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Meta-Analysis

Undertreatment in patients with advanced urothelial cancer: systematic literature review and meta-analysis

, , ORCID Icon, ORCID Icon, &
Pages 1123-1137 | Received 05 Apr 2023, Accepted 04 Jul 2023, Published online: 01 Aug 2023

References

  • Siegel RL, Miller KD, Jemal A. Cancer statistics, 2020. CA Cancer J. Clin. 70(1), 7–30 (2020).
  • Fitzmaurice C, Abate D, Abbasi N et al. Global, regional, and national cancer incidence, mortality, years of life lost, years lived with disability, and disability-adjusted life-years for 29 cancer groups, 1990 to 2017: a systematic analysis for the global burden of disease study. JAMA Oncol. 5(12), 1749–1768 (2019).
  • Sung H, Ferlay J, Siegel RL et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J. Clin. 71(3), 209–249 (2021).
  • Chen D, Ye Y, Guo S, Yao K. Progress in the research and targeted therapy of ErbB/HER receptors in urothelial bladder cancer. Front. Mol. Biosci. 8, 800945 (2021).
  • Hepp Z, Shah SN, Smoyer K, Vadagam P. Epidemiology and treatment patterns for locally advanced or metastatic urothelial carcinoma: a systematic literature review and gap analysis. J. Manag. Care. Spec. Pharm. 27(2), 240–255 (2021).
  • Patel VG, Oh WK, Galsky MD. Treatment of muscle-invasive and advanced bladder cancer in 2020. CA Cancer J. Clin. 70(5), 404–423 (2020).
  • Grisay G, Pierrard J, Confente C, Seront E. Future strategies involving immune checkpoint inhibitors in advanced urothelial carcinoma. Curr. Treat. Options Oncol. 22(1), 7 (2020).
  • Amin MB, Mckenney JK, Paner GP et al. ICUD-EAU international consultation on bladder cancer 2012: pathology. Eur. Urol. 63(1), 16–35 (2013).
  • Park I, Lee JL. Systemic treatment for advanced urothelial cancer: an update on recent clinical trials and current treatment options. Korean J. Intern. Med. 35(4), 834–853 (2020).
  • Kearney M, Knott C, Lamy FX, Harnett J, Amin A, Verpillat P. Treatment patterns and clinical outcomes in patients with locally advanced or metastatic urothelial cancer in England: results of a longitudinal observational cohort study. Value Health. 23(Suppl. 2), S483 (2020).
  • Bilen Ma XA, Wong A, Peng J, Robinson S, Bhanegaonkar A. Real-world treatment patterns and clinical outcomes in patients with metastatic urothelial carcinoma (mUC) receiving first-line (1L) treatment: results from IMPACT UC. Ann. Oncol. 32(Suppl. 5), S713 (2021).
  • Geynisman DM, Broughton E, Hao Y, Zhang Y, Le T, Huo S. Real-world treatment patterns and clinical outcomes among patients with advanced urothelial carcinoma in the United States. Urol. Oncol. 40(5), 195e191–195e111 (2022).
  • Morgans AK, Galsky MD, Hepp Z et al. 704P Treatment patterns among patients with advanced urothelial carcinoma (aUC) in the USA. Ann. Oncol. 32, S714–S715 (2021).
  • Witjes JA, Bruins HM, Carrión A et al. EAU guideline on muscle-invasive and metastatic bladder cancer (2023). https://uroweb.org/guidelines/muscle-invasive-and-metastatic-bladder-cancer
  • Cathomas R, Lorch A, Bruins HM et al. The 2021 updated European Association of Urology guidelines on metastatic urothelial carcinoma. Eur. Urol. 81(1), 95–103 (2022).
  • NCCN Clinical Practice Guidelines in Oncology. Bladder Cancer, Version 3.2023 (2023). https://www.nccn.org/professionals/physician_gls/pdf/bladder.pdf
  • Powles T, Bellmunt J, Comperat E et al. Bladder cancer: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up. Ann. Oncol. 33(3), 244–258 (2022).
