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Review

Third-Generation Smallpox Vaccines: Challenges in the Absence of Clinical Smallpox

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Pages 1367-1382 | Published online: 22 Sep 2010

Bibliography

  • Fenner F , HendersonDA, AritaI, JezekZ, LadnyiID(Eds) : Smallpox and its Eradication. World Health Organization Geneva,Switzerland (1988).
  • Davidovitch N , GreenbergZ: Public health, culture, and colonial medicine: smallpox and variolation in Palestine during the British Mandate.Public Health Rep.122(3) , 398–406 (2007).
  • Dinc G , UlmanYI: The introduction of variolation ‘A La Turca‘ to the West by Lady Mary Montagu and Turkey‘s contribution to this.Vaccine25(21) , 4261–4265 (2007).
  • Jannetta A : Jennerian vaccination and the creation of a national public health agenda in Japan, 1850–1900.Bull. Hist. Med.83(1) , 125–140 (2009).
  • Mark C , Rigau-PerezJG: The world‘s first immunization campaign: the Spanish Smallpox Vaccine Expedition, 1803–1813.Bull. Hist. Med.83(1) , 63–94 (2009).
  • Breman JG , HendersonDA: Diagnosis and management of smallpox.N. Engl. J. Med.346(17) , 1300–1308 (2002).
  • CDC: Public Health Service recommendations on smallpox vaccination. Morb. Mortal. Wkl. Rep. 20 , 339 (1971).
  • Ladnyi ID , BremanJG: Smallpox eradication: progress and problems.Dev. Biol. Stand.41 , 281–290 (1978).
  • Institute of Medicine: Live Variola Virus: Considerations for Continuing Research. The National Academies Press, Washington, DC, USA (2009).
  • Moussatche N , DamasoCR, McFadden: When good vaccines go wild: feral orthopoxvirus in developing countries and beyond.J. Infect. Dev. Ctries2(3) , 156–173 (2008).
  • Levine RS , PetersonAT, YoritaKL, CarrollD, DamonIK, ReynoldsMG: Ecological niche and geographic distribution of human monkeypox in Africa.PLoS One2(1) , e176 (2007).
  • Meyer H , PerrichotM, StemmlerMet al. : Outbreaks of disease suspected of being due to human monkeypox virus infection in the Democratic Republic of Congo in 2001.J. Clin. Microbiol.40(8) , 2919–2921 (2002).
  • Heymann DL , SzczeniowskiM, EstevesK: Re-emergence of monkeypox in Africa: a review of the past six years.Br. Med. Bull.54(3) , 693–702 (1998).
  • CDC: Human monkeypox – Kasai Oriental, Zaire, 1996–1997. Morb. Mortal. Wkl. Rep. 46(14) , 304–307 (1997)
  • Breman JG , KalisaR, SteniowskiMV, ZanottoE, GromykoAI, AritaI: Human monkeypox, 1970–79.Bull. World Health Organ.58(2) , 165–182 (1980).
  • Trindade GS , LobatoZI, DrumondBPet al. : Short report: isolation of two vaccinia virus strains from a single bovine vaccinia outbreak in rural area from Brazil: implications on the emergence of zoonotic orthopoxviruses.Am. J. Trop. Med. Hyg.75(3) , 486–490 (2006).
  • Silva-Fernandes AT , TravassosCE, FerreiraJMet al. : Natural human infections with vaccinia virus during bovine vaccinia outbreaks.J. Clin. Virol.44(4) , 308–313 (2009).
  • Yadav S , HosamaniM, BalamuruganV, BhanuprakashV, SinghRK: Partial genetic characterization of viruses isolated from pox-like infection in cattle and buffaloes: evidence of buffalo pox virus circulation in Indian cows.Arch. Virol.155(2) , 255–261 (2010).
  • Nitsche A , PauliG: Sporadic human cases of cowpox in Germany.Euro. Surveill.12(4) , e070419 3 (2007).
  • Pelkonen PM , TarvainenK, HynninenAet al. : Cowpox with severe generalized eruption, Finland.Emerg. Infect. Dis.9(11) , 1458–1461 (2003).
