References
- Siegel RL , MillerKD, JemalA. Cancer statistics, 2018. CA Cancer J. Clin.68(1), 7–30 (2018).
- Berry DA , CroninKA, PlevritisSKet al. Effect of screening and adjuvant therapy on mortality from breast cancer. N. Engl. J. Med.353(17), 1784–1792 (2005).
- Ni YB , TsangJY, ChanSK, TseGM. A novel morphologic-molecular recurrence predictive model refines traditional prognostic tools for invasive breast carcinoma. Ann. Surg. Oncol.21(9), 2928–2933 (2014).
- Pavlova NN , ThompsonCB. The emerging hallmarks of cancer metabolism. Cell Metab.23(1), 27–47 (2016).
- Ward PS , ThompsonCB. Metabolic reprogramming: a cancer hallmark even Warburg did not anticipate. Cancer Cell21(3), 297–308 (2012).
- Hanahan D , WeinbergRA. Hallmarks of cancer: the next generation. Cell144(5), 646–674 (2011).
- Bustamante E , MorrisHP, PedersenPL. Energy metabolism of tumor cells. Requirement for a form of hexokinase with a propensity for mitochondrial binding. J. Biol. Chem.256(16), 8699–8704 (1981).
- Dias AS , AlmeidaCR, HelgueroLA, DuarteIF. Metabolic crosstalk in the breast cancer microenvironment. Eur. J. Cancer121, 154–171 (2019).
- Jia M , AndreassenT, JensenLet al. Estrogen receptor α promotes breast cancer by reprogramming choline metabolism. Cancer Res.76(19), 5634–5646 (2016).
- Demas DM , DemoS, FallahYet al. Glutamine metabolism drives growth in advanced hormone receptor positive breast cancer. Front. Oncol.9, 686 (2019).
- Zhang ZG , ZhangHS, SunHLet al. KDM5B promotes breast cancer cell proliferation and migration via AMPK-mediated lipid metabolism reprogramming. Exp. Cell Res.379(2), 182–190 (2019).
- Lebok P , Von HasselA, MeinersJet al. Up-regulation of lysophosphatidylcholine acyltransferase 1 (LPCAT1) is linked to poor prognosis in breast cancer. Aging (Albany NY)11(18), 7796–7804 (2019).
- Kwong SC , JamilAHA, RhodesAet al. Metabolic role of fatty acid binding protein 7 in mediating triple-negative breast cancer cell death via PPAR-α signaling. J. Lipid Res.60(11), 1807–1817 (2019).
- Tibshirani R . The lasso method for variable selection in the Cox model. Stat. Med.16(4), 385–395 (1997).
- Wolbers M , KollerMT, WittemanJC, SteyerbergEW. Prognostic models with competing risks: methods and application to coronary risk prediction. Epidemiology20(4), 555–561 (2009).
- Yu G , WangLG, HanY, HeQY. clusterProfiler: an R package for comparing biological themes among gene clusters. OMICS16(5), 284–287 (2012).
- Fouad YA , AaneiC. Revisiting the hallmarks of cancer. Am. J. Cancer Res.7(5), 1016–1036 (2017).
- Zhang L , BailleulJ, YazalTet al. PK-M2-mediated metabolic changes in breast cancer cells induced by ionizing radiation. Breast Cancer Res. Treat.178(1), 75–86 (2019).
- Rodrigues C , MilkovicL, BujakITet al. Lipid profile and aquaporin expression under oxidative stress in breast cancer cells of different malignancies. Oxid. Med. Cell. Longev.2019, 2061830 (2019).
- Cordero A , KanojiaD, MiskaJet al. FABP7 is a key metabolic regulator in HER2+ breast cancer brain metastasis. Oncogene38(37), 6445–6460 (2019).
- Singh K , RoyM, PrajapatiPet al. NLRX1 regulates TNF-α-induced mitochondria-lysosomal crosstalk to maintain the invasive and metastatic potential of breast cancer cells. Biochim. Biophys. Acta Mol. Basis Dis.1865(6), 1460–1476 (2019).
- Liang WH , LiN, YuanZQet al. DSCAM-AS1 promotes tumor growth of breast cancer by reducing miR-204-5p and up-regulating RRM2. Mol. Carcinog.58(4), 461–473 (2019).
- Putluri N , MaityS, KommaganiRet al. Pathway-centric integrative analysis identifies RRM2 as a prognostic marker in breast cancer associated with poor survival and tamoxifen resistance. Neoplasia (New York, N.Y.)16(5), 390–402 (2014).
- Shah KN , MehtaKR, PetersonDet al. AKT-induced tamoxifen resistance is overturned by RRM2 inhibition. Mol. Cancer Res.12(3), 394–407 (2014).
- Shah KN , WilsonEA, MallaRet al. Targeting ribonucleotide reductase M2 and NF-κB activation with didox to circumvent tamoxifen resistance in breast cancer. Mol. Cancer Ther.14(11), 2411–2421 (2015).
- Zhu D , ZhaoZ, CuiGet al. Single-cell transcriptome analysis reveals estrogen signaling coordinately augments one-carbon, polyamine, and purine synthesis in breast cancer. Cell Rep.25(8), 2285–2298.e2284 (2018).
- Yen MC , KanJY, HsiehCJet al. Association of long-chain acyl-coenzyme A synthetase 5 expression in human breast cancer by estrogen receptor status and its clinical significance. Oncol. Rep.37(6), 3253–3260 (2017).
- Desideri E , CiccaroneF, CirioloMR. Targeting glutathione metabolism: partner in crime in anticancer therapy. Nutrients11(8), (2019).
- Lien EC , LyssiotisCA, JuvekarAet al. Glutathione biosynthesis is a metabolic vulnerability in PI(3)K/Akt-driven breast cancer. Nat. Cell Biol.18(5), 572–578 (2016).
- Chiaradonna F , BarozziI, MiccoloCet al. Redox-mediated suberoylanilide hydroxamic acid sensitivity in breast cancer. Antioxid. Redox Signal.23(1), 15–29 (2015).