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Review

Immunotherapy Following Hematopoietic Stem Cell Transplantation: Potential for Synergistic Effects

, &
Pages 399-418 | Published online: 10 May 2010

Bibliography

  • Kurnick NB , MontanoA, GerdesJC, FederBH: Preliminary observations on the treatment of postirradiation hematopoietic depression in man by the infusion of stored autogenous bone marrow.Ann. Intern. Med.49(5) , 973–986 (1958).
  • Varas F , BernadA, BuerenJA: Granulocyte colony-stimulating factor mobilizes into peripheral blood the complete clonal repertoire of hematopoietic precursors residing in the bone marrow of mice.Blood88(7) , 2495–2501 (1996).
  • Plerixafor: AMD3100, AMD3100, JM 3100, SDZ SID 791. Drugs RD8(2) , 113–119 (2007).
  • Cashen AF , NerviB, DiPersioJ: AMD3100: CXCR4 antagonist and rapid stem cell-mobilizing agent.Future Oncol.3(1) , 19–27 (2007).
  • Uy GL , RettigMP, CashenAF: Plerixafor, a CXCR4 antagonist for the mobilization of hematopoietic stem cells.Expert Opin. Biol. Ther.8(11) , 1797–1804 (2008).
  • Blaise D , KuentzM, FortanierCet al.: Randomized trial of bone marrow versus lenograstim-primed blood cell allogeneic transplantation in patients with early-stage leukemia: a report from the Societe Francaise de Greffe de Moelle.J. Clin. Oncol.18(3) , 537–546 (2000).
  • Schmitz N , BacigalupoA, HasencleverDet al.: Allogeneic bone marrow transplantation vs filgrastim-mobilised peripheral blood progenitor cell transplantation in patients with early leukaemia: first results of a randomised multicentre trial of the European Group for Blood and Marrow Transplantation.Bone Marrow Transplant.21(10) , 995–1003 (1998).
  • Singhal S , PowlesR, KulkarniSet al.: Comparison of marrow and blood cell yields from the same donors in a double-blind, randomized study of allogeneic marrow vs blood stem cell transplantation.Bone Marrow Transplant.25(5) , 501–505 (2000).
  • Heldal D , TjonnfjordG, BrinchLet al.: A randomised study of allogeneic transplantation with stem cells from blood or bone marrow.Bone Marrow Transplant.25(11) , 1129–1136 (2000).
  • Powles R , MehtaJ, KulkarniSet al.: Allogeneic blood and bone-marrow stem-cell transplantation in haematological malignant diseases: a randomised trial.Lancet355(9211) , 1231–1237 (2000).
  • Schmitz N , DregerP, SuttorpMet al.: Primary transplantation of allogeneic peripheral blood progenitor cells mobilized by filgrastim (granulocyte colony-stimulating factor).Blood85(6) , 1666–1672 (1995).
  • Appelbaum FR : Haematopoietic cell transplantation as immunotherapy.Nature411(6835) , 385–389 (2001).
  • Thomas ED : Karnofsky memorial lecture. Marrow transplantation for malignant diseases.J. Clin. Oncol.1(9) , 517–531 (1983).
  • Cairo MS , and Wagner JE: Placental and/or umbilical cord blood: an alternative source of hematopoietic stem cells for transplantation. Blood90(12) , 4665–4678 (1997).
  • Rubinstein P , CarrierC, ScaradavouAet al.: Outcomes among 562 recipients of placental-blood transplants from unrelated donors.N. Engl. J. Med.339(22) , 1565–1577 (1998).
  • Wagner JE , KernanNA, SteinbuchM, BroxmeyerHE, GluckmanE: Allogeneic sibling umbilical-cord-blood transplantation in children with malignant and non-malignant disease.Lancet346(8969) , 214–219 (1995).
  • MacMillan ML , WeisdorfDJ, BrunsteinCGet al.: Acute graft-versus-host disease after unrelated donor umbilical cord blood transplantation: analysis of risk factors.Blood113(11) , 2410–2415 (2009).
  • Verneris MR , BrunsteinCG, BarkerJet al.: Relapse risk after umbilical cord blood transplantation: enhanced graft-versus-leukemia effect in recipients of 2 units.Blood114(19) , 4293–4299 (2009).
  • Aversa F : Haploidentical haematopoietic stem cell transplantation for acute leukaemia in adults: experience in Europe and the United States.Bone Marrow Transplant.41(5) , 473–481 (2008).
  • Aversa F , BernemanZN, LocatelliFet al.: Fourth International Workshop on Haploidentical Transplants, Naples, Italy, July 8–10, 2004.Blood Cells Mol. Dis.33(3) , 159–175 (2004).
  • Aversa F , TerenziA, FeliciniRet al.: Haploidentical stem cell transplantation for acute leukemia.Int. J. Hematol.76(Suppl.) 1165–1168 (2002).
  • Aversa F , VelardiA, TabilioA, ReisnerY, MartelliMF: Haploidentical stem cell transplantation in leukemia.Blood Rev.15(3) , 111–119 (2001).
  • Gassas A , SungL, SaundersEF, DoyleJ: Graft-versus-leukemia effect in hematopoietic stem cell transplantation for pediatric acute lymphoblastic leukemia: significantly lower relapse rate in unrelated transplantations.Bone Marrow Transplant.40(10) , 951–955 (2007).
  • Khouri IF , SalibaRM, GiraltSAet al.: Nonablative allogeneic hematopoietic transplantation as adoptive immunotherapy for indolent lymphoma: low incidence of toxicity, acute graft-versus-host disease, and treatment-related mortality.Blood98(13) , 3595–3599 (2001).
  • Schetelig J , ThiedeC, BornhauserMet al.: Reduced non-relapse mortality after reduced intensity conditioning in advanced chronic lymphocytic leukemia.Ann. Hematol.81(Suppl. 2) , S47–S48 (2002).
  • Schetelig J , ThiedeC, BornhauserMet al.: Evidence of a graft-versus-leukemia effect in chronic lymphocytic leukemia after reduced-intensity conditioning and allogeneic stem-cell transplantation: the Cooperative German Transplant Study Group.J. Clin. Oncol.21(14) , 2747–2753 (2003).
