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Review

Defective (Interfering) Viral Genomes Re-Explored: Impact on Antiviral Immunity and Virus Persistence

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Pages 493-503 | Received 06 Feb 2018, Accepted 03 May 2018, Published online: 12 Jun 2018

References

  • Magnus PV . Studies on interference in experimental influenza . Arkiv För Kemi, Mineralogi, Och Geologi24, 1 – 6 ( 1947 ).
  • Gard S , Von MagnusP, SvedmyrA, Birch-AndersenA . Studies on the sedimentation of influenza virus . Arch. Gesamte Virusforsch.4 ( 5 ), 591 – 611 ( 1952 ).
  • Cairns HJ , EdneyM, Fazekas De St GrothS . Quantitative aspects of influenza virus multiplication . J. Immunol.69 ( 2 ), 155 – 181 ( 1952 ).
  • Beale AJ , FinterNB . The infectivity of chorio-allantoic membrane influenza virus and incomplete influenza virus by the six-hour soluble antigen production test . J. Hyg. (Lond.)54 ( 1 ), 68 – 78 ( 1956 ).
  • Mims CA . Rift Valley Fever virus in mice. IV. Incomplete virus; its production and properties . Br. J. Exp. Pathol.37 ( 2 ), 129 – 143 ( 1956 ).
  • Bellett AJ , CooperPD . Some properties of the transmissible interfering component of vesicular stomatitis virus preparations . J. Gen. Microbiol.21, 498 – 509 ( 1959 ).
  • Cooper PD , BellettAJ . A transmissible interfering component of vesicular stomatitis virus preparations . J. Gen. Microbiol.21, 485 – 497 ( 1959 ).
  • Sokol F , NeurathAR, VilcekJ . Formation of incomplete sendai virus in embryonated eggs . Acta Virol.8, 59 – 67 ( 1964 ).
  • Lehmann-Grube F , SlenczkaW, TeesR . A persistent and inapparent infection of L cells with the virus of lymphocytic choriomeningitis . J. Gen. Virol.5 ( 1 ), 63 – 81 ( 1969 ).
  • Huang AS , GreenawaltJW, WagnerRR . Defective T particles of vesicular stomatitis virus. I. Preparation, morphology, and some biologic properties . Virology30 ( 2 ), 161 – 172 ( 1966 ).
  • Huang AS , WagnerRR . Defective T particles of vesicular stomatitis virus. II. Biologic role in homologous interference . Virology30 ( 2 ), 173 – 181 ( 1966 ).
  • Duesberg PH . The RNA of influenza virus . Proc. Natl Acad. Sci. USA59 ( 3 ), 930 – 937 ( 1968 ).
  • Pons M , HirstGK . The single- and double-stranded RNA’s and the proteins of incomplete influenza virus . Virology38 ( 1 ), 4 ( 1969 ).
  • Kingsbury DW , PortnerA, DarlingtonRW . Properties of incomplete Sendai virions and subgenomic viral RNAs . Virology42 ( 4 ), 857 – 871 ( 1970 ).
  • Kingsbury DW , PortnerA . On the genesis of incomplete Sendai virions . Virology42 ( 4 ), 872 – 879 ( 1970 ).
  • Lopez CB . Defective viral genomes: critical danger signals of viral infections . J. Virol.88 ( 16 ), 8720 – 8723 ( 2014 ).
  • Huang AS , BaltimoreD . Defective viral particles and viral disease processes . Nature226 ( 5243 ), 325 – 327 ( 1970 ).
  • Cole CN , SmolerD, WimmerE, BaltimoreD . Defective interfering particles of poliovirus. I. Isolation and physical properties . J. Virol.7 ( 4 ), 478 – 485 ( 1971 ).
  • Kawai A , MatsumotoS, TanabeK . Characterization of rabies viruses recovered from persistently infected BHK cells . Virology67 ( 2 ), 520 – 533 ( 1975 ).
  • Wiktor TJ , DietzscholdB, LeamnsonRN, KoprowskiH . Induction and biological properties of defective interfering particles of rabies virus . J. Virol.21 ( 2 ), 626 – 635 ( 1977 ).
