Panb Over-Representation as Part of Pyrazinamide Action: A Proteomic Insight

References

• World Health Organization . Global tuberculosis report (2019). www.who.int/teams/global-tuberculosis-programme/tb-reports
   Google Scholar
• Lanoix JP , BetoudjiF, NuermbergerE. Sterilizing activity of pyrazinamide in combination with first-line drugs in a C3HeB/FeJ mouse model of tuberculosis. Antimicrob. Agents Chemother.60(2), 1091–1096 (2016).
   PubMed Web of Science ®Google Scholar
• Scorpio A , ZhangY. Mutations in pncA, a gene encoding pyrazinamidase/nicotinamidase, cause resistance to the antituberculous drug pyrazinamide in tubercle bacillus. Nat. Med.2(6), 662–667 (1996).
   PubMed Web of Science ®Google Scholar
• Zhang Y , ScorpioA, NikaidoH, SunZ. Role of acid pH and deficient efflux of pyrazinoic acid in unique susceptibility of Mycobacterium tuberculosis to pyrazinamide. J. Bacteriol.181(7), 2044–2049 (1999).
   PubMed Web of Science ®Google Scholar
• Peterson ND , RosenBC, DillonNA, BaughnAD. Uncoupling environmental pH and intrabacterial acidification from pyrazinamide susceptibility in Mycobacterium tuberculosis. Antimicrob. Agents Chemother.59(12), 7320–7326 (2015).
   PubMed Web of Science ®Google Scholar
• Yeager RL , MunroeWGC, DessauFI. Pyrazinamide (aldinamide) in the treatment of pulmonary tuberculosis. Trans. Annu. Meet. Natl Tuberc. Assoc.48, 178–201 (1952).
   PubMedGoogle Scholar
• Campanerut-Sá PAZ , Ghiraldi-LopesLD, MeneguelloJEet al. Systematic review on the proteomic profile of Mycobacterium tuberculosis exposed to drugs. Proteomics Clin. Appl.201600077, 1–9 (2017).
   Google Scholar
• Baker ES , LiuT, PetyukVAet al. Translational proteomics: the importance of mass spectrometry-based approaches. Genome Med.4(63), 1–11 (2012).
   PubMedGoogle Scholar
• Campanerut PAZ , GhiraldiLD, SposittoFLEet al. Rapid detection of resistance to pyrazinamide in Mycobacterium tuberculosis using the resazurin microtitre assay. J. Antimicrob. Chemother.66(5), 1044–1046 (2011).
   PubMed Web of Science ®Google Scholar
• Meneguello JE , AritaGS, SilvaJV de Oet al. Insight about cell wall remodulation triggered by rifampicin in Mycobacterium tuberculosis. Tuberculosis (Edinb).120, 101903 (2020).
   PubMed Web of Science ®Google Scholar
• Chambers MC , MacleanB, BurkeRet al. A cross-platform toolkit for mass spectrometry and proteomics. Nat. Biotechnol.30, 918 (2012).
   PubMed Web of Science ®Google Scholar
• Perez-Riverol Y , CsordasA, BaiJet al. The PRIDE database and related tools and resources in 2019: improving support for quantification data. Nucleic Acids Res.47(D1), D442–D450 (2019).
   PubMed Web of Science ®Google Scholar
• Anthony RM , den HertogAL, van SoolingenD. ‘Happy the man, who, studying nature's laws, Thro'’ known effects can trace the secret cause.'† Do we have enough pieces to solve the pyrazinamide puzzle?’. J. Antimicrob. Chemother.73(7), 1750–1754 (2018).
   PubMed Web of Science ®Google Scholar
• Munshi T , GuptaA, EvangelopoulosDet al. Characterisation of ATP-dependent Mur ligases involved in the biogenesis of cell wall peptidoglycan in Mycobacterium tuberculosis. PLoS ONE8(3), e60143 (2013).
