Exploring the Tumors of Multiple Endocrine Neoplasia Type 1 in Mouse Models for Basic and Preclinical Studies

References

• Marx SJ . Molecular genetics of multiple endocrine neoplasia types 1 and 2. Nat. Rev. Cancer5(5), 367–375 (2005).
   PubMed Web of Science ®Google Scholar
• Thakker RV . Multiple endocrine neoplasia type 1 (MEN1). Best Pract. Res. Clin. Endocrinol. Metab.24(3), 355–370 (2010).
   PubMed Web of Science ®Google Scholar
• Thakker RV , NeweyPJ, WallsGVet al. Clinical practice guidelines for multiple endocrine neoplasia type 1 (MEN1). J. Clin. Endocrinol. Metab.97(9), 2990–3011 (2012).
   PubMed Web of Science ®Google Scholar
• Schussheim DH , SkarulisMC, AgarwalSKet al. Multiple endocrine neoplasia type 1: new clinical and basic findings. Trends Endocrinol. Metab.12(4), 173–178 (2001).
   PubMed Web of Science ®Google Scholar
• Jensen RT , BernaMJ, BinghamDB, NortonJA. Inherited pancreatic endocrine tumor syndromes: advances in molecular pathogenesis, diagnosis, management, and controversies. Cancer113(7 Suppl.), 1807–1843 (2008).
   PubMed Web of Science ®Google Scholar
• Chandrasekharappa SC , GuruSC, ManickamPet al. Positional cloning of the gene for multiple endocrine neoplasia-type 1. Science276(5311), 404–407 (1997).
   PubMed Web of Science ®Google Scholar
• Lemmens I , Van De VenWJ, KasKet al. Identification of the multiple endocrine neoplasia type 1 (MEN1) gene. The European Consortium on MEN1. Hum. Mol. Genet.6(7), 1177–1183 (1997).
   PubMed Web of Science ®Google Scholar
• Agarwal SK , OzawaA, MateoCM, MarxSJ. The MEN1 gene and pituitary tumours. Horm. Res.71(Suppl. 2), 131–138 (2009).
   PubMedGoogle Scholar
• Jiao Y , ShiC, EdilBHet al. DAXX/ATRX, MEN1, and mTOR pathway genes are frequently altered in pancreatic neuroendocrine tumors. Science331(6021), 1199–1203 (2011).
   PubMed Web of Science ®Google Scholar
• Cromer MK , StarkerLF, ChoiMet al. Identification of somatic mutations in parathyroid tumors using whole-exome sequencing. J. Clin. Endocrinol. Metab.97(9), E1774–E1781 (2012).
   PubMed Web of Science ®Google Scholar
• Newey PJ , NesbitMA, RimmerAJet al. Whole-exome sequencing studies of nonhereditary (sporadic) parathyroid adenomas. J. Clin. Endocrinol. Metab.97(10), E1995–E2005 (2012).
   PubMed Web of Science ®Google Scholar
• Newey PJ , NesbitMA, RimmerAJet al. Whole-exome sequencing studies of nonfunctioning pituitary adenomas. J. Clin. Endocrinol. Metab.98(4), E796–E800 (2013).
   PubMed Web of Science ®Google Scholar
• Lemos MC , ThakkerRV. Multiple endocrine neoplasia type 1 (MEN1): analysis of 1336 mutations reported in the first decade following identification of the gene. Hum. Mutat.29(1), 22–32 (2008).
   PubMed Web of Science ®Google Scholar
• Lee M , PellegataNS. Multiple endocrine neoplasia type 4. Front. Horm. Res.41, 63–78 (2013).
   PubMed Web of Science ®Google Scholar
• Agarwal SK , MateoCM, MarxSJ. Rare germline mutations in cyclin-dependent kinase inhibitor genes in multiple endocrine neoplasia type 1 and related states. J. Clin. Endocrinol. Metab.94(5), 1826–1834 (2009).
   PubMed Web of Science ®Google Scholar
• Francis JM , KiezunA, RamosAHet al. Somatic mutation of CDKN1B in small intestine neuroendocrine tumors. Nat. Genet.45(12), 1483–1486 (2013).
   PubMed Web of Science ®Google Scholar
• Agarwal SK . Multiple endocrine neoplasia type 1. Front. Horm. Res.41, 1–15 (2013).
   PubMedGoogle Scholar
• Francis J , LinW, Rozenblatt-RosenO, MeyersonM. The menin tumor suppressor protein is phosphorylated in response to DNA damage. PLoS ONE6(1), e16119 (2011).
   PubMed Web of Science ®Google Scholar
• Crabtree JS , ScacheriPC, WardJMet al. A mouse model of multiple endocrine neoplasia, type 1, develops multiple endocrine tumors. Proc. Natl Acad. Sci. USA98(3), 1118–1123 (2001).
   PubMed Web of Science ®Google Scholar
• Bertolino P , TongWM, GalendoD, WangZQ, ZhangCX. Heterozygous Men1 mutant mice develop a range of endocrine tumors mimicking multiple endocrine neoplasia type 1. Mol. Endocrinol.17(9), 1880–1892 (2003).