  • Hall WW , MartinSJ, GouldE . Defective interfering particles produced during the replication of measles virus . Med. Microbiol. Immunol.160 ( 2–3 ), 155 – 164 ( 1974 ).
  • Murphy DG , DimockK, KangCY . Defective interfering particles of human parainfluenza virus 3 . Virology158 ( 2 ), 439 – 443 ( 1987 ).
  • Bruton CJ , KennedySI . Defective-interfering particles of Semliki Forest Virus: structural differences between standard virus and defective-interfering particles . J. Gen. Virol.31 ( 3 ), 383 – 395 ( 1976 ).
  • Bruton CJ , PorterA, KennedySI . Defective-interfering particles of Semliki Forest virus: intracellular events during interference . J. Gen. Virol.31 ( 3 ), 397 – 416 ( 1976 ).
  • Fuller FJ , MarcusPI . Interferon induction by viruses. Sindbis virus: defective-interfering particles temperature-sensitive for interferon induction . J. Gen. Virol.48 ( Pt 2 ), 391 – 394 ( 1980 ).
  • Fuller FJ , MarcusPI . Interferon induction by viruses. IV. Sindbis virus: early passage defective-interfering particles induce interferon . J. Gen. Virol.48 ( 1 ), 63 – 73 ( 1980 ).
  • Kennedy SI , BrutonCJ, WeissB, SchlesingerS . Defective interfering passages of Sindbis virus: nature of the defective virion RNA . J. Virol.19 ( 3 ), 1034 – 1043 ( 1976 ).
  • Roux L , WaldvogelFA . Establishment of Sendai virus persistent infection: biochemical analysis of the early phase of a standard plus defective interfering virus infection of BHK cells . Virology112 ( 2 ), 400 – 410 ( 1981 ).
  • Roux L , HollandJJ . Role of defective interfering particles of Sendai virus in persistent infections . Virology93 ( 1 ), 91 – 103 ( 1979 ).
  • Sekellick MJ , MarcusPI . Persistent infection. I interferon-inducing defective-interfering particles as mediators of cell sparing: possible role in persistent infection by vesicular stomatitis virus . Virology85 ( 1 ), 175 – 186 ( 1978 ).
  • Schmaljohn C , BlairCD . Persistent infection of cultured mammalian cells by Japanese encephalitis virus . J. Virol.24 ( 2 ), 580 – 589 ( 1977 ).
  • De BK , NayakDP . Defective interfering influenza viruses and host cells: establishment and maintenance of persistent influenza virus infection in MDBK and HeLa cells . J. Virol.36 ( 3 ), 847 – 859 ( 1980 ).
  • Andzhaparidze OG , BogomolovaNN, BoriskinYS, BektemirovaMS, DrynovID . Comparative study of rabies virus persistence in human and hamster cell lines . J. Virol.37 ( 1 ), 1 – 6 ( 1981 ).
  • Kennedy JC , MacdonaldRD . Persistent infection with infectious pancreatic necrosis virus mediated by defective-interfering (DI) virus particles in a cell line showing strong interference but little DI replication . J. Gen. Virol.58 ( Pt 2 ), 361 – 371 ( 1982 ).
  • Barrett AD , CrossAJ, CrowTJ, JohnsonJA, GuestAR, DimmockNJ . Subclinical infections in mice resulting from the modulation of a lethal dose of Semliki Forest virus with defective interfering viruses: neurochemical abnormalities in the central nervous system . J. Gen. Virol.67 ( Pt 8 ), 1727 – 1732 ( 1986 ).
  • Baczko K , LiebertUG, BilleterM, CattaneoR, BudkaH, Ter MeulenV . Expression of defective measles virus genes in brain tissues of patients with subacute sclerosing panencephalitis . J. Virol.59 ( 2 ), 472 – 478 ( 1986 ).
  • Atkinson T , BarrettAD, MackenzieA, DimmockNJ . Persistence of virulent Semliki Forest virus in mouse brain following co-inoculation with defective interfering particles . J. Gen. Virol.67 ( Pt 6 ), 1189 – 1194 ( 1986 ).
  • Popescu M , LohlerJ, Lehmann-GrubeF . Infectious lymphocytes in mice persistently infected with lymphocytic choriomeningitis virus . Z Naturforsch C32 ( 11–12 ), 1026 – 1028 ( 1977 ).