  • Weiden PL , FlournoyN, ThomasEDet al.: Antileukemic effect of graft-versus-host disease in human recipients of allogeneic-marrow grafts.N. Engl. J. Med.300(19) , 1068–1073 (1979).
  • Deeg HJ , StorbR: Acute and chronic graft-versus-host disease: clinical manifestations, prophylaxis, and treatment.J. Natl Cancer Inst.76(6) , 1325–1328 (1986).
  • Ratanatharathorn V , AyashL, LazarusHM, FuJ, UbertiJP: Chronic graft-versus-host disease: clinical manifestation and therapy.Bone Marrow Transplant.28(2) , 121–129 (2001).
  • Kansu E : The pathophysiology of chronic graft-versus-host disease.Int. J. Hematol.79(3) , 209–215 (2004).
  • Tyndall A , DazziF: Chronic GVHD as an autoimmune disease.Best Pract. Res. Clin. Haematol.21(2) , 281–289 (2008).
  • Bryson JS , JenningsCD, CaywoodBE, DixAR, LoweryDM, KaplanAM: Enhanced graft-versus-host disease in older recipient mice following allogeneic bone marrow transplantation.Bone Marrow Transplant.19(7) , 721–728 (1997).
  • Remberger M , KumlienG, AschanJet al.: Risk factors for moderate-to-severe chronic graft-versus-host disease after allogeneic hematopoietic stem cell transplantation.Biol. Blood Marrow Transplant.8(12) , 674–682 (2002).
  • Fischer AC , HessAD: Age-related factors in cyclosporine-induced syngeneic graft-versus-host disease: regulatory role of marrow-derived T lymphocytes.J. Exp. Med.172(1) , 85–94 (1990).
  • Parmar S , Del Lima M, Zou Y et al.: Donor-recipient mismatches in MHC class I chain-related gene A in unrelated donor transplantation lead to increased incidence of acute graft-versus-host disease. Blood114(14) , 2884–2887 (2009).
  • Anasetti C , BeattyPG, StorbRet al.: Effect of HLA incompatibility on graft-versus-host disease, relapse, and survival after marrow transplantation for patients with leukemia or lymphoma.Hum. Immunol.29(2) , 79–91 (1990).
  • Antin JH , FerraraJL: Cytokine dysregulation and acute graft-versus-host disease.Blood80(12) , 2964–2968 (1992).
  • Ferrara JL , LevineJE, ReddyP, HollerE: Graft-versus-host disease.Lancet373(9674) , 1550–1561 (2009).
  • Loiseau P , BussonM, BalereMLet al.: HLA Association with hematopoietic stem cell transplantation outcome: the number of mismatches at HLA-A, -B, -C, -DRB1, or -DQB1 is strongly associated with overall survival.Biol. Blood Marrow Transplant.13(8) , 965–974 (2007).
  • Antin JH : Clinical practice. Long-term care after hematopoietic-cell transplantation in adults.N. Engl. J. Med.347(1) , 36–42 (2002).
  • Couriel D , CalderaH, ChamplinR, KomanduriK: Acute graft-versus-host disease: pathophysiology, clinical manifestations, and management.Cancer101(9) , 1936–1946 (2004).
  • Barnes DW , LoutitJF: Treatment of murine leukaemia with x-rays and homologous bone marrow. II.Br. J. Haematol.3(3) , 241–252 (1957).
  • Bar BM , SchattenbergA, MensinkEJet al.: Donor leukocyte infusions for chronic myeloid leukemia relapsed after allogeneic bone marrow transplantation.J. Clin. Oncol.11(3) , 513–519 (1993).
  • Marmont AM , HorowitzMM, GaleRPet al.: T-cell depletion of HLA-identical transplants in leukemia.Blood78(8) , 2120–2130 (1991).
  • Mitsuyasu RT , ChamplinRE, GaleRPet al.: Treatment of donor bone marrow with monoclonal anti-T-cell antibody and complement for the prevention of graft-versus-host disease. A prospective, randomized, double-blind trial.Ann. Intern. Med.105(1) , 20–26 (1986).
  • Goldman JM , GaleRP, HorowitzMMet al.: Bone marrow transplantation for chronic myelogenous leukemia in chronic phase. Increased risk for relapse associated with T-cell depletion.Ann. Intern. Med.108(6) , 806–814 (1988).
  • Marks DI , HughesTP, SzydloRet al.: HLA-identical sibling donor bone marrow transplantation for chronic myeloid leukaemia in first chronic phase: influence of GVHD prophylaxis on outcome.Br. J. Haematol.81(3) , 383–390 (1992).
  • Couriel DR , SalibaRM, GiraltSet al.: Acute and chronic graft-versus-host disease after ablative and nonmyeloablative conditioning for allogeneic hematopoietic transplantation.Biol. Blood Marrow Transplant.10(3) , 178–185 (2004).
  • Sorror ML , MarisMB, SandmaierBMet al.: Hematopoietic cell transplantation after nonmyeloablative conditioning for advanced chronic lymphocytic leukemia.J. Clin. Oncol.23(16) , 3819–3829 (2005).
  • Alyea EP , KimHT, HoVet al.: Comparative outcome of nonmyeloablative and myeloablative allogeneic hematopoietic cell transplantation for patients older than 50 years of age.Blood105(4) , 1810–1814 (2005).
  • Vodanovic-Jankovic S , HariP, JacobsP, KomorowskiR, DrobyskiWR: NF-κB as a target for the prevention of graft-versus-host disease: comparative efficacy of bortezomib and PS-1145.Blood107(2) , 827–834 (2006).
  • Welniak LA , BlazarBR, MurphyWJ: Immunobiology of allogeneic hematopoietic stem cell transplantation.Annu. Rev. Immunol.25139–25170 (2007).
  • Ferrara JL : Novel strategies for the treatment and diagnosis of graft-versus-host-disease.Best Pract. Res. Clin. Haematol.20(1) , 91–97 (2007).
  • Ferrara JL , CookeKR, PanL, KrengerW: The immunopathophysiology of acute graft-versus-host-disease.Stem Cells14(5) , 473–489 (1996).
  • Sun Y , TawaraI, ToubaiT, ReddyP: Pathophysiology of acute graft-versus-host disease: recent advances.Transl. Res.150(4) , 197–214 (2007).
