3,608
Views
13
CrossRef citations to date
0
Altmetric
Research Article

Real-World Ibrutinib dose Reductions, Holds and Discontinuations in Chronic Lymphocytic Leukemia

, , , , , , , , & show all
Pages 4959-4969 | Received 06 Aug 2021, Accepted 20 Oct 2021, Published online: 16 Nov 2021

References

  • Siegel RL , MillerKD, JemalA. Cancer statistics, 2020. CA Cancer J. Clin.70(1), 7–30 (2020).
  • Hallek M . Chronic lymphocytic leukemia: 2015 Update on diagnosis, risk stratification, and treatment. Am. J. Hematol.90(5), 446–460 (2015).
  • National Comprehensive Cancer Network . NCCN Clinical Practice guidelines in oncology: chronic lymphocytic leukemia/small lymphocytic lymphoma version 1.2022. National Comprehensive Cancer Network (2021). www.nccn.org/professionals/physician_gls/pdf/cll.pdf
  • Eichhorst B , RobakT, MontserratEet al. Chronic lymphocytic leukaemia: ESMO Clinical Practice guidelines for diagnosis, treatment and follow-up. Ann. Oncol.32(1), 23–33 (2021).
  • Introduction. In: SEER Cancer Statistics Review, 1975–2017.HowladerN, NooneAM, KrapchoMet al. ( et al. Eds). National Cancer Institute, MD, USA, 1–7 (2020).
  • Mato AR , BarrientosJC, GhoshNet al. Prognostic testing and treatment patterns in chronic lymphocytic leukemia in the era of novel targeted therapies: results from the informCLL Registry. Clin. Lymphoma Myeloma Leuk.20(3), 174–183.e173 (2020).
  • Mato A , NabhanC, LamannaNet al. The Connect CLL Registry: final analysis of 1494 patients with chronic lymphocytic leukemia across 199 US sites. Blood Adv.4(7), 1407–1418 (2020).
  • Hallek M , FischerK, Fingerle-RowsonGet al. Addition of rituximab to fludarabine and cyclophosphamide in patients with chronic lymphocytic leukaemia: a randomised, open-label, phase 3 trial. Lancet376(9747), 1164–1174 (2010).
  • Goede V , FischerK, BuschRet al. Obinutuzumab plus chlorambucil in patients with CLL and coexisting conditions. N. Engl. J. Med.370(12), 1101–1110 (2014).
  • Imbruvica [package insert]. Pharmacyclics, Janssen Biotech, Inc, PA, USA (2020). www.imbruvica.com/files/prescribing-information.pdf
  • Sharman JP , Black-ShinnJL, ClarkJ, BitmanB. Understanding ibrutinib treatment discontinuation patterns for chronic lymphocytic leukemia [abstract]. Blood130(Suppl. 1), 4060 (2017).
  • Hampel PJ , DingW, CallTGet al. Rapid disease progression following discontinuation of ibrutinib in patients with chronic lymphocytic leukemia treated in routine clinical practice. Leuk. Lymphoma60(11), 2712–2719 (2019).
  • Parikh SA , AchenbachSJ, CallTGet al. The impact of dose modification and temporary interruption of ibrutinib on outcomes of chronic lymphocytic leukemia patients in routine clinical practice. Cancer Med.9(10), 3390–3399 (2020).
  • Burger JA , TedeschiA, BarrPMet al. Ibrutinib as initial therapy for patients with chronic lymphocytic leukemia. N. Engl. J. Med.373(25), 2425–2437 (2015).
  • Byrd JC , BrownJR, O’BrienSet al. Ibrutinib versus ofatumumab in previously treated chronic lymphoid leukemia. N. Engl. J. Med.371(3), 213–223 (2014).
  • Frei CR , LeH, McHughDet al. Treatment patterns and outcomes of 1205 patients on novel agents in the US Veterans Health Administration (VHA) System: results from the largest retrospective EMR and chart review study in the real-world setting [abstract]. Blood134(Suppl. 1), 795 (2019).
  • Hardy-Abeloos C , PinottiR, GabriloveJ. Ibrutinib dose modifications in the management of CLL. J. Hematol. Oncol.13(1), 66 (2020).
  • Dimou M , IliakisT, PardalisVet al. Safety and efficacy analysis of long-term follow up real-world data with ibrutinib monotherapy in 58 patients with CLL treated in a single-center in Greece. Leuk. Lymphoma60(12), 2939–2945 (2019).
  • Mato AR , NabhanC, ThompsonMCet al. Toxicities and outcomes of 616 ibrutinib-treated patients in the United States: a real-world analysis. Haematologica103(5), 874–879 (2018).
  • Akhtar OS , AttwoodK, LundI, HareR, Hernandez-IlizaliturriFJ, TorkaP. Dose reductions in ibrutinib therapy are not associated with inferior outcomes in patients with chronic lymphocytic leukemia (CLL). Leuk. Lymphoma60(7), 1650–1655 (2019).
  • Burger JA , BarrPM, RobakTet al. Long-term efficacy and safety of first-line ibrutinib treatment for patients with CLL/SLL: 5 years of follow-up from the phase 3 RESONATE-2 study. Leukemia34(3), 787–798 (2020).
  • Huntington SF , SoulosPR, BarrPMet al. Utilization and early discontinuation of first-line ibrutinib for patients with chronic lymphocytic leukemia treated in the community oncology setting in the United States [abstract]. Blood134(Suppl. 1), 797 (2019).
  • Iskierka-Jażdżewska E , HusM, GiannopoulosKet al. Efficacy and toxicity of compassionate ibrutinib use in relapsed/refractory chronic lymphocytic leukemia in Poland: analysis of the Polish Adult Leukemia Group (PALG). Leuk. Lymphoma58(10), 2485–2488 (2017).