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Review

Medical Management of Brain Metastases and Leptomeningeal Disease in Patients with Breast Carcinoma

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Pages 391-407 | Received 03 Jun 2017, Accepted 17 Oct 2017, Published online: 18 Jan 2018

References

  • Cheng X , HungMC. Breast cancer brain metastases. Cancer Metastasis Rev.26(3–4), 635–643 (2007).
  • Lin NU , BellonJR, WinerEP. CNS metastases in breast cancer. J. Clin. Oncol.22(17), 3608–3617 (2004).
  • Barnholtz-Sloan JS , SloanAE, DavisFG, VigneauFD, LaiP, SawayaRE. Incidence proportions of brain metastases in patients diagnosed (1973 to 2001) in the Metropolitan Detroit Cancer Surveillance System. J. Clin. Oncol.22(14), 2865–2872 (2004).
  • Tsukada Y , FouadA, PickrenJW, LaneWW. Central nervous system metastasis from breast carcinoma. Autopsy study. Cancer52(12), 2349–2354 (1983).
  • Pestalozzi BC , ZahriehD, PriceKNet al. Identifying breast cancer patients at risk for central nervous system (CNS) metastases in trials of the International Breast Cancer Study Group (IBCSG). Ann. Oncol.17(6), 935–944 (2006).
  • Nam BH , KimSY, HanHSet al. Breast cancer subtypes and survival in patients with brain metastases. Breast Cancer Res.10(1), R20 (2008).
  • Sperduto PW , KasedN, RobergeDet al. The effect of tumor subtype on the time from primary diagnosis to development of brain metastases and survival in patients with breast cancer. J. Neurooncol.112(3), 467–472 (2013).
  • Aversa C , RossiV, GeunaEet al. Metastatic breast cancer subtypes and central nervous system metastases. Breast23(5), 623–628 (2014).
  • Gaspar L , ScottC, RotmanMet al. Recursive partitioning analysis (RPA) of prognostic factors in three Radiation Therapy Oncology Group (RTOG) brain metastases trials. Int. J. Radiation Oncol. Biol. Phys.37(4), 745–751 (1997).
  • Sperduto PW , BerkeyB, GasparLE, MehtaM, CurranW. A new prognostic index and comparison to three other indices for patients with brain metastases: an analysis of 1,960 patients in the RTOG database. Int. J. Radiation Oncol. Biol. Phys.70(2), 510–514 (2008).
  • Subbiah IM , LeiX, WeinbergJSet al. Validation and development of a modified breast graded prognostic assessment as a tool for survival in patients with breast cancer and brain metastases. J. Clin. Oncol.33(20), 2239–2245 (2015).
  • Eichler AF , LoefflerJS. Multidisciplinary management of brain metastases. Oncologist12(7), 884–898 (2007).
  • Peacock KH , LesserGJ. Current therapeutic approaches in patients with brain metastases. Curr. Treat. Options Oncol.7(6), 479–489 (2006).
  • Arslan C , DizdarO, AltundagK. Systemic treatment in breast-cancer patients with brain metastasis. Expert Opin. Pharmacother.11(7), 1089–1100 (2010).
  • Azad TD , PanJ, ConnollyID, RemingtonA, WilsonCM, GrantGA. Therapeutic strategies to improve drug delivery across the blood–brain barrier. Neurosurg. Focus38(3), E9 (2015).
  • Patel RR , MehtaMP. Targeted therapy for brain metastases: improving the therapeutic ratio. Clin. Cancer Res.13(6), 1675–1683 (2007).
  • Qin DX , ZhengR, TangJ, LiJX, HuYH. Influence of radiation on the blood–brain barrier and optimum time of chemotherapy. Int. J. Radiation Oncol. Biol. Phys.19(6), 1507–1510 (1990).
  • Scott BJ , KesariS. Leptomeningeal metastases in breast cancer. Am J. Cancer Res.3(2), 117–126 (2013).
  • de Azevedo CR , CruzMR, ChinenLTet al. Meningeal carcinomatosis in breast cancer: prognostic factors and outcome. J. Neurooncol.104(2), 565–572 (2011).
  • Lassman AB , AbreyLE, ShahGDet al. Systemic high-dose intravenous methotrexate for central nervous system metastases. J. Neurooncol.78(3), 255–260 (2006).
  • Kumthekar P , GrimmSA, AvramMJet al. Pharmacokinetics and efficacy of pemetrexed in patients with brain or leptomeningeal metastases. J. Neurooncol.112(2), 247–255 (2013).