  • Vorou RM , PapavassiliouVG, PierroutsakosIN: Cowpox virus infection: an emerging health threat.Curr. Opin. Infect. Dis.21(2) , 153–156 (2008).
  • Reed KD , MelskiJW, GrahamMBet al. : The detection of monkeypox in humans in the Western Hemisphere.N. Engl. J. Med.350(4) , 342–350 (2004).
  • CDC: Multistate outbreak of monkeypox – Illinois, Indiana, and Wisconsin. Morb. Mortal. Wkl. Rep. 52(23) , 537–540 (2003)
  • Lane JM , RubenFL, NeffJM, MillarJD: Complications of smallpox vaccination, 1968: results of ten statewide surveys.J. Infect. Dis.122(4) , 303–309 (1970).
  • Redfield RR , WrightDC, JamesWD, JonesTS, BrownC, BurkeDS: Disseminated vaccinia in a military recruit with human immunodeficiency virus (HIV) disease.N. Engl. J. Med.316(11) , 673–676 (1987).
  • Kempe CH , FulginitiV, MinamitaniM, ShinefieldH: Smallpox vaccination of eczema patients with a strain of attenuated live vaccinia (CVI-78).Pediatrics42(6) , 980–985 (1968).
  • Vora S , DamonI, FulginitiVet al. : Severe eczema vaccinatum in a household contact of a smallpox vaccinee.Clin. Infect. Dis.46(10) , 1555–1561 (2008).
  • Arness MK , EckartRE, LoveSSet al. : Myopericarditis following smallpox vaccination.Am. J. Epidemiol.160(7) , 642–651 (2004).
  • Mora LF , KhanAH, SperlingLS: Cardiac complications after smallpox vaccination.South Med. J. (2009) (Epub ahead of print).
  • Van Dam CN , SyedS, EronJJet al. : Severe postvaccinia encephalitis with acute disseminated encephalomyelitis: recovery with early intravenous immunoglobulin, high-dose steroids, and vaccinia immunoglobulin.Clin. Infect. Dis.48(4) , E47–E49 (2009).
  • Bryant-Genevier M , O‘ConnellK, BallR, BraunMM, McMahonA: Passive surveillance for generalized vaccinia in the United States using the Vaccine Adverse Event Reporting System (VAERS).Vaccine24(17) , 3632–3635 (2006).
  • Halsell JS , RiddleJR, AtwoodJEet al. : Myopericarditis following smallpox vaccination among vaccinia-naive US military personnel.JAMA289(24) , 3283–3289 (2003).
  • Eckart RE , ShryEA, JonesSOIV , AtwoodJE, GrabensteinJD: Comparison of clinical presentation of acute myocarditis following smallpox vaccination to acute coronary syndromes in patients <40 years of age.Am. J. Cardiol.95(10) , 1252–1255 (2005).
  • Jacobson IG , SmithTC, SmithB, WellsTS, ReedRJ, RyanMA: US military service members vaccinated against smallpox in 2003 and 2004 experience a slightly higher risk of hospitalization postvaccination.Vaccine26(32) , 4048–4056 (2008).
  • Rivers TM : Cultivation of vaccine virus for Jennerian prophylaxis in man.J. Exp. Med.54(4) , 453–461 (1931).
  • Mayr A , SticklH, MullerHK, DannerK, SingerH: The smallpox vaccination strain MVA: marker, genetic structure, experience gained with the parenteral vaccination and behavior in organisms with a debilitated defence mechanism [author‘s translation].Zentralbl. Bakteriol. B167(5–6) , 375–390 (1978).
  • Hashizume S , YoshizawaH, MoritaM, SuzukiK: Properties of attenuated mutant of vaccinia virus LC16m8, derived from Lister strain.In: Vaccinia Viruses as Vectors for Vaccine Antigens.Quinnan (Ed.) , Elsevier Science Publishing Co.,NY, USA87–99 (1985).
  • Kennedy RB , OvsyannikovaIG, JacobsonRM, PolandGA: The immunology of smallpox vaccines.Curr. Opin. Immunol.21(3) , 314–320 (2009).
  • Paran N , SutterG: Smallpox vaccines: new formulations and revised strategies for vaccination.Hum. Vaccin.5(12) , 824–831 (2009).
