Advanced search
Publication Cover
Future Virology Volume 6, 2011 - Issue 6
Submit an article Journal homepage
21
Views
0
CrossRef citations to date
0
Altmetric
Review

Role of G protein-Coupled Vasoactive Intestinal Peptide Receptors in HIV Integration

Donald R BranchResearch & Development, Canadian Blood Services, Immunology Hub, Toronto Centre, Toronto, OntarioM5G 2M1, Canada. ⏹ Tel.: +1 416 313 4458 ⏹ Fax: +1 416 974 9757 ⏹ [email protected]
Pages 741-753 | Published online: 09 Jun 2011

Bibliography

  • Gottlieb MS , SchroffR, SchankerHM et al.: Pneumocystis carinii pneumonia and mucosal candidiasis in previously healthy homosexual men: evidence of a new acquired cellular immunodeficiency.N. Engl. J. Med.305 , 1425–1431 (1981).
  • Rerks-Ngam S , PitisuttihumP, NitayaphanS et al.: Vaccination with ALVAC and AIDSVAX to prevent HIV-1 infection in Thailand.N. Engl. J. Med.361 , 2209–2220 (2009).
  • McKinnon LR , CardCM: HIV vaccine efficacy trials: a brief history, and options for going forward.AIDS Rev.12 , 209–217 (2010).
  • Voelker R : HIV drug resistance.JAMA284 , 169 (2000).
  • Mocroft A , MillerV, ChiesiA et al.: Virological failure among patients on HAART from across Europe: results from the EuroSIDA study.Antivir. Ther.5 , 107–112 (2000).
  • Mansky LM , BernardLC: 3´-azido-3´deoxythymidine (AZT) and AZT-resistant reverse transcriptase can increase the in vivo mutation rate of human immunodeficiency virus type 1.J. Virol.74 , 9532–9539 (2000).
  • Dalgleish AG , BeverleyPC, ClaphamPR et al.: The CD4(T4) antigen is an essential component of the receptor for the AIDS retrovirus.Nature312 , 763–767 (1984).
  • Klatzmann D , ChampagneS, ChamaretJ et al.: T-lymphocyte T4 molecule behaves as the receptor for human retrovirus LAV.Nature312 , 767–768 (1984).
  • Alkhatib G , CombadiereC, BroderCC et al.: CC CKR5: a RANTES, MIP-1α, MIPβ receptor as a fusion cofactor for macrophage tropic HIV-1.Science272 , 1955–1958 (1996).
  • Choe H , FarzanM, SunY et al.: The β-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates.Cell85 , 1135–1148 (1996).
  • Deng H , LiuR, EllmeierW et al.: Identification of a major co-receptor for primary isolates of HIV-1.Nature381 , 661–666 (1996).
  • Doranz BJ , RuckerJ, YiY et al.: A dual-tropic primary HIV-1 isolate that uses fusin and the β-chemokine receptors CKR-5, CKR-3, and CKR-2b as fusion cofactors.Cell85 , 1149–1158 (1996).
  • Dragic T , LitwinV, AllawayGP et al.: HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5.Nature381 , 667–673 (1996).
  • Feng Y , BroderCC, KennedeyPE, BergerEA: HIV-1 entry cofactor: functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor.Science272 , 872–877 (1996).
  • Wang JH , JanasAM, OlsonWJ et al.: CD4 coexpression regulates DC-SIGN-mediated transmission of human immunodeficiency virus type 1.J. Virol.81 , 2497–2507 (2007).
  • Hatsukari I , SinghP, HitosugiN et al.: DEC-205-mediated internalization of HIV-1 results in the establishment of silent infection in renal tubular cells.J. Am. Soc. Nephrol.18 , 780–787 (2007).
  • Lund N , BranchDR, MylvaganamM et al.: A novel soluble mimic of the glycolipid, globotriaosyl inhibits HIV infection.AIDS20 , 333–343 (2006).
  • Lund N , Olsson,ML, RamkumarS et al.: The human PK histo-blood group antigen provides protection against HIV-1 infection.Blood113 , 4980–4991 (2009).
