Ultradiluted Eupatorium perfoliatum Alleviates DENV-induced Fibrosis By Regulation of TGFβ1, MMP-9 and Interferons

References

• Zompi S , HarrisE. Animal models of dengue virus infection. Viruses., 4(1), 62–82 (2012).
   PubMed Web of Science ®Google Scholar
• European Centre for Disease Prevention and Control. Dengue worldwide overview. Stockholm, Sweden. https://www.ecdc.europa.eu/en/dengue-monthly
   Google Scholar
• Soo KM , KhalidB, ChingSM, ThamCL, BasirR, CheeHY. Meta-analysis of biomarkers for severe dengue infections. Peer J., 5, e3589 (2017).
   PubMed Web of Science ®Google Scholar
• Kraivong R , PunyadeeN, LiszewskiMK, AtkinsonJP, AvirutnanP. Dengue and the lectin pathway of the complement system. Viruses., 13(7), 1219 (2021).
   PubMed Web of Science ®Google Scholar
• Basu A , ChaturvediUC. Vascular endothelium: the battlefield of dengue viruses. FEMS Immunol. Med. Microbiol., 53(3), 287–299 (2008).
   PubMedGoogle Scholar
• Vannice KS , DurbinA, HombachJ. Status of vaccine research and development of vaccines for dengue. Vaccine, 34(26), 2934–2938 (2016).
   PubMed Web of Science ®Google Scholar
• Hadinegoro SR , Arredondo-GarcíaJL, CapedingMRet al. Efficacy and long-term safety of a dengue vaccine in regions of endemic disease. N. Engl. J. Med., 373(13), 1195–1206 (2015).
   PubMed Web of Science ®Google Scholar
• Izmirly AM , AlturkiSO, AlturkiSO, ConnorsJ, HaddadEK. Challenges in dengue vaccines development: pre-existing infections and cross-reactivity. Front. immunol., 11, 1055 (2020).
   PubMed Web of Science ®Google Scholar
• Kayesh MEH , Tsukiyama-KoharaK. Mammalian animal models for dengue virus infection: a recent overview. Arch. Virol., 167, 1–14 (2022).
   PubMed Web of Science ®Google Scholar
• Barua AB , DuitsmanPK, KosticD, BaruaM, OlsonJA. Reduction of serum retinol levels following a single oral dose of all-trans retinoic acid in humans. Int J Vitam Nutr Res., 67(6), 423–426 (1997).
   PubMed Web of Science ®Google Scholar
• Binder BR , ChristG, GruberFet al. Plasminogen activator inhibitor 1: physiological and pathophysiological roles. News Physiol Sci., 17(2), 56–61 (2002).
   PubMedGoogle Scholar
• Botella LM , Sánchez-ElsnerT, Sanz-RodriguezFet al. Transcriptional activation of endoglin and transforming growth factor-β signaling components by cooperative interaction between Sp1 and KLF6: their potential role in the response to vascular injury. Blood, 100(12), 4001–4010 (2002).
   PubMed Web of Science ®Google Scholar
• Nowak-Sliwinska P , SeguraT, Iruela-ArispeML. The chicken chorioallantoic membrane model in biology, medicine and bioengineering. Angiogenesis., 17(4), 779–804 (2014).
   PubMed Web of Science ®Google Scholar
• Aoyama T , Kuwahara-AraiK, UchiyamaAet al. Spleen-derived lipocalin-2 in the portal vein regulates Kupffer cells activation and attenuates the development of liver fibrosis in mice. Lab. Invest., 97(8), 890–902 (2017).
   PubMed Web of Science ®Google Scholar
• Shan L , WangF, ZhaiD, MengX, LiuJ, LvX. Matrix metalloproteinases induce extracellular matrix degradation through various pathways to alleviate hepatic fibrosis. Biomed. Pharmacother., 161, DOI: 10.1016/j.biopha.2023.114472 (2023).
   Web of Science ®Google Scholar
• Fabregat I , Moreno-CàceresJ, SánchezAet al. TGF-β signalling and liver disease. FEBS J., 283(12), 2219–2232 (2016).
   PubMed Web of Science ®Google Scholar
• Brenner DA . Molecular pathogenesis of liver fibrosis. Trans. Am. Clin. Climatol. Assoc., 120, 361 (2009).
   PubMedGoogle Scholar
• Katze MG , HeY, GaleM. Viruses and interferon: a fight for supremacy. Nat. Rev. Immunol., 2(9), 675–687 (2002).
   PubMed Web of Science ®Google Scholar
• Ahmad S , ZahiruddinS, ParveenBet al. Indian medicinal plants and formulations and their potential against COVID-19–preclinical and clinical research. Front. pharmacol., 11, DOI: 10.3389/fphar.2020.578970 (2021).
   Web of Science ®Google Scholar
• Bernstein N , AkramM, DaniyalM, KoltaiH, FridlenderM, GorelickJ. Antiinflammatory potential of medicinal plants: a source for therapeutic secondary metabolites. Adv. Agron., 150, 131–183 (2018).
   Web of Science ®Google Scholar
• Hensel A , MaasM, SendkerJet al. Eupatorium perfoliatum L.: phytochemistry, traditional use and current applications. J Ethnopharmacol., 138(3), 641–651 (2011).
   PubMed Web of Science ®Google Scholar
• Kim J , GousopoulosE, FaleschiniTM, HamburgerM, PotteratO, DetmarM. Pheophorbide a identified in an Eupatorium perfoliatum extract is a novel lymphatic vascular activator. Biomed. Pharmacother., 147, DOI: 10.1016/j.biopha.2022.112664 (2022).
