Antibacterial activity of corydalis saxicola bunting total alkaloids against Porphyromonas gingivalis in vitro

References

• Lam GA, Albarrak H, Mccoll CJ et al. The oral-gut axis: periodontal diseases and gastrointestinal disorders. Inflamm. Bowel Dis. 29(7), 1153–1164 (2022).
   Web of Science ®Google Scholar
• Ximenez-Fyvie LA, Haffajee AD, Socransky SS. Comparison of the microbiota of supra- and subgingival plaque in health and periodontitis. J. Clin. Periodontol. 27(9), 648–657 (2000).
   PubMed Web of Science ®Google Scholar
• Huang R, Li M, Gregory RL. Bacterial interactions in dental biofilm. Virulence 2(5), 435–444 (2011).
   PubMed Web of Science ®Google Scholar
• Bui FQ, Almeida-Da-Silva CLC, Huynh B et al. Association between periodontal pathogens and systemic disease. Biomed. J. 42(1), 27–35 (2019).
   PubMed Web of Science ®Google Scholar
• Dominy SS, Lynch C, Ermini F et al. Porphyromonas gingivalis in Alzheimer's disease brains: evidence for disease causation and treatment with small-molecule inhibitors. Sci. Adv. 5(1), eaau3333 (2019).
   PubMed Web of Science ®Google Scholar
• Leira Y, Rodriguez-Yanez M, Arias S et al. Periodontitis is associated with systemic inflammation and vascular endothelial dysfunction in patients with lacunar infarct. J. Periodontol. 90(5), 465–474 (2019).
   PubMed Web of Science ®Google Scholar
• Hajishengallis G, Chavakis T. Local and systemic mechanisms linking periodontal disease and inflammatory comorbidities. Nat. Rev. Immunol. 21(7), 426–440 (2021).
   PubMed Web of Science ®Google Scholar
• Aleksijevic LH, Aleksijevic M, Skrlec I, Sram M, Sram M, Talapko J. Porphyromonas gingivalis virulence factors and clinical significance in periodontal disease and coronary artery diseases. Pathogens. 11(10), 1173 (2022).
   PubMed Web of Science ®Google Scholar
• Yongqing T, Potempa J, Pike RN, Wijeyewickrema LC. The lysine-specific gingipain of Porphyromonas gingivalis: importance to pathogenicity and potential strategies for inhibition. Adv. Exp. Med. Biol. 712, 15–29 (2011).
   PubMed Web of Science ®Google Scholar
• De Diego I, Veillard F, Sztukowska MN et al. Structure and mechanism of cysteine peptidase gingipain K (Kgp), a major virulence factor of Porphyromonas gingivalis in periodontitis. J. Biol. Chem. 289(46), 32291–32302 (2014).
   PubMed Web of Science ®Google Scholar
• Hocevar K, Potempa J, Turk B. Host cell-surface proteins as substrates of gingipains, the main proteases of Porphyromonas gingivalis. Biol. Chem. 399(12), 1353–1361 (2018).
   PubMed Web of Science ®Google Scholar
• Lepine G, Progulske-Fox A. Duplication and differential expression of hemagglutinin genes in Porphyromonas gingivalis. Oral Microbiol. Immunol. 11(2), 65–78 (1996).
   PubMedGoogle Scholar
• Belanger M, Kozarov E, Song H, Whitlock J, Progulske-Fox A. Both the unique and repeat regions of the Porphyromonas gingivalis hemagglutin A are involved in adhesion and invasion of host cells. Anaerobe 18(1), 128–134 (2012).
   PubMed Web of Science ®Google Scholar
• Lee SW, Hillman JD, Progulske-Fox A. The hemagglutinin genes hagB and hagC of Porphyromonas gingivalis are transcribed in vivo as shown by use of a new expression vector. Infect. Immun. 64(11), 4802–4810 (1996).
   PubMed Web of Science ®Google Scholar
• Cheng T, Lai YT, Wang C et al. Bismuth drugs tackle Porphyromonas gingivalis and attune cytokine response in human cells. Metallomics 11(7), 1207–1218 (2019).
   PubMed Web of Science ®Google Scholar
• Pollreisz A, Huang Y, Roth GA et al. Enhanced monocyte migration and pro-inflammatory cytokine production by Porphyromonas gingivalis infection. J. Periodontal Res. 45(2), 239–245 (2010).
   PubMed Web of Science ®Google Scholar
• Li C, Yu R, Ding Y. Association between Porphyromonas gingivalis and systemic diseases: focus on T cells-mediated adaptive immunity. Front. Cell Infect. Microbiol. 12, 1026457 (2022).
   PubMed Web of Science ®Google Scholar
• Ardila CM, Bedoya-Garcia JA. Antimicrobial resistance of Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis and Tannerella forsythia in periodontitis patients. J. Glob Antimicrob. Resist. 22, 215–218 (2020).