  • Harrison AL , OlssonML, JonesRB et al.: A synthetic globotriaosylceramide analogue inhibits HIV-1 infection in vitro by two mechanisms.Glycoconj. J.27 , 515–524 (2010).
  • Arriaga ME , CarrJ, LiP et al.: Interaction between HIV-1 and APOBEC3 sub-family of proteins.Curr. HIV Res.4 , 401–409 (2006).
  • Cohen OJ , KinterA, FauciAS: Host factors in the pathogenesis of HIV disease.Immunol. Rev.159 , 31–48 (1997).
  • Tremblay MJ , Fortin J-F, Cantin R: The acquisition of host-encoded proteins by nascent HIV-1. Immunol. Today19 , 346–351 (1998).
  • Cantin R , Fortin J-F, Lamontagne G et al.: The acquisition of host-derived major histocompatibility complex class II glycoproteins by human immunodeficiency virus type 1 accelerates the process of virus entry and infection in human T-lymphoid cells. Blood90 , 1091–1100 (1997).
  • Fortin J -F, Cantin R, Lamontagne G et al.: Host-derived ICAM-1 glycoproteins incorporated on human immunodeficiency virus type 1 are biologically active and enhance viral infectivity. J. Virol.71 , 3588–3596 (1997).
  • Henderson LE , SowderR, CopelandTD et al.: Direct identification of class II histocompatibility DR proteins in preparations of human T-cell lymphotropic virus type III.J. Virol.61 , 629–632 (1987).
  • Phipps DJ , YousefiS, BranchDR: Increased enzymatic activity of the T-cell antigen receptor-associated Fyn protein tyrosine kinase in asymptomatic patients infected with the human immunodeficiency virus.Blood90 , 3603–3612 (1997).
  • Yousefi S , MaXZ, SinglaR et al.: HIV-1 infection is facilitated in T cells by decreasing p56lck protein tyrosine kinase activity.Clin. Exp. Immunol.133 , 78–90 (2003).
  • Branch DR , ValentaLJE, YousefiS et al.: VPAC1 is a cellular neuroendocrine receptor expressed on T cells that actively facilitates productive HIV-1 infection.AIDS16 , 309–319 (2002).
  • Bokaei PB , MaXZ, SakacD, BranchDR: HIV-1 integration is inhibited by stimulation of the VPAC2 neuroendocrine receptor.Virology362 , 38–49 (2007).
  • Said SI , MuttV: Polypeptide with broad biological activity: isolation from small intestine.Science169 , 1217–1218 (1970).
  • Goetzl EJ , SreedharanSP: Mediators of communication and adaptation in the neuroendocrine and immune systems.FASEB J.6 , 2646–2652 (1992).
  • Ganea D : Regulatory effects of vasoactive-intestinal-peptide on cytokine production in central and peripheral lymphoid organs.Adv. Neuroimmunol.6 , 61–74 (1996).
  • Goetzl EJ , XiaMH, IngramDA et al.: Neuropeptide signaling of lymphocytes in immunological responses.Int. Arch. Allergy Immunol.107 , 202–204 (1995).
  • McConalogue K , FurnessJB: Gastrointestinal neurotransmitters.Baillieres Clin. Endocrinol. Metab.8 , 51–76 (1994).
  • Waschek JA , EllisonJ, BravoDT et al.: Embryonic expression of vasoactive intestinal peptide (VIP) and VIP receptor genes.J. Neurochem.66 , 1762–1765 (1996).
  • Graber M , BurgunderJM: Ontogeny of vasoactive intestinal peptide gene expression in rat brain.Anat. Embryol. (Berl.)194 , 595–605 (1996).
  • Berson JF , DomsRW: Structure–function studies of the HIV-1 coreceptors.Semin. Immunol.10 , 237–248 (1998).
  • Unutmaz D , KewalRamaniVN, LittmanDR: G protein-coupled receptors in HIV and SIV entry: new perspectives on lentivirus–host interactions and on the utility of animal models.Semin. Immunol.10 , 225–236 (1998).
  • Post GR , BrownJH: G protein-coupled receptors and signaling pathways regulating growth responses.FASEB J.10 , 741–749 (1996).
  • Harmar AJ , ArimuraA, GozesI et al.: International union of pharmacology. XVIII. Nomenclature of receptors for vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide.Pharmacol. Rev.50 , 265–270 (1998).