  • Jacobs BL , LanglandJO, KiblerKVet al. : Vaccinia virus vaccines: past present and future.Antiviral Res.84(1) , 1–13 (2009).
  • Weltzin R , LiuJ, PugachevKVet al. : Clonal vaccinia virus grown in cell culture as a new smallpox vaccine.Nat. Med.9(9) , 1125–1130 (2003).
  • Greenberg RN , KennedyJS: ACAM2000: a newly licensed cell culture-based live vaccinia smallpox vaccine.Expert Opin. Invest. Drugs17(4) , 555–564 (2008).
  • Monath TP , CaldwellJR, MundtWet al. : ACAM2000 clonal Vero cell culture vaccinia virus (New York City Board of Health strain) – a second-generation smallpox vaccine for biological defense.Int. J. Infect. Dis. Suppl.2 , S31–S44 (2004).
  • Weber HG : Utilization of the MVA-immunization schedule from the view point of the public health service.Fortschr. Med.95(21) , 1381–1386 (1977).
  • Cosma A , NagarajR, StaibCet al. : Evaluation of modified vaccinia virus Ankara as an alternative vaccine against smallpox in chronically HIV type 1-infected individuals undergoing HAART.AIDS Res. Hum. Retroviruses23(6) , 782–793 (2007).
  • Kretzschmar M , WallingaJ, TeunisP, XingS, MikolajczykR: Frequency of adverse events after vaccination with different vaccinia strains.PLoS Med.3(8) , E272 (2006).
  • Kenner J , CameronF, EmpigC, JobesDV, GurwithM: LC16m8: an attenuated smallpox vaccine.Vaccine24(47–48) , 7009–7022 (2006).
  • Tartaglia J , PerkusME, TaylorJet al. : NYVAC: a highly attenuated strain of vaccinia virus.Virology188(1) , 217–232 (1992).
  • Coulibaly S , BruhlP, MayrhoferJ, SchmidK, GerencerM, FalknerFG: The nonreplicating smallpox candidate vaccines defective vaccinia Lister (dVV-L) and modified vaccinia Ankara (MVA) elicit robust long-term protection.Virology341(1) , 91–101 (2005)
  • Jentarra GM , HeckMC, YounJWet al. : Vaccinia viruses with mutations in the E3L gene as potential replication-competent, attenuated vaccines: scarification vaccination.Vaccine26(23) , 2860–2872 (2008).
  • Earl PL , AmericoJL, WyattLSet al. : Immunogenicity of a highly attenuated MVA smallpox vaccine and protection against monkeypox.Nature428(6979) , 182–185 (2004)
  • Meseda CA , GarciaAD, KumarAet al. : Enhanced immunogenicity and protective effect conferred by vaccination with combinations of modified vaccinia virus Ankara and licensed smallpox vaccine Dryvax in a mouse model.Virology339(2) , 164–175 (2005).
  • Earl PL , AmericoJL, WyattLSet al. : Rapid protection in a monkeypox model by a single injection of a replication-deficient vaccinia virus.Proc. Natl Acad. Sci. USA105(31) , 10889–10894 (2008).
  • Midgley CM , PutzMM, WeberJN, SmithGL: Vaccinia virus strain NYVAC induces substantially lower and qualitatively different human antibody responses compared with strains Lister and Dryvax.J. Gen. Virol.89(Pt 12) , 2992–2997 (2008).
  • He Y , ManischewitzJ, MesedaCAet al. : Antibodies to the A27 protein of vaccinia virus neutralize and protect against infection but represent a minor component of Dryvax vaccine – induced immunity.J. Infect. Dis.196(7) , 1026–1032 (2007).
  • Fogg CN , AmericoJL, EarlPLet al. : Disparity between levels of in vitro neutralization of vaccinia virus by antibody to the A27 protein and protection of mice against intranasal challenge.J. Virol.82(16) , 8022–8029 (2008).
  • Saito T , FujiiT, KanataniYet al. : Clinical and immunological response to attenuated tissue-cultured smallpox vaccine LC16m8.JAMA301(10) , 1025–1033 (2009).
