Molecular Insights and Therapeutic Implications of Nanoengineered Dietary Polyphenols for Targeting Lung Cancer: Part II

References

• Allemani C , WeirHK, CarreiraHet al. Global surveillance of cancer survival 1995–2009: analysis of individual data for 25 676 887 patients from 279 population-based registries in 67 countries (CONCORD-2). Lancet385(9972), 977–1010 (2015).
   PubMed Web of Science ®Google Scholar
• Chae DK , BanE, YooYS, KimEE, BaikJH, SongEJ. MIR-27a regulates the TGF-β signaling pathway by targeting SMAD2 and SMAD4 in lung cancer. Mol. Carcinog.56(8), 1992–1998 (2017).
   PubMed Web of Science ®Google Scholar
• Bray F , FerlayJ, SoerjomataramI, SiegelRL, TorreLA, JemalA. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J. Clin.68(6), 394–424 (2018).
   PubMed Web of Science ®Google Scholar
• Herbst RS , HeymachJV, LippmanSM. Molecular origins of cancer: lung cancer. N. Engl. J. Med.359(13), 1367–1380 (2008).
   PubMed Web of Science ®Google Scholar
• Clinton SK , GiovannucciEL, HurstingSD. The World Cancer Research Fund/American Institute for Cancer Research third expert report on diet, nutrition, physical activity, and cancer: impact and future directions. J. Nutr.150(4), 663–671 (2020).
   PubMed Web of Science ®Google Scholar
• Das SS , VermaPRP, KarS, SinghSK. Quercetin-loaded nanomedicine as oncotherapy. In: Nanomedicine for BioactivesRahmanM, BegS, KumarV, AhmadF ( Eds). Springer, Singapore (2020).
   Google Scholar
• Cook NC, Samman S. Flavonoids – chemistry, metabolism, cardioprotective effects, and dietary sources. J. Nutr. Biochem.7(2), 66–76 (1996).
   Web of Science ®Google Scholar
• Rice-Evans CA , MillerNJ, BolwellPG, BramleyPM, PridhamJB. The relative antioxidant activities of plant-derived polyphenolic flavonoids. Free Radic. Res.22(4), 375–383 (1995).
   PubMed Web of Science ®Google Scholar
• Budisan L , GuleiD, ZanoagaOMet al. Dietary intervention by phytochemicals and their role in modulating coding and non-coding genes in cancer. Int. J. Mol. Sci.18(6), 1178 (2017).
   PubMed Web of Science ®Google Scholar
• Batra P , SharmaAK. Potential of flavonoids: recent trends and future perspectives. 3 Biotech3(6), 439–459 (2013).
   PubMedGoogle Scholar
• Zanoaga O , BraicuC, JurjA, RusuA, BuigaR, Berindan-NeagoeI. Progress in research on the role of flavonoids in lung cancer. Int. J. Mol. Sci.20(17), 4291 (2019).
   PubMed Web of Science ®Google Scholar
• Xu Q , ZengY, TangWet al. Multi-task joint learning model for segmenting and classifying tongue images using a deep neural network. IEEE J. Biomed. Health. Inf.24(9), 2481–2489 (2020).
   PubMed Web of Science ®Google Scholar
• Li S , YuY, BianXet al. Prediction of oral hepatotoxic dose of natural products derived from traditional Chinese medicines based on SVM classifier and PBPK modeling. Arch. Toxicol.95(5), 1683–1701 (2021).
   PubMed Web of Science ®Google Scholar
• Ferrazzano GF , AmatoI, IngenitoA, ZarrelliA, PintoG, PollioA. Plant polyphenols and their anti-cariogenic properties: a review. Molecules16(2), 1486–1507 (2011).
   PubMed Web of Science ®Google Scholar
• Barkat HA , DasSS, BarkatMA, BegS, HadiHA. Selective targeting of cancer signaling pathways with nanomedicines: challenges and progress. Future Oncol.16(35), 2959–2979 (2020).
