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Editorial

Could JAG1 Protein Inhibition Prevent Colorectal Cancer?

, &
Pages 345-347 | Received 04 Oct 2018, Accepted 18 Oct 2018, Published online: 08 Jan 2019

References

  • Kovall RA , GebeleinB, SprinzakD, KopanR. The canonical notch signaling pathway: structural and biochemical insights into shape, sugar, and force. Dev. Cell41, 228–241 (2017).
  • Pellegrinet L , RodillaV, LiuZet al. Dll1- and Dll4-mediated notch signaling are required for homeostasis of intestinal stem cells. Gastroenterology140, 1230–1240 (2011).
  • López-Arribillaga E , RodillaV, PellegrinetLet al. Bmi1 regulates murine intestinal stem cell proliferation and self-renewal downstream of Notch. Development142, 41–50 (2015).
  • Bigas A , EspinosaL. The multiple usages of Notch signaling in development, cell differentiation and cancer. Curr. Opin. Cell Biol.55, 1–7 (2018).
  • Lu J , YeX, FanFet al. Endothelial cells promote the colorectal cancer stem cell phenotype through a soluble form of Jagged-1. Cancer Cell23, 171–185 (2013).
  • Xue Y , GaoX, LindsellCEet al. Embryonic lethality and vascular defects in mice lacking the Notch ligand Jagged1. Hum. Mol. Genet.8, 723–730 (1999).
  • Oda T , ElkahlounAG, PikeBLet al. Mutations in the human Jagged1 gene are responsible for Alagille syndrome. Nat. Genet.16, 235–242 (1997).
  • Fre S , PallaviSK, HuygheMet al. Notch and Wnt signals cooperatively control cell proliferation and tumorigenesis in the intestine. Proc. Natl Acad. Sci. USA106, 6309–6314 (2009).
  • Chanrion M , KupersteinI, BarrièreCet al. Concomitant Notch activation and p53 deletion trigger epithelial-to-mesenchymal transition and metastasis in mouse gut. Nat. Commun.5, 5005 (2014).
  • Sonoshita M , AokiM, FuwaHet al. Suppression of colon cancer metastasis by aes through inhibition of notch signaling. Cancer Cell19, 125–137 (2011).
  • Sonoshita M , ItataniY, KakizakiFet al. Promotion of colorectal cancer invasion and metastasis through activation of NOTCH-DAB1-ABL-RHOGEF protein TRIO. Cancer Discov.5, 198–211 (2015).
  • Rodilla V , VillanuevaA, Obrador-HeviaAet al. Jagged1 is the pathological link between Wnt and Notch pathways in colorectal cancer. Proc. Natl Acad. Sci. USA106, 6315–6320 (2009).
  • López-Arribillaga E , RodillaV, ColomerCet al. Manic Fringe deficiency imposes Jagged1 addiction to intestinal tumor cells. Nat. Commun.9, 2992 (2018).
  • van Es JH , van GijnME, RiccioOet al. Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells. Nature435, 959–963 (2005).
  • Purow B . Notch inhibition as a promising new approach to cancer therapy. Adv. Exp. Med. Biol.727, 305–319 (2012).
  • Real PJ , ToselloV, PalomeroTet al. Gamma-secretase inhibitors reverse glucocorticoid resistance in T cell acute lymphoblastic leukemia. Nat. Med.15, 50–58 (2009).
  • Wu Y , Cain-HomC, ChoyLet al. Therapeutic antibody targeting of individual Notch receptors. Nature464, 1052–1057 (2010).
  • Riccio O , van GijnME, BezdekACet al. Loss of intestinal crypt progenitor cells owing to inactivation of both Notch1 and Notch2 is accompanied by derepression of CDK inhibitors p27Kip1 and p57Kip2. EMBO Rep.9, 377–383 (2008).
  • Li D , MasieroM, BanhamAH, HarrisAL. The Notch ligand Jagged1 as a target for anti-tumor therapy. Front. Oncol.4, 254 (2014).
  • Czemerska M , PlutaA, Szmigielska-KaplonAet al. Jagged-1: a new promising factor associated with favorable prognosis in patients with acute myeloid leukemia. Leuk. Lymphoma56, 401–406 (2015).

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