  • Wilck MB , SeamanMS, BadenLRet al. : Safety and immunogenicity of modified vaccinia Ankara (ACAM3000): effect of dose and route of administration.J. Infect. Dis.201(9) , 1361–1370 (2010).
  • Seaman MS , WilckMB, BadenLRet al. : Effect of vaccination with modified vaccinia Ankara (ACAM3000) on subsequent challenge with Dryvax.J. Infect. Dis.201(9) , 1353–1360 (2010).
  • Tine JA , LanarDE, SmithDMet al. : NYVAC-Pf7: a poxvirus-vectored, multiantigen, multistage vaccine candidate for Plasmodium falciparum malaria.Infect. Immun.64(9) , 3833–3844 (1996).
  • Esteban M : Attenuated poxvirus vectors MVA and NYVAC as promising vaccine candidates against HIV/AIDS.Hum. Vaccin.5(12) , 867–871 (2009).
  • Weyer J , RupprechtCE, NelLH: Poxvirus-vectored vaccines for rabies – a review.Vaccine27(51) , 7198–7201 (2009).
  • Meseda CA , MayerAE, KumarAet al. : Comparative evaluation of the immune responses and protection engendered by LC16m8 and Dryvax smallpox vaccines in a mouse model.Clin. Vaccine Immunol.16(9) , 1261–1271 (2009).
  • Stabenow J , BullerRM, SchriewerJ, WestC, SagartzJE, ParkerS: A mouse model of lethal infection for evaluating prophylactics and therapeutics against Monkeypox virus.J. Virol.84(8) , 3909–3920 (2010).
  • Garza NL , HatkinJM, LivingstonVet al. : Evaluation of the efficacy of modified vaccinia Ankara (MVA)/IMVAMUNE against aerosolized rabbitpox virus in a rabbit model.Vaccine27(40) , 5496–5504 (2009).
  • Stittelaar KJ , van AmerongenG, KondovaIet al.: Modified vaccinia virus Ankara protects macaques against respiratory challenge with monkeypox virus.J. Virol.79(12) , 7845–7851 (2005).
  • Saijo M , AmiY, SuzakiYet al. : LC16m8, a highly attenuated vaccinia virus vaccine lacking expression of the membrane protein B5R, protects monkeys from monkeypox.J. Virol.80(11) , 5179–5188 (2006).
  • Empig C , KennerJR, Perret-GentilMet al. : Highly attenuated smallpox vaccine protects rabbits and mice against pathogenic orthopoxvirus challenge.Vaccine24(17) , 3686–3694 (2006).
  • Hammarlund E , LewisMW, HansenSGet al. : Duration of antiviral immunity after smallpox vaccination.Nat. Med.9(9) , 1131–1137 (2003).
  • Lai CF , GongSC, EstebanM: The purified 14-kilodalton envelope protein of vaccinia virus produced in Escherichia coli induces virus immunity in animals.J. Virol.65(10) , 5631–5635 (1991).
  • Galmiche MC , GoenagaJ, WittekR, RindisbacherL: Neutralizing and protective antibodies directed against vaccinia virus envelope antigens.Virology254(1) , 71–80 (1999).
  • Fogg C , LustigS, WhitbeckJC, EisenbergRJ, CohenGH, MossB: Protective immunity to vaccinia virus induced by vaccination with multiple recombinant outer membrane proteins of intracellular and extracellular virions.J. Virol.78(19) , 10230–10237 (2004).
  • Davies DH , McCauslandMM, ValdezCet al. : Vaccinia virus H3L envelope protein is a major target of neutralizing antibodies in humans and elicits protection against lethal challenge in mice.J. Virol.79(18) , 11724–11733 (2005).
  • Sakhatskyy P , WangS, ChouTH, LuS: Immunogenicity and protection efficacy of monovalent and polyvalent poxvirus vaccines that include the D8 antigen.Virology355(2) , 164–174 (2006).
  • Benhnia MR , McCauslandMM, SuHPet al. : Redundancy and plasticity of neutralizing antibody responses are cornerstone attributes of the human immune response to the smallpox vaccine.J. Virol.82(7) , 3751–3768 (2008).