  • Tsukada N , KobataT, AizawaY, YagitaH, OkumuraK: Graft-versus-leukemia effect and graft-versus-host disease can be differentiated by cytotoxic mechanisms in a murine model of allogeneic bone marrow transplantation.Blood93(8) , 2738–2747 (1999).
  • Krenger W , HillGR, FerraraJL: Cytokine cascades in acute graft-versus-host disease.Transplantation64(4) , 553–558 (1997).
  • Murphy WJ , WelniakLA, TaubDDet al.: Differential effects of the absence of interferon-gamma and IL-4 in acute graft-versus-host disease after allogeneic bone marrow transplantation in mice.J. Clin. Invest.102(9) , 1742–1748 (1998).
  • Basara N , BlauWI, KiehlMGet al.: Efficacy and safety of mycophenolate mofetil for the treatment of acute and chronic GVHD in bone marrow transplant recipient.Transplant. Proc.30(8) , 4087–4089 (1998).
  • Basara N , KiehlMG, BlauWet al.: Mycophenolate mofetil in the treatment of acute and chronic GVHD in hematopoietic stem cell transplant patients: four years of experience.Transplant. Proc.33(3) , 2121–2123 (2001).
  • Bolanos-Meade J , JacobsohnDA, MargolisJet al.: Pentostatin in steroid-refractory acute graft-versus-host disease.J. Clin. Oncol.23(12) , 2661–2668 (2005).
  • Maraninchi D , GluckmanE, BlaiseDet al.: Impact of T-cell depletion on outcome of allogeneic bone-marrow transplantation for standard-risk leukaemias.Lancet2(8552) , 175–178 (1987).
  • Wagner JE , DonnenbergAD, NogaSJet al.: Lymphocyte depletion of donor bone marrow by counterflow centrifugal elutriation: results of a Phase I clinical trial.Blood72(4) , 1168–1176 (1988).
  • Drobyski WR , AshRC, CasperJTet al.: Effect of T-cell depletion as graft-versus-host disease prophylaxis on engraftment, relapse, and disease-free survival in unrelated marrow transplantation for chronic myelogenous leukemia.Blood83(7) , 1980–1987 (1994).
  • Pavletic SZ , CarterSL, KernanNAet al.: Influence of T-cell depletion on chronic graft-versus-host disease: results of a multicenter randomized trial in unrelated marrow donor transplantation.Blood106(9) , 3308–3313 (2005).
  • Storb R : Bone marrow transplantation.Transplant. Proc.27(5) , 2649–2652 (1995).
  • Feugier P , TheveninS, BillotMet al.: Comparison of T cell depletion strategies from bone marrow, umbilical cord and peripheral blood using five separation systems.Hematol. Cell Ther.39(2) , 67–73 (1997).
  • Hale G , XiaMQ, TigheHP, DyerMJ, WaldmannH: The CAMPATH-1 antigen (CDw52).Tissue Antigens35(3) , 118–127 (1990).
  • Waldmann H , and Hale G: CAMPATH: from concept to clinic. Philos. Trans. R Soc. Lond. B. Biol. Sci.360(1461) , 1707–1711 (2005).
  • Hale G , WaldmannH: Risks of developing Epstein–Barr virus-related lymphoproliferative disorders after T-cell-depleted marrow transplants. CAMPATH Users.Blood91(8) , 3079–3083 (1998).
  • Chu YW , GressRE: Murine models of chronic graft-versus-host disease: insights and unresolved issues.Biol. Blood Marrow Transplant.14(4) , 365–378 (2008).
  • Reddy P , NegrinR, HillGR: Mouse models of bone marrow transplantation.Biol. Blood Marrow Transplant.14(1 Suppl. 1) , 129–135 (2008).
  • Storb R , YuC, WagnerJLet al.: Stable mixed hematopoietic chimerism in DLA-identical littermate dogs given sublethal total body irradiation before and pharmacological immunosuppression after marrow transplantation.Blood89(8) , 3048–3054 (1997).
  • Atkinson K , ShulmanHM, DeegHJet al.: Acute and chronic graft-versus-host disease in dogs given hemopoietic grafts from DLA-nonidentical littermates. Two distinct syndromes.Am. J. Pathol.108(2) , 196–205 (1982).
  • Kolb H , SaleGE, LernerKG, StorbR, ThomasED: Pathology of acute graft-versus-host disease in the dog. An autopsy study of ninety-five dogs.Am. J. Pathol.96(2) , 581–594 (1979).
  • Mestas J , HughesCC: Of mice and not men: differences between mouse and human immunology.J. Immunol.172(5) , 2731–2738 (2004).
  • Stevens JC , BanksGT, FestingMF, FisherEM: Quiet mutations in inbred strains of mice.Trends Mol. Med.13(12) , 512–519 (2007).
  • Taft RA , DavissonM, WilesMV: Know thy mouse.Trends Genet.22(12) , 649–653 (2006).
  • Champlin R , HoW, GajewskiJet al.: Selective depletion of CD8+ T lymphocytes for prevention of graft-versus-host disease after allogeneic bone marrow transplantation.Blood76(2) , 418–423 (1990).
  • Truitt RL , AtasoyluAA: Contribution of CD4+ and CD8+ T cells to graft-versus-host disease and graft-versus-leukemia reactivity after transplantation of MHC-compatible bone marrow.Bone Marrow Transplant.8(1) , 51–58 (1991).
  • Dazzi F , SzydloRM, GoldmanJM: Donor lymphocyte infusions for relapse of chronic myeloid leukemia after allogeneic stem cell transplant: where we now stand.Exp. Hematol.27(10) , 1477–1486 (1999).
  • Martin PJ , RowleySD, AnasettiCet al.: A Phase I–II clinical trial to evaluate removal of CD4 cells and partial depletion of CD8 cells from donor marrowfor HLA-mismatched unrelated recipients.Blood94(7) , 2192–2199 (1999).
  • Rosenberg SA , PackardBS, AebersoldPMet al.: Use of tumor-infiltrating lymphocytes and interleukin-2 in the immunotherapy of patients with metastatic melanoma. A preliminary report.N. Engl. J. Med.319(25) , 1676–1680 (1988).
  • Rosenberg SA , YangJC, TopalianSLet al.: Treatment of 283 consecutive patients with metastatic melanoma or renal cell cancer using high-dose bolus interleukin 2.JAMA271(12) , 907–913 (1994).