  • Ulrich CD , HoltmannM, MillerLJ: Secretin and vasoactive intestinal peptide receptors: members of a unique family of G protein-coupled receptors.Gastroenterology114 , 382–397 (1998).
  • Dickson L , FinlaysonK: VPAC and PAC receptors: from ligands to function.Pharmacol. Ther.121 , 294–316 (2009).
  • Ishihara T , ShigemotoR, MoriK et al.: Functional expression and tissue distribution of a novel receptor for vasoactive intestinal polypeptide.Neuron8 , 811–819 (1992).
  • Sreedharan SP , PatelDR, Huang J-X et al.: Cloning and functional expression of a human neuroendocrine vasoactive intestinal peptide receptor. Biochem. Biophys. Res. Commun.193 , 546–553 (1993).
  • Lutz EM , ShewardWJ, WestKM et al.: The VIP2 receptor: molecular characterisation of a cDNA encoding a novel receptor for vasoactive intestinal peptide.FEBS Lett.334 , 3–8 (1993).
  • Svoboda M , TastenoyM, Van Rampelbergh J et al.: Molecular cloning and functional characterization of a human VIP receptor from SUP-T1 lymphoblasts. Biochem. Biophys. Res. Commun.205 , 1617–1624 (1994).
  • Goetzl EJ , PankhaniyaRR, GaufoGO et al.: Selectivity of effects of vasoactive intestinal peptide on macrophages and lymphocytes in compartmental immune responses.Ann. NY Acad. Sci.840 , 540–550 (1998).
  • Lara-Marquez M , O‘DorisioM, O‘DorisioT et al.: Selective gene expression and activation-dependent regulation of vasoactive intestinal peptide receptor type 1 and type 2 in human T cells.J. Immunol.166 , 2522–2530 (2001).
  • Bokaei PB , MaXZ, ByczynskiB et al.: Identification and characterization of five-transmembrane isoforms of human vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide receptors.Genomics88 , 791–800 (2006).
  • Nicole P , DuK, CouvineauA et al.: Site-directed mutagenesis of human vasoactive intestinal peptide receptor subtypes VIP1 and VIP2: evidence for difference in the structure–function relationship.J. Pharmacol. Exp. Ther.284 , 744–750 (1998).
  • Gourlet P , VandermeersA, VertongenP et al.: Development of high affinity selective VIP1 receptor agonists.Peptides18 , 1539–1545 (1997).
  • Robberecht P , WaelbroeckM, DehayeJP et al.: Evidence that helodermin, a newly extracted peptide from Gila monster venom, is a member of the secretin/VIP/PHI family of peptides with an original pattern of biological properties.FEBS Lett.166 , 277–282 (1984).
  • Robberecht P , GourletP, VertongenP et al.: Characterization of the VIP receptor from SUP T1 lymphoblasts.Adv. Neuroimmunol.6 , 49–57 (1996).
  • Gourlet P , VertongenP, VandermeedrsA et al.: The long-acting vasoactive intestinal polypeptide agonist RO 25-1553 is highly selective for the VIP2 receptor subclass.Peptides18 , 403–408 (1997).
  • Xia M , GaufoGO, WangQ et al.: Transfection of specific inhibition of HuT 78 human T cell chemotaxis by type I vasoactive intestinal peptide receptors.J. Immunol.157 , 1132–1138 (1996).
  • Murphy TJ , AlexanderRW, GriendlingKK et al.: Isolation of a cDNA encoding the vascular type-1 angiotensin II receptor.Nature351 , 233–236 (1991).
  • Mukoyama M , NakajimaM, HoriuchiM et al.: Expression cloning of type 2 angiotensin II receptor reveals a unique class of seven-transmembrane receptors.J. Biol. Chem.268 , 24539–24542 (1993).
  • Alexandre D , VaudryH, GrumolatoL et al.: Novel splice variants of type I pituitary adenylate cyclase-activating polypeptide receptor in frog exhibit altered adenylate cyclase stimulation and differential relative abundance.Endocrinology143 , 2680–2692 (2002).
