia57 ( 11 ), 2374 – 2383 ( 2014 ).
  • Rohde K , KellerM , KlösMet al. Adipose tissue depot specific promoter methylation of TMEM18 . J. Mol. Med.92 ( 8 ), 881 – 888 ( 2014 ).
  • Chakaroun R , RaschpichlerM , KlötingNet al. Effects of weight loss and exercise on chemerin serum concentrations and adipose tissue expression in human obesity . Metabolism61 ( 5 ), 706 – 714 ( 2012 ).
  • Kloting N , FasshauerM , DietrichAet al. Insulin-sensitive obesity . Am. J. Physiol. Endocrinol. Metab.299 ( 3 ), E506 – E515 ( 2010 ).
  • WHO . Obesity and overweight . www.who.int/mediacentre/factsheets/fs311/en/ .
  • Bonferroni correction online . www.quantitativeskills.com/sisa/calculations/bonfer.htm .
  • White UA , TchoukalovaYD . Sex dimorphism and depot differences in adipose tissue function . Biochim. Biophys. Acta1842 ( 3 ), 377 – 392 ( 2014 ).
  • Demerath EW , SunSS , RogersNet al. Anatomical patterning of visceral adipose tissue: race, sex, and age variation . Obesity15 ( 12 ), 2984 – 2993 ( 2007 ).
  • Karastergiou K , SmithSR , GreenbergAS , FriedSK . Sex differences in human adipose tissues – the biology of pear shape . Biol. Sex. Differ.3 ( 1 ), 13 ( 2012 ).
  • Lafontan M , GirardJ . Impact of visceral adipose tissue on liver metabolism . Diabete. Metab.34 ( 4 ), 317 – 327 ( 2008 ).
  • Karimi M , JohanssonS , EkströmT . Using LUMA a luminometric-based assay for global DNA-methylation . Epigenetics1 ( 1 ), 45 – 48 ( 2006 ).
  • Field SF , BeraldiD , BachmanMet al. Accurate measurement of 5-methylcytosine and 5-hydroxymethylcytosine in human cerebellum DNA by oxidative bisulfite on an array (OxBS-Array) . PLoS ONE10 ( 2 ), e0118202 ( 2015 ).
  • Xu Y , WuF , TanLet al. Genome-wide regulation of 5hmC, 5mC, and gene expression by Tet1 hydroxylase in mouse embryonic stem cells . Mol. Cell42 ( 4 ), 451 – 464 ( 2011 ).
  • Rudenko A , DawlatyMM , SeoJet al. Tet1 is critical for neuronal activity-regulated gene expression and memory extinction . Neuron79 ( 6 ), 1109 – 1122 ( 2013 ).
  • Jin S , KadamS , PfeiferGP . Examination of the specificity of DNA methylation profiling techniques towards 5-methylcytosine and 5-hydroxymethylcytosine . Nucleic Acids Res.38 ( 11 ), e125 ( 2010 ).
  • Rang F , BoonstraJ . Causes and consequences of age-related changes in DNA methylation: a role for ROS?Biology3 ( 2 ), 403 – 425 ( 2014 ).
  • Tchernof A , DespresJ . Pathophysiology of human visceral obesity: an update . Physiol. Rev.93 ( 1 ), 359 – 404 ( 2013 ).
  • Cartier A , CôtéM , LemieuxIet al. Age-related differences in inflammatory markers in men: contribution of visceral adiposity . Metabolism58 ( 10 ), 1452 – 1458 ( 2009 ).
  • Cartier A , CoteM , LemieuxIet al. Sex differences in inflammatory markers: what is the contribution of visceral adiposity? Am. J. Clin. Nutr. 89 ( 5 ), 1307 – 1314 ( 2009 ).
  • Iqbal K , JinS , PfeiferGP , SzaboPE . Reprogramming of the paternal genome upon fertilization involves genome-wide oxidation of 5-methylcytosine . Proc. Natl Acad. Sci. USA108 ( 9 ), 3642 – 3647 ( 2011 ).
  • Shen L , ZhangY . 5-Hydroxymethylcytosine: generation, fate, and genomic distribution . Curr. Opin. Cell. Biol.25 ( 3 ), 289 – 296 ( 2013 ).
  • Luka Z , PakhomovaS , LoukachevitchLV , NewcomerME , WagnerC . Folate in demethylation: the crystal structure of the rat dimethylglycine dehydrogenase complexed with tetrahydrofolate . Biochem. Biophys. Res. Commun.449 ( 4 ), 392 – 398 ( 2014 ).
  • Almén MS , NilssonEK , JacobssonJAet al. Genome-wide analysis reveals DNA methylation markers that vary with both age and obesity . Gene548 ( 1 ), 61 – 67 ( 2014 ).
  • Gomes MVM , ToffoliLV , ArrudaDWet al. Age-related changes in the global DNA methylation profile of leukocytes are linked to nutrition but are not associated with the MTHFR C677T genotype or to functional capacities . PLoS ONE7 ( 12 ), e52570 ( 2012 ).
  • Wen L , TangF . Genomic distribution and possible functions of DNA hydroxymethylation in the brain . Genomics104 ( 5 ), 341 – 346 ( 2014 ).
  • Kraus TFJ , GuibourtV , KretzschmarHA . 5-hydroxymethylcytosine, the “sixth base”, during brain development and ageing . J. Neural. Transm.122 ( 7 ), 1035 – 1043 ( 2014 ).
  • Tammen SA , DolnikowskiGG , AusmanLMet al. Aging alters hepatic DNA hydroxymethylation, as measured by liquid chromatography/mass spectrometry . J. Cancer Prev.19 ( 4 ), 301 – 308 ( 2014 ).
  • Kumar A , KumarS , VikramAet al. Histone and DNA methylation-mediated epigenetic downregulation of endothelial Kruppel-like factor 2 by low-density licholesterol . Arterioscler. Thromb. Vasc. Biol.33 ( 8 ), 1936 – 1942 ( 2013 ).
  • Jin S , WuX , LiAX , PfeiferGP . Genomic mapping of 5-hydroxymethylcytosine in the human brain . Nucleic Acids Res.39 ( 12 ), 5015 – 5024 ( 2011 ).
  • Song C , HeC . Potential functional roles of DNA demethylation intermediates . Trends. Bioch. Sci.38 ( 10 ), 480 – 484 ( 2013 ).
  • Wu H , WuX , ShenL , ZhangY . Single-base resolution analysis of active DNA demethylation using methylase-assisted bisulfite sequencing . Nat. Biotechnol.32 ( 12 ), 1231 – 1240 ( 2014 ).

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