  • Rosenberg SA , YannelliJR, YangJCet al.: Treatment of patients with metastatic melanoma with autologous tumor-infiltrating lymphocytes and interleukin 2.J. Natl Cancer Inst.86(15) , 1159–1166 (1994).
  • Rosenberg SA , AebersoldP, CornettaKet al.: Gene transfer into humans – immunotherapy of patients with advanced melanoma, using tumor-infiltrating lymphocytes modified by retroviral gene transduction.N. Engl. J. Med.323(9) , 570–578 (1990).
  • Dudley ME , YangJC, SherryRet al.: Adoptive cell therapy for patients with metastatic melanoma: evaluation of intensive myeloablative chemoradiation preparative regimens.J. Clin. Oncol.26(32) , 5233–5239 (2008).
  • Rosenberg SA , DudleyME: Adoptive cell therapy for the treatment of patients with metastatic melanoma.Curr. Opin. Immunol.21(2) , 233–240 (2009).
  • Morgan RA , DudleyME, WunderlichJRet al.: Cancer regression in patients after transfer of genetically engineered lymphocytes.Science314(5796) , 126–129 (2006).
  • Gattinoni L , FinkelsteinSE, KlebanoffCAet al.: Removal of homeostatic cytokine sinks by lymphodepletion enhances the efficacy of adoptively transferred tumor-specific CD8+ T cells.J. Exp. Med.202(7) , 907–912 (2005).
  • Overwijk WW , TheoretMR, FinkelsteinSEet al.: Tumor regression and autoimmunity after reversal of a functionally tolerant state of self-reactive CD8+ T cells.J. Exp. Med.198(4) , 569–580 (2003).
  • Rosenberg SA , RestifoNP, YangJC, MorganRA, DudleyME: Adoptive cell transfer: a clinical path to effective cancer immunotherapy.Nat. Rev. Cancer8(4) , 299–308 (2008).
  • Wrzesinski C , RestifoNP: Less is more: lymphodepletion followed by hematopoietic stem cell transplant augments adoptive T-cell-based anti-tumor immunotherapy.Curr. Opin. Immunol.17(2) , 195–201 (2005).
  • Berry LJ , MoellerM, DarcyPK: Adoptive immunotherapy for cancer: the next generation of gene-engineered immune cells.Tissue Antigens74(4) , 277–289 (2009).
  • Sadelain M , BrentjensR, RiviereI: The promise and potential pitfalls of chimeric antigen receptors.Curr. Opin. Immunol.21(2) , 215–223 (2009).
  • Wrzesinski C , PaulosCM, GattinoniLet al.: Hematopoietic stem cells promote the expansion and function of adoptively transferred antitumor CD8 T cells.J. Clin. Invest.117(2) , 492–501 (2007).
  • Cooke KR , HillGR, CrawfordJMet al.: Tumor necrosis factor-α production to lipopolysaccharide stimulation by donor cells predicts the severity of experimental acute graft-versus-host disease.J. Clin. Invest.102(10) , 1882–1891 (1998).
  • Hill GR , FerraraJL: The primacy of the gastrointestinal tract as a target organ of acute graft-versus-host disease: rationale for the use of cytokine shields in allogeneic bone marrow transplantation.Blood95(9) , 2754–2759 (2000).
  • Liang H , LiaoC, QiZet al.: Rapamycin or tacrolimus alone fails to resist cardiac allograft accelerated rejection mediated by alloreactive CD4+ memory T cells in mice.Transpl. Immunol.22(3–4) , 128–136 (2010).
  • Bingaman AW , FarberDL: Memory T cells in transplantation: generation, function, and potential role in rejection.Am. J. Transplant.4(6) , 846–852 (2004).
  • Verneris MR , KaramiM, BakerJ, JayaswalA, NegrinRS: Role of NKG2D signaling in the cytotoxicity of activated and expanded CD8+ T cells.Blood103(8) , 3065–3072 (2004).
  • Kim HM , LimJ, KangJSet al.: Inhibition of human cervical carcinoma growth by cytokine-induced killer cells in nude mouse xenograft model.Int. Immunopharmacol.9(3) , 375–380 (2009).
  • Nishimura R , BakerJ, BeilhackAet al.: In vivo trafficking and survival of cytokine-induced killer cells resulting in minimal GVHD with retention of antitumor activity.Blood112(6) , 2563–2574 (2008).
  • Ljunggren HG , KarreK: In search of the ‘missing self‘: MHC molecules and NK cell recognition.Immunol. Today11(7) , 237–244 (1990).
  • Thompson JA , ShulmanKL, BenyunesMCet al.: Prolonged continuous intravenous infusion interleukin-2 and lymphokine-activated killer-cell therapy for metastatic renal cell carcinoma.J. Clin. Oncol.10(6) , 960–968 (1992).
  • Trinchieri G : Biology of natural killer cells.Adv. Immunol.47187–47376 (1989).
  • Koh CY , WelniakLA, MurphyWJ: Adoptive cellular immunotherapy: NK cells and bone marrow transplantation.Histol. Histopathol.15(4) , 1201–1210 (2000).
  • Uhrberg M , ValianteNM, ShumBPet al.: Human diversity in killer cell inhibitory receptor genes.Immunity7(6) , 753–763 (1997).
  • Lanier LL : NK cell recognition.Annu. Rev. Immunol.23 , 225–274 (2005).
  • Bennett M : Rejection of marrow allografts: importance of H-2 homozygosity of donor cells.Transplantation14(3) , 289–298 (1972).
  • Cudkowicz G , BennettM: Peculiar immunobiology of bone marrow allografts. II. Rejection of parental grafts by resistant F1 hybrid mice.J. Exp. Med.134(6) , 1513–1528 (1971).
  • Yu YY , KumarV, BennettM: Murine natural killer cells and marrow graft rejection.Annu. Rev. Immunol.10 , 189–213 (1992).
  • Cudkowicz G , BennettM: Peculiar immunobiology of bone marrow allografts. I. Graft rejection by irradiated responder mice.J. Exp. Med.134(1) , 83–102 (1971).
  • Natarajan K , DimasiN, WangJ, MariuzzaRA, MarguliesDH: Structure and function of natural killer cell receptors: multiple molecular solutions to self, nonself discrimination.Annu. Rev. Immunol.20 , 853–885 (2002).