  • Chaudhary P , BaumannTK: Expression of VPAC2 receptor and PAC1 receptor splice variants in the trigeminal ganglion of the adult rat.Brain Res. Mol. Brain Res.104 , 137–142 (2002).
  • Perron A , SarretP, GendronL, StrohT, BeaudetA: Identification and functional characterization of a 5-transmembrane domain variant isoform of the NTS2 neurotensin receptor in rat central nervous system.J. Biol. Chem.280 , 10219–10227 (2005).
  • Scott DJ , LayfieldS, YanY et al.: Characterization of novel splice variants of LGR7 and LGR8 reveals that receptor signaling is mediated by their unique low density lipoprotein class A modules.J. Biol. Chem.281 , 34942–34954 (2006).
  • Grinninger C , WangW, OskouiKB, VoiceJK, GoetzlEJ: A natural variant type II G protein-coupled receptor for vasoactive intestinal peptide with altered function.J. Biol. Chem.279 , 40259–40262 (2004).
  • Pert CB , RuffMR, HillJM: AIDS as a neuropeptide disorder: peptide T, VIP, and the HIV receptor.Psychopharmacol. Bull.24 , 315–319 (1988).
  • Veazey RS , DeMariaM, ChalifouzLV et al.: Gastrointestinal tract as a major site of CD4+ T cell depletion and viral replication in SIV infection.Science280 , 427–431 (1998).
  • Mehandru S , PolesMA, Tenner-RaczK et al.: Mechanisms of gastrointestinal CD4+ T-cell depletion during acute and early human immunodeficiency virus type 1 infection.J. Virol.81 , 599–612 (2007).
  • Gilles A , MiqauelisA, LuisJ, FaureE: Activation of transcription from the human immunodeficiency virus type 1 (HIV-1) long terminal repeat by the vasoactive intestinal peptide (VIP).Ital. J. Biochem.47 , 101–110 (1998).
  • Delgado M , Munoz-EliasEJ, GomarizRP, GaneaD: Vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide prevent inducible nitric oxide synthase transcription in macrophages by inhibiting NF-κB and IF regulatory factor 1 activation.J. Immunol.162 , 4685–4696 (1999).
  • Veljkovic V , MetlasR, DaniloV et al.: Natural autoantibodies cross-react with a peptide derived from the second conserved region of HIV-1 envelope glycoprotein gp120.Biochem. Biophys. Res. Commun.196 , 1019–1024 (1993).
  • Veljkovic V , MetlasR, RaspopovicJ et al.: Spectral and sequence similarity between vasoactive intestinal peptide and the second conserved region of human immunodeficiency virus type 1 envelope glycoprotein (gp120): possible consequences on prevention and therapy of AIDS.Biochem. Biophys. Res. Commun.189 , 705–710 (1992).
  • Veljkovic V , MetlasR, JevtovicD, StringerWW: The role of passive immunization in HIV-positive patients: a case report.Chest120 , 662–666 (2001).
  • Veljkovic N , BranchDR, MetlasR et al.: Antibodies reactive with the C-terminus of the second conserved region of HIV-1gp120 as possible prognostic marker and therapeutic agent for HIV disease.J. Clin. Virol.31(Suppl. 1) , S39–S44 (2004).
  • Djordjevic A , VeljkovicM, AntoniS et al.: The presence of antibodies recognizing a peptide derived from the second conserved region of HIV-1 gp120 correlates with non-progressive HIV infection.Curr. HIV Res.5 , 443–448 (2007).
  • Gallay P , SwinglerS, SongJ, BushmanF, TronoD: HIV nuclear import is governed by the phosphotyrosine-mediated binding of matrix to the core domain of integrase.Cell83 , 569–576 (1995).
  • Gallay P , SwinglerS, AikenC, TronoD: HIV-1 infection of nondividing cells: C-terminal tyrosine phosphorylation of the viral matrix protein is a key regulator.Cell80 , 379–388 (1995).
  • Camaur D , GallayP, SwinglerS, TronoD: Human immunodeficiency virus matrix tyrosine phosphorylation: characterization of the kinase and its substrate requirements.J. Virol.71 , 6834–6841 (1997).
