458
Views
0
CrossRef citations to date
0
Altmetric
Editorial

FoxM1: A Potential Drug Target for Glioma

, &
Pages 223-226 | Published online: 12 Mar 2012

References

  • Friedman HS , PradosMD, WenPYet al. Bevacizumab alone and in combination with irinotecan in recurrent glioblastoma. J. Clin. Oncol. 27(28), 4733–4740 (2009).
  • Sathornsumetee S , ReardonDA, DesjardinsA, QuinnJA, VredenburghJJ, RichJN. Molecularly targeted therapy formalignant glioma.Cancer110(1), 13–24 (2007).
  • Koo CY , MuirKW, LamEW. FOXM1: from cancer initiation to progression and treatment.Biochim. Biophys. Acta1819(1), 28–37 (2011).
  • Wang IC , ChenYJ, HughesDet al. Forkhead box M1 regulates the transcriptional network of genes essential for mitotic progression and genes encoding the SCF (Skp2-Cks1) ubiquitin ligase. Mol. Cell. Biol. 25(24), 10875–10894 (2005).
  • Laoukili J , KooistraMR, BrasAet al. FoxM1 is required for execution of the mitotic programme and chromosome stability. Nat. Cell Biol. 7(2), 126–136 (2005).
  • Myatt SS , LamEW. The emerging roles of forkhead box (Fox) proteins in cancer.Nat. Rev. Cancer7(11), 847–859 (2007).
  • Wang Z , AhmadA, LiY, BanerjeeS, KongD, SarkarFH. Forkhead box M1 transcription factor: a novel target for cancer therapy.Cancer Treat. Rev.36(2), 151–156 (2010).
  • Cancer Genome Atlas Research Network. Integrated genomic analyses of ovarian carcinoma. Nature 474(7353), 609–615 (2011).
  • Liu M , DaiB, KangSHet al. FoxM1b is overexpressed in human glioblastomas and critically regulates the tumorigenicity of glioma cells. Cancer Res. 66(7), 3593–3602 (2006).
  • Zhang Y , ZhangN, DaiBet al. FoxM1b transcriptionally regulates vascular endothelial growth factor expression and promotes the angiogenesis and growth of glioma cells. Cancer Res. 68(21), 8733–8742 (2008).
  • Dai B , KangSH, GongWet al. Aberrant FoxM1b expression increases matrix metalloproteinase-2 transcription and enhances the invasion of glioma cells. Oncogene 26(42), 6212–6219 (2007).
  • Zhang N , WeiP, GongAet al. FoxM1 promotes beta-catenin nuclear localization and controls Wnt target-gene expression and glioma tumorigenesis. Cancer Cell 20(4), 427–442 (2011).
  • Kalinichenko VV , MajorML, WangXet al. FoxM1b transcription factor is essential for development of hepatocellular carcinomas and is negatively regulated by the p19ARF tumor suppressor. Genes Dev. 18(7), 830–850 (2004).
  • Radhakrishnan SK , BhatUG, HughesDE, WangIC, CostaRH, GartelAL. Identification of a chemical inhibitor of the oncogenic transcription factor forkhead box M1.Cancer Res.66(19), 9731–9735 (2006).
  • Halasi M , ZhaoH, DahariHet al. Thiazole antibiotics against breast cancer. Cell Cycle 9(6), 1214–1217 (2010).
  • Priller M , PöschlJ, AbrãoLet al. Expression of FoxM1 is required for the proliferation of medulloblastoma cells and indicates worse survival of patients. Clin. Cancer Res. 17(21), 6791–6801 (2011).
  • Nakano I , JoshiK, VisnyeiKet al. Siomycin A targets brain tumor stem cells partially through a MELK-mediated pathway. Neuro Oncol. 13(6), 622–634 (2011).
  • Nicolaou KC , ZakM, RahimipourSet al. Discovery of a biologically active thiostrepton fragment. J. Am. Chem. Soc. 127(43), 15042–15044 (2005).
  • Kwok JM , MyattSS, MarsonCM, CoombesRC, ConstantinidouD, LamEW. Thiostrepton selectively targets breast cancer cells through inhibition of forkhead box M1 expression.Mol. Cancer Ther.7(7), 2022–2032 (2008).
  • Hegde NS , SandersDA, RodriguezR, BalasubramanianS. The transcription factor FOXM1 is a cellular target of the natural product thiostrepton.Nat. Chem.3(9), 725–731 (2011).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.