  • Franciosi V , CocconiG, MichiaraMet al. Front-line chemotherapy with cisplatin and etoposide for patients with brain metastases from breast carcinoma, nonsmall cell lung carcinoma, or malignant melanoma: a prospective study. Cancer85(7), 1599–1605 (1999).
  • Gruschow K , KlautkeG, FietkauR. Phase I/II clinical trial of concurrent radiochemotherapy in combination with topotecan for the treatment of brain metastases. Eur. J. Cancer38(3), 367–374 (2002).
  • Christodoulou C , BafaloukosD, KosmidisPet al. Phase II study of temozolomide in heavily pretreated cancer patients with brain metastases. Ann. Oncol.12(2), 249–254 (2001).
  • Addeo R , De RosaC, FaiolaVet al. Phase II trial of temozolomide using protracted low-dose and whole-brain radiotherapy for non-small cell lung cancer and breast cancer patients with brain metastases. Cancer113(9), 2524–2531 (2008).
  • Rivera E , MeyersC, GrovesMet al. Phase I study of capecitabine in combination with temozolomide in the treatment of patients with brain metastases from breast carcinoma. Cancer107(6), 1348–1354 (2006).
  • Glantz MJ , ColeBF, RechtLet al. High-dose intravenous methotrexate for patients with nonleukemic leptomeningeal cancer: is intrathecal chemotherapy necessary? J. Clin. Oncol. 16(4), 1561–1567 (1998).
  • Cocconi G , LotticiR, BisagniGet al. Combination therapy with platinum and etoposide of brain metastases from breast carcinoma. Cancer Invest.8(3–4), 327–334 (1990).
  • Sung C , BlaneySM, ColeDE, BalisFM, DedrickRL. A pharmacokinetic model of topotecan clearance from plasma and cerebrospinal fluid. Cancer Res.54(19), 5118–5122 (1994).
  • Baker SD , HeidemanRL, CromWR, KutteschJF, GajjarA, StewartCF. Cerebrospinal fluid pharmacokinetics and penetration of continuous infusion topotecan in children with central nervous system tumors. Cancer Chemother. Pharmacol.37(3), 195–202 (1996).
  • Oberhoff C , KiebackDG, WürstleinRet al. Topotecan chemotherapy in patients with breast cancer and brain metastases: results of a pilot study. Onkologie24(3), 256–260 (2001).
  • Kocher M , EichHT, SemrauR, GünerSA, MüllerRP. Phase I/II trial of simultaneous whole-brain irradiation and dose-escalating topotecan for brain metastases. Strahlenther. Onkol.181(1), 20–25 (2005).
  • Stupp R , MasonWP, van den BentMJet al. Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N. Engl. J. Med.352(10), 987–996 (2005).
  • Abrey LE , OlsonJD, RaizerJJet al. A Phase II trial of temozolomide for patients with recurrent or progressive brain metastases. J. Neurooncol.53(3), 259–265 (2001).
  • Christodoulou C , BafaloukosD, LinardouHet al. Temozolomide (TMZ) combined with cisplatin (CDDP) in patients with brain metastases from solid tumors: a Hellenic Cooperative Oncology Group (HeCOG) Phase II study. J. Neurooncol.71(1), 61–65 (2005).
  • Ekenel M , HormigoAM, PeakS, DeangelisLM, AbreyLE. Capecitabine therapy of central nervous system metastases from breast cancer. J. Neurooncol.85(2), 223–227 (2007).
  • Chargari C , KirovaYM, DierasVet al. Concurrent capecitabine and whole-brain radiotherapy for treatment of brain metastases in breast cancer patients. J. Neurooncol.93(3), 379–384 (2009).
  • Lin NU , DierasV, PaulDet al. Multicenter Phase II study of lapatinib in patients with brain metastases from HER2-positive breast cancer. Clin. Cancer Res.15(4), 1452–1459 (2009).
  • Bachelot T , RomieuG, CamponeMet al. Lapatinib plus capecitabine in patients with previously untreated brain metastases from HER2-positive metastatic breast cancer (LANDSCAPE): a single-group Phase II study. Lancet Oncol.14(1), 64–71 (2013).
  • Capri G , ChangJ, ChenSCet al. An open-label expanded access study of lapatinib and capecitabine in patients with HER2-overexpressing locally advanced or metastatic breast cancer. Ann. Oncol.21(3), 474–480 (2010).