   PubMed Web of Science ®Google Scholar
• Ben Lagha A, Andrian E, Grenier D. Resveratrol attenuates the pathogenic and inflammatory properties of Porphyromonas gingivalis. Mol. Oral Microbiol. 34(3), 118–130 (2019).
   PubMed Web of Science ®Google Scholar
• Zhang Y, Wang Y, Zhu X, Cao P, Wei S, Lu Y. Antibacterial and antibiofilm activities of eugenol from essential oil of Syzygium aromaticum (L.) Merr. & L. M. Perry (clove) leaf against periodontal pathogen Porphyromonas gingivalis. Microb. Pathog. 113, 396–402 (2017).
   PubMed Web of Science ®Google Scholar
• Kugaji MS, Kumbar VM, Peram MR, Patil S, Bhat KG, Diwan PV. Effect of Resveratrol on biofilm formation and virulence factor gene expression of Porphyromonas gingivalis in periodontal disease. APMIS 127(4), 187–195 (2019).
   PubMed Web of Science ®Google Scholar
• Guo Y, Zhao L, Chang B et al. The traditional uses, phytochemistry, pharmacokinetics, pharmacology, toxicity, and applications of Corydalis saxicola bunting: a review. Front. Pharmacol. 13, 822792 (2022).
   PubMed Web of Science ®Google Scholar
• Qiu Q, Wei Z, Wu L, Liu Y, Meng T. Antibacterial activity of Corydalis Saxicola Bunting total alkaloid in Vitro. Sci. Technol. Innov. (9), 43–44 (2020).
   Google Scholar
• Sun T, Jiang P, Zhong Z et al. Bacteriostasis of Corydalis saxicola combined with antibiotics on Staphylococcus aureus in vitro. J. Jinggangshan Univ. 4(6), 103–106 (2020).
   Google Scholar
• Liu X, Zheng H, Lu R et al. Intervening effects of total alkaloids of Corydalis saxicola bunting on rats with antibiotic-induced gut microbiota dysbiosis based on 16S rRNA gene sequencing and untargeted metabolomics analyses. Front. Microbiol. 10, 1151 (2019).
   PubMed Web of Science ®Google Scholar
• Ye W, Yong X, Wu T, Liao H, Su Z, Tao R. Study on antibacterial activity of Corydalis saxicola Bunting total alkaloids against Porphyromonas gingivalis in vitro. Inter. Med. 17(3), 245–249 (2022).
   Google Scholar
• Takasaki K, Fujise O, Miura M, Hamachi T, Maeda K. Porphyromonas gingivalis displays a competitive advantage over Aggregatibacter actinomycetemcomitans in co-cultured biofilm. J. Periodontal Res. 48(3), 286–292 (2013).
   PubMed Web of Science ®Google Scholar
• Connolly E, Millhouse E, Doyle R, Culshaw S, Ramage G, Moran GP. The Porphyromonas gingivalis hemagglutinins HagB and HagC are major mediators of adhesion and biofilm formation. Mol. Oral Microbiol. 32(1), 35–47 (2017).
   PubMed Web of Science ®Google Scholar
• Zhang R, Yang J, Wu J, Sun WB, Liu Y. Effect of deletion of the rgpA gene on selected virulence of Porphyromonas gingivalis. J. Dent. Sci. 11(3), 279–286 (2016).
   PubMed Web of Science ®Google Scholar
• Wang Q, Luo Z, Li D et al. Investigation of the therapeutic effect of total alkaloids of Corydalis saxicola bunting on CCl(4)-induced liver fibrosis in rats by LC/MS-based metabolomics analysis and network pharmacology. Metabolites. 13(1), 9 (2022).
   PubMed Web of Science ®Google Scholar
• Yang L, Mei GC, Wu JX et al. Corydalis saxicolaBunting total alkaloid eliminates Porphyromonas gingivalis strain 33277 internalized into macrophages by inhibition of TLR2. Microb. Infect. 26(1–2), 105244 (2023).
   PubMed Web of Science ®Google Scholar
• He L, Wang H, Zhang R, Li H. The regulation of Porphyromonas gingivalis biofilm formation by ClpP. Biochem. Biophys. Res. Commun. 509(2), 335–340 (2019).
   PubMed Web of Science ®Google Scholar
• Wang Z, Shen Y, Haapasalo M. Dental materials with antibiofilm properties. Dent. Mater. 30(2), e1–e16 (2014).
   PubMed Web of Science ®Google Scholar
• Guan YH, Lath DL, Graaf T, Lilley TH, Brook AH. Moderation of oral bacterial adhesion on saliva-coated hydroxyapatite by polyaspartate. J. Appl. Microbiol. 94(3), 456–461 (2003).
   PubMed Web of Science ®Google Scholar
• He Z, Wang Q, Hu Y et al. Use of the quorum sensing inhibitor furanone C-30 to interfere with biofilm formation by Streptococcus mutans and its luxS mutant strain. Int. J. Antimicrob. Agents. 40(1), 30–35 (2012).
