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Commentary

The Failure of Epigenetic Combination Therapy for Cancer and what it Might be Telling us about DNA Methylation Inhibitors

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Pages 9-12 | Received 04 Sep 2015, Accepted 18 Sep 2015, Published online: 23 Dec 2015

References

  • Jones PA , BaylinSB . The epigenomics of cancer . Cell128 ( 4 ), 683 – 692 ( 2007 ).
  • Fenaux P , MuftiGJ , Hellstrom-LindbergEet al. Efficacy of azacitidine compared with that of conventional care regimens in the treatment of higher-risk myelodysplastic syndromes: a randomised, open-label, Phase III study . Lancet Oncol.10 ( 3 ), 223 – 232 ( 2009 ).
  • Farydak® (Panobinostat), prescribing information . Novartis Pharmaceuticals Corporation , NJ, USA ( 2015 ).
  • Sekeres MA , OthusM , ListAFet al. A randomized Phase II study of Azacitidine combined with Lenalidomide or with Vorinostat vs Azacitidine monotherapy in higher-risk myelodysplastic syndromes (MDS) and chronic myelomonocytic . Blood124 ( 21 ), LBA-5 ( 2014 ).
  • Prebet T , SunZ , FigueroaMEet al. Prolonged administration of azacitidine with or without entinostat for myelodysplastic syndrome and acute myeloid leukemia with myelodysplasia-related changes: results of the US Leukemia Intergroup trial E1905 . J. Clin. Oncol.32 ( 12 ), 1242 – 1248 ( 2014 ).
  • Issa JP , Garcia-ManeroG , HuangXet al. Results of Phase 2 randomized study of low-dose decitabine with or without valproic acid in patients with myelodysplastic syndrome and acute myelogenous leukemia . Cancer121 ( 4 ), 556 – 561 ( 2015 ).
  • Vidaza® (Azacitidine for injection), prescribing information . Celgene Corporation Summit , NJ, USA ( 2014 ).
  • Dacogen® (Decitabine), prescribing information . Otsuka America Pharmaceutical, Inc. , MD, USA ( 2014 ).
  • Yang AS , DoshiKD , ChoiSWet al. DNA methylation changes after 5-aza-2’-deoxycytidine therapy in patients with leukemia . Cancer Res.66 ( 10 ), 5495 – 5503 ( 2006 ).
  • Shen L , KantarjianH , GuoYet al. DNA methylation predicts survival and response to therapy in patients with myelodysplastic syndromes . J. Clin. Oncol.28 ( 4 ), 605 – 613 ( 2010 ).
  • Zolinza® (Vorinostat), prescribing information . Merck & Co, Inc. , NJ, USA ( 2013 ).
  • Beleodaq® (Belinostat), prescribing information . Spectrum Pharmaceuticals, CA, USA ( 2014 ).
  • Istodax® (Romidepsin), perscribing information . Celgene Corporation Summit, NJ, USA ( 2013 )
  • Griffiths EA , GoreSD . DNA methyltransferase and histone deacetylase inhibitors in the treatment of myelodysplastic syndromes . Semin. Hematol.45 ( 1 ), 23 – 30 ( 2008 ).
  • Ornstein MC , MukherjeeS , SekeresMA . More is better: combination therapies for myelodysplastic syndromes . Best Pract. Res. Clin. Haematol.28 ( 1 ), 22 – 31 ( 2015 ).
  • Bose P , DaiY , GrantS . Histone deacetylase inhibitor (HDACI) mechanisms of action: emerging insights . Pharmacol. Ther.143 ( 3 ), 323 – 336 ( 2014 ).
  • Grishina O , SchmoorC , DohnerKet al. DECIDER: prospective randomized multicenter Phase II trial of low-dose decitabine (DAC) administered alone or in combination with the histone deacetylase inhibitor valproic acid (VPA) and all-trans retinoic acid (ATRA) in patients >60 years with acute myeloid leukemia who are ineligible for induction chemotherapy . BMC Cancer15 , 430 ( 2015 ).
  • Mei Pharma I . MEI pharma announces top-line data from randomized Phase II clinical study of practinostat in front-line myelodysplastic syndrome ( 2015 ). http://investor.meipharma.com/2015-03-23-MEI-Pharma-Announces-Top-Line-Data-From-Randomized-Phase-II-Clinical-Study-Of-Pracinostat-In-Front-Line-Myelodysplastic-Syndrome
  • Voso MT , SantiniV , FabianiEet al. Why methylation is not a marker predictive of response to hypomethylating agents . Haematologica99 ( 4 ), 613 – 619 ( 2014 ).
  • Ley TJ , DingL , WalterMJet al. DNMT3A mutations in acute myeloid leukemia . N. Engl. J. Med.363 ( 25 ), 2424 – 2433 ( 2010 ).
  • Metzeler KH , WalkerA , GeyerSet al. DNMT3A mutations and response to the hypomethylating agent decitabine in acute myeloid leukemia . Leukemia26 ( 5 ), 1106 – 1107 ( 2012 ).
  • Traina F , VisconteV , ElsonPet al. Impact of molecular mutations on treatment response to DNMT inhibitors in myelodysplasia and related neoplasms . Leukemia28 ( 1 ), 78 – 87 ( 2014 ).
  • Im AP , SehgalAR , CarrollMPet al. DNMT3A and IDH mutations in acute myeloid leukemia and other myeloid malignancies: associations with prognosis and potential treatment strategies . Leukemia28 ( 9 ), 1774 – 1783 ( 2014 ).
  • Dinardo CD , PatelKP , Garcia-ManeroGet al. Lack of association of IDH1, IDH2 and DNMT3A mutations with outcome in older patients with acute myeloid leukemia treated with hypomethylating agents . Leukemia Lymphoma55 ( 8 ), 1925 – 1929 ( 2014 ).
  • Cowan LA , TalwarS , YangAS . Will DNA methylation inhibitors work in solid tumors? A review of the clinical experience with azacitidine and decitabine in solid tumors . Epigenomics2 ( 1 ), 71 – 86 ( 2010 ).

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