References
- Attard G , ParkerC, EelesRAet al. Prostate cancer. Lancet387(10013), 70–82 (2016).
- Massard C , FizaziK. Targeting continued androgen receptor signaling in prostate cancer. Clin. Cancer Res.17, 3876–3883 (2011).
- Roviello G , PetrioliR, LaeraL, FranciniE. The third line of treatment for metastatic prostate cancer patients: option or strategy?Crit. Rev. Oncol. Hematol.95(3), 265–271 (2015).
- Titus MA , SchellMJ, LihFBet al. Testosterone and dihydrotestosterone tissue levels in recurrent prostate cancer. Clin. Cancer Res.11, 4653–4657 (2005).
- Dillard PR , LinMF, KhanSA. Androgen-independent prostate cancer cells acquire the complete steroidogenic potential of synthesizing testosterone from cholesterol. Mol. Cell Endocrinol.295, 115–120 (2008).
- Antonarakis ES , LuC, WangHet al. AR-V7 and resistance to enzalutamide and abiraterone in prostate cancer. N Engl. J. Med.371(11), 1028–1038 (2014).
- Hu R , LuC, MostaghelEAet al. Distinct transcriptional programs mediated by the ligand-dependent full-length androgen receptor and its splice variants in castration-resistant prostate cancer. Cancer Res.72, 3457–3462 (2012).
- Nakazawa M , LuC, ChenYet al. Serial blood-based analysis of AR-V7 in men with advanced prostate cancer. Ann. Oncol.26(9), 1859–1865 (2015).
- Thadani-Mulero M , PortellaL, SunSet al. Androgen receptor splice variants determine taxane sensitivity in prostate cancer. Cancer Res.74(8), 2270–2282 (2014).
- Onstenk W , SieuwertsAM, KraanJet al. Efficacy of cabazitaxel in castration-resistant prostate cancer is independent of the presence of AR-V7 in circulating tumor cells. Eur. Urol.68(6), 939–945 (2015).
- Debes JD , TindallDJ. Mechanisms of androgen-refractory prostate cancer. N. Engl. J. Med.351, 1488–1490 (2004).
- Carver BS , ChapinskiC, WongvipatJet al. Reciprocal feedback regulation of PI3K and androgen receptor signaling in PTEN-deficient prostate cancer. Cancer Cell19, 575–586 (2011).
- Nan B , SnabboonT, UnniE, YuanXJ, WhangYE, MarcelliM. The PTEN tumor suppressor is a negative modulator of androgen receptor transcriptional activity. J. Mol. Endocrinol.31, 169–183 (2003).
- McMenamin ME , SoungP, PereraS, KaplanI, LodaM, SellersWR. Loss of PTEN expression in paraffin-embedded primary prostate cancer correlates with high Gleason score and advanced stage. Cancer Res.59(17), 4291–4296 (1999).
- Kato M , BanuelosCA, ImamuraYet al. Cotargeting androgen receptor splice variants and mTOR signaling pathway for the treatment of castration-resistant prostate cancer. Clin Cancer Res. doi: 10.1158/1078-0432.CCR-15-2119 (2016) ( Epub ahead of print).
- Kaarbo M , MikkelsenOL, MalerodL, QuS, LobertVH, AkgulG. PI3K–AKT–mTOR pathway is dominant over androgen receptor signaling in prostate cancer cells. Cell Oncol.32, 11–27 (2010).
- Ferraldeschi R , Nava RodriguesD, RiisnaesRet al. PTEN protein loss and clinical outcome from castration-resistant prostate cancer treated with abiraterone acetate. Eur. Urol.67(4), 795–802 (2015).
- Nakabayashi M , WernerL, CourtneyKDet al. Phase II trial of RAD001 and bicalutamide for castration-resistant prostate cancer. BJU Int.110, 1729–1735 (2012).
- Templeton AJ , DutoitV, CathomasRet al. Phase 2 trial of single-agent everolimus in chemotherapy-naive patients with castration-resistant prostate cancer (SAKK 08/08). Eur. Urol.64(1), 150–158 (2013).
- Baselga J , CamponeM, PiccartMet al. Everolimus in postmenopausal hormone-receptor-positive advanced breast cancer. N. Engl. J. Med.366(6), 520–529 (2012).