  • Yu YY , GeorgeT, DorfmanJR, RolandJ, KumarV, BennettM: The role of Ly49A and 5E6(Ly49C) molecules in hybrid resistance mediated by murine natural killer cells against normal T cell blasts.Immunity4(1) , 67–76 (1996).
  • Asai O , LongoDL, TianZGet al.: Suppression of graft-versus-host disease and amplification of graft-versus-tumor effects by activated natural killer cells after allogeneic bone marrow transplantation.J. Clin. Invest.101(9) , 1835–1842 (1998).
  • Ruggeri L , AversaF, MartelliMF, VelardiA: Allogeneic hematopoietic transplantation and natural killer cell recognition of missing self.Immunol. Rev.214 , 202–218 (2006).
  • Ruggeri L , CapanniM, UrbaniEet al.: Effectiveness of donor natural killer cell alloreactivity in mismatched hematopoietic transplants.Science295(5562) , 2097–2100 (2002).
  • Passweg JR , TichelliA, Meyer-MonardSet al.: Purified donor NK-lymphocyte infusion to consolidate engraftment after haploidentical stem cell transplantation.Leukemia18(11) , 1835–1838 (2004).
  • Koh CY , RaziuddinA, WelniakLA, BlazarBR, BennettM, MurphyWJ: NK inhibitory-receptor blockade for purging of leukemia: effects on hematopoietic reconstitution.Biol. Blood Marrow Transplant.8(1) , 17–25 (2002).
  • Ljunggren HG , MalmbergKJ: Prospects for the use of NK cells in immunotherapy of human cancer.Nat. Rev. Immunol.7(5) , 329–339 (2007).
  • Romagne F , AndreP, SpeePet al.: Preclinical characterization of 1–7F9, a novel human anti-KIR receptor therapeutic antibody that augments natural killer-mediated killing of tumor cells.Blood114(13) , 2667–2677 (2009).
  • Sola C , AndreP, LemmersCet al.: Genetic and antibody-mediated reprogramming of natural killer cell missing-self recognition in vivo.Proc. Natl Acad. Sci. USA106(31) , 12879–12884 (2009).
  • Shevach EM , ThorntonA, Suri-PayerE: T lymphocyte-mediated control of autoimmunity.Novartis Found. Symp.215 , 200–211; discussion 211–230 (1998).
  • Battaglia M , RoncaroloMG: Induction of transplantation tolerance via regulatory T cells.Inflamm. Allergy Drug Targets5(3) , 157–165 (2006).
  • Nguyen VH , ZeiserR, NegrinRS: Role of naturally arising regulatory T cells in hematopoietic cell transplantation.Biol. Blood Marrow Transplant.12(10) , 995–1009 (2006).
  • Yong Z , ChangL, MeiYX, YiL: Role and mechanisms of CD4+CD25+ regulatory T cells in the induction and maintenance of transplantation tolerance.Transpl. Immunol.17(2) , 120–129 (2007).
  • Sakaguchi S , SakaguchiN, AsanoM, ItohM, TodaM: Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor α-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases.J. Immunol.155(3) , 1151–1164 (1995).
  • Graca L , CobboldSP, WaldmannH: Identification of regulatory T cells in tolerated allografts.J. Exp. Med.195(12) , 1641–1646 (2002).
  • Gregori S , CasoratiM, AmuchasteguiS, SmiroldoS, DavalliAM, AdoriniL: Regulatory T cells induced by 1 α,25-dihydroxyvitamin D3 and mycophenolate mofetil treatment mediate transplantation tolerance.J. Immunol.167(4) , 1945–1953 (2001).
  • Hara M , KingsleyCI, NiimiMet al.: IL-10 is required for regulatory T cells to mediate tolerance to alloantigens in vivo.J. Immunol.166(6) , 3789–3796 (2001).
  • Hoffmann P , ErmannJ, EdingerM, FathmanCG, StroberS: Donor-type CD4+CD25+ regulatory T cells suppress lethal acute graft-versus-host disease after allogeneic bone marrow transplantation.J. Exp. Med.196(3) , 389–399 (2002).
  • Blazar BR , TaylorPA, NoelleRJ, ValleraDA: CD4+ T cells tolerized ex vivo to host alloantigen by anti-CD40 ligand (CD40L:CD154) antibody lose their graft-versus-host disease lethality capacity but retain nominal antigen responses.J. Clin. Invest.102(3) , 473–482 (1998).
  • Godfrey WR , SpodenDJ, GeYGet al.: Cord blood CD4+CD25+-derived T regulatory cell lines express FoxP3 protein and manifest potent suppressor function.Blood105(2) , 750–758 (2005).
  • Edinger M , HoffmannP, ErmannJet al.: CD4+CD25+ regulatory T cells preserve graft-versus-tumor activity while inhibiting graft-versus-host disease after bone marrow transplantation.Nat. Med.9(9) , 1144–1150 (2003).
  • Jones SC , MurphyGF, KorngoldR: Post-hematopoietic cell transplantation control of graft-versus-host disease by donor CD425 T cells to allow an effective graft-versus-leukemia response.Biol. Blood Marrow Transplant.9(4) , 243–256 (2003).
  • Trenado A , CharlotteF, FissonSet al.: Recipient-type specific CD4+CD25+ regulatory T cells favor immune reconstitution and control graft-versus-host disease while maintaining graft-versus-leukemia.J. Clin. Invest.112(11) , 1688–1696 (2003).
  • Hill GR , CrawfordJM, CookeKR, BrinsonYS, PanL, FerraraJL: Total body irradiation and acute graft-versus-host disease: the role of gastrointestinal damage and inflammatory cytokines.Blood90(8) , 3204–3213 (1997).
  • Hill GR , TeshimaT, GerbitzAet al.: Differential roles of IL-1 and TNF-α on graft-versus-host disease and graft versus leukemia.J. Clin. Invest.104(4) , 459–467 (1999).
  • van Bekkum DW , RoodenburgJ, HeidtPJ, van der Waaij D: Mitigation of secondary disease of allogeneic mouse radiation chimeras by modification of the intestinal microflora. J. Natl Cancer Inst.52(2) , 401–404 (1974).
  • Teshima T , OrdemannR, ReddyPet al.: Acute graft-versus-host disease does not require alloantigen expression on host epithelium.Nat. Med.8(6) , 575–581 (2002).
