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Research Article

The Molluscum Contagiosum Virus Protein MC163 Inhibits TNF-α-induced NF-κB Activation

, , , , & ORCID Icon
Pages 319-333 | Received 08 Feb 2019, Accepted 05 Apr 2019, Published online: 31 May 2019

References

  • Randall CM , ShislerJL. Molluscum contagiosum virus: persistence pays off. Future Virol., 8(6), 561–573 (2013).
  • Chen X , AnsteyAV, BugertJJ. Molluscum contagiosum virus infection. Lancet Infect. Dis., 13(10), 877–888 (2013).
  • Vermi W , FisogniS, SalogniLet al. Spontaneous regression of highly immunogenic molluscum contagiosum virus (MCV)-induced skin lesions is associated with plasmacytoid dendritic cells and IFN-DC infiltration. J. Invest. Dermatol., 131(2), 426–434 (2011).
  • Senkevich TG , KooninEV, BugertJJ, DaraiG, MossB. The genome of molluscum contagiosum virus: analysis and comparison with other poxviruses. Virology, 233(1), 19–42 (1997).
  • Shisler JL . Immune evasion strategies of molluscum contagiosum virus. Adv. Virus Res., 92, 201–252 (2015).
  • Ofengeim D , YuanJ. Regulation of RIP1 kinase signalling at the crossroads of inflammation and cell death. Nat. Rev. Mol. Cell Biol., 14(11), 727–736 (2013).
  • Hayden MS , GhoshS. Shared principles in NF-kappaB signaling. Cell, 132(3), 344–362 (2008).
  • Chen G , CaoP, GoeddelDV. TNF-induced recruitment and activation of the IKK complex require Cdc37 and Hsp90. Mol. Cell., 9(2), 401–410 (2002).
  • Ku JK , KwonHJ, KimMYet al. Expression of Toll-like receptors in verruca and molluscum contagiosum. J. Korean Med. Sci., 23(2), 307–314 (2008).
  • Georgala S , KatoulisAC, KanelleasA, BefonA, GeorgalaC. Letter: human papilloma virus and molluscum contagiosum lesions related to infliximab therapy for psoriasis: a case series. Dermatol. Online J., 18(4), 9 (2012).
  • Murao LE , ShislerJL. The MCV MC159 protein inhibits late, but not early, events of TNF-alpha-induced NF-kappaB activation. Virology, 340(2), 255–264 (2005).
  • Nichols DB , ShislerJL. The MC160 protein expressed by the dermatotropic poxvirus molluscum contagiosum virus prevents tumor necrosis factor alpha-induced NF-kappaB activation via inhibition of I kappa kinase complex formation. J. Virol., 80(2), 578–586 (2006).
  • Nichols DB , ShislerJL. Poxvirus MC160 protein utilizes multiple mechanisms to inhibit NF-kappaB activation mediated via components of the tumor necrosis factor receptor 1 signal transduction pathway. J. Virol., 83(7), 3162–3174 (2009).
  • Randall CM , JokelaJA, ShislerJL. The MC159 protein from the molluscum contagiosum poxvirus inhibits NF-kappaB activation by interacting with the IkappaB kinase complex. J. Immunol., 188(5), 2371–2379 (2012).
  • Brady G , HaasDA, FarrellPJ, PichlmairA, BowieAG. Poxvirus protein MC132 from molluscum contagiosum virus inhibits NF-B activation by targeting p65 for degradation. J. Virol., 89(16), 8406–8415 (2015).
  • Brady G , HaasDA, FarrellPJ, PichlmairA, BowieAG. Molluscum contagiosum virus protein MC005 inhibits NF-kappaB activation by targeting NEMO-regulated IkappaB kinase activation. J. Virol., 91(15), e00545-17 (2017).
  • Nichols DB , DeMartini W, CottrellJ. Poxviruses utilize multiple strategies to inhibit apoptosis. Viruses, 9(8), 215 (2017).
  • Smith GL , BenfieldCT, Maluquerde Motes Cet al. Vaccinia virus immune evasion: mechanisms, virulence and immunogenicity. J. Gen. Virol., 94(Pt 11), 2367–2392 (2013).
  • Coutu J , RyersonMR, BugertJ, NicholsDB. The molluscum contagiosum virus protein MC163 localizes to the mitochondria and dampens mitochondrial mediated apoptotic responses. Virology, 505, 91–101 (2017).
  • Teoh ML , TurnerPV, EvansDH. Tumorigenic poxviruses up-regulate intracellular superoxide to inhibit apoptosis and promote cell proliferation. J. Virol., 79(9), 5799–5811 (2005).
  • Teoh ML , WalasekPJ, EvansDH. Leporipoxvirus Cu,Zn-superoxide dismutase (SOD) homologs are catalytically inert decoy proteins that bind copper chaperone for SOD. J. Biol. Chem., 278(35), 33175–33184 (2003).
  • Shisler JL , MossB. Molluscum contagiosum virus inhibitors of apoptosis: the MC159 v-FLIP protein blocks Fas-induced activation of procaspases and degradation of the related MC160 protein. Virology, 282(1), 14–25 (2001).
  • Aoyagi M , ZhaiD, JinCet al. Vaccinia virus N1L protein resembles a B cell lymphoma-2 (Bcl-2) family protein. Protein Sci., 16(1), 118–124 (2007).
