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Review

Predicting and Preventing Viral Escape from Therapy

Pages 483-487 | Published online: 17 May 2012

References

  • Berkhout B . HIV-1 evolution under pressure of protease inhibitors, climbing the stairs of viral fitness. J. Biomed. Sci.6 , 298–305 (1999).
  • Hache G , AbbinkTE, BerkhoutB, HarrisRS. Optimal translation initiation enables Vif-deficient human immunodeficiency virus type 1 to escape restriction by APOBEC3G. J. Virol.83(11) , 5956–5960 (2009).
  • Berkhout B . A new Houdini act: multiple routes for HIV-1 escape from RNAi-mediated inhibition. Future Microbiol.4(2) , 151–154 (2009).
  • Eggink D , BerkhoutB, SandersRW. Inhibition of HIV-1 by fusion inhibitors. Curr. Pharm. Des.16 , 3716–3728 (2010).
  • Ray N , BlackburnLA, DomsRW. HR-2 mutations in human immunodeficiency virus type 1 gp41 restore fusion kinetics delayed by HR-1 mutations that cause clinical resistance to enfuvirtide. J. Virol.83(7) , 2989–2995 (2009).
  • Baldwin CE , SandersRW, DengY et al. Emergence of a drug-dependent human immunodeficiency virus type 1 variant during therapy with the T20 fusion inhibitor. J. Virol. 78(22) , 12428–12437 (2004).
  • Izumi K , KodamaE, ShimuraK et al. Design of peptide-based inhibitors for human immunodeficiency virus type 1 strains resistant to T-20. J. Biol. Chem. 284(8) , 4914–4920 (2009).
  • Eggink D , LangedijkJP, BonvinAM et al. Detailed mechanistic insights into HIV-1 sensitivity to three generations of fusion inhibitors. J. Biol. Chem. 284(39) , 26941–26950 (2009).
  • Dwyer JJ , WilsonKL, DavisonDK et al. Design of helical, oligomeric HIV-1 fusion inhibitor peptides with potent activity against enfuvirtide-resistant virus. Proc. Natl Acad. Sci. USA 104(31) , 12772–12777 (2007).
  • Lefebvre E , SchifferCA. Resilience to resistance of HIV-1 protease inhibitors: profile of darunavir. AIDS Rev.10(3) , 131–142 (2008).
  • Zhou J , RossiJJ. Current progress in the development of RNAi-based therapeutics for HIV-1. Gene Ther.18(12) , 1134–1138 (2011).
  • Boden D , PuschO, LeeF, TuckerL, RamratnamB. Human immunodeficiency virus type 1 escape from RNA interference. J. Virol.77(21) , 11531–11535 (2003).
  • Das AT , BrummelkampTR, WesterhoutEM et al. Human immunodeficiency virus type 1 escapes from RNA interference-mediated inhibition. J. Virol. 78(5) , 2601–2605 (2004).
  • Westerhout EM , OomsM, VinkM, DasAT, BerkhoutB. HIV-1 can escape from RNA interference by evolving an alternative structure in its RNA genome. Nucleic Acids Res.33(2) , 796–804 (2005).
  • Ter Brake O , BerkhoutB. A novel approach for inhibition of HIV-1 by RNA interference: counteracting viral escape with a second generation of siRNAs. J. RNAi Gene Silencing1 , 56–65 (2005).
  • Schopman NC , Ter Brake O, Berkhout B. Anticipating and blocking HIV-1 escape by second generation antiviral shRNAs. Retrovirology7 , 52 (2010).
  • Nevot M , MartrusG, ClotetB, MartinezMA. RNA interference as a tool for exploring HIV-1 robustness. J. Mol. Biol.413(1) , 84–96 (2011).
  • Ter Brake O , von Eije KJ, Berkhout B. Probing the sequence space available for HIV-1 evolution. AIDS22(14) , 1875–1877 (2008).
  • Ter Brake O , BerkhoutB. Lentiviral vectors that carry anti-HIV shRNAs: problems and solutions. J. Gene Med.9(9) , 743–750 (2007).