  • Rabinowitz SG , HuprikarJ . The influence of defective-interfering particles of the PR-8 strain of influenza A virus on the pathogenesis of pulmonary infection in mice . J. Infect. Dis.140 ( 3 ), 305 – 315 ( 1979 ).
  • Barrett AD , DimmockNJ . Modulation of Semliki Forest virus-induced infection of mice by defective-interfering virus . J. Infect. Dis.150 ( 1 ), 98 – 104 ( 1984 ).
  • Marcus PI , SekellickMJ . Defective interfering particles with covalently linked [+/−]RNA induce interferon . Nature266 ( 5605 ), 815 – 819 ( 1977 ).
  • Paucker K , CantellK, HenleW . Quantitative studies on viral interference in suspended L cells. III. Effect of interfering viruses and interferon on the growth rate of cells . Virology17, 324 – 334 ( 1962 ).
  • Johnston MD . The characteristics required for a Sendai virus preparation to induce high levels of interferon in human lymphoblastoid cells . J. Gen. Virol.56 ( Pt 1 ), 175 – 184 ( 1981 ).
  • Calain P , MonroeMC, NicholST . Ebola virus defective interfering particles and persistent infection . Virology262 ( 1 ), 114 – 128 ( 1999 ).
  • Treuhaft MW , BeemMO . Defective interfering particles of respiratory syncytial virus . Infect. Immun.37 ( 2 ), 439 – 444 ( 1982 ).
  • Andzhaparidze OG , BogomolovaNN, Boriskin YuS, DrynovID . Chronic non-cytopathic infection of human continuous cell lines with mumps virus . Acta Virol.27 ( 4 ), 318 – 328 ( 1983 ).
  • Viola MV , ScottC, DuffyPD . Persistent measles virus infection in vitro and in man . Arthritis Rheum.21 ( 5 Suppl. ), S47 – S51 ( 1978 ).
  • Sun Y , JainD, Koziol-WhiteCJet al. Immunostimulatory defective viral genomes from respiratory Syncytial virus promote a strong innate antiviral response during infection in mice and humans . PLoS Pathog.11 ( 9 ), e1005122 ( 2015 ).
  • Vasilijevic J , ZamarrenoN, OliverosJCet al. Reduced accumulation of defective viral genomes contributes to severe outcome in influenza virus infected patients . PLoS Pathog.13 ( 10 ), e1006650 ( 2017 ).
  • Portner A , KingsburyDW . Homologous interference by incomplete Sendai virus particles: changes in virus-specific ribonucleic acid synthesis . J. Virol.8 ( 4 ), 388 – 394 ( 1971 ).
  • Salinas Y , RouxL . Replication and packaging properties of short Paramyxovirus defective RNAs . Virus Res.109 ( 2 ), 125 – 132 ( 2005 ).
  • Stampfer M , BaltimoreD, HuangAS . Ribonucleic acid synthesis of vesicular stomatitis virus. I. Species of ribonucleic acid found in Chinese hamster ovary cells infected with plaque-forming and defective particles . J. Virol.4 ( 2 ), 154 – 161 ( 1969 ).
  • Calain P , RouxL . Functional characterisation of the genomic and antigenomic promoters of Sendai virus . Virology212 ( 1 ), 163 – 173 ( 1995 ).
  • Dimmock NJ , KennedySI . Prevention of death in Semliki Forest virus-infected mice by administration of defective-interfering Semliki Forest virus . J. Gen. Virol.39 ( 2 ), 231 – 242 ( 1978 ).
  • Shingai M , EbiharaT, BegumNAet al. Differential type I IFN-inducing abilities of wild-type versus vaccine strains of measles virus . J. Immunol.179 ( 9 ), 6123 – 6133 ( 2007 ).
  • Tapia K , KimWK, SunYet al. Defective viral genomes arising in vivo provide critical danger signals for the triggering of lung antiviral immunity . PLoS Pathog.9 ( 10 ), e1003703 ( 2013 ).
  • Yount JS , KrausTA, HorvathCM, MoranTM, LopezCB . A novel role for viral-defective interfering particles in enhancing dendritic cell maturation . J. Immunol.177 ( 7 ), 4503 – 4513 ( 2006 ).
