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Review

The Gut Microbiota and its Potential Role in Obesity

, &
Pages 589-603 | Received 16 Aug 2017, Accepted 01 Dec 2017, Published online: 13 Mar 2018

References

  • Ng M , FlemingT, RobinsonMet al. Global, regional, and national prevalence of overweight and obesity in children and adults during 1980–2013: a systematic analysis for the global burden of disease study 2013. Lancet384 (9945), 766–781 (2014).
  • Romieu I , DossusL, BarqueraSet al. Energy balance and obesity: what are the main drivers? Cancer Causes Control 28 (3), 247–258 (2017).
  • Singh RK , KumarP, MahalingamK . Molecular genetics of human obesity: a comprehensive review. CR Biol.340 (2), 87–108 (2017).
  • Everard A , LazarevicV, GaïaNet al. Microbiome of prebiotic-treated mice reveals novel targets involved in host response during obesity. ISME J.8 (10), 2116–2130 (2014).
  • Aagaard K , MaJ, AntonyKM, GanuR, PetrosinoJ, VersalovicJ . The placenta harbors a unique microbiome. Sci. Transl. Med.6 (237), 237ra265–237ra265 (2014).
  • Nicholson JK , HolmesE, KinrossJet al. Host–gut microbiota metabolic interactions. Science336 (6086), 1262–1267 (2012).
  • Dominguez-Bello MG , CostelloEK, ContrerasMet al. Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns. Proc. Natl Acad. Sci. USA107 (26), 11971–11975 (2010).
  • Von Mutius E . The shape of the microbiome in early life. Nat. Med.23 (3), 274–275 (2017).
  • Turroni F , PeanoC, PassDAet al. Diversity of bifidobacteria within the infant gut microbiota. PLoS ONE7 (5), e36957 (2012).
  • Morelli L . Postnatal development of intestinal microflora as influenced by infant nutrition. J. Nutr.138 (9), 1791S–1795S (2008).
  • Penders J , ThijsC, VinkCet al. Factors influencing the composition of the intestinal microbiota in early infancy. Pediatrics118 (2), 511–521 (2006).
  • Ley RE , PetersonDA, GordonJI . Ecological and evolutionary forces shaping microbial diversity in the human intestine. Cell124 (4), 837–848 (2006).
  • Goodrich JK , WatersJL, PooleACet al. Human genetics shape the gut microbiome. Cell159 (4), 789–799 (2014).
  • Turnbaugh PJ , RidauraVK, FaithJJ, ReyFE, KnightR, GordonJI . The effect of diet on the human gut microbiome: a metagenomic analysis in humanized gnotobiotic mice. Sci. Transl. Med.1 (6), 6ra14–16ra14 (2009).
  • Carmody RN , GerberGK, LuevanoJMet al. Diet dominates host genotype in shaping the murine gut microbiota. Cell Host Microbe.17 (1), 72–84 (2015).
  • David LA , MauriceCF, CarmodyRNet al. Diet rapidly and reproducibly alters the human gut microbiome. Nature505 (7484), 559–563 (2014).
  • Lozupone CA , StombaughJI, GordonJI, JanssonJK, KnightR . Diversity, stability and resilience of the human gut microbiota. Nature489 (7415), 220–230 (2012).
  • Claesson MJ , O'sullivanO, WangQet al. Comparative analysis of pyrosequencing and a phylogenetic microarray for exploring microbial community structures in the human distal intestine. PLoS ONE4 (8), e6669 (2009).
  • Eckburg PB , BikEM, BernsteinCNet al. Diversity of the human intestinal microbial flora. Science308 (5728), 1635–1638 (2005).
  • Turnbaugh PJ , HamadyM, YatsunenkoTet al. A core gut microbiome in obese and lean twins. Nature457 (7228), 480–484 (2009).
  • Gérard P . Le microbiote intestinal: composition et fonctions. Phytothérapie9 (2), 72–75 (2011).
  • Hooper LV , GordonJI . Commensal host–bacterial relationships in the gut. Science292 (5519), 1115–1118 (2001).
  • Kim M-S , ParkE-J, RohSW, BaeJ-W . Diversity and abundance of single-stranded DNA viruses in human feces. Appl. Environ. Microbiol.77 (22), 8062–8070 (2011).