  • Koh SW : Signal transduction through the vasoactive intestinal peptide receptor stimulates phosphorylation of the tyrosine kinase pp60c-Src.Biochem. Biophys. Res. Commun.174 , 452–458 (1991).
  • Dikic I , TokiwaG, LevS, CourtneidgeSA, SchlessingerJ: A role for Pyk2 and Src in linking G-protein-coupled receptors with MAP kinase activation.Nature383 , 547–550 (1996).
  • Davis CB , KikicI, UnutmazD et al.: Signal transduction due to HIV-1 envelope interactions with chemokine receptors CSCR4 or CCR5.J. Exp. Med.186 , 1793–1798 (1997).
  • Stevenson M , StanwickTL, DempseyMP, LamonicaCA: HIV-1 replication is controlled at the level of T cell activation and proviral integration.EMBO J.9 , 1551–1560 (1990).
  • Bovolenta C , StanwickTL, DempseyMP, LamonicaCA: HIV infection and signal transduction.J. Biol. Regul. Homeost. Agents12 , 63–66 (1998).
  • Phipps DJ , ReadSE, PiovesanJP, MillsGB, BranchDR: HIV infection in vitro enhances the activity of Src-family protein tyrosine kinases.AIDS10 , 1191–1198 (1996).
  • Ziegler RJ : HIV-1 gp120 effects on signal transduction processes and cytokines: increased Src-family protein tyrosine kinase activity.J. NeuroAIDS1 , 51–71 (1997).
  • Yang X , GabuzdaD: Regulation of human immunodeficiency virus type 1 infectivity by the ERK mitogen-activated protein kinase signalling pathway.J. Virol.73 , 3460–3466 (1999).
  • Stantchev TS , MarkovicI, TelfordWG, ClouseKA, BroderCC: The tyrosine kinase inhibitor genistein blocks HIV-1 infection in primary human macrophages.Virus Res.123 , 178–189 (2007).
  • Fortin JF , BarbeauB, RobichaudGA, ParéME, LemieuxAM, TremblayMJ: Regulation of nuclear factor of activated T cells by phophotyrosyl-specific phosphatase activity: a positive effect on HIV-1 long terminal repeat-driven transcription and a possible implication of SHP-1.Blood97 , 2390–2400 (2001).
  • Ouellet M , BarbeauB, TremblayMJ: Protein tyrosyl phosphatases in T cell activation: implication for human immunodeficiency virus transcriptional activity.Prog. Nucleic Acid Res. Mol. Biol.73 , 69–105 (2003).
  • Kim MO , SuhHS, SiQ, TermanBI, LeeSC: Anti-CD45RO suppresses human immunodeficiency virus type 1 replication in microglia: role of Hck tyrosine kinase and implications for AIDS dementia.J. Virol.80 , 62–72 (2006).
  • Do HT , BaarsW, BornsK, WindhagenA, SchwinzerR: The 77C>G mutation in the human CD45 (PRPRC) gene leads to increased intensity of TCR signaling in T cell lines from healthy individuals and patients with multiple sclerosis.J. Immunol.176 , 931–938 (2006)
  • Ma XZ , JinT, SakacD et al.: Abnormal splicing of SHP-1 protein tyrosine phosphatase in human T cells. Implications for lymphomagenesis.Exp. Hematol.31 , 131–142 (2003).
  • Florio T : Somatostatin/somatostatin receptor signaling: phosphotyrosine phosphatases.Mol. Cell. Endocrinol.286 , 40–48 (2008).
  • Mitchell D , O‘MearaSJ, GaffneyA, CreanJK, KinsellaBT, GodsonC: The lipoxin A4 receptor is coupled to SHP-2 activation: implications for regulation of receptor tyrosine kinases.J. Biol. Chem.282 , 15606–15618 (2007).
  • Lee YH , MungunsukhO, TutinoRL, MarquezAP, DayRM: Angiotensin-II-induced apoptosis requires regulation of nucleolin and Bcl-xL by SHP-2 in primary lung endothelial cells.J. Cell Sci.123 , 1634–1643 (2010).
  • Branch DR : Neuropeptide receptors: novel targets for HIV/AIDS therapeutics.Pharmaceuticals4 , 485–493 (2011).

Websites

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.