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Research Article

Delineating Effect of Headgroup and Preparation Method on Transfection Versus Toxicity of DNA-Loaded Lipid Nanocarriers

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Pages 1921-1940 | Received 05 Aug 2023, Accepted 05 Oct 2023, Published online: 11 Dec 2023

References

  • Sharma D , AroraS , SinghJ , LayekB. A review of the tortuous path of nonviral gene delivery and recent progress. Int. J. Biol. Macromol.183, 2055–2073 (2021).
  • Quagliarini E , RenziS , DigiacomoLet al. Microfluidic formulation of DNA-loaded multicomponent lipid nanoparticles for gene delivery. Pharmaceutics13(8), 1292 (2021).
  • Lim SA , CoxA , TungM , ChungEJ. Clinical progress of nanomedicine-based RNA therapies. Bioact. Mater.12, 203–213 (2022).
  • Thi TTH , SuysEJA , LeeJS , NguyenDH , ParkKD , TruongNP. Lipid-based nanoparticles in the clinic and clinical trials: from cancer nanomedicine to COVID-19 vaccines. Vaccines (Basel)9(4), 359 (2021).
  • Sahel DK , VoraLK , SaraswatAet al. CRISPR/Cas9 genome editing for tissue-specific in vivo targeting: nanomaterials and translational perspective. Adv. Sci. (Weinh.)10(19), 2207512 (2023).
  • Sun D , LuZR. Structure and function of cationic and ionizable lipids for nucleic acid delivery. Pharm. Res.40(1), 27–46 (2023).
  • Kolasinac R , KleuschC , BraunT , MerkelR , CsiszarA. Deciphering the functional composition of fusogenic liposomes. Int. J. Mol. Sci.19(2), 346 (2018).
  • Patel K , TyagiM , MonparaJ , VoraL , GuptaS , VaviaP. Arginoplexes: an arginine-anchored nanoliposomal carrier for gene delivery. J. Nanopart. Res.16, 1–10 (2014).
  • Rosa M , PenachoN , SimoesS , LimaMC , LindmanB , MiguelMG. DNA pre-condensation with an amino acid-based cationic amphiphile. A viable approach for liposome-based gene delivery. Mol. Membr. Biol.25(1), 23–34 (2008).
  • Han X , ZhangH , ButowskaKet al. An ionizable lipid toolbox for RNA delivery. Nat. Commun.12(1), 7233 (2021).
  • Hald Albertsen C , KulkarniJA , WitzigmannD , LindM , PeterssonK , SimonsenJB. The role of lipid components in lipid nanoparticles for vaccines and gene therapy. Adv. Drug Deliv. Rev.188, 114416 (2022).
  • Karmacharya P , PatilBR , KimJO. Recent advancements in lipid–mRNA nanoparticles as a treatment option for cancer immunotherapy. J. Pharm. Investig.52(4), 415–426 (2022).
  • Paraiso KH , XiangY , RebeccaVWet al. PTEN loss confers BRAF inhibitor resistance to melanoma cells through the suppression of BIM expression. Cancer Res.71(7), 2750–2760 (2011).
  • Catalanotti F , ChengDT , ShoushtariANet al. PTEN loss-of-function alterations are associated with intrinsic resistance to BRAF inhibitors in metastatic melanoma. JCO Precis. Oncol.1, 1–15 (2017).
  • Rathod D , FuY , PatelK. BRD4 PROTAC as a novel therapeutic approach for the treatment of vemurafenib resistant melanoma: preformulation studies, formulation development and in vitro evaluation. Eur. J. Pharm. Sci.138, 105039 (2019).
  • Fu Y , SaraswatA , WeiZet al. Development of dual ARV-825 and nintedanib-loaded PEGylated nano-liposomes for synergistic efficacy in vemurafnib-resistant melanoma. Pharmaceutics13(7), 1005 (2021).
  • Vemana HP , SaraswatA , BhutkarS , PatelK , DukhandeVV. A novel gene therapy for neurodegenerative Lafora disease via EPM2A-loaded DLinDMA lipoplexes. Nanomedicine (Lond.)16(13), 1081–1095 (2021).
  • Saraswat A , VemanaHP , DukhandeVV , PatelK. Galactose-decorated liver tumor-specific nanoliposomes incorporating selective BRD4-targeted PROTAC for hepatocellular carcinoma therapy. Heliyon8(1), e08702 (2022).
  • Saraswat AL , MaherTJ. Development and optimization of stealth liposomal system for enhanced in vitro cytotoxic effect of quercetin. J. Drug Deliv. Sci. Technol.55, 101477 (2020).