   PubMedGoogle Scholar
• Loffler KA , BiondiCA, GartsideMet al. Broad tumor spectrum in a mouse model of multiple endocrine neoplasia type 1. Int. J. Cancer120(2), 259–267 (2007).
   PubMed Web of Science ®Google Scholar
• Harding B , LemosMC, ReedAAet al. Multiple endocrine neoplasia type 1 knockout mice develop parathyroid, pancreatic, pituitary and adrenal tumours with hypercalcaemia, hypophosphataemia and hypercorticosteronaemia. Endocr. Relat. Cancer16(4), 1313–1327 (2009).
   PubMed Web of Science ®Google Scholar
• Biondi C , GartsideM, TonksI, PatersonC, HaywardNK, KayGF. Targeting and conditional inactivation of the murine Men1 locus using the Cre recombinase: loxP system. Genesis32(2), 150–151 (2002).
   PubMed Web of Science ®Google Scholar
• Bertolino P , RadovanovicI, CasseH, AguzziA, WangZQ, ZhangCX. Genetic ablation of the tumor suppressor menin causes lethality at mid-gestation with defects in multiple organs. Mech. Dev.120(5), 549–560 (2003).
   PubMed Web of Science ®Google Scholar
• Lemos MC , HardingB, ReedAAet al. Genetic background influences embryonic lethality and the occurrence of neural tube defects in Men1 null mice: relevance to genetic modifiers. J. Endocrinol.203(1), 133–142 (2009).
   PubMed Web of Science ®Google Scholar
• Balasubramanian D , ScacheriPC. Functional studies of menin through genetic manipulation of the Men1 homolog in mice. Adv. Exp. Med. Biol.668, 105–115 (2009).
   PubMed Web of Science ®Google Scholar
• Goudet P , Bonithon-KoppC, MuratAet al. Gender-related differences in MEN1 lesion occurrence and diagnosis: a cohort study of 734 cases from the Groupe d’etude des Tumeurs Endocrines. Eur. J. Endocrinol.165(1), 97–105 (2011).
   PubMed Web of Science ®Google Scholar
• Wartman LD , LarsonDE, XiangZet al. Sequencing a mouse acute promyelocytic leukemia genome reveals genetic events relevant for disease progression. J. Clin. Invest.121(4), 1445–1455 (2011).
   PubMed Web of Science ®Google Scholar
• Libutti SK , CrabtreeJS, LorangDet al. Parathyroid gland-specific deletion of the mouse Men1 gene results in parathyroid neoplasia and hypercalcemic hyperparathyroidism. Cancer Res.63(22), 8022–8028 (2003).
   PubMed Web of Science ®Google Scholar
• Veniaminova NA , HayesMM, VarneyJM, MerchantJL. Conditional deletion of menin results in antral G cell hyperplasia and hypergastrinemia. Am. J. Physiol. Gastrointest. Liver Physiol.303(6), G752–G764 (2012).
   PubMed Web of Science ®Google Scholar
• Crabtree JS , ScacheriPC, WardJMet al. Of mice and MEN1: insulinomas in a conditional mouse knockout. Mol. Cell Biol.23(17), 6075–6085 (2003).
   PubMed Web of Science ®Google Scholar
• Bertolino P , TongWM, HerreraPL, CasseH, ZhangCX, WangZQ. Pancreatic beta-cell-specific ablation of the multiple endocrine neoplasia type 1 (MEN1) gene causes full penetrance of insulinoma development in mice. Cancer Res.63(16), 4836–4841 (2003).
   PubMed Web of Science ®Google Scholar
• Biondi CA , GartsideMG, WaringPet al. Conditional inactivation of the MEN1 gene leads to pancreatic and pituitary tumorigenesis but does not affect normal development of these tissues. Mol. Cell Biol.24(8), 3125–3131 (2004).
   PubMed Web of Science ®Google Scholar
• Shen HC , YlayaK, PechholdKet al. Multiple endocrine neoplasia type 1 deletion in pancreatic alpha-cells leads to development of insulinomas in mice. Endocrinology151(8), 4024–4030 (2010).
   PubMed Web of Science ®Google Scholar
• Lu J , HerreraPL, CarreiraCet al. Alpha cell-specific Men1 ablation triggers the transdifferentiation of glucagon-expressing cells and insulinoma development. Gastroenterology138(5), 1954–1965 (2010).
   PubMed Web of Science ®Google Scholar
• Shen HC , HeM, PowellAet al. Recapitulation of pancreatic neuroendocrine tumors in human multiple endocrine neoplasia type I syndrome via Pdx1-directed inactivation of Men1. Cancer Res.69(5), 1858–1866 (2009).
   PubMed Web of Science ®Google Scholar
• Scacheri PC , KennedyAL, ChinKet al. Pancreatic insulinomas in multiple endocrine neoplasia, type I knockout mice can develop in the absence of chromosome instability or microsatellite instability. Cancer Res.64(19), 7039–7044 (2004).