  • Harbeck N , HuangCS, HurvitzSet al. Afatinib plus vinorelbine versus trastuzumab plus vinorelbine in patients with HER2-overexpressing metastatic breast cancer who had progressed on one previous trastuzumab treatment (LUX-Breast 1): an open-label, randomised, Phase III trial. Lancet Oncol.17(3), 357–366 (2016).
  • Cortes J , DierasV, RoJet al. Afatinib alone or afatinib plus vinorelbine versus investigator’s choice of treatment for HER2-positive breast cancer with progressive brain metastases after trastuzumab, lapatinib, or both (LUX-Breast 3): a randomised, open-label, multicentre, Phase II trial. Lancet Oncol. 16(16), 1700–1710 (2015).
  • Freedman RA , GelmanRS, WefelJSet al. Translational Breast Cancer Research Consortium (TBCRC) 022: a Phase II trial of neratinib for patients with human epidermal growth factor receptor 2-positive breast cancer and brain metastases. J. Clin. Oncol.34(9), 945–952 (2016).
  • Cortes J , O’ShaughnessyJ, LoeschDet al. Eribulin monotherapy versus treatment of physician’s choice in patients with metastatic breast cancer (EMBRACE): a Phase III open-label randomised study. Lancet377(9769), 914–923 (2011).
  • Stemmler HJ , SchmittM, WillemsA, BernhardH, HarbeckN, HeinemannV. Ratio of trastuzumab levels in serum and cerebrospinal fluid is altered in HER2-positive breast cancer patients with brain metastases and impairment of blood–brain barrier. Anticancer Drugs18(1), 23–28 (2007).
  • Park YH , ParkMJ, JiSHet al. Trastuzumab treatment improves brain metastasis outcomes through control and durable prolongation of systemic extracranial disease in HER2-overexpressing breast cancer patients. Br. J. Cancer100(6), 894–900 (2009).
  • Bartsch R , BerghoffA, PluschnigUet al. Impact of anti-HER2 therapy on overall survival in HER2-overexpressing breast cancer patients with brain metastases. Br. J. Cancer106(1), 25–31 (2012).
  • Bartsch R , RottenfusserA, WenzelCet al. Trastuzumab prolongs overall survival in patients with brain metastases from Her2 positive breast cancer. J. Neurooncol.85(3), 311–317 (2007).
  • Yau T , SwantonC, ChuaSet al. Incidence, pattern and timing of brain metastases among patients with advanced breast cancer treated with trastuzumab. Acta Oncol.45(2), 196–201 (2006).
  • Bendell JC , DomchekSM, BursteinHJet al. Central nervous system metastases in women who receive trastuzumab-based therapy for metastatic breast carcinoma. Cancer97(12), 2972–2977 (2003).
  • Lin NU , CareyLA, LiuMCet al. Phase II trial of lapatinib for brain metastases in patients with human epidermal growth factor receptor 2-positive breast cancer. J. Clin. Oncol.26(12), 1993–1999 (2008).
  • Lin NU , FreedmanRA, RamakrishnaNet al. A Phase I study of lapatinib with whole brain radiotherapy in patients with human epidermal growth factor receptor 2 (HER2)-positive breast cancer brain metastases. Breast Cancer Res. Treat.142(2), 405–414 (2013).
  • Kaplan MA , IsikdoganA, KocaDet al. Clinical outcomes in patients who received lapatinib plus capecitabine combination therapy for HER2-positive breast cancer with brain metastasis and a comparison of survival with those who received trastuzumab-based therapy: a study by the Anatolian Society of Medical Oncology. Breast Cancer21(6), 677–683 (2014).
  • Lin NU , EiermanW, GreilRet al. Randomized Phase II study of lapatinib plus capecitabine or lapatinib plus topotecan for patients with HER2-positive breast cancer brain metastases. J. Neurooncol.105(3), 613–620 (2011).
  • Martin M , BonneterreJ, GeyerCEJret al. A Phase II randomised trial of neratinib monotherapy versus lapatinib plus capecitabine combination therapy in patients with HER2+ advanced breast cancer. Eur. J. Cancer49(18), 3763–3772 (2013).
  • Saura C , Garcia-SaenzJA, XuBet al. Safety and efficacy of neratinib in combination with capecitabine in patients with metastatic human epidermal growth factor receptor 2-positive breast cancer. J. Clin. Oncol.32(32), 3626–3633 (2014).
  • Morabito A , LongoR, GattusoDet al. Trastuzumab in combination with gemcitabine and vinorelbine as second-line therapy for HER-2/neu overexpressing metastatic breast cancer. Oncol. Rep.16(2), 393–398 (2006).