   PubMed Web of Science ®Google Scholar
• Cincin ZB , UnluM, KiranB, BirellerES, BaranY, CakmakogluB. Anti-proliferative, apoptotic and signal transduction effects of hesperidin in non-small-cell lung cancer cells. Cell. Oncol. (Dordr.)38(3), 195–204 (2015).
   PubMed Web of Science ®Google Scholar
• Xia R , ShengX, XuX, YuC, LuH. Hesperidin induces apoptosis and G0/G1 arrest in human non-small-cell lung cancer A549 cells. Int. J. Mol. Med.41(1), 464–472 (2018).
   PubMed Web of Science ®Google Scholar
• Jin CY , ParkC, HwangHJet al. Naringenin up-regulates the expression of death receptor 5 and enhances TRAIL-induced apoptosis in human lung cancer A549 cells. Mol. Nutr. Food Res.55(2), 300–309 (2011).
   PubMed Web of Science ®Google Scholar
• Adigun TO , JoelIY, BankoleOOet al. Discovery of eriodictyol as putative exportin-1 inhibitor for non-small-cell lung cancer therapy. Preprints (2020). doi: 10.20944/preprints202010.0477.v1.
   Google Scholar
• Wang R , ZhuX, WangQet al. The anti-tumor effect of taxifolin on lung cancer via suppressing stemness and epithelial-mesenchymal transition in vitro and oncogenesis in nude mice. Ann. Transl. Med.8(9), 590 (2020).
   PubMed Web of Science ®Google Scholar
• Wang Q , ZhangL, HuangM, ZhengY, ZhengK. Immunomodulatory effect of eriocitrin in experimental animals with benzo(a)pyrene-induced lung carcinogenesis. J. Environ. Pathol. Toxicol. Oncol.39(2), 137–147 (2020).
   PubMed Web of Science ®Google Scholar
• Hung JY , HsuYL, KoYCet al. Didymin, a dietary flavonoid glycoside from citrus fruits, induces Fas-mediated apoptotic pathway in human non-small-cell lung cancer cells in vitro and in vivo. Lung Cancer68(3), 366–374 (2010).
   PubMed Web of Science ®Google Scholar
• Santos EL , MaiaBHLS, TeixeiraAPFD. Flavonoids: Classification, Biosynthesis and Chemical Ecology. In: JustinoGC ( Ed.). Flavonoids – From Biosynthesis to Human Health.IntechOpen, London (2017). doi: 10.5772/67861Chapter1.
   Google Scholar
• Arunakaran J , ArunkumarR, ElumalaiP, SenthilkumarS. Impact of quercetin, diallyl disulfide and nimbolide on the regulation of nuclear factor kappa B expression in prostate and breast cancer cell lines. Biochem. Pharmacol2(4), 50 (2013).
   Google Scholar
• Klimaszewska-Wisniewska A , Halas-WisniewskaM, IzdebskaM, GagatM, GrzankaA, GrzankaD. Antiproliferative and antimetastatic action of quercetin on A549 non-small-cell lung cancer cells through its effect on the cytoskeleton. Acta Histochem.119(2), 99–112 (2017).
   PubMed Web of Science ®Google Scholar
• Mukherjee A , Khuda-BukhshAR. Quercetin down-regulates IL-6/STAT-3 signals to induce mitochondrial-mediated apoptosis in a non-small-cell lung-cancer cell line, A549. J. Pharmacopuncture18(1), 19–26 (2015).
   PubMedGoogle Scholar
• Leung HWC , LinCJ, HourMJ, YangWH, WangMY, LeeHZ. Kaempferol induces apoptosis in human lung non-small carcinoma cells accompanied by an induction of antioxidant enzymes. Food Chem. Toxicol.45(10), 2005–2013 (2007).
   PubMed Web of Science ®Google Scholar
• Han X , LiuCF, GaoN, ZhaoJ, XuJ. Kaempferol suppresses proliferation but increases apoptosis and autophagy by up-regulating microRNA-340 in human lung cancer cells. Biomed. Pharmacother.108, 809–816 (2018).
