167
Views
0
CrossRef citations to date
0
Altmetric
Editorial

Multidrug-Resistant Neisseria Gonorrhoeae: Future Therapeutic Options

Pages 499-501 | Received 01 Nov 2017, Accepted 02 Nov 2017, Published online: 08 Mar 2018

References

  • Centers for Disease Control and Prevention. Antibiotic resistance threats in the United States, 2013. US Department of Health and Human Services (Eds.) . 1–114 (2013)
  • Goire N , SpeersDJ, LahraMM, WhileyDM . Neisseria gonorrhoeae: The pathogen, diagnosis, and antimicrobial resistance. In:Human Emerging and Re-emerging Infections, Volume 1.SinghSK( Ed. ). John Wiley & Sons, Inc., NJ, USA, 683–697 (2015).
  • Wi T , LahraMM, NdowaFet al. Antimicrobial resistance in Neisseria gonorrhoeae: global surveillance and a call for international collaborative action. PLoS Med.14, e1002344 (2017).
  • Fifer H , NatarajanU, JonesLet al. Failure of dual antimicrobial therapy in treatment of gonorrhea. N. Engl. J. Med.374, 2504–2506 (2016).
  • Goire N , LahraMM, ChenMet al. Molecular approaches to enhance surveillance of gonococcal antimicrobial resistance. Nat. Rev. Microbiol.12, 223–229 (2014).
  • Brook G . The performance of non-NAAT point-of-care (POC) tests and rapid NAAT tests for chlamydia and gonorrhoea infections. An assessment of currently available assays. Sex. Transm. Infect.91, 539–544 (2015).
  • Balashov S , MordechaiE, AdelsonME, GygaxSE . Multiplex bead suspension array for screening Neisseria gonorrhoeae antibiotic resistance genetic determinants in noncultured clinical samples. J. Mol. Diagn.15, 116–129 (2013).
  • Chow EPF , WalkerS, HockingJSet al. A multicentre double-blind randomised controlled trial evaluating the efficacy of daily use of antibacterial mouthwash against oropharyngeal gonorrhoea among men who have sex with men: the OMEGA (oral mouthwash use to eradicate gonorrhoea) study protocol. BMC Infect. Dis.17, 456 (2017).
  • Lewis DA . Global resistance of Neisseria gonorrhoeae: when theory becomes reality. Curr. Opin. Infect. Dis.27, 62–67 (2014).
  • Dickey SW , CheungGYC, OttoM . Different drugs for bad bugs: antivirulence strategies in the age of antibiotic resistance. Nat. Rev. Drug Discov.16, 457–471 (2017).
  • Golparian D , ShaferWM, OhnishiM, UnemoM . Importance of multidrug efflux pumps in the antimicrobial resistance property of clinical multidrug-resistant isolates of Neisseria gonorrhoeae. Antimicrob. Agents Chemother.58, 3556–3559 (2014).
  • Radchenko M , SymerskyJ, NieR, LuM . Structural basis for the blockade of MATE multidrug efflux pumps. Nat. Commun.6, 7995 (2015).
  • Criss AK , SeifertHS . A bacterial siren song: intimate interactions between Neisseria and neutrophils. Nat. Rev. Microbiol.10, 178–190 (2012).
  • Anandan A , EvansGL, Condic-JurkicKet al. Structure of a lipid A phosphoethanolamine transferase suggests how conformational changes govern substrate binding. Proc. Natl Acad. Sci. USA114, 2218–2223 (2017).
  • Handing JW , CrissAK . The lipooligosaccharide-modifying enzyme LptA enhances gonococcal defence against human neutrophils. Cell Microbiol.17, 910–921 (2015).
  • Reimer A , SeufertF, WeiwadMet al. Inhibitors of macrophage infectivity potentiator-like PPIases affect neisserial and chlamydial pathogenicity. Int. J. Antimicrob. Agents48, 401–408 (2016).
  • Gottlieb SL , DealCD, GiersingBet al. The global roadmap for advancing development of vaccines against sexually transmitted infections: update and next steps. Vaccine34, 2939–2947 (2016).
  • Edwards JL , JenningsMP, ApicellaMA, SeibKL . Is gonococcal disease preventable? The importance of understanding immunity and pathogenesis in vaccine development. Crit. Rev. Microbiol.42, 928–941 (2016).
  • Petousis-Harris H , PaynterJ, MorganJet al. Effectiveness of a group B outer membrane vesicle meningococcal vaccine against gonorrhoea in New Zealand: a retrospective case-control study. Lancet390, 1603–1610 (2017).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.