Ultrasound-Guided Delivery of Thymidine Kinase–Nitroreductase Dual Therapeutic Genes By PEGylated-PLGA/PEI Nanoparticles for Enhanced Triple Negative Breast Cancer Therapy

References

• Brewster AM Chavez-Macgregor M Brown P . Epidemiology, biology, and treatment of triple-negative breast cancer in women of African ancestry . Lancet Oncol.15 ( 13 ), E625 – E634 ( 2014 ).
   PubMed Web of Science ®Google Scholar
• Kalimutho M Parsons K Mittal D Lopez JA Srihari S Khanna KK . Targeted therapies for triple-negative breast cancer: combating a stubborn disease . Trends Pharmacol. Sci.36 ( 12 ), 822 – 846 ( 2015 ).
   PubMed Web of Science ®Google Scholar
• Anderson WF . Gene therapy scores against cancer . Nat. Med.6 ( 8 ), 862 – 863 ( 2000 ).
   PubMed Web of Science ®Google Scholar
• Greco O Dachs GU . Gene directed enzyme/prodrug therapy of cancer: historical appraisal and future prospectives . J. Cell. Physiol.187 ( 1 ), 22 – 36 ( 2001 ).
   PubMed Web of Science ®Google Scholar
• Zhang J Kale V Chen M . Gene-directed enzyme prodrug therapy . AAPS J.17 ( 1 ), 102 – 110 ( 2015 ).
   PubMed Web of Science ®Google Scholar
• Denny WA . Prodrugs for gene-directed enzyme-prodrug therapy (suicide gene therapy) . J. Biomed. Biotechnol.2003 ( 1 ), 48 – 70 ( 2003 ).
   PubMedGoogle Scholar
• Dachs GU Hunt MA Syddall S Singleton DC Patterson AV . Bystander or no bystander for gene directed enzyme prodrug therapy . Molecules (Basel, Switzerland)14 ( 11 ), 4517 – 4545 ( 2009 ).
   PubMed Web of Science ®Google Scholar
• Sangro B Mazzolini G Ruiz M et al. A Phase I clinical trial of thymidine kinase-based gene therapy in advanced hepatocellular carcinoma . Cancer Gene Ther.17 ( 12 ), 837 – 843 ( 2010 ).
   PubMed Web of Science ®Google Scholar
• Bridgewater JA Springer CJ Knox RJ Minton NP Michael NP Collins MK . Expression of the bacterial nitroreductase enzyme in mammalian cells renders them selectively sensitive to killing by the prodrug CB1954 . Eur. J. Cancer31A ( 13–14 ), 2362 – 2370 ( 1995 ).
   PubMed Web of Science ®Google Scholar
• Sekar TV Foygel K Willmann JK Paulmurugan R . Dual-therapeutic reporter genes fusion for enhanced cancer gene therapy and imaging . Gene Ther.20 ( 5 ), 529 – 537 ( 2013 ).
   PubMed Web of Science ®Google Scholar
• Devulapally R Sekar TV Paulmurugan R . Formulation of anti-miR-21 and 4-hydroxytamoxifen co-loaded biodegradable polymer nanoparticles and their antiproliferative effect on breast cancer cells . Mol. Pharm.12 ( 6 ), 2080 – 2092 ( 2015 ).
   PubMed Web of Science ®Google Scholar
• Devulapally R Sekar NM Sekar TV et al. Polymer nanoparticles mediated codelivery of antimiR-10b and antimiR-21 for achieving triple negative breast cancer therapy . ACS Nano9 ( 3 ), 2290 – 2302 ( 2015 ).
   PubMed Web of Science ®Google Scholar
• Devulapally R Paulmurugan R . Polymer nanoparticles for drug and small silencing RNA delivery to treat cancers of different phenotypes . Wiley Interdiscip. Rev. Nanomed. Nanobiotechnol.6 ( 1 ), 40 – 60 ( 2014 ).
   PubMed Web of Science ®Google Scholar
• Devulapally R Foygel K Sekar TV Willmann JK Paulmurugan R . Gemcitabine and antisense-microRNA co-encapsulated PLGA-PEG polymer nanoparticles for hepatocellular carcinoma therapy . ACS Appl. Mater. Interfaces8 ( 49 ), 33412 – 33422 ( 2016 ).
   PubMed Web of Science ®Google Scholar
• Wang TY Choe JW Pu K et al. Ultrasound-guided delivery of microRNA loaded nanoparticles into cancer . J. Control. Rel.203 , 99 – 108 ( 2015 ).
   PubMed Web of Science ®Google Scholar
• Mullick Chowdhury S Wang TY Bachawal S et al. Ultrasound-guided therapeutic modulation of hepatocellular carcinoma using complementary microRNAs . J. Control. Rel.238 , 272 – 280 ( 2016 ).
