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Future Virology Volume 9, 2014 - Issue 12
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Editorial

Could Inhibiting IL-8 Enhance HBV IFN-α Treatment?

Teresa Pollicino1 Unit of Clinical & Molecular Hepatology, Department of Pediatric, Gynecologic, Microbiologic, & Biomedical Sciences, University Hospital of Messina, Messina, ItalyCorrespondence[email protected]
&
Lemonica J Koumbi2 Department of Medicine, Hepatology & Gastroenterology Section, Variety Wing Floor D, St. Mary’s Campus, Imperial College London, LondonW2 1PG, UK
Pages 1015-1017 | Published online: 23 Dec 2014

References

  • Dienstag JL . Hepatitis B virus infection . N. Engl. J. Med.359 ( 14 ), 1486 – 1500 ( 2008 ).
  • Lee WM . Hepatitis B virus infection . N. Engl. J. Med.337 ( 24 ), 1733 – 1745 ( 1997 ).
  • Seeger C , MasonWS . Hepatitis B virus biology . Microbiol. Mol. Biol. Rev.64 ( 1 ), 51 – 68 ( 2000 ).
  • Bock CT , SchranzP , SchroderCH , ZentgrafH . Hepatitis B virus genome is organized into nucleosomes in the nucleus of the infected cell . Virus Genes8 ( 3 ), 215 – 229 ( 1994 ).
  • Pollicino T , BelloniL , RaffaGet al. Hepatitis B virus replication is regulated by the acetylation status of hepatitis B virus cccDNA-bound H3 and H4 histones . Gastroenterology130 ( 3 ), 823 – 837 ( 2006 ).
  • Zoulim F . Are novel combination therapies needed for chronic hepatitis B?Antiviral Res.96 ( 2 ), 256 – 259 ( 2012 ).
  • Easl : EASL clinical practice guidelines: management of chronic hepatitis B virus infection . J. Hepatol.57 ( 1 ), 167 – 185 ( 2012 ).
  • Zoulim F , LocarniniS . Hepatitis B virus resistance to nucleos(t)ide analogues . Gastroenterology137 ( 5 ), 1593 – 1608e1591 – 1592 ( 2009 ).
  • Thimme R , DandriM . Dissecting the divergent effects of interferon-alpha on immune cells: time to rethink combination therapy in chronic hepatitis B?J. Hepatol.58 ( 2 ), 205 – 209 ( 2013 ).
  • Taub DD , AnverM , OppenheimJJ , LongoDL , MurphyWJ . T lymphocyte recruitment by interleukin-8 (IL-8). IL-8-induced degranulation of neutrophils releases potent chemoattractants for human T lymphocytes both in vitro and in vivo . J. Clin. Invest.97 ( 8 ), 1931 – 1941 ( 1996 ).
  • Mukaida N . Interleukin-8: an expanding universe beyond neutrophil chemotaxis and activation . Int. J. Hematol.72 ( 4 ), 391 – 398 ( 2000 ).
  • Khabar KS , Al-ZoghaibiF , Al-AhdalMNet al. The alpha chemokine, interleukin 8, inhibits the antiviral action of interferon alpha . J. Exp. Med.186 ( 7 ), 1077 – 1085 ( 1997 ).
  • Polyak SJ , KhabarKS , RezeiqM , GretchDR . Elevated levels of interleukin-8 in serum are associated with hepatitis C virus infection and resistance to interferon therapy . J. Virol.75 ( 13 ), 6209 – 6211 ( 2001 ).
  • Lee CM , YenYH , HungCHet al. Liver interleukin-8 messenger RNA expression and interferon sensitivity-determining region mutations relate to treatment response in hepatitis C 1b . Antivir. Ther.16 ( 6 ), 825 – 832 ( 2011 ).
  • Pollicino T , BellinghieriL , RestucciaAet al. Hepatitis B virus (HBV) induces the expression of interleukin-8 that in turn reduces HBV sensitivity to interferon-alpha . Virology444 ( 1–2 ), 317 – 328 ( 2013 ).
  • Yu Y , GongR , MuYet al. Hepatitis B virus induces a novel inflammation network involving three inflammatory factors, IL-29, IL-8, and cyclooxygenase-2 . J. Immunol.187 ( 9 ), 4844 – 4860 ( 2011 ).
  • Bertoletti A , MainiMK , FerrariC . The host-pathogen interaction during HBV infection: immunological controversies . Antivir. Ther.15 ( Suppl. 3 ), 15 – 24 ( 2010 ).
  • Epperson ML , LeeCA , FremontDH . Subversion of cytokine networks by virally encoded decoy receptors . Immunol. Rev.250 ( 1 ), 199 – 215 ( 2012 ).
  • Versteeg GA , Garcia-SastreA . Viral tricks to grid-lock the type I interferon system . Curr. Opin. Microbiol.13 ( 4 ), 508 – 516 ( 2010 ).
  • Grimm D , HeegM , ThimmeR . Hepatitis B virus: from immunobiology to immunotherapy . Clin. Sci.124 ( 2 ), 77 – 85 ( 2013 ).

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