  • Schopman NC , BraunA, BerkhoutB. Directed HIV-1 evolution of protease inhibitor resistance by second-generation short hairpin RNAs. Antimicrob. Agents Chemother.56(1) , 479–486 (2012).
  • Perrin V , MammanoF. Parameters driving the selection of nelfinavir-resistant human immunodeficiency virus type 1 variants. J. Virol.77(18) , 10172–10175 (2003).
  • Burnett JC , RossiJJ. RNA-based therapeutics: current progress and future prospects. Chem. Biol.19(1) , 60–71 (2012).
  • Bushman FD , MalaniN, FernandesJ et al. Host cell factors in HIV replication: meta-analysis of genome-wide studies. PLoS Pathog. 5(5) , e1000437 (2009).
  • Eekels JJM , BerkhoutB. Towards a durable treatment of HIV-1 infection using RNA interference. Prog. Mol. Biol. Transl. Sci.102 , 141–163 (2011).
  • Agrawal-Gamse C , LeeFH, HaggartyB et al. Adaptive mutations in a human immunodeficiency virus type 1 envelope protein with a truncated V3 loop restore function by improving interactions with CD4. J. Virol. 83(21) , 11005–11015 (2009).
  • Westby M , Smith-BurchnellC, MoriJ et al. Reduced maximal inhibition in phenotypic susceptibility assays indicates that viral strains resistant to the CCR5 antagonist maraviroc utilize inhibitor-bound receptor for entry. J. Virol. 81(5) , 2359–2371 (2007).
  • Nedellec R , CoetzerM, LedermanMM et al. Resistance to the CCR5 inhibitor 5P12-RANTES requires a difficult evolution from CCR5 to CXCR4 coreceptor use. PLoS One 6(7) , e22020 (2011).
  • Liu R , PaxtonWA, ChoeS et al. Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection. Cell 86(3) , 367–377 (1996).
  • Ogg GS , JinX, BonhoefferS et al. Quantitation of HIV-1-specific cytotoxic T lymphocytes and plasma load of viral RNA. Science 279(5359) , 2103–2106 (1998).
  • Goulder PJ , WatkinsDI. HIV and SIV CTL escape: implications for vaccine design. Nat. Rev. Immunol.4(8) , 630–640 (2004).
  • Brumme ZL , JohnM, CarlsonJM et al. HLA-associated immune escape pathways in HIV-1 subtype B Gag, Pol and Nef proteins. PloS One 4(8) , e6687 (2009).
  • Martinez-Picado J , PradoJG, FryEE et al. Fitness cost of escape mutations in p24 Gag in association with control of human immunodeficiency virus type 1. J. Virol. 80(7) , 3617–3623 (2006).
  • Sturmer M , DoerrHW, GurtlerL. Human immunodeficiency virus: 25 years of diagnostic and therapeutic strategies and their impact on hepatitis B and C virus. Med.Microbiol. Immunol.198(3) , 147–155 (2009).
  • Pan Q , TilanusHW, JanssenHL, van der Laan LJ. Prospects of RNAi and microRNA-based therapies for hepatitis C. Expert. Opin.Biol. Ther.9(6) , 713–724 (2009).
  • Soriano V , VispoE, PovedaE et al. Directly acting antivirals against hepatitis C virus. J. Antimicrob. Chemother. 66(8) , 1673–1686 (2011).
  • Ivacik D , ElyA, ArbuthnotP. Countering hepatitis B virus infection using RNAi: how far are we from the clinic? Rev. Med. Virol.21(6) , 383–396 (2011).
  • Berkhout B . Toward a durable anti-HIV gene therapy based on RNA interference. Ann. NY Acad. Sci.1175 , 3–14 (2009).
  • Allers K , HutterG, HofmannJ et al. Evidence for the cure of HIV infection by CCR5-delta32/delta32 stem cell transplantation. Blood 117 , 2791–2799 (2010).

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