   PubMed Web of Science ®Google Scholar
• Rajendran P , MaheshwariU, MuthukrishnanAet al. Myricetin: versatile plant based flavonoid for cancer treatment by inducing cell cycle arrest and ROS-reliant mitochondria-facilitated apoptosis in A549 lung cancer cells and in silico prediction. Mol. Cell. Biochem.476(1), 57–68 (2021).
   PubMed Web of Science ®Google Scholar
• Du Y , JiaC, LiuY, LiY, WangJ, SunK. Isorhamnetin enhances the radiosensitivity of A549 cells through interleukin-13 and the NF-kappaB signaling pathway. Front. Pharmacol.11, 610772 (2020).
   PubMed Web of Science ®Google Scholar
• Zhang BY , WangYM, GongHet al. Isorhamnetin flavonoid synergistically enhances the anticancer activity and apoptosis induction by cis-platin and carboplatin in non-small-cell lung carcinoma (NSCLC). Int. J. Clin. Exp. Pathol.8(1), 25–37 (2015).
   PubMed Web of Science ®Google Scholar
• Kumar S , PandeyAK. Chemistry and biological activities of flavonoids: an overview. Sci. World J.2013, 162750 (2013).
   Web of Science ®Google Scholar
• Bakhtiyari S , ZaheraraM, HaghaniK, KhatamiM, RashidinejadA. The phosphorylation of IRS1S307 and AktS473 molecules in insulin-resistant C2C12 cells induced with palmitate is influenced by epigallocatechin gallate from green tea. Lipids54(2-3), 141–148 (2019).
   PubMed Web of Science ®Google Scholar
• Sun H , YinM, HaoD, ShenY. Anti-cancer activity of catechin against A549 lung carcinoma cells by induction of cyclin kinase inhibitor p21 and suppression of cyclin E1 and P-AKT. Appl. Sci.10(6), 2065 (2020).
   Google Scholar
• Milligan SA , BurkeP, ColemanDTet al. The green tea polyphenol EGCG potentiates the antiproliferative activity of c-Met and epidermal growth factor receptor inhibitors in non-small-cell lung cancer cells. Clin. Cancer Res.15(15), 4885–4894 (2009).
   PubMed Web of Science ®Google Scholar
• Fasco MJ , HurteauGJ, SpivackSD. Gender-dependent expression of alpha and beta estrogen receptors in human nontumor and tumor lung tissue. Mol. Cell. Endocrinol.188(1-2), 125–140 (2002).
   PubMed Web of Science ®Google Scholar
• Dubey S , SiegfriedJM, TraynorAM. Non-small-cell lung cancer and breast carcinoma: chemotherapy and beyond. Lancet Oncol.7(5), 416–424 (2006).
   PubMed Web of Science ®Google Scholar
• Lian F , BhuiyanM, LiYW, WallN, KrautM, SarkarFH. Genistein-induced G2-M arrest, p21WAF1 upregulation, and apoptosis in a non-small-cell lung cancer cell line. Nutr. Cancer31(3), 184–191 (1998).
   PubMed Web of Science ®Google Scholar
• Lian F , LiY, BhuiyanM, SarkarFH. p53-independent apoptosis induced by genistein in lung cancer cells. Nutr. Cancer33(2), 125–131 (1999).
   PubMed Web of Science ®Google Scholar
• Liu D , YanL, WangL, TaiW, WangW, YangC. Genistein enhances the effect of cisplatin on the inhibition of non-small-cell lung cancer A549 cell growth in vitro and in vivo. Oncol. Lett.8(6), 2806–2810 (2014).
   PubMed Web of Science ®Google Scholar
• Tian T , LiJ, LiBet al. Genistein exhibits effects via down-regulating FoxM1 in H446 small-cell lung cancer cells. Tumour Biol.35(5), 4137–4145 (2014).
   PubMed Web of Science ®Google Scholar
• Versantvoort CH , BroxtermanHJ, LankelmaJ, FellerN, PinedoHM. Competitive inhibition by genistein and ATP dependence of daunorubicin transport in intact MRP overexpressing human small-cell lung cancer cells. Biochem. Pharmacol.48(6), 1129–1136 (1994).