  • De Santis M, Bellmunt J, Mead G et al. Randomized phase II/III trial assessing gemcitabine/carboplatin and methotrexate/carboplatin/vinblastine in patients with advanced urothelial cancer who are unfit for cisplatin-based chemotherapy: EORTC study 30986. J. Clin. Oncol. 30(2), 191–199 (2012).
  • Galsky MD, Chen GJ, Oh WK et al. Comparative effectiveness of cisplatin-based and carboplatin-based chemotherapy for treatment of advanced urothelial carcinoma. Ann. Oncol. 23(2), 406–410 (2012).
  • Galsky MD, Hahn NM, Rosenberg J et al. Treatment of patients with metastatic urothelial cancer “unfit” for cisplatin-based chemotherapy. J. Clin. Oncol. 29(17), 2432–2438 (2011).
  • Powles T, Park SH, Voog E et al. Avelumab maintenance therapy for advanced or metastatic urothelial carcinoma. N. Engl. J. Med. 383(13), 1218–1230 (2020).
  • Swami U, Grivas P, Pal SK, Agarwal N. Utilization of systemic therapy for treatment of advanced urothelial carcinoma: lessons from real world experience. Cancer Treat. Res. Commun. 27, 100325 (2021).
  • Vafaei-Nodeh S, Beigi A, Huang L, Mimmack G, Sun SZ, Ko JJ. Survival outcomes associated with different palliative systemic therapies (PSTs) in patients with metastatic bladder cancer (mBC). J. Clin. Oncol. 38(6), abstract 450 (2020).
  • Richters A, Mehra N, Meijer RP et al. Utilization of systemic treatment for metastatic bladder cancer in everyday practice: results of a nation-wide population-based cohort study. Cancer Treat Res. Commun. 25, 100266 (2020).
  • Reesink DJ, Van De Garde EMW, Peters BJM et al. Treatment patterns and clinical outcomes of chemotherapy treatment in patients with muscle-invasive or metastatic bladder cancer in the Netherlands. Sci. Rep. 10(1), 15822 (2020).
  • Petkau V, Alekseeva G, Zukov R et al. The association of access to systemic therapy and overall survival in metastatic bladder cancer in Russia: an analysis of URRU register. J. Clin. Oncol. 39(28), abstract 88 (2021).
  • Fisher MD, Shenolikar R, Miller PJ, Fenton M, Walker MS. Treatment patterns and outcomes in stage iv bladder cancer in a community oncology setting: 2008–2015. Clin. Genitourin. Cancer. 16(6), e1171–e1179 (2018).
  • Doshi G, Bhanegaonkar A, Bharmal M et al. PCN339 - SPEAR-BLADDER (study informing treatment pathway decision in bladder cancer): timing of treatment following first-line therapy in patients with locally advanced and metastatic urothelial cancer in the community oncology setting in the United States. Value Health. 21, S72 (2018).
  • Russo L, Esposito D, Lamy F-X et al. Characteristics, treatment patterns and safety events from 4 cohorts of advanced or metastatic cancer patients based on health care claims data. J. Clin. Oncol. 36(Suppl. 15), e13603 (2018).
  • Parikh RB, Galsky MD, Gyawali B et al. Trends in checkpoint inhibitor therapy for advanced urothelial cell carcinoma at the end of life: insights from real-world practice. Oncologist. 24(6), e397–e399 (2019).
  • Flannery K, Boyd M, Black-Shinn J, Robert N, Kamat AM. Outcomes in patients with metastatic bladder cancer in the USA: a retrospective electronic medical record study. Future Oncol. 15(12), 1323–1334 (2019).
  • Pollock G, Hsu CH, Batai K, Lee BR, Chipollini J. Postoperative and survival outcomes after cytoreductive surgery in the treatment of metastatic upper tract urothelial carcinoma. Urology 153, 244–249 (2021).
  • Mao W, Ma B, Huang X et al. Which treatment is best for patients with AJCC stage IV bladder cancer? Int. Urol. Nephrol. 51(7), 1145–1156 (2019).
  • Davies FJ, Knott C, Kerr C, Adedokun L, Lockhat DM. Utilising Public Health England datasets to establish a standing cohort of patients with metastatic bladder cancer: initial results and algorithm defining disease progression. Value Health. 23(Suppl. 2), S480–S481 (2020).
