Facing SARS-CoV-2 Outbreak in Immunotherapy Era

References

• Li Q , GuanX, WuPet al. Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia. N. Engl. J. Med. 382(13), 1199–1207 (2020).
   PubMed Web of Science ®Google Scholar
• Coronavirus disease 2019 (COVID-19) . Situation Report (2020). www.who.int/docs/default-source/coronaviruse/situation-reports/20200311-sitrep-51-covid-19.pdf?sfvrsn=1ba62e57_10
   Google Scholar
• Li G , FanY, LaiYet al. Coronavirus infections and immune responses. J. Med. Virol. 92(4), 424–432 (2020).
   PubMed Web of Science ®Google Scholar
• Wang D , HuB, HuCet al. Clinical characteristics of 138 hospitalized patients With 2019 novel coronavirus–infected pneumonia in Wuhan, China. JAMA 323(11), 1061–1069 (2020).
   PubMed Web of Science ®Google Scholar
• Zhou S , WangY, ZhuT, XiaL. CT features of coronavirus disease 2019 (COVID-19) pneumonia in 62 patients in Wuhan, China.AJR Am. J. Roentgenol.214(6), 1287–1294 (2020).
   PubMed Web of Science ®Google Scholar
• Huang C , WangY, LiXet al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet 395(10223), 497–506 (2020).
   PubMed Web of Science ®Google Scholar
• Zhou P , YangXL, WangXGet al. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature 579(7798), 270–273 (2020).
   PubMed Web of Science ®Google Scholar
• Zhao Y , ZhaoZ, WangY, ZhouY, MaY, ZuoW. Single-cell RNA expression profiling of ACE2, the receptor of SARS-CoV-2.bioRxiv2020.01.26.919985 (2020).
   Google Scholar
• Chen I-Y , MoriyamaM, ChangM-F, IchinoheT. Severe acute respiratory syndrome coronavirus viroporin 3a activates the NLRP3 inflammasome.Front. Microbiol.10, 50 (2019).
   PubMed Web of Science ®Google Scholar
• Ming Y . Cell pyroptosis, a potential pathogenic mechanism of 2019-nCoV infection (2020). papers.ssrn.com/sol3/papers.cfm?abstract_id=3527420
   Google Scholar
• Jiang Y , LiJ, TengYet al. Complement receptor C5aR1 inhibition reduces pyroptosis in hDPP4-transgenic mice infected with MERS-CoV. Viruses 11(9), 39 (2019).
   PubMedGoogle Scholar
• Glowacka I , BertramS, HerzogPet al. Differential downregulation of ACE2 by the spike proteins of severe acute respiratory syndrome coronavirus and human coronavirus NL63. J. Virol. 84(2), 1198–1205 (2010).
   PubMed Web of Science ®Google Scholar
• Wang S , GuoF, LiuKet al. Endocytosis of the receptor-binding domain of SARS-CoV spike protein together with virus receptor ACE2. Virus Res. 136(1–2), 8–15 (2008).
   PubMed Web of Science ®Google Scholar
• Imai Y , KubaK, RaoSet al. Angiotensin-converting enzyme 2 protects from severe acute lung failure. Nature 436(7047), 112–116 (2005).
   PubMed Web of Science ®Google Scholar
• Kuba K , ImaiY, RaoSet al. A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus-induced lung injury. Nat. Med. 11(8), 875–879 (2005).
   PubMed Web of Science ®Google Scholar
• Lambert DW , YarskiM, WarnerFJet al. Tumor necrosis factor-alpha convertase (ADAM17) mediates regulated ectodomain shedding of the severe-acute respiratory syndrome-coronavirus (SARS-CoV) receptor, angiotensin-converting enzyme-2 (ACE2). J. Biol. Chem. 280(34), 30113–30119 (2005).
   PubMed Web of Science ®Google Scholar
• Jia HP , LookDC, TanP, ShiLet al. Ectodomain shedding of angiotensin converting enzyme 2 in human airway epithelia. Am. J. Physiol. Lung Cell. Mol. Physiol. 297(1), L84–96 (2009).
   PubMed Web of Science ®Google Scholar
• Haga S , YamamotoN, Nakai-MurakamiCet al. Modulation of TNF-alpha-converting enzyme by the spike protein of SARS-CoV and ACE2 induces TNF-alpha production and facilitates viral entry. Proc. Natl Acad. Sci. USA 105(22), 7809–7814 (2008).
