Prognostic Significance of OXR1 in Urothelial Carcinoma: Low OXR1 Expression is Associated with Worse Survival

References

• Miyazaki J , NishiyamaH. Epidemiology of urothelial carcinoma. Int. J. Urol.24(10), 730–734 (2017).
   PubMed Web of Science ®Google Scholar
• Debelle FD , VanherweghemJL, NortierJL. Aristolochic acid nephropathy: a worldwide problem. Kidney Int.74(2), 158–169 (2008).
   PubMed Web of Science ®Google Scholar
• Pommer W , BronderE, KlimpelA, HelmertU, GreiserE, MolzahnM. Urothelial cancer at different tumour sites: role of smoking and habitual intake of analgesics and laxatives. Results of the Berlin Urothelial Cancer Study. Nephrol. Dial. Transplant.14(12), 2892–2897 (1999).
   PubMed Web of Science ®Google Scholar
• Reulen RC , KellenE, BuntinxF, BrinkmanM, ZeegersMP. A meta-analysis on the association between bladder cancer and occupation. Scand. J. Urol. Nephrol. (Suppl. 218), 64–78 (2008).
   Google Scholar
• Shinka T , MiyaiM, SawadaY, InagakiT, OkawaT. Factors affecting the occurrence of urothelial tumors in dye workers exposed to aromatic amines. Int. J. Urol.2(4), 243–248 (1995).
   PubMedGoogle Scholar
• Sosa V , MolinéT, SomozaR, PaciucciR, KondohH, LLME. Oxidative stress and cancer: an overview. Ageing Res. Rev.12(1), 376–390 (2013).
   PubMed Web of Science ®Google Scholar
• Durand M , KolpakA, FarrellTet al. The OXR domain defines a conserved family of eukaryotic oxidation resistance proteins. BMC Cell Biol.8, 13 (2007).
   PubMedGoogle Scholar
• Elliott NA , VolkertMR. Stress induction and mitochondrial localization of Oxr1 proteins in yeast and humans. Mol. Cell. Biol.24(8), 3180–3187 (2004).
   PubMed Web of Science ®Google Scholar
• Volkert MR , ElliottNA, HousmanDE. Functional genomics reveals a family of eukaryotic oxidation protection genes. Proc. Natl Acad. Sci. USA97(26), 14530–14535 (2000).
   PubMed Web of Science ®Google Scholar
• Williamson MG , FinelliMJ, SleighJNet al. Neuronal over-expression of Oxr1 is protective against ALS-associated mutant TDP-43 mislocalisation in motor neurons and neuromuscular defects in vivo. Hum. Mol. Genet.28(21), 3584–3599 (2019).
   PubMed Web of Science ®Google Scholar
• Pedro NF , BiselliJM, ManigliaJVet al. Candidate biomarkers for oral squamous cell carcinoma: differential expression of oxidative stress-related genes. Asian Pac. J. Cancer Prev.19(5), 1343–1349 (2018).
   PubMedGoogle Scholar
• Pires-Luís AS , Costa-PinheiroP, FerreiraMJet al. Identification of clear cell renal cell carcinoma and oncocytoma using a three-gene promoter methylation panel. J. Transl. Med.15(1), 149 (2017).
   PubMedGoogle Scholar
• Yang M , LunaL, SørbøJGet al. Human OXR1 maintains mitochondrial DNA integrity and counteracts hydrogen peroxide-induced oxidative stress by regulating antioxidant pathways involving p21. Free Radic. Biol. Med.77, 41–48 (2014).
   PubMed Web of Science ®Google Scholar
• Sanada Y , AsaiS, IkemotoAet al. Oxidation resistance 1 is essential for protection against oxidative stress and participates in the regulation of aging in Caenorhabditis elegans. Free Radic. Res.48(8), 919–928 (2014).
   PubMed Web of Science ®Google Scholar
• Matsui A , KobayashiJ, KannoSIet al. Oxidation resistance 1 prevents genome instability through maintenance of G2/M arrest in gamma-ray-irradiated cells. J. Radiat. Res.61(1), 1–13 (2020).
   PubMed Web of Science ®Google Scholar
• Yang M , LinX, RoweA, RognesT, EideL, BjorasM. Transcriptome analysis of human OXR1 depleted cells reveals its role in regulating the p53 signaling pathway. Sci. Rep.5, 17409 (2015).
   PubMed Web of Science ®Google Scholar
• Isogai C , LaugWE, ShimadaHet al. Plasminogen activator inhibitor-1 promotes angiogenesis by stimulating endothelial cell migration toward fibronectin. Cancer Res.61(14), 5587–5594 (2001).
   PubMed Web of Science ®Google Scholar
• Wei Q , ZhangF, RichardsonMMet al. CD82 restrains pathological angiogenesis by altering lipid raft clustering and CD44 trafficking in endothelial cells. Circulation130(17), 1493–1504 (2014).
   PubMed Web of Science ®Google Scholar
• Chai J , DuL, JuJet al. Overexpression of KAI1/CD82 suppresses in vitro cell growth, migration, invasion and xenograft growth in oral cancer. Mol. Med. Rep.15(4), 1527–1532 (2017).
   PubMed Web of Science ®Google Scholar
• Stambolic V , SuzukiA, dela Pompa JLet al. Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN. Cell95(1), 29–39 (1998).
   PubMed Web of Science ®Google Scholar
• Armengol G , RojoF, CastellviJet al. 4E-binding protein 1: a key molecular ‘funnel factor’ in human cancer with clinical implications. Cancer Res.67(16), 7551–7555 (2007).
   PubMed Web of Science ®Google Scholar
• Barlund M , ForozanF, KononenJet al. Detecting activation of ribosomal protein S6 kinase by complementary DNA and tissue microarray analysis. J. Natl Cancer Inst.92(15), 1252–1259 (2000).
   PubMed Web of Science ®Google Scholar
• De Benedetti A , GraffJR. eIF-4E expression and its role in malignancies and metastases. Oncogene23(18), 3189–3199 (2004).
   PubMed Web of Science ®Google Scholar
• Nakamura JL , GarciaE, PieperRO. S6K1 plays a key role in glial transformation. Cancer Res.68(16), 6516–6523 (2008).
   PubMed Web of Science ®Google Scholar
• Seront E , PintoA, BouzinC, BertrandL, MachielsJP, FeronO. PTEN deficiency is associated with reduced sensitivity to mTOR inhibitor in human bladder cancer through the unhampered feedback loop driving PI3K/Akt activation. Br. J. Cancer109(6), 1586–1592 (2013).
   PubMed Web of Science ®Google Scholar
• Rajabi M , MousaSA. The role of angiogenesis in cancer treatment. Biomedicines5(2), 34 (2017).
   PubMed Web of Science ®Google Scholar
• Kim YW , ByzovaTV. Oxidative stress in angiogenesis and vascular disease. Blood123(5), 625–631 (2014).
   PubMed Web of Science ®Google Scholar
• Huang YJ , NanGX. Oxidative stress-induced angiogenesis. J. Clin. Neurosci.63, 13–16 (2019).
   PubMed Web of Science ®Google Scholar
• Kim J , KoyanagiT, Mochly-RosenD. PKCδ activation mediates angiogenesis via NADPH oxidase activity in PC-3 prostate cancer cells. Prostate71(9), 946–954 (2011).
   PubMed Web of Science ®Google Scholar
• West XZ , MalininNL, MerkulovaAAet al. Oxidative stress induces angiogenesis by activating TLR2 with novel endogenous ligands. Nature467(7318), 972–976 (2010).
   PubMed Web of Science ®Google Scholar