  • Sevillano E, Rodriguez-Moreno JF, Barquin A et al. Clinical outcome in terms of survival and treatment response of patients with metastatic urothelial carcinoma harboring FGFR alterations compared to wild-type tumors. J. Clin. Oncol. 38(Suppl. 15), e17042 (2020).
  • Richters A, Boormans JL, van der Heijden MS et al. Overall survival of patients receiving cisplatin or carboplatin for primary metastatic urothelial carcinoma of the bladder: a contemporary Dutch nationwide cohort study. Eur. Urol. Focus 8(14), 995–1002 (2022).
  • Jensen JB, Hauberg DS, Duus Hjortsoe M, Madsen ME, Olsen J, Agerbaek M. Treatment pattern and overall survival among patients with locally advanced or metastatic urothelial carcinoma: results from a complete nationwide unselected real-world registry study in Denmark from 2010 to 2017. Ann. Oncol. 32(5), S716 (2021).
  • Fukushima H, Nakanishi Y, Kataoka M, Tobisu K-I, Koga F. Prognostic significance of serum γ-glutamyltransferase in advanced urothelial carcinoma patients. J. Urol. 197(4), e433–434 (2017).
  • Miyake M, Shimizu T, Nishimura N et al. Response to pembrolizumab after dose-reduced cisplatin plus gemcitabine chemotherapy is inferior to that after carboplatin plus gemcitabine chemotherapy in cisplatin-unfit patients with advanced urothelial carcinoma. Clin. Genitourin. Cancer. 20(2), 196e191–196e199 (2022).
  • Diamantopoulos LN, Khaki AR, Sonpavde GP et al. Central nervous system metastasis in patients with urothelial carcinoma: institutional experience and a comprehensive review of the literature. Clin. Genitourin. Cancer. 18(3), e266–276 (2020).
  • Abu-Hijlih RA, Salah S, Al-Ibraheem A et al. Bladder cancer in young adults: disease and treatment characteristics of patients treated at tertiary cancer center. J. Clin. Oncol. 39(Suppl. 15), e16521 (2021).
  • Park K, Nam JK, Koo BJ et al. Clinical characteristics, treatment delivery, and cisplatin eligibility in Korean patients initially diagnosed with urothelial carcinoma. Ewha Med. J. 44(3), 63–69 (2021).
  • Kohei N, Sugiyama K, Chihara I et al. Impact of relative dose intensity in gemcitabine-cisplatin chemotherapy for metastatic urothelial carcinoma. SAGE Open Med. 6, 2050312118783011 (2018).
  • Ikeda M, Matsumoto K, Hirayama T et al. Oncologic outcomes of salvage chemotherapy in patients with recurrent or metastatic lesions after radical nephroureterectomy: a multi-institutional retrospective study. Chemotherapy 65(5–6), 134–140 (2020).
  • Grass GD, Awasthi S, Jain R et al. A population-based assessment of local therapy for de novo oligometastatic urothelial carcinoma of the bladder. Int. J. Radiat. Oncol. Biol. Physics. 111(3), E259 (2021).
  • Sørup S, Darvalics B, Kearney M et al. Treatment patterns, clinical outcomes, and healthcare resource use among patients with stage IV urothelial cancer: findings from a nationwide cohort study in Denmark. Value Health. 24(Suppl. 1), S65 (2021).
  • Okuyama A, Higashi T. Patterns of cancer treatment in different age groups in Japan: an analysis of hospital-based cancer registry data, 2012–2015. Jpn J. Clin. Oncol. 48(5), 417–425 (2018).
  • Aguilar KM, Grivas P, Seal B et al. Adoption of immune checkpoint inhibitors (ICI) for unresectable locally advanced or metastatic urothelial carcinoma (u/mUC): a retrospective assessment of community oncology practices. J. Clin. Oncol. 39 (Suppl. 28), 293 (2021).
  • Katayama S, Kobayashi Y, Takamoto A et al. Impact of paclitaxel, cisplatin, and gemcitabine as first-line chemotherapy in cisplatin-fit and -unfit patients with advanced/metastatic urothelial carcinoma. Urol. Oncol. Semin. Original Invest. 39(10), 731.e725–731.e732 (2021).