   PubMed Web of Science ®Google Scholar
• Kumbar VM, Peram MR, Kugaji MS et al. Effect of curcumin on growth, biofilm formation and virulence factor gene expression of Porphyromonas gingivalis. Odontology 109(1), 18–28 (2021).
   PubMed Web of Science ®Google Scholar
• Hakelius M, Koskela A, Reyhani V et al. Interleukin-1-mediated effects of normal oral keratinocytes and head and neck squamous carcinoma cells on extracellular matrix related gene expression in fibroblasts. Oral Oncol. 48(12), 1236–1241 (2012).
   PubMed Web of Science ®Google Scholar
• Yoshimasu Y, Ikeda T, Sakai N et al. Rapid bactericidal action of propolis against Porphyromonas gingivalis. J. Dent Res. 97(8), 928–936 (2018).
   PubMed Web of Science ®Google Scholar
• He Z, Zhang X, Song Z et al. Quercetin inhibits virulence properties of Porphyromas gingivalis in periodontal disease. Sci. Rep. 10(1), 18313 (2020).
   PubMed Web of Science ®Google Scholar
• Kuboniwa M, Tribble GD, Hendrickson EL, Amano A, Lamont RJ, Hackett M. Insights into the virulence of oral biofilms: discoveries from proteomics. Exp. Rev. Proteomics. 9(3), 311–323 (2012).
   PubMed Web of Science ®Google Scholar
• Guo Y, Nguyen KA, Potempa J. Dichotomy of gingipains action as virulence factors: from cleaving substrates with the precision of a surgeon's knife to a meat chopper-like brutal degradation of proteins. Periodontol. 54(1), 15–44 (2010).
   Google Scholar
• Abe N, Baba A, Takii R et al. Roles of Arg- and Lys-gingipains in coaggregation of Porphyromonas gingivalis: identification of its responsible molecules in translation products of rgpA, kgp, and hagA genes. Biol. Chem. 385(11), 1041–1047 (2004).
   PubMed Web of Science ®Google Scholar
• Bao K, Belibasakis GN, Thurnheer T, Aduse-Opoku J, Curtis MA, Bostanci N. Role of Porphyromonas gingivalis gingipains in multi-species biofilm formation. BMC Microbiol. 14, 258 (2014).
   PubMed Web of Science ®Google Scholar
• Tantivitayakul P, Kaypetch R, Muadchiengka T. Thymoquinone inhibits biofilm formation and virulence properties of periodontal bacteria. Arch. Oral Biol. 115, 104744 (2020).
   PubMed Web of Science ®Google Scholar
• Sroka A, Sztukowska M, Potempa J, Travis J, Genco CA. Degradation of host heme proteins by lysine- and arginine-specific cysteine proteinases (gingipains) of Porphyromonas gingivalis. J. Bacteriol. 183(19), 5609–5616 (2001).
   PubMed Web of Science ®Google Scholar
• Mendez KN, Hoare A, Soto C et al. Variability in genomic and virulent properties of Porphyromonas gingivalis strains isolated from healthy and severe chronic periodontitis individuals. Front. Cell Infect. Microbiol. 9, 246 (2019).
   PubMed Web of Science ®Google Scholar
• Alharbi MS, Alshehri FA. High molecular weight hyaluronic acid reduces the expression of virulence genes fimA, mfa1, hagA, rgpA, and kgp in the oral pathogen Porphyromonas gingivalis. Pharmaceutics. 14(8), 1628 (2022).
   PubMed Web of Science ®Google Scholar
• Fournier-Larente J, Morin MP, Grenier D. Green tea catechins potentiate the effect of antibiotics and modulate adherence and gene expression in Porphyromonas gingivalis. Arch. Oral Biol. 65, 35–43 (2016).
   PubMed Web of Science ®Google Scholar
• Jia L, Han N, Du J, Guo L, Luo Z, Liu Y. Pathogenesis of important virulence factors of Porphyromonas gingivalis via toll-like receptors. Front. Cell Infect. Microbiol. 9, 262 (2019).
   PubMed Web of Science ®Google Scholar
• Groeger S, Meyle J. Oral mucosal epithelial cells. Front. Immunol. 10, 208 (2019).
   PubMed Web of Science ®Google Scholar
• Takahashi Y, Cueno ME, Kamio N, Iinuma T, Hasegawa Y, Imai K. Porphyromonas gingivalis Mfa1 fimbria putatively binds to TLR2 and induces both IL-6 and IL-8 production in human bronchial epithelial cells. Biochem. Biophys. Res. Commun. 589, 35–40 (2022).
   PubMed Web of Science ®Google Scholar
• Jones SA, Jenkins BJ. Recent insights into targeting the IL-6 cytokine family in inflammatory diseases and cancer. Nat. Rev. Immunol. 18(12), 773–789 (2018).
   PubMed Web of Science ®Google Scholar
• Gao Z, Weng X, Yu D et al. Porphyromonas gingivalis-derived lipopolysaccharide promotes glioma cell proliferation and migration via activating Akt signaling pathways. Cells 11(24), 4088 (2022).
   PubMed Web of Science ®Google Scholar