  • Nelson GE , SislerJR, ChandranD, MossB: Vaccinia virus entry/fusion complex subunit A28 is a target of neutralizing and protective antibodies.Virology380(2) , 394–401 (2008).
  • Sirven P , CastelliFA, ProbstA, SzelyN, MaillereB: In vitro human CD4+ T cell response to the vaccinia protective antigens B5R and A33R.Mol. Immunol.46(7) , 1481–1487 (2009).
  • Smith GL , VanderplasschenA, LawM: The formation and function of extracellular enveloped vaccinia virus.J. Gen. Virol.83(Pt 12) , 2915–2931 (2002).
  • Roberts KL , SmithGL: Vaccinia virus morphogenesis and dissemination.Trends Microbiol.16(10) , 472–479 (2008).
  • Condit RC , MoussatcheN, TraktmanP: In a nutshell: structure and assembly of the vaccinia virion.Adv. Virus Res.66 , 31–124 (2006).
  • Appleyard G , HapelAJ, BoulterEA: An antigenic difference between intracellular and extracellular rabbitpox virus.J. Gen. Virol.13(1) , 9–17 (1971).
  • Boulter EA , ZwartouwHT, TitmussDH, MaberHB: The nature of the immune state produced by inactivated vaccinia virus in rabbits.Am. J. Epidemiol.94(6) , 612–620 (1971).
  • Sette A , GreyH, OseroffCet al. : Definition of epitopes and antigens recognized by vaccinia specific immune responses: their conservation in variola virus sequences, and use as a model system to study complex pathogens.Vaccine27(Suppl. 6) , G21–G26 (2009).
  • Moutaftsi M , TscharkeDC, VaughanKet al. : Uncovering the interplay between CD8, CD4 and antibody responses to complex pathogens.Future Microbiol.5(2) , 221–239 (2010).
  • McIntosh K , CherryJD, BenensonASet al. : Clinical and serologic study of four smallpox vaccines comparing variations of dose and route of administration. Standard percutaneous revaccination of children who receive primary percutaneous vaccination.J. Infect. Dis.135(1) , 155–166 (1977).
  • Mack TM , NobleJJr , ThomasDB: A prospective study of serum antibody and protection against smallpox.Am. J. Trop. Med. Hyg.21(2) , 214–218 (1972).
  • Fenner F : Studies in infectious ectromelia of mice; immunization of mice against ectromelia with living vaccinia virus.Aust. J. Exp. Biol. Med. Sci.25(Pt 3) , 257–274 (1947).
  • Kempe CH , BowlesC, MeiklejohnGet al. : The use of vaccinia hyperimmune g-globulin in the prophylaxis of smallpox.Bull. World Health Organ.25 , 41–48 (1961).
  • Goldstein JA , NeffJM, LaneJM, KoplanJP: Smallpox vaccination reactions, prophylaxis, and therapy of complications.Pediatrics55(3) , 342–347 (1975).
  • Lustig S , Maik-RachlineG, ParanNet al. : Effective post-exposure protection against lethal orthopoxviruses infection by vaccinia immune globulin involves induction of adaptive immune response.Vaccine27(11) , 1691–1699 (2009).
  • Edghill-Smith Y , GoldingH, ManischewitzJet al. : Smallpox vaccine-induced antibodies are necessary and sufficient for protection against monkeypox virus.Nat. Med.11(7) , 740–747 (2005).
  • Chaudhri G , PanchanathanV, BluethmannH, KarupiahG: Obligatory requirement for antibody in recovery from a primary poxvirus infection.J. Virol.80(13) , 6339–6344 (2006).
  • Panchanathan V , ChaudhriG, KarupiahG: Antiviral protection following immunization correlates with humoral but not cell-mediated immunity.Immunol. Cell Biol.88(4) , 461–467 (2010).
  • Karupiah G , XieQW, BullerRM, NathanC, DuarteC, MacMickingJD: Inhibition of viral replication by interferon-γ-induced nitric oxide synthase.Science261(5127) , 1445–1448 (1993).
  • Karupiah G , BullerRM, Van RooijenN, DuarteCJ, ChenJ: Different roles for CD4+ and CD8+ T lymphocytes and macrophage subsets in the control of a generalized virus infection.J. Virol.70(12) , 8301–8309 (1996).