  • Klein A, Parikh R, Kurosky S, Esterberg E, Kaye JA. PCN311 Clinical characteristics, treatment patterns, and healthcare resource utilization in patients with advanced urothelial carcinoma after progression on platinum-based therapy: a medical record review study in the United States and Canada. Value Health. 22, S115 (2019).
  • Gomez de Liano Lista A, van Dijk N, de Velasco Oria de Rueda G et al. Clinical outcome after progressing to frontline and second-line anti-PD-1/PD-L1 in advanced urothelial cancer. Eur. Urol. 77(2), 269–276 (2020).
  • Motzer RJ, Escudier B, Mcdermott DF et al. Survival outcomes and independent response assessment with nivolumab plus ipilimumab versus sunitinib in patients with advanced renal cell carcinoma: 42-month follow-up of a randomized phase 3 clinical trial. J. Immunother. Cancer. 8(2), e000891 (2020).
  • Gupta S, Su C, Bhanegaonkar A et al. Disease management and frontline treatment of locally advanced or metastatic urothelial (la/mUC) carcinoma: The U.S. physician PARADIGM study. J. Clin. Oncol. 39 (Suppl. 28), 293 (2022).
  • Knott C, Kearney M, Mahmoudpour H, Verpillat P. 1750P Factors associated with receipt of systemic treatment (tx) for metastatic urothelial carcinoma (mUC) in England. Ann. Oncol. 33(Suppl. 7), S1338 (2022).
  • Gironés Sarrió R, Antonio Rebollo M, Molina Garrido MJ et al. General recommendations paper on the management of older patients with cancer: the SEOM geriatric oncology task force's position statement. Clin. Transl. Oncol. 20(10), 1246–1251 (2018).
  • Jodon G, Fischer SM, Kessler ER. Treatment of urothelial cancer in elderly patients: focus on immune checkpoint inhibitors. Drugs Aging 35(5), 409–421 (2018).
  • Mohile SG, Velarde C, Hurria A et al. Geriatric assessment-guided care processes for older adults: a Delphi consensus of geriatric oncology experts. J. Natl Compr. Cancer Network. 13(9), 1120–1130 (2015).
  • Aly A, Johnson C, Doleh Y, Shenolikar R, Botteman MF, Hussain A. Medical oncology referral and systemic therapy of patients with advanced stage urothelial carcinoma. J. Comp. Effectiveness Res. 9(13), 945–957 (2020).
  • Hupe MC, Merseburger AS, De Wit M, Rexer H, Gschwend JE, Krege S. Practice pattern of systemic therapy for urothelial cancer in Germany - a survey of the German cancer society. Aktuelle Urol. 49(4), 346–354 (2018).
  • Galsky MD, Ma E, Shah-Manek B et al. Cisplatin ineligibility for patients with metastatic urothelial carcinoma: a survey of clinical practice perspectives among US oncologists. Bladder Cancer. 5, 281–288 (2019).
  • Jindal K, Mendoza L, Moehler T, Anger C. Adoption of immune checkpoint inhibitors (ICIs) in bladder cancer: findings from a real-world study in EU5. Ann. Oncol. 31, S595 (2020).
  • Gourd E. EMA restricts use of anti-PD-1 drugs for bladder cancer. Lancet Oncol. 19(7), e341 (2018).
  • Crist M, Iyer G, Hsu M, Huang WC, Balar AV. Pembrolizumab in the treatment of locally advanced or metastatic urothelial carcinoma: clinical trial evidence and experience. Ther. Adv. Urol. 11, 1756287219839285 (2019).
  • Powles T, Csőszi T, Özgüroğlu M et al. Pembrolizumab alone or combined with chemotherapy versus chemotherapy as first-line therapy for advanced urothelial carcinoma (KEYNOTE-361): a randomised, open-label, phase 3 trial. Lancet Oncol. 22(7), 931–945 (2021).
  • Stenehjem DD, Tran D, Nkrumah MA, Gupta S. PD1/PDL1 inhibitors for the treatment of advanced urothelial bladder cancer. Onco. Targets Ther. 11, 5973–5989 (2018).
  • ESMO Congress and ISPOR Europe (2022).