   PubMed Web of Science ®Google Scholar
• Lu G , WangQ, GaoGF. Bat-to-human: spike features determining “host jump” of coronaviruses SARS-CoV, MERS-CoV, and beyond.Trends Microbiol.23(8), 468–478 (2015).
   PubMed Web of Science ®Google Scholar
• Du L , HeY, ZhouY, LiuS, ZhengBJ, JiangS. The spike protein of SARS-CoV--a target for vaccine and therapeutic development.Nat. Rev. Microbiol.7(3), 226–236 (2009).
   PubMed Web of Science ®Google Scholar
• Peiris JS , ChuCM, ChengVCet al. Clinical progression and viral load in a community outbreak of coronavirus-associated SARS pneumonia: a prospective study. Lancet 361(9371), 1767–1772 (2003).
   PubMed Web of Science ®Google Scholar
• Zhang L , ZhangF, YuWet al. Antibody responses against SARS coronavirus are correlated with disease outcome of infected individuals. J. Med. Virol. 78(1), 1–8 (2006).
   PubMed Web of Science ®Google Scholar
• Liu L , WeiQ, LinQet al. Anti-spike IgG causes severe acute lung injury by skewing macrophage responses during acute SARS-CoV infection. JCI Insight 4(4), e123158 (2019).
   PubMed Web of Science ®Google Scholar
• Herold S , MayerK, LohmeyerJ. Acute lung injury: how macrophages orchestrate resolution of inflammation and tissue repair.Front. Immunol.2, 65 (2011).
   PubMed Web of Science ®Google Scholar
• Murray PJ , WynnTA. Protective and pathogenic functions of macrophage subsets.Nat. Rev. Immunol.11(11), 723–737 (2011).
   PubMed Web of Science ®Google Scholar
• Channappanavar R , FehrAR, VijayRet al. Dysregulated Type I interferon and inflammatory monocyte-macrophage responses cause lethal pneumonia in SARS-CoV-infected mice. Cell Host Microbe 19(2), 181–193 (2016).
   PubMed Web of Science ®Google Scholar
• Stockman LJ , MassoudiMS, HelfandRet al. Severe acute respiratory syndrome in children. Pediatr. Infect. Dis. J. 26(1), 68–74 (2007).
   PubMed Web of Science ®Google Scholar
• Yang ZY , WernerHC, KongWPet al. Evasion of antibody neutralization in emerging severe acute respiratory syndrome coronaviruses. Proc. Natl Acad. Sci. USA 102(3), 797–801 (2005).
   PubMed Web of Science ®Google Scholar
• Wu Z , YangL, RenXet al. Deciphering the bat virome catalog to better understand the ecological diversity of bat viruses and the bat origin of emerging infectious diseases. ISME J. 10(3), 609–620 (2016).
   PubMed Web of Science ®Google Scholar
• Leung GM , LimWW, HoLMet al. Seroprevalence of IgG antibodies to SARS-coronavirus in asymptomatic or subclinical population groups. Epidemiol. Infect. 134(2), 211–221 (2006).
   PubMed Web of Science ®Google Scholar
• Cecere TE , ToddSM, LeroithT. Regulatory T cells in arterivirus and coronavirus infections: do they protect against disease or enhance it?Viruses4(5), 833–846 (2012).
   PubMed Web of Science ®Google Scholar
• Chen J , LauYF, LamirandeEWet al. Cellular immune responses to severe acute respiratory syndrome coronavirus (SARS-CoV) infection in senescent BALB/c mice: CD4+ T cells are important in control of SARS-CoV infection. J. Virol. 84(3), 1289–1301 (2010).
   PubMed Web of Science ®Google Scholar
• Conti P , RonconiG, CaraffaAet al. Induction of pro-inflammatory cytokines (IL-1 and IL-6) and lung inflammation by Coronavirus-19 (COVI-19 or SARS-CoV-2): anti-inflammatory strategies. J. Biol. Regul. Homeost. Agents 34(2), (2020).
   Web of Science ®Google Scholar
• Mehta P , McAuleyDF, BrownM, SanchezE, TattersallRS, MansonJJ. COVID-19: consider cytokine storm syndromes and immunosuppression.Lancet395(10229), 1033–1034 (2020).