  • Duffner UA , MaedaY, CookeKRet al.: Host dendritic cells alone are sufficient to initiate acute graft-versus-host disease.J. Immunol.172(12) , 7393–7398 (2004).
  • Shlomchik WD , CouzensMS, TangCBet al.: Prevention of graft versus host disease by inactivation of host antigen-presenting cells.Science285(5426) , 412–415 (1999).
  • Reddy V , IturraspeJA, TzolasAC, Meier-KriescheHU, ScholdJ, WingardJR: Low dendritic cell count after allogeneic hematopoietic stem cell transplantation predicts relapse, death, and acute graft-versus-host disease.Blood103(11) , 4330–4335 (2004).
  • Auffermann-Gretzinger S , LossosIS, VayntrubTAet al.: Rapid establishment of dendritic cell chimerism in allogeneic hematopoietic cell transplant recipients.Blood99(4) , 1442–1448 (2002).
  • Chakraverty R , SykesM: The role of antigen-presenting cells in triggering graft-versus-host disease and graft-versus-leukemia.Blood110(1) , 9–17 (2007).
  • Edinger M , PowrieF, ChakravertyR: Regulatory mechanisms in graft-versus-host responses.Biol. Blood Marrow Transplant.15(Suppl. 1) , 2–6 (2008).
  • Matte CC , LiuJ, CormierJet al.: Donor APCs are required for maximal GVHD but not for GVL.Nat. Med.10(9) , 987–992 (2004).
  • Anderson BE , McNiffJM, JainD, BlazarBR, ShlomchikWD, ShlomchikMJ: Distinct roles for donor- and host-derived antigen-presenting cells and costimulatory molecules in murine chronic graft-versus-host disease: requirements depend on target organ.Blood105(5) , 2227–2234 (2005).
  • Pahl HL : Activators and target genes of Rel/NF-κB transcription factors.Oncogene18(49) , 6853–6866 (1999).
  • Siebenlist U , FranzosoG, BrownK: Structure, regulation and function of NF-kappa B.Annu. Rev. Cell Biol.10405–10455 (1994).
  • Dejardin E : The alternative NF-kappaB pathway from biochemistry to biology: pitfalls and promises for future drug development.Biochem. Pharmacol.72(9) , 1161–1179 (2006).
  • Richardson PG , MitsiadesC, HideshimaT, AndersonKC: Bortezomib: proteasome inhibition as an effective anticancer therapy.Annu. Rev. Med.57 , 33–47 (2006).
  • Markovina S , CallanderNS, O‘ConnorSLet al.: Bortezomib-resistant nuclear factor-κB activity in multiple myeloma cells.Mol. Cancer Res.6(8) , 1356–1364 (2008).
  • Kane RC , BrossPF, FarrellAT, PazdurR: Velcade: US FDA approval for the treatment of multiple myeloma progressing on prior therapy.Oncologist8(6) , 508–513 (2003).
  • Sun K , WelniakLA, Panoskaltsis-MortariAet al.: Inhibition of acute graft-versus-host disease with retention of graft-versus-tumor effects by the proteasome inhibitor bortezomib.Proc. Natl Acad. Sci. USA101(21) , 8120–8125 (2004).
  • Sun K , LiM, SayersTJ, WelniakLA, MurphyWJ: Differential effects of donor T-cell cytokines on outcome with continuous bortezomib administration after allogeneic bone marrow transplantation.Blood112(4) , 1522–1529 (2008).
  • Sayers TJ , BrooksAD, KohCYet al.: The proteasome inhibitor PS-341 sensitizes neoplastic cells to TRAIL-mediated apoptosis by reducing levels of c-FLIP.Blood102(1) , 303–310 (2003).
  • Koreth J , StevensonKE, KimHTet al.: Bortezomib, tacrolimus, and methotrexate for prophylaxis of graft-versus-host disease after reduced-intensity conditioning allogeneic stem cell transplantation from HLA-mismatched unrelated donors.Blood114(18) , 3956–3959 (2009).
  • Lonial S , WallerEK, RichardsonPGet al.: Risk factors and kinetics of thrombocytopenia associated with bortezomib for relapsed, refractory multiple myeloma.Blood106(12) , 3777–3784 (2005).
  • Reddy P , MaedaY, HotaryKet al.: Histone deacetylase inhibitor suberoylanilide hydroxamic acid reduces acute graft-versus-host disease and preserves graft-versus-leukemia effect.Proc. Natl Acad. Sci. USA101(11) , 3921–3926 (2004).
  • Marks P , RifkindRA, RichonVM, BreslowR, MillerT, KellyWK: Histone deacetylases and cancer: causes and therapies.Nat. Rev. Cancer1(3) , 194–202 (2001).
  • Butler LM , AgusDB, ScherHIet al.: Suberoylanilide hydroxamic acid, an inhibitor of histone deacetylase, suppresses the growth of prostate cancer cells in vitro and in vivo.Cancer Res.60(18) , 5165–5170 (2000).
  • Cohen LA , MarksPA, RifkindRAet al.: Suberoylanilide hydroxamic acid (SAHA), a histone deacetylase inhibitor, suppresses the growth of carcinogen-induced mammary tumors.AntiCancer Res.22(3) , 1497–1504 (2002).
  • Leoni F , ZalianiA, BertoliniGet al.: The antitumor histone deacetylase inhibitor suberoylanilide hydroxamic acid exhibits antiinflammatory properties via suppression of cytokines.Proc. Natl Acad. Sci. USA99(5) , 2995–3000 (2002).
  • Kelly WK , RichonVM, O‘ConnorOet al.: Phase I clinical trial of histone deacetylase inhibitor: suberoylanilide hydroxamic acid administered intravenously.Clin. Cancer Res.9(10 Pt 1) , 3578–3588 (2003).
  • Linsley PS , GreeneJL, BradyW, BajorathJ, LedbetterJA, PeachR: Human B7–1 (CD80) and B7–2 (CD86) bind with similar avidities but distinct kinetics to CD28 and CTLA-4 receptors.Immunity1(9) , 793–801 (1994).
  • Linsley PS , GreeneJL, TanPet al.: Coexpression and functional cooperation of CTLA-4 and CD28 on activated T lymphocytes.J. Exp. Med.176(6) , 1595–1604 (1992).