   PubMed Web of Science ®Google Scholar
• Yang Y , ZangA, JiaYet al. Genistein inhibits A549 human lung cancer cell proliferation via miR-27a and MET signaling. Oncol. Lett.12(3), 2189–2193 (2016).
   PubMed Web of Science ®Google Scholar
• Yu Y , XingY, ZhangQet al. Soy isoflavone genistein inhibits hsa_circ_0031250/miR-873-5p/FOXM1 axis to suppress non-small-cell lung cancer progression. IUBMB Life73(1), 92–107 (2021).
   PubMed Web of Science ®Google Scholar
• Zhang Z , JinF, LianXet al. Genistein promotes ionizing radiation-induced cell death by reducing cytoplasmic Bcl-xL levels in non-small-cell lung cancer. Sci. Rep.8(1), 328 (2018).
   PubMed Web of Science ®Google Scholar
• Zhu H , ChengH, RenY, LiuZG, ZhangYF, DeLuo B. Synergistic inhibitory effects by the combination of gefitinib and genistein on NSCLC with acquired drug-resistance in vitro and in vivo. Mol. Biol. Rep.39(4), 4971–4979 (2012).
   PubMed Web of Science ®Google Scholar
• Guo S , WangY, LiY, LiY, FengC, LiZ. Daidzein-rich isoflavones aglycone inhibits lung cancer growth through inhibition of NF-kappaB signaling pathway. Immunol. Lett.222, 67–72 (2020).
   PubMed Web of Science ®Google Scholar
• Chen J , XuB, SunJ, JiangX, BaiW. Anthocyanin supplement as a dietary strategy in cancer prevention and management: a comprehensive review. Crit. Rev. Food Sci. Nutr.62(26), 7242–7254 (2021).
   PubMed Web of Science ®Google Scholar
• Pal HC , SharmaS, StricklandLRet al. Delphinidin reduces cell proliferation and induces apoptosis of non-small-cell lung cancer cells by targeting EGFR/VEGFR2 signaling pathways. PLOS ONE8(10), e77270 (2013).
   PubMed Web of Science ®Google Scholar
• Chen PN , ChuSC, ChiouHL, KuoWH, ChiangCL, HsiehYS. Mulberry anthocyanins, cyanidin 3-rutinoside and cyanidin 3-glucoside, exhibited an inhibitory effect on the migration and invasion of a human lung cancer cell line. Cancer Lett.235(2), 248–259 (2006).
   PubMed Web of Science ®Google Scholar
• Singh P , AnandA, KumarV. Recent developments in biological activities of chalcones: a mini review. Eur. J. Med. Chem.85, 758–777 (2014).
   PubMed Web of Science ®Google Scholar
• Wang Y , HedblomA, KoernerSKet al. Novel synthetic chalcones induce apoptosis in the A549 non-small-cell lung cancer cells harboring a KRAS mutation. Bioorg. Med. Chem. Lett.26(23), 5703–5706 (2016).
   PubMed Web of Science ®Google Scholar
• Chen G , ZhouD, LiXZet al. A natural chalcone induces apoptosis in lung cancer cells: 3D-QSAR, docking and an in vivo/vitro assay. Sci. Rep.7(1), 10729 (2017).
   PubMedGoogle Scholar
• Dobrzynska M , NapieralaM, FlorekE. Flavonoid nanoparticles: a promising approach for cancer therapy. Biomolecules10(9), 1268 (2020).
   PubMed Web of Science ®Google Scholar
• Pelaz B , AlexiouC, Alvarez-PueblaRAet al. Diverse applications of nanomedicine. ACS Nano11(3), 2313–2381 (2017).
   PubMed Web of Science ®Google Scholar
• Wang S , SunZ, HouY. Engineering nanoparticles toward the modulation of emerging cancer immunotherapy. Adv. Healthc. Mater.10(5), 2000845 (2021).
   Web of Science ®Google Scholar
• Li S , XuS, LiangXet al. Nanotechnology: breaking the current treatment limits of lung cancer. Adv. Healthc. Mater.10(12), 2100078 (2021).