   PubMed Web of Science ®Google Scholar
• Yimer SA , BirhanuAG, KalayouSet al. Comparative proteomic analysis of Mycobacterium tuberculosis Lineage 7 and Lineage 4 strains reveals differentially abundant proteins linked to slow growth and virulence. Front. Microbiol.8, 1–14 (2017).
   PubMed Web of Science ®Google Scholar
• Brown L , WolfJM, Prados-RosalesR, CasadevallA. Through the wall: extracellular vesicles in Gram-positive bacteria, mycobacteria and fungi. Nat. Rev. Microbiol.13(10), 620–630 (2015).
   PubMed Web of Science ®Google Scholar
• Amir A , RanaK, AryaA, KapoorN, KumarH, SiddiquiMA. Mycobacterium tuberculosis H37Rv: in silico drug targets identification by metabolic pathways analysis. Int. J. Evol. Biol.2014, 284170 (2014).
   PubMedGoogle Scholar
• Boshoff HIM , MyersTG, CoppBR, McNeilMR, WilsonMA, BarryCE. The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. Novel insights into drug mechanisms of action. J. Biol. Chem.279(38), 40174–40184 (2004).
   PubMed Web of Science ®Google Scholar
• Sugantino M , ZhengR, YuM, BlanchardJS. Mycobacterium tuberculosis ketopantoate hydroxymethyltransferase: tetrahydrofolate-independent hydroxymethyltransferase and enolization reactions with α-keto acids. Biochemistry42(1), 191–199 (2003).
   PubMed Web of Science ®Google Scholar
• Zheng R , BlanchardJS. Steady-state and pre-steady-state kinetic analysis of Mycobacterium tuberculosis pantothenate synthetase. Biochemistry40(43), 12904–12912 (2001).
   PubMed Web of Science ®Google Scholar
• Shi W , ChenJ, FengJet al. Aspartate decarboxylase (PanD) as a new target of pyrazinamide in Mycobacterium tuberculosis. Emerg. Microbes Infect.3(8), e58 (2014).
   PubMedGoogle Scholar
• Sambandamurthy VK , WangX, ChenBet al. A pantothenate auxotroph of Mycobacterium tuberculosis is highly attenuated and protects mice against tuberculosis. Nat. Med.8(10), 1171–1174 (2002).
   PubMed Web of Science ®Google Scholar
• Gopal P , SarathyJP, YeeMet al. Pyrazinamide triggers degradation of its target aspartate decarboxylase. Nat. Commun.11(1), 1–10 (2020).
   PubMed Web of Science ®Google Scholar
• Xu Z , YinW, MartinelliLKet al. Reaction intermediate analogues as bisubstrate inhibitors of pantothenate synthetase. Bioorganic Med. Chem.22(5), 1726–1735 (2014).
   PubMed Web of Science ®Google Scholar
• White EL , SouthworthK, RossLet al. A novel inhibitor of Mycobacterium tuberculosis pantothenate synthetase. J. Biomol. Screen.12(1), 100–105 (2007).
   PubMed Web of Science ®Google Scholar
• Velaparthi S , BrunsteinerM, UddinR, WanB, FranzblauSG, PetukhovPA. 5-tert-butyl-N-pyrazol-4-yl-4, 5, 6,7-tetrahydrobenzo[d]isoxazole-3- carboxamide derivatives as novel potent inhibitors of Mycobacterium tuberculosis pantothenate synthetase: initiating a quest for new antitubercular drugs. J. Med. Chem.51(7), 1999–2002 (2008).
   PubMed Web of Science ®Google Scholar
• Evans JC , TrujilloC, WangZet al. Validation of CoaBC as a bactericidal target in the coenzyme a pathway of Mycobacterium tuberculosis. ACS Infect. Dis.2(12), 958–968 (2016).
   PubMed Web of Science ®Google Scholar
• Côté JP , FrenchS, GehrkeSSet al. The genome-wide interaction network of nutrient stress genes in Escherichia coli. MBio7(6), 1–12 (2016).
   Web of Science ®Google Scholar