Piezoelectric nanomaterials: latest applications in biomedicine and challenges in clinical translation

References

• Wang X, Shi J. Piezoelectric nanogenerators for self-powered nanodevices. In: Piezoelectric Nanomaterials for Biomedical Applications. Ciofani G, Menciassi A (Eds.), Springer-Verlag Berlin, Heidelberg, Germany, 135–172 (2012).
   Google Scholar
• Cafarelli A, Marino A, Vannozzi L et al. Piezoelectric nanomaterials activated by ultrasound: the pathway from discovery to future clinical adoption. ACS Nano 15(7), 11066–11086 (2021).
   PubMed Web of Science ®Google Scholar
• Kapat K, Shubhra QTH, Zhou M, Leeuwenburgh S. Piezoelectric nano-biomaterials for biomedicine and tissue regeneration. Adv. Funct. Mater. 30(44), 1909045 (2020).
   Web of Science ®Google Scholar
• Sezer N, Koç M. A comprehensive review on the state-of-the-art of piezoelectric energy harvesting. Nano Energy 80, 105567 (2021).
   Web of Science ®Google Scholar
• Tang Y, Wu C, Wu Z, Hu L, Zhang W, Zhao K. Fabrication and in vitro biological properties of piezoelectric bioceramics for bone regeneration. Sci. Rep. 7(1), 1–12 (2017).
   PubMed Web of Science ®Google Scholar
• Bera S, Mondal S, Xue B, Shimon LJW, Cao Y, Gazit E. Rigid helical-like assemblies from a self-aggregating tripeptide. Nat. Mater. 18(5), 503–509 (2019).
   PubMed Web of Science ®Google Scholar
• Kholkin A, Amdursky N, Bdikin I, Gazit E, Rosenman G. Strong piezoelectricity in bioinspired peptide nanotubes. ACS Nano 4(2), 610–614 (2010).
   PubMed Web of Science ®Google Scholar
• Wang X, Song J, Liu J, Zhong LW. Direct-current nanogenerator driven by ultrasonic waves. Science 316(5821), 102–105 (2007).
   PubMed Web of Science ®Google Scholar
• Ciofani G, Danti S, D'Alessandro D et al. Enhancement of neurite outgrowth in neuronal-like cells following boron nitride nanotube-mediated stimulation. ACS Nano 4(10), 6267–6277 (2010).
   PubMed Web of Science ®Google Scholar
• Marino A, Arai S, Hou Y et al. Piezoelectric nanoparticle-assisted wireless neuronal stimulation. ACS Nano 9(7), 7678–7689 (2015).
   PubMed Web of Science ®Google Scholar
• Rojas C, Tedesco M, Massobrio P et al. Acoustic stimulation can induce a selective neural network response mediated by piezoelectric nanoparticles. J. Neural Eng. 15(3), 036016 (2018).
   PubMed Web of Science ®Google Scholar
• Genchi GG, Ceseracciu L, Marino A et al. P(VDF-TrFE)/BaTiO3 nanoparticle composite films mediate piezoelectric stimulation and promote differentiation of SH-SY5Y neuroblastoma cells. Adv. Healthc. Mater. 5(14), 1808–1820 (2016).
   PubMed Web of Science ®Google Scholar
• Liu L, Chen B, Liu K et al. Wireless manipulation of magnetic/piezoelectric micromotors for precise neural stem-like cell stimulation. Adv. Funct. Mater. 30(11), 1910108 (2020).
   Web of Science ®Google Scholar
• Kim T, Kim HJ, Choi W et al. Deep brain stimulation by blood–brain-barrier-crossing piezoelectric nanoparticles generating current and nitric oxide under focused ultrasound. Nat. Biomed. Eng. 7(2), 149–163 (2022).
   PubMed Web of Science ®Google Scholar
• Marino A, Genchi GG, Mattoli V, Ciofani G. Piezoelectric nanotransducers: the future of neural stimulation. Nano Today 14, 9–12 (2017).
   Web of Science ®Google Scholar
• Zhao D, Feng P-J, Liu J-H et al. Electromagnetized-nanoparticle-modulated neural plasticity and recovery of degenerative dopaminergic neurons in the mid-brain. Adv. Mater. 32(43), 2003800 (2020).