  • Rossen NG , BartA, VerhaarNet al. Low prevalence of Blastocystis sp. in active ulcerative colitis patients. Eur. J. Clin. Microbiol. Infect. Dis.34 (5), 1039–1044 (2015).
  • Kumamoto CA . Inflammation and gastrointestinal Candida colonization. Curr. Opin. Microbiol.14 (4), 386–391 (2011).
  • Frank DN , AmandALS, FeldmanRA, BoedekerEC, HarpazN, PaceNR . Molecular–phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases. Proc. Natl Acad. Sci. USA104 (34), 13780–13785 (2007).
  • Hsiao WW , Fraser-LiggettCM . Human Microbiome Project – paving the way to a better understanding of ourselves and our microbes. Drug Discov. Today14 (7), 331–333 (2009).
  • Clemente JC , UrsellLK, ParfreyLW, KnightR . The impact of the gut microbiota on human health: an integrative view. Cell148 (6), 1258–1270 (2012).
  • Wu GD , ChenJ, HoffmannCet al. Linking long-term dietary patterns with gut microbial enterotypes. Science334 (6052), 105–108 (2011).
  • De Moraes AC , FernandesGR, Da SilvaITet al. Enterotype may drive the dietary-associated cardiometabolic risk factors. Front. Cell Infect. Microbiol.7, 47 (2017).
  • Gérard P . Gut microbiota and obesity. Cell Mol. Life Sci.73 (1), 147–162 (2016).
  • Vieira-Silva S , FalonyG, DarziYet al. Species–function relationships shape ecological properties of the human gut microbiome. Nat. Microbiol.1, 16088 (2016).
  • Sekirov I , RussellSL, AntunesLCM, FinlayBB . Gut microbiota in health and disease. Physiol. Rev.90 (3), 859–904 (2010).
  • Adlerberth I , WoldAE . Establishment of the gut microbiota in western infants. Acta Paediatr.98 (2), 229–238 (2009).
  • Blaut M , CollinsM, WellingG, DoreJ, Van LooJ, De VosW . Molecular biological methods for studying the gut microbiota: the EU human gut flora project. Br. J. Nutr.87 (S2), S203–S211 (2002).
  • Mccartney AL . Application of molecular biological methods for studying probiotics and the gut flora. Br. J. Nutr.88 (S1), s29–s37 (2002).
  • Peter H , SommarugaR . An evaluation of methods to study the gut bacterial community composition of freshwater zooplankton. J. Plankton Res.30 (9), 997–1006 (2008).
  • Gong J , YangC . Advances in the methods for studying gut microbiota and their relevance to the research of dietary fiber functions. Food Res. Int.48 (2), 916–929 (2012).
  • Dumont MG , MurrellJC . Stable isotope probing – linking microbial identity to function. Nat. Rev. Microbiol.3 (6), 499–504 (2005).
  • Gill SR , PopM, DeboyRTet al. Metagenomic analysis of the human distal gut microbiome. Science312 (5778), 1355–1359 (2006).
  • Wang Z , GersteinM, SnyderM . RNA-Seq: a revolutionary tool for transcriptomics. Nat. Rev. Genet.10 (1), 57–63 (2009).
  • Zoetendal E , Rajilić-StojanovićM, De VosW . High-throughput diversity and functionality analysis of the gastrointestinal tract microbiota. Gut57 (11), 1605–1615 (2008).
  • Yap IK , LiJV, SaricJet al. Metabonomic and microbiological analysis of the dynamic effect of vancomycin-induced gut microbiota modification in the mouse. J. Proteome Res.7 (9), 3718–3728 (2008).
  • Lagier J-C , KhelaifiaS, AlouMTet al. Culture of previously uncultured members of the human gut microbiota by culturomics. Nat. Microbiol.1, 16203 (2016).
  • Mahowald MA , ReyFE, SeedorfHet al. Characterizing a model human gut microbiota composed of members of its two dominant bacterial phyla. Proc. Natl Acad. Sci. USA106 (14), 5859–5864 (2009).
  • Naseer MI , BibiF, AlqahtaniMHet al. Role of gut microbiota in obesity, Type 2 diabetes and Alzheimer's disease. CNS Neurol. Disord. Drug Targets13 (2), 305–311 (2014).
