References
- Boucher HW , TalbotGH , BradleyJSet al. Bad bugs, no drugs: no ESKAPE! An update from the Infectious Diseases Society of America . Clin. Infect. Dis.48 ( 1 ), 1 – 12 ( 2009 ).
- Napier BA , BurdEM , SatolaSWet al. Clinical use of colistin induces cross-resistance to host antimicrobials in Acinetobacter baumannii . MBio4 ( 3 ), e00021 – e00013 ( 2013 ).
- Antibiotic Resistance Threats in the United States, 2013. U.S. Centers for Disease Control and Prevention (CDC) , Atlanta, GA, USA ( 2013 ).
- Butler MS , BlaskovichMA , CooperMA . Antibiotics in the clinical pipeline in 2013 . J. Antibiot.66 ( 10 ), 571 – 591 ( 2013 ).
- Kirst HA . Developing new antibacterials through natural product research . Expert Opin. Drug Discov.8 ( 5 ), 479 – 493 ( 2013 ).
- Gwynn MN , PortnoyA , RittenhouseSF , PayneDJ . Challenges of antibacterial discovery revisited . Ann. NY Acad. Sci.1213 , 5 – 19 ( 2010 ).
- Macielag MJ . Chemical properties of antimicrobials and their uniqueness . In : Antibiotic Discovery and Development . DoughertyTJ , PucciMJ ( Eds ). Springer , New York, NY, USA793 – 820 ( 2012 ).
- Luo H , LinY , GaoF , ZhangCT , ZhangR . DEG 10, an update of the database of essential genes that includes both protein-coding genes and noncoding genomic elements . Nucleic Acids Res.42 , D574 – D580 ( 2014 ).
- Panjkovich A , GibertI , DauraX . antibacTR: dynamic antibacterial-drug-target ranking integrating comparative genomics, structural analysis and experimental annotation . BMC Genomics15 , 36 ( 2014 ).
- Salama NR , ShepherdB , FalkowS . Global transposon mutagenesis and essential gene analysis of Helicobacter pylori . J. Bacteriol.186 ( 23 ), 7926 – 7935 ( 2004 ).
- D’elia MA , PereiraMP , BrownED . Are essential genes really essential?Trends Microbiol.17 ( 10 ), 433 – 438 ( 2009 ).
- Joyce AR , ReedJL , WhiteAet al. Experimental and computational assessment of conditionally essential genes in Escherichia coli . J. Bacteriol.188 ( 23 ), 8259 – 8271 ( 2006 ).
- Van Opijnen T , CamilliA . A fine scale phenotype-genotype virulence map of a bacterial pathogen . Genome Res.22 ( 12 ), 2541 – 2551 ( 2012 ).
- Brinster S , LamberetG , StaelsB , Trieu-CuotP , GrussA , PoyartC . Type II fatty acid synthesis is not a suitable antibiotic target for Gram-positive pathogens . Nature458 ( 7234 ), 83 – 86 ( 2009 ).
- Parsons JB , FrankMW , SubramanianC , SaenkhamP , RockCO . Metabolic basis for the differential susceptibility of Gram-positive pathogens to fatty acid synthesis inhibitors . Proc. Natl Acad. Sci. USA108 ( 37 ), 15378 – 15383 ( 2011 ).
- Russo TA , LukeNR , BeananJMet al. The K1 capsular polysaccharide of Acinetobacter baumannii strain 307–0294 is a major virulence factor . Infect. Immun.78 ( 9 ), 3993 – 4000 ( 2010 ).
- Russo TA , MacdonaldU , BeananJMet al. Penicillin-binding protein 7/8 contributes to the survival of Acinetobacter baumannii in vitro and in vivo . J. Infect. Dis.199 ( 4 ), 513 – 521 ( 2009 ).
- Umland TC , SchultzLW , MacDonaldU , BeananJM , OlsonR , RussoTA . In vivo-validated essential genes identified in Acinetobacter baumannii by using human ascites overlap poorly with essential genes detected on laboratory media . MBio3 ( 4 ), pii: e00113–12 ( 2012 ).
- Fahnoe KC , FlanaganME , GibsonG , ShanmugasundaramV , CheY , TomarasAP . Non-traditional antibacterial screening approaches for the identification of novel inhibitors of the glyoxylate shunt in Gram-negative pathogens . PLoS ONE7 ( 12 ), e51732 ( 2012 ).
- Silver LL . Challenges of antibacterial discovery . Clin. Microbiol. Rev.24 ( 1 ), 71 – 109 ( 2011 ).