   PubMed Web of Science ®Google Scholar
• Bhaumik S Sekar TV Depuy J Klimash J Paulmurugan R . Noninvasive optical imaging of nitroreductase gene-directed enzyme prodrug therapy system in living animals . Gene Ther.19 ( 3 ), 295 – 302 ( 2012 ).
   PubMed Web of Science ®Google Scholar
• Boussif O Lezoualc'h F Zanta MA et al. A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine . Proc. Natl Acad. Sci. USA92 ( 16 ), 7297 – 7301 ( 1995 ).
   PubMed Web of Science ®Google Scholar
• Khansarizadeh M Mokhtarzadeh A Rashedinia M et al. Identification of possible cytotoxicity mechanism of polyethylenimine by proteomics analysis . Hum. Exp. Toxicol.35 ( 4 ), 377 – 387 ( 2016 ).
   PubMed Web of Science ®Google Scholar
• Kirtane AR Panyam J . Polymer nanoparticles: weighing up gene delivery . Nat. Nanotechnol.8 ( 11 ), 805 – 806 ( 2013 ).
   PubMed Web of Science ®Google Scholar
• Gardlik R Palffy R Hodosy J Lukacs J Turna J Celec P . Vectors and delivery systems in gene therapy . Med. Sci. Monit.11 ( 4 ), RA110 – RA121 ( 2005 ).
   PubMed Web of Science ®Google Scholar
• Nayak S Herzog RW . Progress and prospects: immune responses to viral vectors . Gene Ther.17 ( 3 ), 295 – 304 ( 2010 ).
   PubMed Web of Science ®Google Scholar
• Yin H Kanasty RL Eltoukhy AA Vegas AJ Dorkin JR Anderson DG . Non-viral vectors for gene-based therapy . Nat. Rev. Genet.15 ( 8 ), 541 – 555 ( 2014 ).
   PubMed Web of Science ®Google Scholar
• Shau MD Shih MF Lin CC et al. A one-step process in preparation of cationic nanoparticles with poly(lactide-co-glycolide)-containing polyethylenimine gives efficient gene delivery . Eur. J. Pharm. Sci.46 ( 5 ), 522 – 529 ( 2012 ).
   PubMed Web of Science ®Google Scholar
• Bivas-Benita M Romeijn S Junginger HE Borchard G . PLGA-PEI nanoparticles for gene delivery to pulmonary epithelium . Eur. J. Pharm. Biopharm.58 ( 1 ), 1 – 6 ( 2004 ).
   PubMed Web of Science ®Google Scholar
• Ortega-Munoz M Giron-Gonzalez MD Salto-Gonzalez R et al. Polyethyleneimine-coated gold nanoparticles: straightforward preparation of efficient DNA delivery nanocarriers . Chem. Asian J.11 ( 23 ), 3365 – 3375 ( 2016 ).
   PubMed Web of Science ®Google Scholar
• Kim IS Lee SK Park YM et al. Physicochemical characterization of poly(L-lactic acid) and poly(D,L-lactide-co-glycolide) nanoparticles with polyethylenimine as gene delivery carrier . Int. J. Pharm.298 ( 1 ), 255 – 262 ( 2005 ).
   PubMedGoogle Scholar
• Mellott AJ Forrest ML Detamore MS . Physical non-viral gene delivery methods for tissue engineering . Ann. Biomed. Eng.41 ( 3 ), 446 – 468 ( 2013 ).
   PubMed Web of Science ®Google Scholar
• Ramamoorth M Narvekar A . Non viral vectors in gene therapy – an overview . J. Clin. Diagn. Res.9 ( 1 ), GE01 – GE06 ( 2015 ).
   PubMed Web of Science ®Google Scholar
• Sekar TV Foygel K Ilovich O Paulmurugan R . Noninvasive theranostic imaging of HSV1-sr39TK-NTR/GCV-CB1954 dual-prodrug therapy in metastatic lung lesions of MDA-MB-231 triple negative breast cancer in mice . Theranostics4 ( 5 ), 460 – 474 ( 2014 ).
   PubMed Web of Science ®Google Scholar
• Figueiredo M Esenaliev R . PLGA nanoparticles for ultrasound-mediated gene delivery to solid tumors . J. Drug Deliv.2012 , 767839 ( 2012 ).
   PubMedGoogle Scholar
• Panje CM Wang DS Willmann JK . Ultrasound and microbubble-mediated gene delivery in cancer: progress and perspectives . Invest. Radiol.48 ( 11 ), 755 – 769 ( 2013 ).
   PubMed Web of Science ®Google Scholar
• Tzu-Yin W Wilson KE Machtaler S Willmann JK . Ultrasound and microbubble guided drug delivery: mechanistic understanding and clinical implications . Curr. Pharm. Biotechnol.14 ( 8 ), 743 – 752 ( 2013 ).