  • Chaudhri G , PanchanathanV, BullerRMet al. : Polarized type 1 cytokine response and cell-mediated immunity determine genetic resistance to mousepox.Proc. Natl Acad. Sci. USA101(24) , 9057–9062 (2004).
  • Panchanathan V , ChaudhriG, KarupiahG: Protective immunity against secondary poxvirus infection is dependent on antibody but not on CD4 or CD8 T-cell function.J. Virol.80(13) , 6333–6338 (2006).
  • Senkevich TG , WardBM, MossB: Vaccinia virus entry into cells is dependent on a virion surface protein encoded by the A28L gene.J. Virol.78(5) , 2357–2366 (2004).
  • Senkevich TG , OjedaS, TownsleyA, NelsonGE, MossB: Poxvirus multiprotein entry-fusion complex.Proc. Natl Acad. Sci. USA102(51) , 18572–18577 (2005).
  • Fang M , ChengH, DaiZ, BuZ, SigalLJ: Immunization with a single extracellular enveloped virus protein produced in bacteria provides partial protection from a lethal orthopoxvirus infection in a natural host.Virology345(1) , 231–243 (2006)
  • Hooper JW , ThompsonE, WilhelmsenCet al. : Smallpox DNA vaccine protects nonhuman primates against lethal monkeypox.J. Virol.78(9) , 4433–4443 (2004).
  • Golden JW , HooperJW: Heterogeneity in the A33 protein impacts the cross-protective efficacy of a candidate smallpox DNA vaccine.Virology377(1) , 19–29 (2008).
  • Aldaz-Carroll L , WhitbeckJC, Ponce deLeon Met al.: Epitope-mapping studies define two major neutralization sites on the vaccinia virus extracellular enveloped virus glycoprotein B5R.J. Virol.79(10) , 6260–6271 (2005).
  • Barefoot B , ThornburgNJ, BarouchDHet al. : Comparison of multiple vaccine vectors in a single heterologous prime-boost trial.Vaccine26(48) , 6108–6118 (2008).
  • Hooper JW , FerroAM, GoldenJWet al. : Molecular smallpox vaccine delivered by alphavirus replicons elicits protective immunity in mice and non-human primates.Vaccine28(2) , 494–511 (2009).
  • O‘Connell CJ , KarzonDT, BarronAL, PlautME, AliVM: Progressive vaccinia with normal antibodies. A case possibly due to deficient cellular immunity.Ann. Intern. Med.60 , 282–289 (1964).
  • Blanden RV : Mechanisms of recovery from a generalized viral infection: mousepox. II. Passive transfer of recovery mechanisms with immune lymphoid cells.J. Exp. Med.133(5) , 1074–1089 (1971).
  • Mullbacher A , LobigsM, YewdellJW, BenninkJR, Tha HlaR, BlandenRV: High peptide affinity for MHC class I does not correlate with immunodominance.Scand. J. Immunol.50(4) , 420–426 (1999).
  • Ennis FA , CruzJ, DemkowiczWEJr , RothmanAL, McClainDJ: Primary induction of human CD8+ cytotoxic T lymphocytes and interferon-g-producing T cells after smallpox vaccination.J. Infect. Dis.185(11) , 1657–1659 (2002).
  • Kim SH , YeoSG, ChoJHet al. : Cell-mediated immune responses to smallpox vaccination.Clin. Vaccine Immunol.13(10) , 1172–1174 (2006).
  • Dong Y , DennyTN: HLA-A2-restricted human CD8+ cytotoxic T lymphocyte responses to a novel epitope in vaccinia virus that is conserved among orthopox viruses.J. Infect. Dis.194(2) , 168–175 (2006).
  • Terajima M , CruzJ, RainesGet al. : Quantitation of CD8+ T cell responses to newly identified HLA-A*0201-restricted T cell epitopes conserved among vaccinia and variola (smallpox) viruses.J. Exp. Med.197(7) , 927–932 (2003).
  • Flesch IE , WooWP, WangYet al. : Altered CD8+ T cell immunodominance after vaccinia virus infection and the naive repertoire in inbred and F(1) mice.J. Immunol.184(1) , 45–55 (2010).