  • Strahle L , GarcinD, KolakofskyD . Sendai virus defective-interfering genomes and the activation of interferon-beta . Virology351 ( 1 ), 101 – 111 ( 2006 ).
  • Ho TH , KewC, LuiPYet al. PACT- and RIG-I-dependent activation of type I interferon production by a defective interfering RNA derived from Measles virus vaccine . J. Virol.90 ( 3 ), 1557 – 1568 ( 2015 ).
  • Yount JS , GitlinL, MoranTM, LopezCB . MDA5 participates in the detection of paramyxovirus infection and Is essential for the early activation of dendritic cells in response to sendai virus defective interfering particles . J. Immunol.180 ( 7 ), 4910 – 4918 ( 2008 ).
  • Dimmock NJ , EastonAJ . Defective interfering influenza virus RNAs: time to re-evaluate their clinical potential as broad-spectrum antivirals?J. Virol.88 ( 10 ), 5217 – 5227 ( 2014 ).
  • Dimmock NJ , EastonAJ . Cloned defective interfering Influenza RNA and a possible pan-specific treatment of respiratory virus diseases . Viruses7 ( 7 ), 3768 – 3788 ( 2015 ).
  • Barrett AD , GuestAR, MackenzieA, DimmockNJ . Protection of mice infected with a lethal dose of Semliki Forest virus by defective interfering virus: modulation of virus multiplication . J. Gen. Virol.65 ( Pt 11 ), 1909 – 1920 ( 1984 ).
  • Holland JJ , DoyleM . Attempts to detect homologous autointerference in vivo with influenza virus and vesicular stomatitis virus . Infect. Immun.7 ( 4 ), 526 – 531 ( 1973 ).
  • Martinez-Gil L , GoffPH, HaiR, Garcia-SastreA, ShawML, PaleseP . A sendai virus-derived RNA agonist of RIG-I as a virus vaccine adjuvant . J. Virol.87 ( 3 ), 1290 – 1300 ( 2013 ).
  • Mercado-Lopez X , CotterCR, KimWKet al. Highly immunostimulatory RNA derived from a Sendai virus defective viral genome . Vaccine31 ( 48 ), 5713 – 5721 ( 2013 ).
  • Bellocq C , MottetG, RouxL . Wide occurrence of measles virus subgenomic RNAs in attenuated live-virus vaccines . Biologicals18 ( 4 ), 337 – 343 ( 1990 ).
  • Mclaren LC , HollandJJ . Defective interfering particles from poliovirus vaccine and vaccine reference strains . Virology60 ( 2 ), 579 – 583 ( 1974 ).
  • Singanayagam A , ZambonM, LalvaniA, BarclayW . Can defective interfering RNAs affect the live attenuated influenza vaccine? – Authors’ reply . Lancet Infect. Dis.17 ( 12 ), 1235 – 1236 ( 2017 ).
  • Xue J , ChambersBS, HensleySE, LopezCB . Propagation and characterization of influenza virus stocks that lack high levels of defective viral genomes and hemagglutinin mutations . Front. Microbiol.7, 326 ( 2016 ).
  • Xu J , Mercado–LopezX, GrierJTet al. Identification of a natural viral RNA motif that optimizes sensing of viral RNA by RIG-I . MBio6 ( 5 ), e01265-15 ( 2015 ).
  • Poirier EZ , GoicBet al. Dicer-2-dependent generation of viral DNA from defective viral genomes modulats immune control of RNA virus infection in insects . Cell Host Microbe23 ( 3 ), 353.e8 – 365.e8 ( 2018 ).
  • Sikkel MB , QuintJK, MalliaP, WedzichaJA, JohnstonSL . Respiratory syncytial virus persistence in chronic obstructive pulmonary disease . Pediatr. Infect. Dis. J.27 ( 10 Suppl. ), S63 – S70 ( 2008 ).
  • Falsey AR , FormicaMA, HennesseyPA, CriddleMM, SullenderWM, WalshEE . Detection of respiratory syncytial virus in adults with chronic obstructive pulmonary disease . Am. J. Respir. Crit. Care Med.173 ( 6 ), 639 – 643 ( 2006 ).