  • Cooray S , BaharMW, AbresciaNGet al. Functional and structural studies of the vaccinia virus virulence factor N1 reveal a Bcl-2-like anti-apoptotic protein. J. Gen. Virol., 88(Pt 6), 1656–1666 (2007).
  • DiPerna G , StackJ, BowieAGet al. Poxvirus protein N1L targets the I-kappaB kinase complex, inhibits signaling to NF-kappaB by the tumor necrosis factor superfamily of receptors, and inhibits NF-kappaB and IRF3 signaling by toll-like receptors. J. Biol. Chem., 279(35), 36570–36578 (2004).
  • Maluquer de Motes C , CoorayS, RenHet al. Inhibition of apoptosis and NF-kappaB activation by vaccinia protein N1 occur via distinct binding surfaces and make different contributions to virulence. PLoS Pathog., 7(12), e1002430 (2011).
  • Bugert JJ , DaraiG. Stability of molluscum contagiosum virus DNA among 184 patient isolates: evidence for variability of sequences in the terminal inverted repeats. J. Med. Virol., 33(3), 211–217 (1991).
  • Schmittgen TD , LivakKJ. Analyzing real-time PCR data by the comparative C(T) method. Nat. Protoc., 3(6), 1101–1108 (2008).
  • Hayden MS , GhoshS. NF-kappaB, the first quarter-century: remarkable progress and outstanding questions. Genes Dev., 26(3), 203–234 (2012).
  • Seth RB , SunL, EaCK, ChenZJ. Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3. Cell, 122(5), 669–682 (2005).
  • Kawai T , TakahashiK, SatoSet al. IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction. Nat. Immunol., 6(10), 981–988 (2005).
  • Kato H , TakeuchiO, SatoSet al. Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses. Nature, 441(7089), 101–105 (2006).
  • Yoneyama M , KikuchiM, NatsukawaTet al. The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses. Nat. Immunol., 5(7), 730–737 (2004).
  • Hornung V , EllegastJ, KimSet al. 5′-Triphosphate RNA is the ligand for RIG-I. Science, 314(5801), 994–997 (2006).
  • Pichlmair A , SchulzO, TanCPet al. RIG-I-mediated antiviral responses to single-stranded RNA bearing 5′-phosphates. Science, 314(5801), 997–1001 (2006).
  • Fitzgerald KA , McWhirterSM, FaiaKLet al. IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway. Nat. Immunol., 4(5), 491–496 (2003).
  • Sato M , SuemoriH, HataNet al. Distinct and essential roles of transcription factors IRF-3 and IRF-7 in response to viruses for IFN-alpha/beta gene induction. Immunity, 13(4), 539–548 (2000).
  • Randall CM , BiswasS, SelenCV, ShislerJL. Inhibition of interferon gene activation by death-effector domain-containing proteins from the molluscum contagiosum virus. Proc. Natl Acad. Sci. USA, 111(2), e265–e272 (2014).
  • Houde C , DickinsonRJ, HoutzagerVMet al. Hippi is essential for node cilia assembly and sonic hedgehog signaling. Dev. Biol., 300(2), 523–533 (2006).
  • Biswas S , ShislerJL. Molluscum contagiosum virus MC159 abrogates cIAP1-NEMO interactions and inhibits NEMO polyubiquitination. J. Virol., 91(15) (2017).
  • Le Negrate G . Viral interference with innate immunity by preventing NF-kappaB activity. Cell. Microbiol., 14(2), 168–181 (2012).
  • Chen RA , RyzhakovG, CoorayS, RandowF, SmithGL. Inhibition of IkappaB kinase by vaccinia virus virulence factor B14. PLoS Pathog., 4(2), e22 (2008).
  • Graham SC , BaharMW, CooraySet al. Vaccinia virus proteins A52 and B14 share a Bcl-2-like fold but have evolved to inhibit NF-kappaB rather than apoptosis. PLoS Pathog., 4(8), e1000128 (2008).
  • Ember SW , RenH, FergusonBJ, SmithGL. Vaccinia virus protein C4 inhibits NF-kappaB activation and promotes virus virulence. J. Gen. Virol., 93(Pt 10), 2098–2108 (2012).
  • Ji J , SuL, LiuZ. Critical role of calpain in inflammation. Biomed. Rep., 5(6), 647–652 (2016).
  • Conus S , SimonHU. Cathepsins: key modulators of cell death and inflammatory responses. Biochem. Pharmacol., 76(11), 1374–1382 (2008).
  • Schmitz ML , KrachtM, SaulVV. The intricate interplay between RNA viruses and NF-kappaB. Biochim. Biophys. Acta, 1843(11), 2754–2764 (2014).
  • Liu S , ChenJ, CaiXet al. MAVS recruits multiple ubiquitin E3 ligases to activate antiviral signaling cascades. Elife, 2, e00785 (2013).
  • Fang R , JiangQ, ZhouXet al. MAVS activates TBK1 and IKKepsilon through TRAFs in NEMO dependent and independent manner. PLoS Pathog., 13(11), e1006720 (2017).
  • Biswas S , SmithGL, RoyEJ, WardB, ShislerJL. A comparison of the effect of molluscum contagiosum virus MC159 and MC160 proteins on vaccinia virus virulence in intranasal and intradermal infection routes. J. Gen. Virol., 99(2), 246–252 (2018).

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