  • van der Merwe PA , BodianDL, DaenkeS, LinsleyP, DavisSJ: CD80 (B7–1) binds both CD28 and CTLA-4 with a low affinity and very fast kinetics.J. Exp. Med.185(3) , 393–403 (1997).
  • Walunas TL , LenschowDJ, BakkerCYet al.: CTLA-4 can function as a negative regulator of T cell activation.Immunity1(5) , 405–413 (1994).
  • Carreno BM , BennettF, ChauTAet al.: CTLA-4 (CD152) can inhibit T cell activation by two different mechanisms depending on its level of cell surface expression.J. Immunol.165(3) , 1352–1356 (2000).
  • Krummel MF , AllisonJP: CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation.J. Exp. Med.182(2) , 459–465 (1995).
  • Blazar BR , TaylorPA, LinsleyPS, ValleraDA: In vivo blockade of CD28/CTLA4: B7/BB1 interaction with CTLA4-Ig reduces lethal murine graft-versus-host disease across the major histocompatibility complex barrier in mice.Blood83(12) , 3815–3825 (1994).
  • Blazar BR , TaylorPA, Panoskaltsis-MortariA, SharpeAH, ValleraDA: Opposing roles of CD28:B7 and CTLA-4:B7 pathways in regulating in vivo alloresponses in murine recipients of MHC disparate T cells.J. Immunol.162(11) , 6368–6377 (1999).
  • Fife BT , BluestoneJA: Control of peripheral T-cell tolerance and autoimmunity via the CTLA-4 and PD-1 pathways.Immunol. Rev.224166–182 (2008).
  • Greenwald RJ , FreemanGJ, SharpeAH: The B7 family revisited.Annu. Rev. Immunol.23515–23548 (2005).
  • Alderson KL , ZhouQ, BernerVet al.: Regulatory and conventional CD4+ T cells show differential effects correlating with PD-1 and B7-H1 expression after immunotherapy.J. Immunol.180(5) , 2981–2988 (2008).
  • Ozkaynak E , WangL, GoodearlAet al.: Programmed death-1 targeting can promote allograft survival.J. Immunol.169(11) , 6546–6553 (2002).
  • Blazar BR , CarrenoBM, Panoskaltsis-MortariAet al.: Blockade of programmed death-1 engagement accelerates graft-versus-host disease lethality by an IFN-γ-dependent mechanism.J. Immunol.171(3) , 1272–1277 (2003).
  • Blazar BR , SharpeAH, ChenAIet al.: Ligation of OX40 (CD134) regulates graft-versus-host disease (GVHD) and graft rejection in allogeneic bone marrow transplant recipients.Blood101(9) , 3741–3748 (2003).
  • Jung U , FoleyJE, ErdmannAAet al.: Ex vivo rapamycin generates Th1/Tc1 or Th2/Tc2 Effector T cells with enhanced in vivo function and differential sensitivity to post-transplant rapamycin therapy.Biol. Blood Marrow Transplant.12(9) , 905–918 (2006).
  • Foley JE , JungU, MieraAet al.: Ex vivo rapamycin generates donor Th2 cells that potently inhibit graft-versus-host disease and graft-versus-tumor effects via an IL-4-dependent mechanism.J. Immunol.175(9) , 5732–5743 (2005).
  • Kappel LW , GoldbergGL, KingCGet al.: IL-17 contributes to CD4-mediated graft-versus-host disease.Blood113(4) , 945–952 (2009).
  • Yi T , ZhaoD, LinCLet al.: Absence of donor Th17 leads to augmented Th1 differentiation and exacerbated acute graft-versus-host disease.Blood112(5) , 2101–2110 (2008).
  • Couriel D , SalibaR, HicksKet al.: Tumor necrosis factor-α blockade for the treatment of acute GVHD.Blood104(3) , 649–654 (2004).
  • Chiang KY , AbhyankarS, BridgesK, GodderK, Henslee-DowneyJP: Recombinant human tumor necrosis factor receptor fusion protein as complementary treatment for chronic graft-versus-host disease.Transplantation73(4) , 665–667 (2002).
  • Przepiorka D , KernanNA, IppolitiCet al.: Daclizumab, a humanized anti-interleukin-2 receptor alpha chain antibody, for treatment of acute graft-versus-host disease.Blood95(1) , 83–89 (2000).
  • Wolff D , RoesslerV, SteinerBet al.: Treatment of steroid-resistant acute graft-versus-host disease with daclizumab and etanercept.Bone Marrow Transplant.35(10) , 1003–1010 (2005).
  • Yanik G , HellerstedtB, CusterJet al.: Etanercept (Enbrel) administration for idiopathic pneumonia syndrome after allogeneic hematopoietic stem cell transplantation.Biol. Blood Marrow Transplant.8(7) , 395–400 (2002).
  • Bartholomew A , SturgeonC, SiatskasMet al.: Mesenchymal stem cells suppress lymphocyte proliferation in vitro and prolong skin graft survival in vivo.Exp. Hematol.30(1) , 42–48 (2002).
  • Le Blanc K , TammikL, SundbergB, HaynesworthSE, RingdenO: Mesenchymal stem cells inhibit and stimulate mixed lymphocyte cultures and mitogenic responses independently of the major histocompatibility complex.Scand. J. Immunol.57(1) , 11–20 (2003).
  • Tian Y , DengYB, HuangYJ, WangY: Bone marrow-derived mesenchymal stem cells decrease acute graft-versus-host disease after allogeneic hematopoietic stem cells transplantation.Immunol. Invest.37(1) , 29–42 (2008).
  • Barrett AJ , and Le Blanc K: Prophylaxis of acute GVHD: manipulate the graft or the environment? Best Pract. Res. Clin. Haematol.21(2) , 165–176 (2008).
  • Le Blanc K , FrassoniF, BallLet al.: Mesenchymal stem cells for treatment of steroid-resistant, severe, acute graft-versus-host disease: a Phase II study.Lancet371(9624) , 1579–1586 (2008).
  • Ning H , YangF, JiangMet al.: The correlation between cotransplantation of mesenchymal stem cells and higher recurrence rate in hematologic malignancy patients: outcome of a pilot clinical study.Leukemia22(3) , 593–599 (2008).