  • Mutlu H , BuyukcelikA. The combination of weekly trastuzumab plus vinorelbine may be preferable regimen in HER-2 positive breast cancer patients with brain metastasis. J. Oncol. Pharm. Pract.21(4), 310–312 (2015).
  • Iwamoto FM , OmuroAM, RaizerJJet al. A Phase II trial of vinorelbine and intensive temozolomide for patients with recurrent or progressive brain metastases. J. Neurooncol.87(1), 85–90 (2008).
  • Byun KD , AhnSG, BaikHJet al. Eribulin mesylate combined with local treatment for brain metastasis from breast cancer: two case reports. J. Breast Cancer19(2), 214–217 (2016).
  • Adams S , GrayRJ, DemariaSet al. Prognostic value of tumor-infiltrating lymphocytes in triple-negative breast cancers from two Phase III randomized adjuvant breast cancer trials: ECOG 2197 and ECOG 1199. J. Clin. Oncol.32(27), 2959–2966 (2014).
  • Ali HR , ProvenzanoE, DawsonSJet al. Association between CD8+ T-cell infiltration and breast cancer survival in 12,439 patients. Ann. Oncol.25(8), 1536–1543 (2014).
  • Loi S , MichielsS, SalgadoRet al. Tumor infiltrating lymphocytes are prognostic in triple negative breast cancer and predictive for trastuzumab benefit in early breast cancer: results from the FinHER trial. Ann. Oncol.25(8), 1544–1550 (2014).
  • Mittendorf EA , CliftonGT, HolmesJPet al. Final report of the Phase I/II clinical trial of the E75 (nelipepimut-S) vaccine with booster inoculations to prevent disease recurrence in high-risk breast cancer patients. Ann. Oncol.25(9), 1735–1742 (2014).
  • Dirix L , TakacsI, NikolinakosPet al. Avelumab (MSB0010718C), an anti-PD-L1 antibody, in patients with locally advanced or metastatic breast cancer: a Phase Ib JAVELIN solid tumor trial. Presented at: 38th Annual CTRC-AACR San Antonio Breast Cancer Symposium. TX, USA, December 8–12 2015 ( Abstract S1-04).
  • Rugo H , DelordJ-P, ImS-Aet al. Abstract S5–07: preliminary efficacy and safety of pembrolizumab (MK-3475) in patients with PD-L1-positive, estrogen receptor-positive (ER+)/HER2-negative advanced breast cancer enrolled in KEYNOTE-028. Cancer Res.76(Suppl. 4), S5–S7 (2016).
  • Goldberg SB , GettingerSN, MahajanAet al. Pembrolizumab for patients with melanoma or non-small-cell lung cancer and untreated brain metastases: early analysis of a non-randomised, open-label, Phase II trial. Lancet Oncol.17(7), 976–983 (2016).
  • Margolin K , ErnstoffMS, HamidOet al. Ipilimumab in patients with melanoma and brain metastases: an open-label, Phase II trial. Lancet Oncol.13(5), 459–465 (2012).
  • Di Giacomo AM , AsciertoPA, PillaLet al. Ipilimumab and fotemustine in patients with advanced melanoma (NIBIT-M1): an open-label, single-arm Phase II trial. Lancet Oncol.13(9), 879–886 (2012).
  • Di Giacomo AM , AsciertoPA, QueiroloPet al. Three-year follow-up of advanced melanoma patients who received ipilimumab plus fotemustine in the Italian Network for Tumor Biotherapy (NIBIT)-M1 Phase II study. Ann. Oncol.26(4), 798–803 (2015).
  • Barok M , IsolaJ, Palyi-KrekkZet al. Trastuzumab causes antibody-dependent cellular cytotoxicity-mediated growth inhibition of submacroscopic JIMT-1 breast cancer xenografts despite intrinsic drug resistance. Mol. Cancer Ther.6(7), 2065–2072 (2007).
  • Clynes R , KnutsonKL, BallmanKVet al. Combination trastuzumab and chemotherapy to induce immunity to multiple tumor antigens in patients with HER2-positive metastatic breast cancer: NCCTG (Alliance) studies N0337 and N98–32–52. J. Clin. Oncol.31(Suppl. 15), 521 (2013).
  • Vonderheide RH , LorussoPM, KhalilMet al. Tremelimumab in combination with exemestane in patients with advanced breast cancer and treatment-associated modulation of inducible costimulator expression on patient T cells. Clin. Cancer Res.16(13), 3485–3494 (2010).