   PubMed Web of Science ®Google Scholar
• Yao XH , LiTY, HeZCet al. [A pathological report of three COVID-19 cases by minimally invasive autopsies]. Zhonghua Bing Li Xue Za Zhi. 49(0), E009 (2020).
   Google Scholar
• Wu J , WuX, ZengWet al. Chest CT findings in patients with corona virus disease 2019 and its relationship with clinical features. Invest. Radiol. 55(5), 257–261 (2020).
   PubMed Web of Science ®Google Scholar
• Zhou F , YuT, DuRet al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet 395(10229), 1054–1062 (2020).
   PubMed Web of Science ®Google Scholar
• Khot WY , NadkarMY. The 2019 novel coronavirus outbreak – a global threat.J. Assoc. Physicians India68(3), 67–71 (2020).
   PubMedGoogle Scholar
• Magdi M , RahilA. Severe immune thrombocytopenia complicated by intracerebral haemorrhage associated with coronavirus infection: a case report and literature review.Eur. J. Case Rep. Intern. Med.6(7), 1155 (2019).
   Google Scholar
• Ling Y , XuSB, LinYXet al. Persistence and clearance of viral RNA in 2019 novel coronavirus disease rehabilitation patients. Chin. Med. J. 133(9), 1039–1043 (2020).
   PubMed Web of Science ®Google Scholar
• Hamming I , TimensW, BulthuisML, LelyAT, NavisGJ, van GoorH. Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. A first step in understanding SARS pathogenesis.J. Pathol.203(2), 631–637 (2004).
   PubMed Web of Science ®Google Scholar
• Russell CD , MillarJE, BaillieJK. Clinical evidence does not support corticosteroid treatment for 2019-nCoV lung injury.Lancet395(10223), 473–475 (2020).
   PubMed Web of Science ®Google Scholar
• Ai T , YangZ, HouHet al. Correlation of chest CT and RT-PCR testing in coronavirus disease 2019 (COVID-19) in China: a report of 1014 cases. Radiology 200642, (2020).
   PubMed Web of Science ®Google Scholar
• Chinese Clinical Trial Registry . A multicenter, randomized controlled trial for the efficacy and safety of tocilizumab in the treatment of new coronavirus pneumonia (COVID-19) (2020). www.chictr.org.cn/showprojen.aspx?proj=49409
   Google Scholar
• Thibult ML , MamessierE, Gertner-DardenneJet al. PD-1 is a novel regulator of human B-cell activation. Int. Immunol. 25(2), 129–137 (2013).
   PubMed Web of Science ®Google Scholar
• Osorio JC , NiA, ChaftJEet al. Antibody-mediated thyroid dysfunction during T-cell checkpoint blockade in patients with non-small-cell lung cancer. Ann. Oncol. 28(3), 583–589 (2017).
   PubMed Web of Science ®Google Scholar
• Sage PT , FranciscoLM, CarmanCV, SharpeAH. The receptor PD-1 controls follicular regulatory T cells in the lymph nodes and blood.Nat. Immunol.14(2), 152–161 (2013).
   PubMed Web of Science ®Google Scholar
• Ribas A , RobertC, HodiFSet al. Association of response to programmed death receptor 1 (PD-1) blockade with pembrolizumab (MK-3475) with an interferon-inflammatory immune gene signature. JCO 33(Suppl. 15), 3001–3001 (2015).
   Web of Science ®Google Scholar
• Ribas A , ShinDS, ZaretskyJet al. PD-1 blockade expands intratumoral memory T cells. Cancer. Immunol. Res. 4(3), 194–203 (2016).
   PubMed Web of Science ®Google Scholar
• Huang AC , PostowMA, OrlowskiRJet al. T-cell invigoration to tumour burden ratio associated with anti-PD-1 response. Nature 545(7652), 60–65 (2017).
   PubMed Web of Science ®Google Scholar
• Pardoll DM . The blockade of immune checkpoints in cancer immunotherapy.Nat. Rev. Cancer12(4), 252–264 (2012).
   PubMed Web of Science ®Google Scholar
• Velu V , TitanjiK, ZhuBet al. Enhancing SIV-specific immunity in vivo by PD-1 blockade. Nature 458(7235), 206–210 (2009).