  • Liu Y , HaasDL, PooreSet al. Human metapneumovirus establishes persistent infection in the lungs of mice and is reactivated by glucocorticoid treatment . J. Virol.83 ( 13 ), 6837 – 6848 ( 2009 ).
  • Tan JJL , BalnePK, LeoYS, TongL, NgLFP, AgrawalR . Persistence of Zika virus in conjunctival fluid of convalescence patients . Sci. Rep.7 ( 1 ), 5 ( 2017 ).
  • Labadie K , LarcherT, JoubertCet al. Chikungunya disease in nonhuman primates involves long-term viral persistence in macrophages . J. Clin. Invest.120 ( 3 ), 894 – 906 ( 2010 ).
  • Borgherini G , PoubeauP, JossaumeAet al. Persistent arthralgia associated with chikungunya virus: a study of 88 adult patients on reunion island . Clin. Infect. Dis.47 ( 4 ), 469 – 475 ( 2008 ).
  • Chughtai AA , BarnesM, MacintyreCR . Persistence of Ebola virus in various body fluids during convalescence: evidence and implications for disease transmission and control . Epidemiol. Infect.144 ( 8 ), 8 ( 2016 ).
  • Thorley-Lawson DA . EBV persistence--introducing the virus . Curr. Top. Microbiol. Immunol.390 ( Pt 1 ), 151 – 209 ( 2015 ).
  • Sidhu MS , CrowleyJ, LowenthalAet al. Defective measles virus in human subacute sclerosing panencephalitis brain . Virology202 ( 2 ), 10 ( 1994 ).
  • Martin JG , SiddiquiS, HassanM . Immune responses to viral infections: relevance for asthma . Paediatr. Respir. Rev.7 ( Suppl. 1 ), S125 – S127 ( 2006 ).
  • Diallo B , SissokoD, LomanNJet al. Resurgence of Ebola virus disease in Guinea linked to a survivor with virus persistence in seminal fluid for more than 500 days . Clin. Infect. Dis.63 ( 10 ), 1353 – 1356 ( 2016 ).
  • Mate SE , KugelmanJR, NyenswahTGet al. Molecular evidence of sexual transmission of Ebola virus . N. Engl. J. Med.373 ( 25 ), 2448 – 2454 ( 2015 ).
  • Jacobs M , RodgerA, BellDJet al. Late Ebola virus relapse causing meningoencephalitis: a case report . Lancet388 ( 10043 ), 498 – 503 ( 2016 ).
  • Palma EL , HuangA . Cyclic production of vesicular stomatitis virus caused by defective interfering particles . J. Infect. Dis.129 ( 4 ), 402 – 410 ( 1974 ).
  • Frensing T , HeldtFS, PflugmacherAet al. Continuous influenza virus production in cell culture shows a periodic accumulation of defective interfering particles . PLoS ONE8 ( 9 ), e72288 ( 2013 ).
  • Cave DR , HendricksonFM, HuangAS . Defective interfering virus particles modulate virulence . J. Virol.55 ( 2 ), 366 – 373 ( 1985 ).
  • Stauffer Thompson KA , RempalaGA, YinJ . Multiple-hit inhibition of infection by defective interfering particles . J. Gen. Virol.90 ( Pt 4 ), 888 – 899 ( 2009 ).
  • Thompson KA , YinJ . Population dynamics of an RNA virus and its defective interfering particles in passage cultures . Virol. J.7, 257 ( 2010 ).
  • Moscona A . Defective interfering particles of human parainfluenza virus type 3 are associated with persistent infection in cell culture . Virology183 ( 2 ), 821 – 824 ( 1991 ).
  • Xu J , SunY, LiYet al. Replication defective viral genomes exploit a cellular pro-survival mechanism to establish paramyxovirus persistence . Nat. Commun.8 ( 1 ), 799 ( 2017 ).
  • Brenner D , BlaserH, MakTW . Regulation of tumour necrosis factor signalling: live or let die . Nat. Rev. Immunol.15 ( 6 ), 362 – 374 ( 2015 ).
  • Moscona A , PelusoRW . Persistent infection with human parainfluenza virus 3 in CV-1 cells: analysis of the role of defective interfering particles . Virology194 ( 1 ), 399 – 402 ( 1993 ).