Bibliography
- Rossini AA , MordesJP, LikeAA: Immunology of insulin-dependent diabetes mellitus.Annu. Rev. Immunol.3 , 289–320 (1985).
- Ballinger WF , LacyPE: Transplantation of intact pancreatic islets in rats.Surgery72 , 175–186 (1972).
- Lacy PE , KostianovskyM: Method for the isolation of intact islets of Langerhans from the rat pancreas.Diabetes16 , 35–39 (1967).
- Ricordi C , StromTB: Clinical islet transplantation: advances and immunological challenges.Nat. Rev. Immunol.4 , 259–268 (2004).
- Shapiro AM , LakeyJR, RyanEAet al.: Islet transplantation in seven patients with Type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen.N. Engl. J. Med.343 , 230–238 (2000).
- Shapiro AM , RicordiC, HeringBJet al.: International trial of the Edmonton protocol for islet transplantation.N. Engl. J. Med.355 , 1318–1330 (2006).
- Herold KC , HagopianW, AugerJAet al.: Anti-CD3 monoclonal antibody in new-onset Type 1 diabetes mellitus.N. Engl. J. Med.346 , 1692–1698 (2002).
- Shoda LK , YoungDL, RamanujanSet al.: A comprehensive review of interventions in the NOD mouse and implications for translation.Immunity23 , 115–126 (2005).
- Belghith M , BluestoneJA, BarriotSet al.: TGF-β-dependent mechanisms mediate restoration of self-tolerance induced by antibodies to CD3 in overt autoimmune diabetes.Nat. Med.9 , 1202–1208 (2003).
- Koulmanda M , BudoE, Bonner-WeirSet al.: Modification of adverse inflammation is required to cure new-onset Type 1 diabetic hosts.Proc. Natl Acad. Sci. USA104 , 13074–13079 (2007).
- Ogawa N , ListJF, HabenerJF, MakiT: Cure of overt diabetes in NOD mice by transient treatment with anti-lymphocyte serum and exendin-4.Diabetes53 , 1700–1705 (2004).
- Tarbell KV , PetitL, ZuoXet al.: Dendritic cell-expanded, islet-specific CD4+ CD25+ CD62L+ regulatory T cells restore normoglycemia in diabetic NOD mice.J. Exp. Med.204 , 191–201 (2007).
- Bresson D , TogherL, RodrigoEet al.: Anti-CD3 and nasal proinsulin combination therapy enhances remission from recent-onset autoimmune diabetes by inducing Tregs.J. Clin. Invest.116 , 1371–1381 (2006).
- Bettelli E , CarrierY, GaoWet al.: Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells.Nature441 , 235–238 (2006).
- Tato CM , O‘SheaJJ: Immunology: what does it mean to be just 17?Nature441 , 166–168 (2006).
- Veldhoen M , HockingRJ, AtkinsCJ, LocksleyRM, StockingerB: TGFβ in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells.Immunity24 , 179–189 (2006).
- Barshes NR , WyllieS, GossJA: Inflammation-mediated dysfunction and apoptosis in pancreatic islet transplantation: implications for intrahepatic grafts.J. Leukoc. Biol.77 , 587–597 (2005).
- Eizirik DL , Mandrup-PoulsenT: A choice of death – the signal-transduction of immune-mediated β-cell apoptosis.Diabetologia44 , 2115–2133 (2001).
- Hotamisligil GS : Inflammation and metabolic disorders.Nature444 , 860–867 (2006).
- Sandler S , AnderssonA, HellerstromC: Inhibitory effects of interleukin 1 on insulin secretion, insulin biosynthesis, and oxidative metabolism of isolated rat pancreatic islets.Endocrinology121 , 1424–1431 (1987).
- Zheng XX , Sanchez-FueyoA, ShoMet al.: Favorably tipping the balance between cytopathic and regulatory T cells to create transplantation tolerance.Immunity19 , 503–514 (2003).