  • Tscharke DC , KarupiahG, ZhouJet al. : Identification of poxvirus CD8+ T cell determinants to enable rational design and characterization of smallpox vaccines.J. Exp. Med.201(1) , 95–104 (2005).
  • Doherty PC , BiddisonWE, BenninkJR, KnowlesBB: Cytotoxic T-cell responses in mice infected with influenza and vaccinia viruses vary in magnitude with H-2 genotype.J. Exp. Med.148(2) , 534–543 (1978).
  • Phelps A , GatesAJ, HillierM, EastaughL, UlaetoDO: Comparative efficacy of replicating smallpox vaccine strains in a murine challenge model.Vaccine23(27) , 3500–3507 (2005).
  • Kaufman DR , GoudsmitJ, HoltermanLet al. : Differential antigen requirements for protection against systemic and intranasal vaccinia virus challenges in mice.J. Virol.82(14) , 6829–6837 (2008).
  • Yu W , FangQ, ZhuWet al. : One time intranasal vaccination with a modified vaccinia Tiantan strain MVTT(ZCI) protects animals against pathogenic viral challenge.Vaccine28(9) , 2088–2096 (2010).
  • Rock MT , YoderSM, TalbotTR, EdwardsKM, CroweJEJr : Cellular immune responses to diluted and undiluted aventis pasteur smallpox vaccine.J. Infect. Dis.194(4) , 435–443 (2006).
  • Frey SE , NewmanFK, KennedyJSet al. : Comparison of the safety and immunogenicity of ACAM1000, ACAM2000 and Dryvax in healthy vaccinia-naive adults.Vaccine27(10) , 1637–1644 (2009).
  • Luttge BG , MoyerRW: Suppressors of a host range mutation in the rabbitpox virus serpin SPI-1 map to proteins essential for viral DNA replication.J. Virol.79(14) , 9168–9179 (2005).
  • Roper RL , WolffeEJ, WeisbergA, MossB: The envelope protein encoded by the A33R gene is required for formation of actin-containing microvilli and efficient cell-to-cell spread of vaccinia virus.J. Virol.72(5) , 4192–4204 (1998).
  • Hooper JW , GoldenJW, FerroAM, KingAD: Smallpox DNA vaccine delivered by novel skin electroporation device protects mice against intranasal poxvirus challenge.Vaccine25(10) , 1814–1823 (2007).
  • Heraud JM , Edghill-SmithY, AyalaVet al. : Subunit recombinant vaccine protects against monkeypox.J. Immunol.177(4) , 2552–2564 (2006).
  • Putz MM , MidgleyCM, LawM, SmithGL: Quantification of antibody responses against multiple antigens of the two infectious forms of Vaccinia virus provides a benchmark for smallpox vaccination.Nat. Med.12(11) , 1310–1315 (2006).
  • Hooper JW , CusterDM, SchmaljohnCS, SchmaljohnAL: DNA vaccination with vaccinia virus L1R and A33R genes protects mice against a lethal poxvirus challenge.Virology266(2) , 329–339 (2000).
  • Hooper JW , CusterDM, ThompsonE: Four-gene-combination DNA vaccine protects mice against a lethal vaccinia virus challenge and elicits appropriate antibody responses in nonhuman primates.Virology306(1) , 181–195 (2003).
  • Trojan A , RajeswaranR, MontemurroM, MutschM, SteffenR. Real time PCR for the assessment of CD8+ T cellular immune response after prophylactic vaccinia vaccination.J. Clin. Virol.40(1) , 80–83 (2007).
  • Davies DH , WyattLS, NewmanFKet al. : Antibody profiling by proteome microarray reveals the immunogenicity of the attenuated smallpox vaccine modified vaccinia virus ankara is comparable to that of Dryvax.J. Virol.82(2) , 652–663 (2008).
  • Bedson HS , DuckworthMJ: Rabbit pox: an experimental study of the pathways of infection in rabbits.J. Pathol. Bacteriol.85 , 1–20 (1963).
