Decreasing Antibiotic use through a Joint Intervention Targeting Physicians and Pharmacists

References

• WHOM. Antimicrobial Resistance: Global Report On Surveillance (2014). www.who.int/drugresistance/documents/surveillancereport/en/.
   Google Scholar
• Goossens H. Antibiotic consumption and link to resistance. Clin. Microbiol. Infect. 15, 12 – 15 (2009).
   PubMed Web of Science ®Google Scholar
• Goossens H, Ferech M, Coenen S, Stephens P. Comparison of outpatient systemic antibacterial use in 2004 in the United States and 27 European countries. Clin. Infect. Dis. 44 (8 ), 1091 – 1095 (2007).
   PubMed Web of Science ®Google Scholar
• Goossens H, Ferech M, Vander Stichele R, Elseviers M, Group EP. Outpatient antibiotic use in Europe and association with resistance: a cross-national database study. Lancet 365 (9459 ), 579 – 587 (2005).
   PubMed Web of Science ®Google Scholar
• Bell BG, Schellevis F, Stobberingh E, Goossens H, Pringle M. A systematic review and meta-analysis of the effects of antibiotic consumption on antibiotic resistance. BMC Infect. Dis. 14 (1 ), 13 (2014).
   PubMed Web of Science ®Google Scholar
• Costelloe C, Metcalfe C, Lovering A, Mant D, Hay AD. Effect of antibiotic prescribing in primary care on antimicrobial resistance in individual patients: systematic review and meta-analysis. BMJ 340, c2096 (2010).
   PubMed Web of Science ®Google Scholar
• Eliopoulos GM, Cosgrove SE, Carmeli Y. The impact of antimicrobial resistance on health and economic outcomes. Clin. Infect. Dis. 36 (11 ), 1433 – 1437 (2003).
   PubMed Web of Science ®Google Scholar
• Howard DH, Scott RD. The economic burden of drug resistance. Clin. Infect. Dis. 41 (Suppl. 4 ), S283 – S286 (2005).
   PubMedGoogle Scholar
• McGowan JE Jr. Economic impact of antimicrobial resistance. Emerg. Infect. Dis. 7 (2 ), 286 (2001).
   PubMed Web of Science ®Google Scholar
• ECDC/EMEA Joint Working Group. Technical Report – The Bacterial Challenge: Time To React. Stockholm, Sweden (2009). http://ecdc.europa.eu/en/publications/Publications/0909_TER_The_Bacterial_Challe nge_Time_to_React.pdf.
   Google Scholar
• European Centre for Disease Prevention And Control. Summary of latest data on antibiotic resistance in the EU. Antimicrobial Resistance Surveillance Network (EARS-Net) (2014). http://ecdc.europa.eu/en/publications/Documents/antibiotic-resistance-in-EU-summary.pdf.
   Google Scholar
• European Centre for Disease Prevention and Control. Antimicrobial resistance surveillance in Europe 2013. Annual Report Of The European Antimicrobial Resistance Surveillance Network (EARS-Net). Stockholm, Sweden (2014). http://ecdc.europa.eu/en/publications/Publications/antimicrobial-resistance-surveillance-europe-2013.pdf.
   Google Scholar
• Morgan DJ, Okeke IN, Laxminarayan R, Perencevich EN, Weisenberg S. nonprescription antimicrobial use worldwide: a systematic review. Lancet Infect. Dis. 11 (9 ), 692 – 701 (2011).
   PubMed Web of Science ®Google Scholar
• Special Eurobarometer 407. Antimicrobial Resistance. Survey carried out by TNS Opinion & Social at the request of the Directorate-General for health and consumers. European Commission (2013). http://ec.europa.eu/health/antimicrobial_resistance/docs/ebs_407_en.pdf.
   Google Scholar
• Roque F, Herdeiro M, Soares S, Teixeira Rodrigues A, Breitenfeld L, Figueiras A. Educational interventions to improve prescription and dispensing of antibiotics: a systematic review. BMC Public Health 14 (1 ), 1276 (2014).
   PubMedGoogle Scholar
• Van der Velden AW, Pijpers EJ, Kuyvenhoven MM, Tonkin-Crine SK, Little P, Verheij TJ. Effectiveness of physician-targeted interventions to improve antibiotic use for respiratory tract infections. Br. J. Gen. Pract. 62 (605 ), e801 – e807 (2012).
   PubMed Web of Science ®Google Scholar
• Arnold SR, Straus SE, Arnold S. Interventions to improve antibiotic prescribing practices in ambulatory care. Cochrane Database Syst. Rev. 4 (4 ), CD003539 (2005).
   Google Scholar
• Roque F, Soares S, Breitenfeld L, Figueiras A, Herdeiro MT. Influence of community pharmacists’ attitudes on antibiotic dispensing behavior: a cross-sectional study in Portugal. Clin. Ther. 37 (1 ), 168 – 177 (2015).
   PubMed Web of Science ®Google Scholar
• Roque F, Soares S, Breitenfeld L, López-Durán A, Figueiras A, Herdeiro MT. Attitudes of community pharmacists to antibiotic dispensing and microbial resistance: a qualitative study in Portugal. Int. J. Clin. Pharm. 35 (3 ), 417 – 424 (2013).
   PubMed Web of Science ®Google Scholar
• Vazquez-Lago JM, Lopez-Vazquez P, López-Durán A, Taracido-Trunk M, Figueiras A. Attitudes of primary care physicians to the prescribing of antibiotics and antimicrobial resistance: a qualitative study from Spain. Fam. Pract. 29 (3 ), 352 – 360 (2011).