   Web of Science ®Google Scholar
• Vasilev K , ChenH, MurrayP, MantovaniD. The potential of nanomaterials for drug delivery, cell tracking, and regenerative medicine 2014. J. Nanomater.2015, 1–2 (2015).
   Web of Science ®Google Scholar
• Wang J , ZhouT, LiuY, ChenS, YuZ. Application of nanoparticles in the treatment of lung cancer with emphasis on receptors. Front. Pharmacol.12, 781425 (2021).
   PubMed Web of Science ®Google Scholar
• Zhou Q , PanH, LiJ. Molecular insights into potential contributions of natural polyphenols to lung cancer treatment. Cancers (Basel)11(10), 1565 (2019).
   PubMed Web of Science ®Google Scholar
• Maeda H . The enhanced permeability and retention (EPR) effect in tumor vasculature: the key role of tumor-selective macromolecular drug targeting. Adv. Enzyme Regul.41, 189–207 (2001).
   PubMedGoogle Scholar
• Dinauer N , BalthasarS, WeberC, KreuterJ, LangerK, Von BriesenH. Selective targeting of antibody-conjugated nanoparticles to leukemic cells and primary T-lymphocytes. Biomaterials26(29), 5898–5906 (2005).
   PubMed Web of Science ®Google Scholar
• Maeda H , WuJ, SawaT, MatsumuraY, HoriK. Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review. J. Control. Rel.65(1-2), 271–284 (2000).
   PubMed Web of Science ®Google Scholar
• Yan J , YaoY, YanS, GaoR, LuW, HeW. Chiral protein supraparticles for tumor suppression and synergistic immunotherapy: an enabling strategy for bioactive supramolecular chirality construction. Nano Lett.20(8), 5844–5852 (2020).
   PubMed Web of Science ®Google Scholar
• Yang W , LiuW, LiX, YanJ, HeW. Turning chiral peptides into a racemic supraparticle to induce the self-degradation of MDM2. J. Adv. Res.S2090-1232(22), 00121–7 (2022).
   Google Scholar
• Doroudian M , MacloughlinR, PoyntonF, Prina-MelloA, DonnellySC. Nanotechnology based therapeutics for lung disease. Thorax74(10), 965 (2019).
   PubMed Web of Science ®Google Scholar
• Abbad S , WangC, WaddadAY, LvH, ZhouJ. Preparation, in vitro and in vivo evaluation of polymeric nanoparticles based on hyaluronic acid-poly(butyl cyanoacrylate) and D-alpha-tocopheryl polyethylene glycol 1000 succinate for tumor-targeted delivery of morin hydrate. Int. J. Nanomed.10, 305–320 (2015).
   PubMed Web of Science ®Google Scholar
• Jangid AK , AgravalH, GuptaNet al. Designing of fatty acid-surfactant conjugate based nanomicelles of morin hydrate for simultaneously enhancing anticancer activity and oral bioavailability. Colloids Surf. B Biointerfaces175, 202–211 (2019).
   PubMed Web of Science ®Google Scholar
• Jangid AK , AgravalH, GuptaNet al. Amorphous nano morin outperforms native molecule in anticancer activity and oral bioavailability. Drug Dev. Ind. Pharm.46(7), 1123–1132 (2020).
   PubMed Web of Science ®Google Scholar
• Velavan B , DivyaT, SureshkumarA, SudhandiranG. Nano-chemotherapeutic efficacy of (-) -epigallocatechin 3-gallate mediating apoptosis in A549 cells: involvement of reactive oxygen species mediated Nrf2/Keap1signaling. Biochem. Biophys. Res. Commun.503(3), 1723–1731 (2018).
   PubMed Web of Science ®Google Scholar
• Ahmad N , AhmadR, AlrasheedRAet al. A chitosan–PLGA based catechin hydrate nanoparticles used in targeting of lungs and cancer treatment. Saudi J. Biol. Sci.27(9), 2344–2357 (2020).
   PubMed Web of Science ®Google Scholar
• Zhang L , ChenW, TuGet al. Enhanced chemotherapeutic efficacy of PLGA-encapsulated epigallocatechin gallate (EGCG) against human lung cancer. Int. J. Nanomed.15, 4417–4429 (2020).