- Fontenot JD , RasmussenJP, GavinMA, RudenskyAY: A function for interleukin 2 in Foxp3-expressing regulatory T cells.Nat. Immunol.6 , 1142–1151 (2005).
- Zheng XX , MaslinskiW, Ferrari-LacrazS, StromTB: Cytokines in the treatment and prevention of autoimmune responses – a role of IL-15.Adv. Exp. Med. Biol.520 , 87–95 (2003).
- Ferrari-Lacraz S , ZhengXX, KimYSet al.: An antagonist IL-15/Fc protein prevents costimulation blockade-resistant rejection.J. Immunol.167 , 3478–3485 (2001).
- Waldmann TA , DuboisS, TagayaY: Contrasting roles of IL-2 and IL-15 in the life and death of lymphocytes: implications for immunotherapy.Immunity14 , 105–110 (2001).
- Li Y , LiXC, ZhengXXet al.: Blocking both signal 1 and signal 2 of T-cell activation prevents apoptosis of alloreactive T cells and induction of peripheral allograft tolerance.Nat. Med.5 , 1298–1302 (1999).
- Zheng XX , SteeleAW, HancockWWet al.: IL-2 receptor-targeted cytolytic IL-2/Fc fusion protein treatment blocks diabetogenic autoimmunity in nonobese diabetic mice.J. Immunol.163 , 4041–4048 (1999).
- Breit SN , WakefieldD, RobinsonJPet al.: The role of α 1-antitrypsin deficiency in the pathogenesis of immune disorders.Clin. Immunol. Immunopathol.35 , 363–380 (1985).
- Churg A , DaiJ, ZayKet al.: α-1-antitrypsin and a broad spectrum metalloprotease inhibitor, RS113456, have similar acute anti-inflammatory effects.Lab. Invest.81 , 1119–1131 (2001).
- Jie Z , CaiY, YangWet al.: Protective effects of α 1-antitrypsin on acute lung injury in rabbits induced by endotoxin.Chin. Med. J. (Engl.)116 , 1678–1682 (2003).
- Lewis EC , ShapiroL, BowersOJ, DinarelloCA: α1-antitrypsin monotherapy prolongs islet allograft survival in mice.Proc. Natl Acad. Sci. USA102 , 12153–12158 (2005).
- Petrache I , FijalkowskaI, ZhenLet al.: A novel antiapoptotic role for α1-antitrypsin in the prevention of pulmonary emphysema.Am. J. Respir. Crit. Care Med.173 , 1222–1228 (2006).
- Abbas AK , CorsonJM, CarpenterCBet al.: Immunologic enhancement of rat renal allografts. III. Immunopathologic lesions and rejection in long-surviving passively enhanced grafts.Am. J. Pathol.79 , 255–270 (1975).
- Brantly M : α1-antitrypsin: not just an antiprotease: extending the half-life of a natural anti-inflammatory molecule by conjugation with polyethylene glycol.Am. J. Respir. Cell Mol. Biol.27 , 652–654 (2002).
- Koulmanda M , BhasinM, HoffmanLet al.: Curative and β cell regenerative effects of α1-antitrypsin treatment in autoimmune diabetic NOD mice.Proc. Natl Acad. Sci. USA105 , 16242–16247 (2008).
- Bruning JC , WinnayJ, Bonner-WeirSet al.: Development of a novel polygenic model of NIDDM in mice heterozygous for IR and IRS-1 null alleles.Cell88 , 561–572 (1997).
- Chaparro RJ , KonigshoferY, BeilhackGFet al.: Nonobese diabetic mice express aspects of both Type 1 and Type 2 diabetes.Proc. Natl Acad. Sci. USA103 , 12475–12480 (2006).
- Shoelson SE , LeeJ, GoldfineAB: Inflammation and insulin resistance.J. Clin. Invest.116 , 1793–1801 (2006).
- Hotamisligil GS , ShargillNS, SpiegelmanBM: Adipose expression of tumor necrosis factor-α: direct role in obesity-linked insulin resistance.Science259 , 87–91 (1993).