   PubMed Web of Science ®Google Scholar
• Leung SW , WlogaEH, CastroAF, NguyenT, BronsonRT, YamasakiL. A dynamic switch in Rb+/- mediated neuroendocrine tumorigenesis. Oncogene23(19), 3296–3307 (2004).
   PubMed Web of Science ®Google Scholar
• Franklin DS , GodfreyVL, O’BrienDA, DengC, XiongY. Functional collaboration between different cyclin-dependent kinase inhibitors suppresses tumor growth with distinct tissue specificity. Mol. Cell Biol.20(16), 6147–6158 (2000).
   PubMed Web of Science ®Google Scholar
• Rane SG , CosenzaSC, MettusRV, ReddyEP. Germ line transmission of the Cdk4(R24C) mutation facilitates tumorigenesis and escape from cellular senescence. Mol. Cell Biol.22(2), 644–656 (2002).
   PubMed Web of Science ®Google Scholar
• Zhang X , GaspardJP, MizukamiY, LiJ, Graeme-CookF, ChungDC. Overexpression of cyclin D1 in pancreatic beta-cells in vivo results in islet hyperplasia without hypoglycemia. Diabetes54(3), 712–719 (2005).
   PubMed Web of Science ®Google Scholar
• Bai F , PeiXH, NishikawaT, SmithMD, XiongY. p18Ink4c, but not p27Kip1, collaborates with Men1 to suppress neuroendocrine organ tumors. Mol. Cell Biol.27(4), 1495–1504 (2007).
   PubMed Web of Science ®Google Scholar
• Loffler KA , BiondiCA, GartsideMGet al. Lack of augmentation of tumor spectrum or severity in dual heterozygous Men1 and Rb1 knockout mice. Oncogene26(27), 4009–4017 (2007).
   PubMed Web of Science ®Google Scholar
• Matoso A , ZhouZ, HayamaR, Flesken-NikitinA, NikitinAY. Cell lineage-specific interactions between Men1 and Rb in neuroendocrine neoplasia. Carcinogenesis29(3), 620–628 (2008).
   PubMed Web of Science ®Google Scholar
• Gillam MP , NimbalkarD, SunLet al. MEN1 tumorigenesis in the pituitary and pancreatic islet requires Cdk4 but not Cdk2. Oncogene doi: 10.1038/onc.2014.3 (2014) ( Epub ahead of print).
   PubMed Web of Science ®Google Scholar
• Karnik SK , HughesCM, GuXet al. Menin regulates pancreatic islet growth by promoting histone methylation and expression of genes encoding p27Kip1 and p18INK4c. Proc. Natl Acad. Sci. USA102(41), 14659–14664 (2005).
   PubMed Web of Science ®Google Scholar
• Hughes CM , Rozenblatt-RosenO, MilneTAet al. Menin associates with a trithorax family histone methyltransferase complex and with the hoxc8 locus. Mol. Cell13(4), 587–597 (2004).
   PubMed Web of Science ®Google Scholar
• Yokoyama A , WangZ, WysockaJet al. Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression. Mol. Cell Biol.24(13), 5639–5649 (2004).
   PubMed Web of Science ®Google Scholar
• Christensen J , AggerK, CloosPAet al. RBP2 belongs to a family of demethylases, specific for tri-and dimethylated lysine 4 on histone 3. Cell128(6), 1063–1076 (2007).
   PubMed Web of Science ®Google Scholar
• Lin W , CaoJ, LiuJet al. Loss of the retinoblastoma binding protein 2 (RBP2) histone demethylase suppresses tumorigenesis in mice lacking Rb1 or Men1. Proc. Natl Acad. Sci. USA108(33), 13379–13386 (2011).
   PubMed Web of Science ®Google Scholar
• Walls GV , ReedAA, JeyabalanJet al. Proliferation rates of multiple endocrine neoplasia type 1 (MEN1)-associated tumors. Endocrinology153(11), 5167–5179 (2012).
   PubMed Web of Science ®Google Scholar
• Walls GV , LemosMC, JavidMet al. MEN1 gene replacement therapy reduces proliferation rates in a mouse model of pituitary adenomas. Cancer Res.72(19), 5060–5068 (2012).
   PubMed Web of Science ®Google Scholar
• Korsisaari N , RossJ, WuXet al. Blocking vascular endothelial growth factor-A inhibits the growth of pituitary adenomas and lowers serum prolactin level in a mouse model of multiple endocrine neoplasia type 1. Clin. Cancer Res.14(1), 249–258 (2008).
   PubMed Web of Science ®Google Scholar
• Chu X , GaoX, JanssonL, QuachM, SkogseidB, BarbuA. Multiple microvascular alterations in pancreatic islets and neuroendocrine tumors of a Men1 mouse model. Am. J. Pathol.182(6), 2355–2367 (2013).
   PubMed Web of Science ®Google Scholar
• Quinn TJ , YuanZ, AdemAet al. Pasireotide (SOM230) is effective for the treatment of pancreatic neuroendocrine tumors (PNETs) in a multiple endocrine neoplasia type 1 (MEN1) conditional knockout mouse model. Surgery152(6), 1068–1077 (2012).
   PubMed Web of Science ®Google Scholar