   PubMed Web of Science ®Google Scholar
• Chen BH , HsiehCH, TsaiSY, WangCY, WangCC. Anticancer effects of epigallocatechin-3-gallate nanoemulsion on lung cancer cells through the activation of AMP-activated protein kinase signaling pathway. Sci. Rep.10(1), 5163 (2020).
   PubMed Web of Science ®Google Scholar
• Chen Y-J , WangZ-W, LuT-Let al. The synergistic anticancer effect of dual drug- (cisplatin/epigallocatechin gallate) loaded gelatin nanoparticles for lung cancer treatment. J. Nanomater.2020, 9181549 (2020).
   Web of Science ®Google Scholar
• Yuan ZP , ChenLJ, FanLYet al. Liposomal quercetin efficiently suppresses growth of solid tumors in murine models. Clin. Cancer Res.12(10), 3193–3199 (2006).
   PubMed Web of Science ®Google Scholar
• Tan BJ , LiuY, ChangKL, LimBK, ChiuGN. Perorally active nanomicellar formulation of quercetin in the treatment of lung cancer. Int. J. Nanomed.7, 651–661 (2012).
   PubMed Web of Science ®Google Scholar
• Khonkarn R , MankhetkornS, HenninkWE, OkonogiS. PEG-OCL micelles for quercetin solubilization and inhibition of cancer cell growth. Eur. J. Pharm. Biopharm.79(2), 268–275 (2011).
   PubMed Web of Science ®Google Scholar
• Lai W-F , TangR, WongW-T. Ionically crosslinked complex gels loaded with oleic acid-containing vesicles for transdermal drug delivery. Pharmaceutics12(8), 725 (2020).
   PubMed Web of Science ®Google Scholar
• Liu K , ChenW, YangTet al. Paclitaxel and quercetin nanoparticles co-loaded in microspheres to prolong retention time for pulmonary drug delivery. Int. J. Nanomed.12, 8239–8255 (2017).
   PubMed Web of Science ®Google Scholar
• Daglioglu C . Enhancing tumor cell response to multidrug resistance with pH-sensitive quercetin and doxorubicin conjugated multifunctional nanoparticles. Colloids Surf. B Biointerfaces156, 175–185 (2017).
   PubMed Web of Science ®Google Scholar
• Arbain NH , SalimN, MasoumiHRF, WongTW, BasriM, AbdulRahman MB. In vitro evaluation of the inhalable quercetin loaded nanoemulsion for pulmonary delivery. Drug Deliv. Transl. Res.9(2), 497–507 (2019).
   PubMed Web of Science ®Google Scholar
• Arbain NH , SalimN, WuiWT, BasriM, RahmanMBA. Optimization of quercetin loaded palm oil ester based nanoemulsion formulation for pulmonary delivery. J. Oleo Sci.67(8), 933–940 (2018).
   PubMed Web of Science ®Google Scholar
• Zhou X , LiuHY, ZhaoH, WangT. RGD-modified nanoliposomes containing quercetin for lung cancer targeted treatment. Onco. Targets Ther.11, 5397–5405 (2018).
   PubMed Web of Science ®Google Scholar
• Baksi R , SinghDP, BorseSP, RanaR, SharmaV, NivsarkarM. In vitro and in vivo anticancer efficacy potential of quercetin loaded polymeric nanoparticles. Biomed. Pharmacother.106, 1513–1526 (2018).
   PubMed Web of Science ®Google Scholar
• Riaz MK , ZhangX, WongKHet al. Pulmonary delivery of transferrin receptors targeting peptide surface-functionalized liposomes augments the chemotherapeutic effect of quercetin in lung cancer therapy. Int. J. Nanomed.14, 2879–2902 (2019).
   PubMed Web of Science ®Google Scholar
• Lai W-F , GuiD, WongMet al. A self-indicating cellulose-based gel with tunable performance for bioactive agent delivery. J. Drug Deliv. Sci. Technol.63, 102428 (2021).