  • Pérez LM , Pareja-GaleanoH, Sanchis-GomarF, EmanueleE, LuciaA, GálvezBG . ‘Adipaging’: ageing and obesity share biological hallmarks related to a dysfunctional adipose tissue. J. Physiol.594 (12), 3187–3207 (2016).
  • Wostmann BS , LarkinC, MoriartyA, Bruckner-KardossE . Dietary intake, energy metabolism, and excretory losses of adult male germfree Wistar rats. J. Am. Assoc. Lab Anim. Sci.33 (1), 46–50 (1983).
  • Bäckhed F , DingH, WangTet al. The gut microbiota as an environmental factor that regulates fat storage. Proc. Natl Acad. Sci. USA101 (44), 15718–15723 (2004).
  • Ravussin Y , KorenO, SporAet al. Responses of gut microbiota to diet composition and weight loss in lean and obese mice. Obesity20 (4), 738–747 (2012).
  • Bäckhed F , ManchesterJK, SemenkovichCF, GordonJI . Mechanisms underlying the resistance to diet-induced obesity in germ-free mice. Proc. Natl Acad. Sci. USA104 (3), 979–984 (2007).
  • Turnbaugh PJ , LeyRE, MahowaldMA, MagriniV, MardisER, GordonJI . An obesity-associated gut microbiome with increased capacity for energy harvest. Nature444 (7122), 1027–1131 (2006).
  • Swartz TD , SakarY, DucaFA, CovasaM . Preserved adiposity in the Fischer 344 rat devoid of gut microbiota. FASEB J.27 (4), 1701–1710 (2013).
  • Ridaura VK , FaithJJ, ReyFEet al. Gut microbiota from twins discordant for obesity modulate metabolism in mice. Science341 (6150), 1241214 (2013).
  • Duca FA , SakarY, LepagePet al. Replication of obesity and associated signaling pathways through transfer of microbiota from obese prone rat. Diabetes DB_131526 (2014).
  • Nguyen TLA , Vieira-SilvaS, ListonA, RaesJ . How informative is the mouse for human gut microbiota research?Disease Models Mech.8 (1), 1–16 (2015).
  • Ley RE , BäckhedF, TurnbaughP, LozuponeCA, KnightRD, GordonJI . Obesity alters gut microbial ecology. Proc. Natl Acad. Sci. USA102 (31), 11070–11075 (2005).
  • Ley RE , TurnbaughPJ, KleinS, GordonJI . Microbial ecology: human gut microbes associated with obesity. Nature444 (7122), 1022–1023 (2006).
  • Armougom F , HenryM, VialettesB, RaccahD, RaoultD . Monitoring bacterial community of human gut microbiota reveals an increase in Lactobacillus in obese patients and Methanogens in anorexic patients. PLoS ONE4 (9), e7125 (2009).
  • Angelakis E , ArmougomF, MillionM, RaoultD . The relationship between gut microbiota and weight gain in humans. Future Microbiol.7 (1), 91–109 (2012).
  • Kalliomäki M , ColladoMC, SalminenS, IsolauriE . Early differences in fecal microbiota composition in children may predict overweight. Am. J. Clin. Nut.87 (3), 534–538 (2008).
  • Collado MC , IsolauriE, LaitinenK, SalminenS . Distinct composition of gut microbiota during pregnancy in overweight and normal-weight women. Am. J. Clin. Nut.88 (4), 894–899 (2008).
  • Million M , MaraninchiM, HenryMet al. Obesity-associated gut microbiota is enriched in Lactobacillus reuteri and depleted in Bifidobacterium animalis and Methanobrevibacter smithii. Int. J. Obes.36 (6), 817 (2012).
  • Million M , AngelakisE, MaraninchiMet al. Correlation between body mass index and gut concentrations of Lactobacillus reuteri, Bifidobacterium animalis, Methanobrevibacter smithii and Escherichia coli. Int. J. Obes.37 (11), 1460 (2013).
  • Million M , ThunyF, AngelakisEet al. Lactobacillus reuteri and Escherichia coli in the human gut microbiota may predict weight gain associated with vancomycin treatment. Nutr. Diabetes3 (9), e87 (2013).