   PubMed Web of Science ®Google Scholar
• Larina IV Evers BM Esenaliev RO . Optimal drug and gene delivery in cancer cells by ultrasound-induced cavitation . Anticancer Res.25 ( 1A ), 149 – 156 ( 2005 ).
   PubMed Web of Science ®Google Scholar
• Hernot S Klibanov AL . Microbubbles in ultrasound-triggered drug and gene delivery . Adv. Drug Deliv. Rev.60 ( 10 ), 1153 – 1166 ( 2008 ).
   PubMed Web of Science ®Google Scholar
• Lee JL Lo CW Inserra C Bera JC Chen WS . Ultrasound enhanced PEI-mediated gene delivery through increasing the intracellular calcium level and PKC-delta protein expression . Pharm. Res.31 ( 9 ), 2354 – 2366 ( 2014 ).
   PubMed Web of Science ®Google Scholar
• Panje CM Wang DS Pysz MA et al. Ultrasound-mediated gene delivery with cationic versus neutral microbubbles: effect of DNA and microbubble dose on in vivo transfection efficiency . Theranostics2 ( 11 ), 1078 – 1091 ( 2012 ).
   PubMed Web of Science ®Google Scholar
• Liao WH Hsiao MY Lo CW et al. Intracellular triggered release of DNA-quaternary ammonium polyplex by ultrasound . Ultrason. Sonochem.36 , 70 – 77 ( 2017 ).
   PubMed Web of Science ®Google Scholar
• Chen S Grayburn PA . Ultrasound-targeted microbubble destruction for cardiac gene delivery . In : Cardiac Gene Therapy: Methods and Protocols . IshikawaK . Springer , New York, NY, USA , 205 – 218 ( 2017 ).
   Google Scholar
• Chumakova OV Liopo AV Andreev VG et al. Composition of PLGA and PEI/DNA nanoparticles improves ultrasound-mediated gene delivery in solid tumors in vivo . Cancer Lett.261 ( 2 ), 215 – 225 ( 2008 ).
   PubMed Web of Science ®Google Scholar
• Hosseinkhani H Aoyama T Ogawa O Tabata Y . Ultrasound enhancement of in vitro transfection of plasmid DNA by a cationized gelatin . J. Drug Target10 ( 3 ), 193 – 204 ( 2002 ).
   PubMed Web of Science ®Google Scholar
• Larina IV Evers BM Ashitkov TV Bartels C Larin KV Esenaliev RO . Enhancement of drug delivery in tumors by using interaction of nanoparticles with ultrasound radiation . Technol. Cancer Res. Treat4 ( 2 ), 217 – 226 ( 2005 ).
   PubMed Web of Science ®Google Scholar
• Makadia HK Siegel SJ . Poly lactic-co-glycolic acid (PLGA) as biodegradable controlled drug delivery carrier . Polymers (Basel)3 ( 3 ), 1377 – 1397 ( 2011 ).
   PubMed Web of Science ®Google Scholar
• Acharya S Sahoo SK . PLGA nanoparticles containing various anticancer agents and tumour delivery by EPR effect . Adv. Drug Deliv. Rev.63 ( 3 ), 170 – 183 ( 2011 ).
   PubMed Web of Science ®Google Scholar
• Bhargava-Shah A Foygel K Devulapally R Paulmurugan R . Orlistat and antisense-miRNA-loaded PLGA-PEG nanoparticles for enhanced triple negative breast cancer therapy . Nanomedicine (Lond.)11 ( 3 ), 235 – 247 ( 2016 ).
   PubMed Web of Science ®Google Scholar
• Harris JM Chess RB . Effect of pegylation on pharmaceuticals . Nat. Rev. Drug Discov.2 ( 3 ), 214 – 221 ( 2003 ).
   PubMed Web of Science ®Google Scholar
• Baker A Saltik M Lehrmann H et al. Polyethylenimine (PEI) is a simple, inexpensive and effective reagent for condensing and linking plasmid DNA to adenovirus for gene delivery . Gene Ther.4 ( 8 ), 773 – 782 ( 1997 ).
   PubMed Web of Science ®Google Scholar
• Mccormack E Silden E West RM et al. Nitroreductase, a near-infrared reporter platform for in vivo time-domain optical imaging of metastatic cancer . Cancer Res.73 ( 4 ), 1276 – 1286 ( 2013 ).
   PubMed Web of Science ®Google Scholar
• Bauer M Kristensen BW Meyer M et al. Toxic effects of lipid-mediated gene transfer in ventral mesencephalic explant cultures . Basic Clin. Pharmacol. Toxicol.98 ( 4 ), 395 – 400 ( 2006 ).
   PubMed Web of Science ®Google Scholar
• Knudsen KB Northeved H Kumar PE et al. In vivo toxicity of cationic micelles and liposomes . Nanomedicine11 ( 2 ), 467 – 477 ( 2015 ).
   PubMed Web of Science ®Google Scholar