   Web of Science ®Google Scholar
• Rofeal MG , ElzoghbyAO, HelmyMW, KhalilR, KhairyH, OmarS. Dual therapeutic targeting of lung infection and carcinoma using lactoferrin-based green nanomedicine. ACS Biomater. Sci. Eng.6(10), 5685–5699 (2020).
   PubMed Web of Science ®Google Scholar
• Sun X , LiY, XuLet al. Heparin coated meta-organic framework co-delivering doxorubicin and quercetin for effective chemotherapy of lung carcinoma. J. Int. Med. Res.48(2), 300060519897185 (2020).
   PubMed Web of Science ®Google Scholar
• Shen Y , TantaiJ. Co-delivery anticancer drug nanoparticles for synergistic therapy against lung cancer cells. Drug Des. Devel. Ther.14, 4503–4510 (2020).
   PubMed Web of Science ®Google Scholar
• Wang Y , YuH, WangSet al. Targeted delivery of quercetin by nanoparticles based on chitosan sensitizing paclitaxel-resistant lung cancer cells to paclitaxel. Mater. Sci. Eng. C Mater. Biol. Appl.119, 111442 (2021).
   PubMed Web of Science ®Google Scholar
• Khorsandi L , MansouriE, RashnoM, KaramiMA, AshtariA. Myricetin loaded solid lipid nanoparticles upregulate MLKL and RIPK3 in human lung adenocarcinoma. Int. J. Pept. Res. Ther.26(2), 899–910 (2019).
   Web of Science ®Google Scholar
• Nafee N , GaberDM, ElzoghbyAO, HelmyMW, AbdallahOY. Promoted antitumor activity of myricetin against lung carcinoma via nanoencapsulated phospholipid complex in respirable microparticles. Pharm. Res.37(4), 82 (2020).
   PubMed Web of Science ®Google Scholar
• Song Y , ZhouB, DuXet al. Folic acid (FA)-conjugated mesoporous silica nanoparticles combined with MRP-1 siRNA improves the suppressive effects of myricetin on non-small-cell lung cancer (NSCLC). Biomed. Pharmacother.125, 109561 (2020).
   PubMed Web of Science ®Google Scholar
• Bharathi D , RanjithkumarR, ChandarshekarB, BhuvaneshwariV. Bio-inspired synthesis of chitosan/copper oxide nanocomposite using rutin and their activity in human lung cancer cells. Int. J. Biol. Macromol.141, 476–483 (2019).
   PubMed Web of Science ®Google Scholar
• Paudel KR , WadhwaR, TewXNet al. Rutin loaded liquid crystalline nanoparticles inhibit non-small-cell lung cancer proliferation and migration in vitro. Life Sci.276, 119436 (2021).
   PubMed Web of Science ®Google Scholar
• Jiang J , MaoQ, LiH, LouJ. Apigenin stabilized gold nanoparticles increased radiation therapy efficiency in lung cancer cells. Int. J. Clin. Exp. Med.10, 13298–13305 (2017).
   Web of Science ®Google Scholar
• Jin X , YangQ, ZhangY. Synergistic apoptotic effects of apigenin TPGS liposomes and tyroservatide: implications for effective treatment of lung cancer. Int. J. Nanomed.12, 5109–5118 (2017).
   PubMed Web of Science ®Google Scholar
• Mahmoudi S , GhorbaniM, SabzichiM, RamezaniF, HamishehkarH, SamadiN. Targeted hyaluronic acid-based lipid nanoparticle for apigenin delivery to induce Nrf2-dependent apoptosis in lung cancer cells. J. Drug Deliv. Sci. Technol.49, 268–276 (2019).
   Web of Science ®Google Scholar
• Sen R , GangulyS, GangulySet al. Apigenin-loaded PLGA-DMSA nanoparticles: a novel strategy to treat melanoma lung metastasis. Mol. Pharm.18(5), 1920–1938 (2021).
   PubMedGoogle Scholar
• Majumdar D , JungKH, ZhangHet al. Luteolin nanoparticle in chemoprevention: in vitro and in vivo anticancer activity. Cancer Prev. Res. (Phila.)7(1), 65–73 (2014).