   PubMed Web of Science ®Google Scholar
• Huttner B, Goossens H, Verheij T, Harbarth S. Characteristics and outcomes of public campaigns aimed at improving the use of antibiotics in outpatients in high-income countries. Lancet Infect. Dis. 10 (1 ), 17 – 31 (2010).
   PubMed Web of Science ®Google Scholar
• WHO Collaborating Centre for Drug Statistics Methodology. Anatomical Therapeutic Chemical (ATC) Classification System. Guidelines for ATC Classification and DDD Assignment (2011). http://www.whocc.no/filearchive/publications/2011guidelines.pdf.
   Google Scholar
• Bruyndonckx R, Hens N, Aerts M, Goossens H, Molenberghs G, Coenen S. Measuring trends of outpatient antibiotic use in Europe: jointly modelling longitudinal data in defined daily doses and packages. J. Antimicrob. Chemother. 69 (7 ), 1981 – 1986 (2014).
   PubMed Web of Science ®Google Scholar
• Bruyndonckx R, Hens N, Aerts M, Goossens H, Abrahantes JC, Coenen S. Exploring the association between resistance and outpatient antibiotic use expressed as DDDs or packages. J. Antimicrob. Chemother. 70 (4 ), 1241 – 1244 (2015).
   PubMed Web of Science ®Google Scholar
• Coenen S, Gielen B, Blommaert A, Beutels P, Hens N, Goossens H. Appropriate international measures for outpatient antibiotic prescribing and consumption: recommendations from a national data comparison of different measures. J. Antimicrob. Chemother. 69 (2 ), 529 – 534 (2014).
   PubMed Web of Science ®Google Scholar
• Bates DM. lme4: Mixed-Effects Modeling With R. Springer, NY, USA (2010).
   Google Scholar
• The R Project For Statistical Computing. www.r-project.org.
   Google Scholar
• Bates DM, Bolker B, Walker S. lme4: linear mixed-effects models using Eigen and S4. R package version 1.1–7 (2014). http://CRAN.R-project.org/package=lme4.
   Google Scholar
• Kuznetsova AB. lmerTest: tests for random and fixed effects for linear mixed effect models (lmer objects of lme4 package). R package version 2.0–11 (2014). http://CRAN.R-project.org/package=lmerTest.
   Google Scholar
• Altiner A, Brockmann S, Sielk M, Wilm S, Wegscheider K, Abholz H-H. Reducing antibiotic prescriptions for acute cough by motivating GPs to change their attitudes to communication and empowering patients: a cluster-randomized intervention study. J. Antimicrob. Chemother. 60 (3 ), 638 – 44 (2007).
   PubMed Web of Science ®Google Scholar
• Greene RA, Beckman H, Chamberlain J et al. Increasing adherence to a community-based guideline for acute sinusitis through education, physician profiling, and financial incentives. Am. J. Manag. Care 10 (10 ), 670 – 678 (2004).
   PubMed Web of Science ®Google Scholar
• Coenen S, Van Royen P, Michiels B, Denekens J. Optimizing antibiotic prescribing for acute cough in general practice: a cluster-randomized controlled trial. J. Antimicrob. Chemother. 54 (3 ), 661 – 672 (2004).
   PubMed Web of Science ®Google Scholar
• Teng CL, Achike FI, Phua KL et al. Modifying antibiotic prescribing: the effectiveness of academic detailing plus information leaflet in a Malaysian primary care setting. Med. J. Malaysia 61 (3 ), 323 – 331 (2006).
   PubMedGoogle Scholar
• Meeker D, Knight TK, Friedberg MW et al. Nudging guideline-concordant antibiotic prescribing: a randomized clinical trial. JAMA Intern. Med. 174 (3 ), 425 – 431 (2014).
   PubMed Web of Science ®Google Scholar
• Butler CC, Simpson SA, Dunstan F et al. Effectiveness of multifaceted educational programme to reduce antibiotic dispensing in primary care: practice based randomized controlled trial. BMJ 344, d8173 (2012).
   PubMed Web of Science ®Google Scholar
• Colomina Rodríguez J, Domínguez Márquez V, Gimeno Vilarrasa F, Sarrió Montes G, Guerrero Espejo A. Impacto de un modelo integrado para el uso racional de antimicrobianos (proyecto MIURA) en un área de salud. Rev. Esp. Salud Publica 84 (3 ), 281 – 291 (2010).
   PubMedGoogle Scholar
• McKay RM, Vrbova L, Fuertes E et al. Evaluation of the Do Bugs Need Drugs? Program in British Columbia: can we curb antibiotic prescribing? Can J. Infect. Dis. Med. Microbiol. 22 (1 ), 19 (2011).
   PubMed Web of Science ®Google Scholar
• Sabuncu E, David J, Bernède-Bauduin C et al. Significant reduction of antibiotic use in the community after a nationwide campaign in France, 2002–2007. PLoS Med. 6 (6 ), 622 (2009).
   Web of Science ®Google Scholar
• Francis NA, Gillespie D, Nuttall J et al. Antibiotics for acute cough: an international observational study of patient adherence in primary care. Br. J. Gen. Pract. 62 (599 ), e429 – e437 (2012).
   PubMed Web of Science ®Google Scholar
• European Centre for Disease Prevention and Control (ECDC). Antimicrobial consumption interactive database: ESAC-Net > Data Source overview of antimicrobial consumption. http://ecdc.europa.eu/en/healthtopics/antimicrobial_resistance/esac-net-database/pages/overview-consumption.aspx.
   Google Scholar