  • Ribas A . Overcoming immunologic tolerance to melanoma: targeting CTLA-4 with tremelimumab (CP-675,206). Oncologist13(Suppl. 4), 10–15 (2008).
  • Ribas A , CamachoLH, Lopez-BeresteinGet al. Antitumor activity in melanoma and anti-self responses in a Phase I trial with the anti-cytotoxic T lymphocyte-associated antigen 4 monoclonal antibody CP-675,206. J. Clin. Oncol.23(35), 8968–8977 (2005).
  • Camacho LH , AntoniaS, SosmanJet al. Phase I/II trial of tremelimumab in patients with metastatic melanoma. J. Clin. Oncol.27(7), 1075–1081 (2009).
  • Tarhini AA , KirkwoodJM. Tremelimumab (CP-675, 206): a fully human anticytotoxic T lymphocyte-associated antigen 4 monoclonal antibody for treatment of patients with advanced cancers. Expert Opin. Biol. Ther.8(10), 1583–1593 (2008).
  • Mittendorf EA , PeoplesGE. Injecting hope – a review of breast cancer vaccines. Oncology30(5), 475–481, 485 (2016).
  • Pusztai L , KarnT, SafonovA, Abu-KhalafMM, BianchiniG. New strategies in breast cancer: immunotherapy. Clin. Cancer Res.22(9), 2105–2110 (2016).
  • Pardoll DM . The blockade of immune checkpoints in cancer immunotherapy. Nat. Rev. Cancer12(4), 252–264 (2012).
  • Keir ME , ButteMJ, FreemanGJ, SharpeAH. PD-1 and its ligands in tolerance and immunity. Annu. Rev. Immunol.26, 677–704 (2008).
  • Emens LA , BraitehFS, CassierPet al. Abstract 2859: inhibition of PD-L1 by MPDL3280A leads to clinical activity in patients with metastatic triple-negative breast cancer (TNBC). Cancer Res.75(Suppl. 15), 2859 (2015).
  • Adams S , DiamondJ, HamiltonEet al. Abstract P2–11–06: safety and clinical activity of atezolizumab (anti-PDL1) in combination with nab-paclitaxel in patients with metastatic triple-negative breast cancer. Cancer Res.76(Suppl. 4), P2–11–06 (2016).
  • Nanda R , ChowLQ, DeesECet al. Abstract S1–09: a Phase Ib study of pembrolizumab (MK-3475) in patients with advanced triple-negative breast cancer. Cancer Res.75(Suppl. 9), S1–S9 (2015).
  • Queirolo P , SpagnoloF, AsciertoPAet al. Efficacy and safety of ipilimumab in patients with advanced melanoma and brain metastases. J. Neurooncol.118(1), 109–116 (2014).
  • Knisely JP , YuJB, FlaniganJ, SznolM, KlugerHM, ChiangVL. Radiosurgery for melanoma brain metastases in the ipilimumab era and the possibility of longer survival. J. Neurosurgery117(2), 227–233 (2012).
  • Ongerboer de Visser BW , SomersR, NooyenWH, van HeerdeP, HartAA, McVieJG. Intraventricular methotrexate therapy of leptomeningeal metastasis from breast carcinoma. Neurology33(12), 1565–1572 (1983).
  • Glantz MJ , JaeckleKA, ChamberlainMCet al. A randomized controlled trial comparing intrathecal sustained-release cytarabine (DepoCyt) to intrathecal methotrexate in patients with neoplastic meningitis from solid tumors. Clin. Cancer Res.5(11), 3394–3402 (1999).
  • Zagouri F , SergentanisTN, BartschRet al. Intrathecal administration of trastuzumab for the treatment of meningeal carcinomatosis in HER2-positive metastatic breast cancer: a systematic review and pooled analysis. Breast Cancer Res. Treat.139(1), 13–22 (2013).
  • Jaeckle KA , PhuphanichS, BentMJet al. Intrathecal treatment of neoplastic meningitis due to breast cancer with a slow-release formulation of cytarabine. Br. J. Cancer84(2), 157–163 (2001).
  • Lu NT , RaizerJ, GaborEPet al. Intrathecal trastuzumab: immunotherapy improves the prognosis of leptomeningeal metastases in HER-2+ breast cancer patient. J. Immunother. Cancer3, 41 (2015).
  • Park WY , KimHJ, KimKet al. Intrathecal trastuzumab treatment in patients with breast cancer and leptomeningeal carcinomatosis. Cancer Res. Treat.48(2), 843–847 (2016).

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