  • Karnoub AE , DashAB, VoAPet al.: Mesenchymal stem cells within tumour stroma promote breast cancer metastasis.Nature449(7162) , 557–563 (2007).
  • Gesundheit B , ShapiraMY, ResnickIBet al.: Successful cell-mediated cytokine-activated immunotherapy for relapsed acute myeloid leukemia after hematopoietic stem cell transplantation.Am. J. Hematol.84(3) , 188–190 (2009).
  • Huang XJ , LiuDH, LiuKYet al.: Treatment of acute leukemia with unmanipulated HLA-mismatched/haploidentical blood and bone marrow transplantation.Biol. Blood Marrow Transplant.15(2) , 257–265 (2009).
  • Kebriaei P , DetryMA, GiraltSet al.: Long-term follow-up of allogeneic hematopoietic stem-cell transplantation with reduced-intensity conditioning for patients with chronic myeloid leukemia.Blood110(9) , 3456–3462 (2007).
  • Poire X , ArtzA, LarsonRAet al.: Allogeneic stem cell transplantation with alemtuzumab-based conditioning for patients with advanced chronic myelogenous leukemia.Leuk. Lymphoma50(1) , 85–91 (2009).
  • Wrench D , GribbenJG: Stem cell transplantation for non-Hodgkin‘s lymphoma.Hematol. Oncol. Clin. North Am.22(5) , 1051–1079, XI (2008).
  • Boyiadzis M , FoonKA, PavleticS: Hematopoietic stem cell transplantation for chronic lymphocytic leukemia: potential cure for an incurable disease.Expert Opin. Biol. Ther.7(12) , 1789–1797 (2007).
  • Gribben JG : Stem cell transplantation in chronic lymphocytic leukemia.Biol. Blood Marrow Transplant.15(Suppl. 1) , 53–58 (2008).
  • Laport GG , SandmaierBM, StorerBEet al.: Reduced-intensity conditioning followed by allogeneic hematopoietic cell transplantation for adult patients with myelodysplastic syndrome and myeloproliferative disorders.Biol. Blood Marrow Transplant.14(2) , 246–255 (2008).
  • Warlick ED , CiocA, DeforT, DolanM, WeisdorfD: Allogeneic stem cell transplantation for adults with myelodysplastic syndromes: importance of pretransplant disease burden.Biol. Blood Marrow Transplant.15(1) , 30–38 (2009).
  • Armand P , and Antin JH: Allogeneic stem cell transplantation for aplastic anemia. Biol. Blood Marrow Transplant.13(5) , 505–516 (2007).
  • Kim HJ , ParkCY, ParkYHet al.: Successful allogeneic hematopoietic stem cell transplantation using triple agent immunosuppression in severe aplastic anemia patients.Bone Marrow Transplant.31(2) , 79–86 (2003).
  • Min CK , KimDW, LeeJW, HanCW, MinWS, KimCC: Hematopoietic stem cell transplantation for high-risk adult patients with severe aplastic anemia; reduction of graft failure by enhancing stem cell dose.Haematologica86(3) , 303–310 (2001).
  • Bourquin JP , ThornleyI, NeubergDet al.: Favorable outcome of allogeneic hematopoietic stem cell transplantation for relapsed or refractory acute promyelocytic leukemia in childhood.Bone Marrow Transplant.34(9) , 795–798 (2004).
  • Friedrich W , and Muller SM: Allogeneic stem cell transplantation for treatment of immunodeficiency. Springer Semin. Immunopathol.26(1–2) , 109–118 (2004).
  • Gennery AR , CantAJ: Advances in hematopoietic stem cell transplantation for primary immunodeficiency.Immunol. Allergy Clin. North Am.28(2) , 439–456, X–XI (2008).
  • Gratwohl A : Allogeneic hematopoietic stem cell transplantation for severe autoimmune diseases.Autoimmunity41(8) , 673–678 (2008).
  • Nash RA : Allogeneic HSCT for autoimmune diseases: conventional conditioning regimens.Bone Marrow Transplant.32(Suppl. 1) , S77–S80 (2003).
  • Forrest DL , ThompsonK, NevillTJ, CoubanS, FernandezLA: Allogeneic hematopoietic stem cell transplantation for progressive follicular lymphoma.Bone Marrow Transplant.29(12) , 973–978 (2002).
  • Childs RW , ClaveE, TisdaleJ, PlanteM, HenselN, BarrettJ: Successful treatment of metastatic renal cell carcinoma with a nonmyeloablative allogeneic peripheral-blood progenitor-cell transplant: evidence for a graft-versus-tumor effect.J. Clin. Oncol.17(7) , 2044–2049 (1999).
  • Takahashi Y , ChildsRW: Nonmyeloablative transplantation: an allogeneic-based immunotherapy for renal cell carcinoma.Clin. Cancer Res.10(18 Pt 2) , S6353–S6359 (2004).
  • Nakashima Y , ShiratsuchiM, AbeYet al.: Sustained molecular remission by non-myeloablative stem cell transplantation after autologous hematopoietic stem cell transplantation in a patient with multiple myeloma.Leuk. Lymphoma46(8) , 1217–1222 (2005).
  • Zeiser R , BertzH, SpyridonidisA, HouetL, FinkeJ: Donor lymphocyte infusions for multiple myeloma: clinical results and novel perspectives.Bone Marrow Transplant.34(11) , 923–928 (2004).
  • Claviez A , SuredaA, SchmitzN: Haematopoietic SCT for children and adolescents with relapsed and refractory Hodgkin‘s lymphoma.Bone Marrow Transplant.42(Suppl. 2) , S16–S24 (2008).
  • Vose JM , SharpG, ChanWCet al.: Autologous transplantation for aggressive non-Hodgkin‘s lymphoma: results of a randomized trial evaluating graft source and minimal residual disease.J. Clin. Oncol.20(9) , 2344–2352 (2002).
  • Drabko K , ChomaM, Zaucha-PrazmoAet al.: Megachemotherapy and autologous hematopoietic stem cell transplantation in children with solid tumours excluding neuroblastoma – experience of Polish paediatric centres.Med. Wieku Rozwoj.10(3 Pt 1) , 785–792 (2006).
  • Manilay JO , SykesM: Natural killer cells and their role in graft rejection.Curr. Opin. Immunol.10(5) , 532–538 (1998).

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