  • Westwood JC , BoulterEA, BowenET, MaberHB: Experimental respiratory infection with poxviruses. I. Clinical virological and epidemiological studies.Br. J. Exp. Pathol.47(5) , 453–465 (1966).
  • Adams MM , RiceAD, MoyerRW: Rabbitpox virus and vaccinia virus infection of rabbits as a model for human smallpox.J. Virol.81(20) , 11084–11095 (2007).
  • Esteban DJ , BullerRM: Ectromelia virus: the causative agent of mousepox.J. Gen. Virol.86(Pt 10) , 2645–2659 (2005).
  • Xiao Y , Aldaz-CarrollL, OrtizAMet al. : A protein-based smallpox vaccine protects mice from vaccinia and ectromelia virus challenges when given as a prime and single boost.Vaccine25(7) , 1214–1224 (2007).
  • Zaucha GM , JahrlingPB, GeisbertTW, SwearengenJR, HensleyL: The pathology of experimental aerosolized monkeypox virus infection in cynomolgus monkeys (Macaca fascicularis).Lab. Invest.81(12) , 1581–1600 (2001).
  • MacNeill AL , MoldawerLL, MoyerRW: The role of the cowpox virus crmA gene during intratracheal and intradermal infection of C57BL/6 mice.Virology384(1) , 151–160 (2009).
  • Schultz DA , SagartzJE, HusoDL, BullerRM: Experimental infection of an African dormouse (Graphiurus kelleni) with monkeypox virus.Virology383(1) , 86–92 (2009).
  • Tesh RB , WattsDM, SbranaE, SiirinM, PopovVL, XiaoSY: Experimental infection of ground squirrels (Spermophilus tridecemlineatus) with monkeypox virus.Emerg. Infect. Dis.10(9) , 1563–1567 (2004).
  • Xiao SY , SbranaE, WattsDM, SiirinM, da RosaAP, TeshRB: Experimental infection of prairie dogs with monkeypox virus.Emerg. Infect. Dis.11(4) , 539–545 (2005).
  • Hutson CL , OlsonVA, CarrollDSet al. : A prairie dog animal model of systemic orthopoxvirus disease using West African and Congo Basin strains of monkeypox virus.J. Gen. Virol.90(Pt 2) , 323–333 (2009).
  • Jahrling PB , HensleyLE, MartinezMJet al. : Exploring the potential of variola virus infection of cynomolgus macaques as a model for human smallpox.Proc. Natl Acad. Sci. USA101(42) , 15196–15200 (2004).
  • Eckart RE , ShryEA, AtwoodJEet al. : Smallpox vaccination and ischemic coronary events in healthy adults.Vaccine25(50) , 8359–8364 (2007).
  • US FDA, HHS: New drug and biological drug products; evidence needed to demonstrate effectiveness of new drugs when human efficacy studies are not ethical or feasible. Final Rule. Fed. Regist. 67 , 37988–37998 (2002).
  • Liszewski MK , LeungMK, HauhartR, FangCJ, BertramP, AtkinsonJP: Smallpox inhibitor of complement enzymes (SPICE): dissecting functional sites and abrogating activity.J. Immunol.183(5) , 3150–3159 (2009).
  • Bell E , ShamimM, WhitbeckJC, SfyroeraG, LambrisJD, IsaacsSN: Antibodies against the extracellular enveloped virus B5R protein are mainly responsible for the EEV neutralizing capacity of vaccinia immune globulin.Virology325(2) , 425–431 (2004).
  • Aldaz-Carroll L , XiaoY, WhitbeckJCet al. : Major neutralizing sites on vaccinia virus glycoprotein B5 are exposed differently on variola virus ortholog B6.J. Virol.81(15) , 8131–8139 (2007).
  • Walsh SR , GillisJ, PetersBet al. : Diverse recognition of conserved orthopoxvirus CD8+ T cell epitopes in vaccinated rhesus macaques.Vaccine27(36) , 4990–5000 (2009).
  • Lehmann MH , KastenmullerW, KandemirJD, BrandtF, SuezerY, SutterG: Modified vaccinia virus ankara triggers chemotaxis of monocytes and early respiratory immigration of leukocytes by induction of CCL2 expression.J. Virol.83(6) , 2540–2552 (2009).

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