  • Vartak R , PatilSM , SaraswatA , PatkiM , KundaNK , PatelK. Aerosolized nanoliposomal carrier of remdesivir: an effective alternative for COVID-19 treatment in vitro. Nanomedicine (Lond.)16(14), 1187–1202 (2021).
  • Saraswat A , PatkiM , FuY , BarotS , DukhandeVV , PatelK. Nanoformulation of proteolysis targeting chimera targeting ‘undruggable’ c-Myc for the treatment of pancreatic cancer. Nanomedicine (Lond.)15(18), 1761–1777 (2020).
  • Vartak R , SaraswatA , YangY , ChenZS , PatelK. Susceptibility of lung carcinoma cells to nanostructured lipid carrier of ARV-825, a BRD4 degrading proteolysis targeting chimera. Pharm. Res.39(11), 2745–2759 (2022).
  • Carrasco MJ , AlishettyS , AlamehMGet al. Ionization and structural properties of mRNA lipid nanoparticles influence expression in intramuscular and intravascular administration. Commun. Biol.4(1), 956 (2021).
  • Durymanov M , ReinekeJ. Non-viral delivery of nucleic acids: insight into mechanisms of overcoming intracellular barriers. Front. Pharmacol.9, 971 (2018).
  • Patel P , IbrahimNM , ChengK. The importance of apparent pKa in the development of nanoparticles encapsulating siRNA and mRNA. Trends Pharmacol. Sci.42(6), 448–460 (2021).
  • Lv H , ZhangS , WangB , CuiS , YanJ. Toxicity of cationic lipids and cationic polymers in gene delivery. J. Control. Rel.114(1), 100–109 (2006).
  • Terada T , KulkarniJA , HuynhA , TamYYC , CullisP. Protective effect of edaravone against cationic lipid-mediated oxidative stress and apoptosis. Biol. Pharm. Bull.44(1), 144–149 (2021).
  • Jorgensen AM , WibelR , Bernkop-SchnurchA. Biodegradable cationic and ionizable cationic lipids: a roadmap for safer pharmaceutical excipients. Small19(17), e2206968 (2023).
  • Singh J , MichelD , ChitandaJM , VerrallRE , BadeaI. Evaluation of cellular uptake and intracellular trafficking as determining factors of gene expression for amino acid-substituted gemini surfactant-based DNA nanoparticles. J. Nanobiotechnol.10, 7 (2012).
  • Blakney AK , McKayPF , YusBI , AldonY , ShattockRJ. Inside out: optimization of lipid nanoparticle formulations for exterior complexation and in vivo delivery of saRNA. Gene Ther.26(9), 363–372 (2019).
  • Ayad C , YavuzA , SalviJ-Pet al. Comparison of physicochemical properties of lipoparticles as mRNA carrier prepared by automated microfluidic system and bulk method. Pharmaceutics14(6), 1297 (2022).
  • Ly HH , DanielS , SorianoSK , KisZ , BlakneyAK. Optimization of lipid nanoparticles for saRNA expression and cellular activation using a design-of-experiment approach. Mol. Pharm.19(6), 1892–1905 (2022).
  • Dahiya UR , MishraS , ChattopadhyayS , KumariA , GangalA , GanguliM. Role of cellular retention and intracellular state in controlling gene delivery efficiency of multiple nonviral carriers. ACS Omega4(24), 20547–20557 (2019).
  • Monfared YK , MahmoudianM , CeconeCet al. Hyper-branched cationic cyclodextrin polymers for improving plasmid transfection in 2D and 3D spheroid cells. Pharmaceutics14(12), 2690 (2022).
  • Niora M , PedersbækD , MünterRet al. Head-to-head comparison of the penetration efficiency of lipid-based nanoparticles into tumor spheroids. ACS Omega5(33), 21162–21171 (2020).
  • Tchoryk A , TarescoV , ArgentRHet al. Penetration and uptake of nanoparticles in 3D tumor spheroids. Bioconjug. Chem.30(5), 1371–1384 (2019).
  • Gilmore SF , CarpenterTS , IngolfssonHIet al. Lipid composition dictates serum stability of reconstituted high-density lipoproteins: implications for in vivo applications. Nanoscale10(16), 7420–7430 (2018).
  • Kubota K , OnishiK , SawakiKet al. Effect of the nanoformulation of siRNA–lipid assemblies on their cellular uptake and immune stimulation. Int. J. Nanomed.12, 5121 (2017).

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