95
Views
0
CrossRef citations to date
0
Altmetric
Case Report

Ticagrelor and Primidone Interaction Masquerading as Dual Antiplatelet Therapy Noncompliance

ORCID Icon, , , , &
Pages 189-195 | Received 21 Jan 2023, Accepted 16 May 2023, Published online: 14 Jun 2023

References

  • Lenkapothula N , CascellaM. Primidone. In: StatPearls.StatPearls Publishing (2022). www.ncbi.nlm.nih.gov/books/NBK562297/
  • Koller WC , RoyseVL. Efficacy of primidone in essential tremor. Neurology36(1), 121–124 (1986).
  • Fincham RW , SchotteliusDD, SahsAL. The influence of diphenylhydantoin on primidone metabolism. Arch. Neurol.30(3), 259–262 (1974).
  • Reddy M , YangRS, AndersenME, ClewellHJ III. Chapter 10. In: Physiologically Based Pharmacokinetic Modeling: Science and Applications.John Wiley & Sons, NJ, USA, 292–293 (2005).
  • Bentué-Ferrer D , VerdierMC, TributO. Therapeutic drug monitoring of primidone and phenobarbital. Therapie67(4), 381–390 (2012).
  • Mauri L , KereiakesDJ, YehRWet al. Twelve or 30 months of dual antiplatelet therapy after drug-eluting stents. N. Engl. J. Med.371(23), 2155–2166 (2014).
  • Kamran H , JneidH, KayaniWTet al. Oral antiplatelet therapy after acute coronary syndrome: a review. J. Am. Med. Assoc.325(15), 1545–1555 (2021).
  • Kabil MF , AboDena AS, El-SherbinyIM. Ticagrelor. Profiles Drug Subst. Excip. Relat. Methodol.47, 91–111 (2022).
  • Bonaca MP , BhattDL, CohenMet al. Long-term use of ticagrelor in patients with prior myocardial infarction. N. Engl. J. Med.372(19), 1791–1800 (2015).
  • Teng R , ButlerK. The effect of ticagrelor on the metabolism of midazolam in healthy volunteers. Clin. Ther.35(7), 1025–1037 (2013).
  • Akkaif MA , NgML, SKAbdul Kader MA, DaudNAA, Sha'abanA, IbrahimB. A review of the effects of ticagrelor on adenosine concentration and its clinical significance. Pharmacol. Rep.73(6), 1551–1564 (2021).
  • Adamski P , BuszkoK, SikoraJet al. Metabolism of ticagrelor in patients with acute coronary syndromes. Sci. Rep.8(1), 11746 (2018).
  • Dobesh PP , OestreichJH. Ticagrelor: pharmacokinetics, pharmacodynamics, clinical efficacy, and safety. Pharmacotherapy34(10), 1077–1090 (2014).
  • Bates ER , LauWC, AngiolilloDJ. Clopidogrel–drug interactions. J. Am. Coll. Cardiol.57(11), 1251–1263 (2011).
  • Wang ZY , ChenM, ZhuLLet al. Pharmacokinetic drug interactions with clopidogrel: updated review and risk management in combination therapy. Ther. Clin. Risk Manag.11, 449–467 (2015).
  • Wiviott SD , AntmanEM. Clopidogrel resistance: a new chapter in a fast-moving story. Circulation109(25), 3064–3067 (2004).
  • Matetzky S , ShenkmanB, GuettaVet al. Clopidogrel resistance is associated with increased risk of recurrent atherothrombotic events in patients with acute myocardial infarction. Circulation109(25), 3171–3175 (2004).
  • De Miguel A , IbanezB, BadimónJJ. Clinical implications of clopidogrel resistance. Thromb. Haemost.100(2), 196–203 (2008).
  • van Werkum JW , HarmszeAM, ElsenbergEHAM, BoumanHJ, ten BergJM, HackengCM. The use of the VerifyNow system to monitor antiplatelet therapy: a review of the current evidence. Platelets19(7), 479–488 (2008).
  • Jeong YH , BlidenKP, AntoninoMJ, ParkKS, TantryUS, GurbelPA. Usefulness of the VerifyNow P2Y12 assay to evaluate the antiplatelet effects of ticagrelor and clopidogrel therapies. Am. Heart J.164(1), 35–42 (2012).
  • Kim YG , SuhJW, ParkJJet al. Different influences of hematocrit on the results of two point-of-care platelet function tests, the VerifyNow assay and multiple electrode platelet aggregometry. PLOS ONE9(11), e114053 (2014).
  • Kakouros N , KicklerTS, LawsKM, RadeJJ. Hematocrit alters VerifyNow P2Y12 assay results independently of intrinsic platelet reactivity and clopidogrel responsiveness. J. Thromb. Haemost.11(10), 1814–1822 (2013).
  • Danielak D , KomosaA, TomczakAet al. Determinants of high on-treatment platelet reactivity and agreement between VerifyNow and Multiplate assays. Scand. J. Clin. Lab. Invest.77(3), 190–198 (2017).
  • Yazji K , AbdulF, ElangovanSet al. Baseline anemia in patients undergoing percutaneous coronary intervention after an acute coronary syndrome-A paradox of high bleeding risk, high ischemic risk, and complex coronary disease. J. Interv. Cardiol.30(5), 491–499 (2017).
  • Gragnano F , MehranR, BrancaMet al. P2Y12 inhibitor monotherapy or dual antiplatelet therapy after complex percutaneous coronary interventions. J. Am. Coll. Cardiol.81(6), 537–552 (2023).
  • Brilinta™ (ticagrelor) Tablets: A P2Y(12) platelet inhibitor indicated to reduce the rate of thrombotic cardiovascular events in patients with acute coronary syndrome (ACS). PT37(4 section 2), 4–18 (2012). https://pubmed.ncbi.nlm.nih.gov/22605912/

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.