  • Beaumont M . Genetic and environmental factors affecting the human gut microbiom in obesity. Front. Microbiol. doi:10.3389/fmicb.2016.01357 (2016) ( Epub ahead of print ).
  • Zhang H , DibaiseJK, ZuccoloAet al. Human gut microbiota in obesity and after gastric bypass. Proc. Natl Acad. Sci. USA106 (7), 2365–2370 (2009).
  • Torres-Fuentes C , SchellekensH, DinanTG, CryanJF . The microbiota–gut–brain axis in obesity. Lancet Gastroenterol. Hepatol.2 (10), 747–756 (2017).
  • Dibaise JK , FrankDN, MathurR . Impact of the gut microbiota on the development of obesity: current concepts. Am. J. Clin. Nut. Suppl.1 (1), 22–27 (2012).
  • Shabana , HasnainS . The p.N103K mutation of leptin (LEP) gene and severe early onset obesity in Pakistan. Biol. Res.49 (1), 23 (2016).
  • Schéle E , GrahnemoL, AnestenF, HallénA, BäckhedF, JanssonJ-O . The gut microbiota reduces leptin sensitivity and the expression of the obesity-suppressing neuropeptides proglucagon (Gcg) and brain-derived neurotrophic factor (BDNF) in the central nervous system. Endocrinology154 (10), 3643–3651 (2013).
  • Rosenbaum M , KnightR, LeibelRL . The gut microbiota in human energy homeostasis and obesity. Trends Endocrinol. Metab.26 (9), 493–501 (2015).
  • Marchesi JR , AdamsDH, FavaFet al. The gut microbiota and host health: a new clinical frontier. Gut65 (2), 330–339 (2016).
  • Rooks MG , GarrettWS . Gut microbiota, metabolites and host immunity. Nat. Rev. Immunol.16 (6), 341–352 (2016).
  • Lin HV , FrassettoAKowalikEJJret al. Butyrate and propionate protect against diet-induced obesity and regulate gut hormones via free fatty acid receptor 3-independent mechanisms. PLoS ONE7 (4), e35240 (2012).
  • Lupp C , SkipperM, WeissU . Gut microbes and health. Nature489 (7415), 219–219 (2012).
  • Hara T , IchimuraA, HirasawaA . Therapeutic role and ligands of medium-to long-chain fatty acid receptors. Front. Endocrinol.5, 83 (2014).
  • Santacruz A , ColladoMDC, Garcia-ValdesLet al. Gut microbiota composition is associated with body weight, weight gain and biochemical parameters in pregnant women. Br. J. Nutr.104 (1), 83 (2010).
  • Duncan SH , LobleyG, HoltropGet al. Human colonic microbiota associated with diet, obesity and weight loss. Int. J. Obes.32 (11), 1720–1724 (2008).
  • Schwiertz A , TarasD, SchäferKet al. Microbiota and SCFA in lean and overweight healthy subjects. Obesity18 (1), 190–195 (2010).
  • Yin Y-N , YuQ-F, FuN, LiuX-W, LuF-G . Effects of four Bifidobacteria on obesity in high-fat diet induced rats. World J. Gastroenterol.16 (27), 3394–3401 (2010).
  • Kozyrskyj A , KaluR, KolevaP, BridgmanS . Fetal programming of overweight through the microbiome: boys are disproportionately affected. J. Dev. Orig. Health Dis.7 (01), 25–34 (2016).
  • Furet J-P , KongL-C, TapJet al. Differential adaptation of human gut microbiota to bariatric surgery-induced weight loss links with metabolic and low-grade inflammation markers. Diabetes59 (12), 3049–3057 (2010).
  • Greenblum S , TurnbaughPJ, BorensteinE . Metagenomic systems biology of the human gut microbiome reveals topological shifts associated with obesity and inflammatory bowel disease. Proc. Natl Acad. Sci. USA109 (2), 594–599 (2012).
  • Le Chatelier E , NielsenT, QinJet al. Richness of human gut microbiome correlates with metabolic markers. Nature500 (7464), 541–546 (2013).
  • Cotillard A , KennedySP, KongLCet al. Dietary intervention impact on gut microbial gene richness. Nature500 (7464), 585–588 (2013).