   Web of Science ®Google Scholar
• Ricotti L, Cafarelli A, Manferdini C et al. Ultrasound stimulation of piezoelectric nanocomposite hydrogels boosts chondrogenic differentiation in vitro, in both a normal and inflammatory milieu. ACS Nano 18(3), 2047–2065 (2024).
   PubMed Web of Science ®Google Scholar
• Zhao F, Zhang C, Liu J et al. Periosteum structure/function-mimicking bioactive scaffolds with piezoelectric/chem/nano signals for critical-sized bone regeneration. Chem. Eng. J. 402, 126203 (2020).
   Web of Science ®Google Scholar
• Kaliannagounder VK, Raj NPMJ, Unnithan AR et al. Remotely controlled self-powering electrical stimulators for osteogenic differentiation using bone inspired bioactive piezoelectric whitlockite nanoparticles. Nano Energy 85, 105901 (2021).
   Web of Science ®Google Scholar
• Marino A, Battaglini M, De Pasquale D, Degl'Innocenti A, Ciofani G. Ultrasound-activated piezoelectric nanoparticles inhibit proliferation of breast cancer cells. Sci. Rep. 8(1), 6257 (2018).
   PubMedGoogle Scholar
• Marino A, Almici E, Migliorin S et al. Piezoelectric barium titanate nanostimulators for the treatment of glioblastoma multiforme. J. Colloid Interf. Sci. 538, 449–461 (2019).
   PubMed Web of Science ®Google Scholar
• Pucci C, Marino A, Şen Ö et al. Ultrasound-responsive nutlin-loaded nanoparticles for combined chemotherapy and piezoelectric treatment of glioblastoma cells. Acta Biomater. 139, 218–236 (2022).
   PubMed Web of Science ®Google Scholar
• Şen Ö, Marino A, Pucci C, Ciofani G. Modulation of anti-angiogenic activity using ultrasound-activated nutlin-loaded piezoelectric nanovectors. Mater. Today Bio. 13, 100196 (2022).
   PubMedGoogle Scholar
• Li C, Xiao C, Zhan L et al. Wireless electrical stimulation at the nanoscale interface induces tumor vascular normalization. Bioact. Mater. 18, 399–408 (2022).
   PubMed Web of Science ®Google Scholar
• Wu M, Zhang Z, Liu Z et al. Piezoelectric nanocomposites for sonodynamic bacterial elimination and wound healing. Nano Today 37, 101104 (2021).
   Web of Science ®Google Scholar
• Zhao H, Xue S, Hussherr MD, Teixeira AP, Fussenegger M. Autonomous push button-controlled rapid insulin release from a piezoelectrically activated subcutaneous cell implant. Sci. Adv. 8(24), 4389 (2022).
   Web of Science ®Google Scholar
• Chen Y, Shi J, Yang G et al. High-performance sono-piezoelectric nanocomposites enhanced by interfacial coupling effects for implantable nanogenerators and actuators. Mater. Horizons 11(4), 995–1007 (2024).
   PubMed Web of Science ®Google Scholar
• Dani SS, Tripathy A, Alluri NR, Balasubramaniam S, Ramadoss A. A critical review: the impact of electrical poling on the longitudinal piezoelectric strain coefficient. Mater. Adv. 3(24), 8886–8921 (2022).
   Google Scholar
• Yu S, Milam-Guerrero JA, Tai Y et al. Maximizing polyacrylonitrile nanofiber piezoelectric properties through the optimization of electrospinning and post-thermal treatment processes. ACS Appl. Polym. Mater. 4(1), 635–644 (2022).
   Web of Science ®Google Scholar
• Han M, Yildiz E, Bozuyuk U et al. Janus microparticles-based targeted and spatially-controlled piezoelectric neural stimulation via low-intensity focused ultrasound. Nat. Commun. 15(1), 1–17 (2024).
   PubMed Web of Science ®Google Scholar
• Truong Hoang Q, Kim DY, Park HS et al. Oxygen-supplying piezocatalytic therapy of hypoxic tumors by intratumoral delivery of pH-responsive multicompartmental carriers with sequential drug release capability. Adv. Funct. Mater. 2306078 (2024).
   Web of Science ®Google Scholar