   PubMed Web of Science ®Google Scholar
• Li J , ChengX, ChenYet al. Vitamin E TPGS modified liposomes enhance cellular uptake and targeted delivery of luteolin: an in vivo/in vitro evaluation. Int. J. Pharm.512(1), 262–272 (2016).
   PubMedGoogle Scholar
• Wolfram J , ScottB, BoomKet al. Hesperetin liposomes for cancer therapy. Curr. Drug Deliv.13(5), 711–719 (2016).
   PubMed Web of Science ®Google Scholar
• Kumar SP , BirundhaK, KaveriK, DeviKT. Antioxidant studies of chitosan nanoparticles containing naringenin and their cytotoxicity effects in lung cancer cells. Int. J. Biol. Macromol.78, 87–95 (2015).
   PubMed Web of Science ®Google Scholar
• Parashar P , TripathiCB, AryaMet al. Biotinylated naringenin intensified anticancer effect of gefitinib in urethane-induced lung cancer in rats: favourable modulation of apoptotic regulators and serum metabolomics. Artif. Cells Nanomed. Biotechnol.46(Suppl. 3), S598–S610 (2018).
   PubMedGoogle Scholar
• Parashar P , RathorM, DwivediM, SarafSA. Hyaluronic acid decorated naringenin nanoparticles: appraisal of chemopreventive and curative potential for lung cancer. Pharmaceutics10(1), 33 (2018).
   PubMed Web of Science ®Google Scholar
• Md S , AlhakamyNA, AldawsariHMet al. Formulation design, statistical optimization, and in vitro evaluation of a naringenin nanoemulsion to enhance apoptotic activity in A549 lung cancer cells. Pharmaceuticals (Basel)13(7), 152 (2020).
   PubMedGoogle Scholar
• Morais RP , NovaisGB, SangenitoLSet al. Naringenin-functionalized multi-walled carbon nanotubes: a potential approach for site-specific remote-controlled anticancer delivery for the treatment of lung cancer cells. Int. J. Mol. Sci.21(12), 4557 (2020).
   PubMed Web of Science ®Google Scholar
• Wang Z , LiuL, YinW, LiuZ, ShiL, TangM. A novel drug delivery system: the encapsulation of naringenin in metal–organic frameworks into liposomes. AAPS PharmSciTech22(2), 61 (2021).
   PubMed Web of Science ®Google Scholar
• Dos Santos T , VarelaJ, LynchI, SalvatiA, DawsonKA. Effects of transport inhibitors on the cellular uptake of carboxylated polystyrene nanoparticles in different cell lines. PLOS ONE6(9), e24438 (2011).
   PubMed Web of Science ®Google Scholar
• Kamel NM , HelmyMW, SamahaMW, RagabD, ElzoghbyAO. Multicompartmental lipid–protein nanohybrids for combined tretinoin/herbal lung cancer therapy. Nanomedicine (Lond.)14(18), 2461–2479 (2019).
   PubMed Web of Science ®Google Scholar
• Kamel NM , HelmyMW, AbdelfattahEZet al. Inhalable dual-targeted hybrid lipid nanocore-protein shell composites for combined delivery of genistein and all-trans retinoic acid to lung cancer cells. ACS Biomater. Sci. Eng.6(1), 71–87 (2020).
   PubMed Web of Science ®Google Scholar
• Sacko K , ThangavelK, ShoyeleSA. Codelivery of genistein and miRNA-29b to A549 cells using aptamer-hybrid nanoparticle bioconjugates. Nanomaterials (Basel)9(7), 1052 (2019).
   PubMedGoogle Scholar
• Jin K , YanY, ChenMet al. Multimodal deep learning with feature level fusion for identification of choroidal neovascularization activity in age-related macular degeneration. Acta Ophthalmol.100(2), e512–e520 (2022).
   PubMed Web of Science ®Google Scholar
• Elbaz S . Therapeutic effect of luteolin natural extract versus its nanoparticles on tongue squamous cell carcinoma cell line. ( NCT03288298) (2017).
   Google Scholar