   PubMed Web of Science ®Google Scholar
• Li X , ShaoC, ShiY, HanW. Lessons learned from the blockade of immune checkpoints in cancer immunotherapy.J. Hematol. Oncol.11(1), 31 (2018).
   PubMedGoogle Scholar
• Alegre ML , NoelPJ, EisfelderBJet al. Regulation of surface and intracellular expression of CTLA4 on mouse T cells. J. Immunol. 157(11), 4762–4770 (1996).
   PubMed Web of Science ®Google Scholar
• Takahashi T , TagamiT, YamazakiSet al. Immunologic self-tolerance maintained by CD25(+) CD4(+) regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4. J. Exp. Med. 192(2), 303–310 (2000).
   PubMed Web of Science ®Google Scholar
• Wing K , OnishiY, Prieto-MartinPet al. CTLA-4 control over Foxp3+ regulatory T cell function. Science 322(5899), 271–275 (2008).
   PubMed Web of Science ®Google Scholar
• Yamazaki T , AkibaH, IwaiHet al. Expression of programmed death 1 ligands by murine T cells and APC. J. Immunol. 169(10), 5538–5545 (2002).
   PubMed Web of Science ®Google Scholar
• Latchman Y , WoodCR, ChernovaTet al. PD-L2 is a second ligand for PD-1 and inhibits T cell activation. Nat. Immunol. 2(3), 261–268 (2001).
   PubMed Web of Science ®Google Scholar
• Messal N , SerriariNE, PastorS, NunèsJA, OliveD. PD-L2 is expressed on activated human T cells and regulates their function.Mol. Immunol.48(15–16), 2214–2219 (2011).
   PubMed Web of Science ®Google Scholar
• Keir ME , ButteMJ, FreemanGJ, SharpeAH. PD-1 and its ligands in tolerance and immunity.Annu. Rev. Immunol.26, 677–704 (2008).
   PubMed Web of Science ®Google Scholar
• Parry RV , ChemnitzJM, FrauwirthKAet al. CTLA-4 and PD-1 receptors inhibit T-cell activation by distinct mechanisms. Mol. Cell. Biol. 25(21), 9543–9553 (2005).
   PubMed Web of Science ®Google Scholar
• Chikuma S , TerawakiS, HayashiTet al. PD-1-mediated suppression of IL-2 production induces CD8+ T cell anergy in vivo. J. Immunol. 182(11), 6682–6689 (2009).
   PubMed Web of Science ®Google Scholar
• Sharpe AH , WherryEJ, AhmedR, FreemanGJ. The function of programmed cell death 1 and its ligands in regulating autoimmunity and infection.Nat. Immunol.8(3), 239–245 (2007).
   PubMed Web of Science ®Google Scholar
• Youngblood B , OestreichKJ, HaSJet al. Chronic virus infection enforces demethylation of the locus that encodes PD-1 in antigen-specific CD8(+) T cells. Immunity 35(3), 400–412 (2011).
   PubMed Web of Science ®Google Scholar
• Badoual C , HansS, MerillonNet al. PD-1-expressing tumor-infiltrating T cells are a favorable prognostic biomarker in HPV-associated head and neck cancer. Cancer Res. 73(1), 128–138 (2013).
   PubMed Web of Science ®Google Scholar
• Gros A , RobbinsPF, YaoXet al. PD-1 identifies the patient-specific CD8+ tumor-reactive repertoire infiltrating human tumors. J. Clin. Invest. 124(5), 2246–2259 (2014).
   PubMed Web of Science ®Google Scholar
• Gros A , ParkhurstMR, TranEet al. Prospective identification of neoantigen-specific lymphocytes in the peripheral blood of melanoma patients. Nat. Med. 22(4), 433–438 (2016).
   PubMed Web of Science ®Google Scholar
• Das R , BarN, FerreiraMet al. Early B cell changes predict autoimmunity following combination immune checkpoint blockade. J. Clin. Invest. 128(2), 715–720 (2018).
   PubMed Web of Science ®Google Scholar
• Berner F , BomzeD, DiemSet al. Association of checkpoint inhibitor-induced toxic effects with shared cancer and tissue antigens in non-small cell lung cancer. JAMA Oncol. 5(7), 1043–1047 (2019).
   PubMed Web of Science ®Google Scholar
• Kamran A , OtaibiZ, ShahRA, FinleyG. Lymphopenia as an early predictor of immune related adverse events.Blood132(Suppl. 1), 4958–4958 (2018).