   Web of Science ®Google Scholar
• Sinha M , ChakrabortyU, KoolAet al. In-vitro antiviral action of Eupatorium perfoliatum against dengue virus infection: modulation of mTOR signaling and autophagy. J. Ethnopharmacol., 282, DOI: 10.1016/j.jep.2021.114627 (2022).
   Web of Science ®Google Scholar
• Kar M , NisheethaA, KumarAet al. Isolation and molecular characterization of dengue virus clinical isolates from pediatric patients in New Delhi. Int. J. Infect. Dis., 84, S25–S33 (2019).
   Web of Science ®Google Scholar
• Reed LV , MuenchH. A simple method of estimating of fifty percent end points. Am. J. Hyg., 27, 493 (1938).
   Google Scholar
• Roy A , SarkarA, ParveenS, GhoshPM, NayakD, DasS. Safety evaluation of Arsenicum album 6C in cell lines and BALB/c mice through toxicity, proliferation and apoptosis studies. Proc. Zool. Soc., 76, 123–133 (2023).
   Google Scholar
• Bolla SR , Al-SubaieAM, Al-JindanRYet al. In vitro wound healing potency of methanolic leaf extract of Aristolochia saccata is possibly mediated by its stimulatory effect on collagen-1 expression. Heliyon., 5(5), e01648 (2019).
   PubMed Web of Science ®Google Scholar
• Brauer R , ChenP. Influenza Virus Propagation in Embryonated Chicken Eggs. J Vis Exp., 97, e52421 (2015).
   Google Scholar
• Cunningham CH . A laboratory Guide in Virology.Burgess Publishing Company, MA, USA (1966).
   Google Scholar
• Conroy AL , MargaritaG, MichaelHet al. Host biomarkers are associated with progression to dengue haemorrhagic fever: a nested case-control study. Int J Infect Dis., 40, 45–53 (2015).
   PubMed Web of Science ®Google Scholar
• Roy A , SarkarA, NayakD, DasS. Ultradiluted SARS-CoV-2 Spike Protein mitigates hyperinflammation in lung via ferritin and MMP-9 regulation in BALB/c mice. Virus Res., 329, DOI: 10.1016/j.virusres.2023.199091 (2023).
   PubMed Web of Science ®Google Scholar
• Reich NG , ShresthaS, KingAAet al. Interactions between serotypes of dengue highlight epidemiological impact of cross-immunity. J. R. Soc. Interface., 10(86), DOI: 10.1098/rsif.2013.0414 (2013).
   PubMed Web of Science ®Google Scholar
• Mawson AR . Retinoids, race and the pathogenesis of dengue hemorrhagic fever. Med. Hypotheses, 81, 1069–1074 (2013).
   PubMed Web of Science ®Google Scholar
• Thomas A , FonsM, BoldoghI, RabsonAS. Effects on cells. Medical Microbiology (4th Edition).BaronS ( Ed.). University of Texas Medical Branch at Galveston, TX, USA (1996).
   Google Scholar
• Costantini E , AielliL, SerraFet al. Evaluation of cell migration and cytokines expression changes under the radiofrequency electromagnetic field on wound healing in vitro model. Int. J. Mol. Sci., 23(4), 2205 (2022).
   PubMed Web of Science ®Google Scholar
• Almatroodi SA , AlsahliMA, AlmatroudiAet al. Potential therapeutic targets of quercetin, a plant flavonol, and its role in the therapy of various types of cancer through the modulation of various cell signaling pathways. Molecules., 6(5), 1315 (2021).
   Google Scholar
• Bhatt P , SabeenaSP, VarmaM, ArunkumarG. Current Understanding of the Pathogenesis of Dengue Virus Infection. Curr Microbiol., 78, 17–32 (2021).
   PubMed Web of Science ®Google Scholar
• Lin CF , LeiHY, ShiauALet al. Antibodies from dengue patient sera cross-react with endothelial cells and induce damage. J. Med. Virol., 69(1), 82–90 (2003).
   PubMed Web of Science ®Google Scholar
• Kolios G , ValatasV, KouroumalisE. Role of Kupffer cells in the pathogenesis of liver disease. World J. Gastroenterol., 12(46), 7413 (2006).
   PubMed Web of Science ®Google Scholar
• Kim KK , SheppardD, ChapmanHA. TGF-β1 signaling and tissue fibrosis. Cold Spring Harb. Perspect. Biol., 10(4), DOI: 10.1101/cshperspect.a022293 (2018).
   Web of Science ®Google Scholar
• Shin JY , BeckettJD, BagirzadehRet al. Epigenetic activation and memory at a TGFB2 enhancer in systemic sclerosis. Sci. Transl. Med., 11(497), eaaw0790 (2019).
   PubMed Web of Science ®Google Scholar
• Behairy OG , El-BakryMM, MansourAI, AbdelrahmanAM, EmamGM. Matrix metalloproteinase-1 as a non-invasive biomarker to assess liver fibrosis in children with chronic liver disease. Egypt. Liver J., 11, 80 (2021).
   Google Scholar
• Nie L , WuG, ZhangW. Correlation of mRNA expression and protein abundance affected by multiple sequence features related to translational efficiency in Desulfovibrio vulgaris: a quantitative analysis. Genetics, 174(4), 2229–2243 (2006).
   PubMed Web of Science ®Google Scholar