  • Moreno-Indias I , CardonaF, TinahonesFJ, Queipo-OrtuñoMI . Impact of the gut microbiota on the development of obesity and Type 2 diabetes mellitus. Front Microbiol.5, 190 (2015).
  • Trehan I , GoldbachHS, LagroneLNet al. Antibiotics as part of the management of severe acute malnutrition. N. Engl. J. Med.368 (5), 425–435 (2013).
  • Thuny F , RichetH, CasaltaJ-P, AngelakisE, HabibG, RaoultD . Vancomycin treatment of infective endocarditis is linked with recently acquired obesity. PLoS ONE5 (2), e9074 (2010).
  • Brugman S , KlatterF, VisserJet al. Antibiotic treatment partially protects against Type 1 diabetes in the bio-breeding diabetes-prone rat. Is the gut flora involved in the development of Type 1 diabetes? Diabetologia 49 (9), 2105–2108 (2006).
  • Hernández E , BargielaR, DiezMSet al. Functional consequences of microbial shifts in the human gastrointestinal tract linked to antibiotic treatment and obesity. Gut Microbes4 (4), 306–315 (2013).
  • Moya-Pérez A , NeefA, SanzY . Bifidobacterium pseudocatenulatum CECT 7765 reduces obesity-associated inflammation by restoring the lymphocyte–macrophage balance and gut microbiota structure in high-fat diet-fed mice. PLoS ONE10 (7), e0126976 (2015).
  • Okubo T , TakemuraN, YoshidaA, SonoyamaK . KK/Ta mice administered Lactobacillus plantarum strain no. 14 have lower adiposity and higher insulin sensitivity. Biosci. Microbiota Food Health32 (3), 93 (2013).
  • Million M , AngelakisE, PaulM, ArmougomF, LeiboviciL, RaoultD . Comparative meta-analysis of the effect of Lactobacillus species on weight gain in humans and animals. Microb. Pathog.53 (2), 100–108 (2012).
  • Parnell JA , ReimerRA . Prebiotic fibres dose-dependently increase satiety hormones and alter Bacteroidetes and Firmicutes in lean and obese JCR: LA-cp rats. Br. J. Nutr.107 (04), 601–613 (2012).
  • Cani PD , NeyrinckAM, MatonN, DelzenneNM . Oligofructose promotes satiety in rats fed a high-fat diet: involvement of glucagon-like peptide-1. Obes. Res.13 (6), 1000–1007 (2005).
  • Neyrinck AM , PossemiersS, DruartCet al. Prebiotic effects of wheat arabinoxylan related to the increase in bifidobacteria, Roseburia and Bacteroides/Prevotella in diet-induced obese mice. PLoS ONE6 (6), e20944 (2011).
  • Kellow NJ , CoughlanMT, ReidCM . Metabolic benefits of dietary prebiotics in human subjects: a systematic review of randomised controlled trials. Br. J. Nutr.111 (07), 1147–1161 (2014).
  • Cavallari JF , FullertonMD, DugganBMet al. Muramyl dipeptide-based postbiotics mitigate obesity-induced insulin resistance via IRF4. Cell Metabol.25 (5), 1063–1074 (2017).
  • Woodard GA , EncarnacionB, DowneyJRet al. Probiotics improve outcomes after Roux-en-Y gastric bypass surgery: a prospective randomized trial. J. Gastrointest. Surg.13 (7), 1198–1204 (2009).
  • Aroniadis OC , BrandtLJ . Fecal microbiota transplantation: past, present and future. Curr. Opin. Gastroenterol.29 (1), 79–84 (2013).
  • Eiseman B , SilenW, BascomG, KauvarA . Fecal enema as an adjunct in the treatment of pseudomembranous enterocolitis. Surgery44 (5), 854–859 (1958).
  • Kassam Z , LeeCH, YuanY, HuntRH . Fecal microbiota transplantation for Clostridium difficile infection: systematic review and meta-analysis. Am. J. Clin. Nut.108 (4), 500–508 (2013).
  • Vrieze A , Van NoodE, HollemanFet al. Transfer of intestinal microbiota from lean donors increases insulin sensitivity in individuals with metabolic syndrome. Gastroenterology143 (4), 913–916 (2012).

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