   Google Scholar
• Genin M , ClementF, FattaccioliA, RaesM, MichielsC. M1 and M2 macrophages derived from THP-1 cells differentially modulate the response of cancer cells to etoposide.BMC Cancer15, 577 (2015).
   PubMed Web of Science ®Google Scholar
• Wang J , SuX, YangLet al. The influence of myeloid-derived suppressor cells on angiogenesis and tumor growth after cancer surgery. Int. J. Cancer 138(11), 2688–2699 (2016).
   PubMed Web of Science ®Google Scholar
• Haabeth OA , LorvikKB, YagitaH, BogenB, CorthayA. Interleukin-1 is required for cancer eradication mediated by tumor-specific Th1 cells.Oncoimmunology5(1), e1039763 (2016).
   PubMed Web of Science ®Google Scholar
• Scheller J , ChalarisA, Schmidt-ArrasD, Rose-JohnS. The pro- and anti-inflammatory properties of the cytokine interleukin-6.Biochim. Biophys. Acta1813(5), 878–888 (2011).
   PubMed Web of Science ®Google Scholar
• Chang Q , DalyL, BrombergJ. The IL-6 feed-forward loop: a driver of tumorigenesis.Semin. Immunol.26(1), 48–53 (2014).
   PubMed Web of Science ®Google Scholar
• Bharti R , DeyG, MandalM. Cancer development, chemoresistance, epithelial to mesenchymal transition and stem cells: a snapshot of IL-6 mediated involvement.Cancer Lett.375(1), 51–61 (2016).
   PubMed Web of Science ®Google Scholar
• Ando K , TakahashiF, MotojimaSet al. Possible role for tocilizumab, an anti-interleukin-6 receptor antibody, in treating cancer cachexia. J. Clin. Oncol. 31(6), e69–72 (2013).
   PubMed Web of Science ®Google Scholar
• Shinriki S , JonoH, OtaKet al. Humanized anti-interleukin-6 receptor antibody suppresses tumor angiogenesis and in vivo growth of human oral squamous cell carcinoma. Clin. Cancer Res. 15(17), 5426–5434 (2009).
   PubMed Web of Science ®Google Scholar
• Valpione S , PasqualiS, CampanaLGet al. Sex and interleukin-6 are prognostic factors for autoimmune toxicity following treatment with anti-CTLA4 blockade. J. Transl. Med. 16(1), 94 (2018).
   PubMedGoogle Scholar
• Kinter AL , GodboutEJ, McNallyJPet al. The common gamma-chain cytokines IL-2, IL-7, IL-15, and IL-21 induce the expression of programmed death-1 and its ligands. J. Immunol. 181(10), 6738–6746 (2008).
   PubMed Web of Science ®Google Scholar
• Bachmann MF , OxeniusA. Interleukin 2: from immunostimulation to immunoregulation and back again.EMBO Rep.8(12), 1142–1148 (2007).
   PubMed Web of Science ®Google Scholar
• Baron S , DianzaniF. The interferons: a biological system with therapeutic potential in viral infections.Antiviral Res.24(2–3), 97–110 (1994).
   PubMed Web of Science ®Google Scholar
• Cho HY , LeeSW, SeoSK, ChoiIW, ChoiI, LeeSW. Interferon-sensitive response element (ISRE) is mainly responsible for IFN-alpha-induced upregulation of programmed death-1 (PD-1) in macrophages.Biochim. Biophys. Acta1779(12), 811–819 (2008).
   PubMed Web of Science ®Google Scholar
• Accolla RS , TosiG. Optimal MHC-II-restricted tumor antigen presentation to CD4+ T helper cells: the key issue for development of anti-tumor vaccines.J. Transl. Med.10, 154 (2012).
   PubMed Web of Science ®Google Scholar
• Peng W , LiuC, XuCet al. PD-1 blockade enhances T-cell migration to tumors by elevating IFN-γ inducible chemokines. Cancer Res. 72(20), 5209–5218 (2012).
   PubMed Web of Science ®Google Scholar
• Weide B , MartensA, HasselJCet al. Baseline biomarkers for outcome of melanoma patients treated with pembrolizumab. Clin. Cancer Res. 22(22), 5487–5496 (2016).
   Web of Science ®Google Scholar