Advanced search
Publication Cover
Nanomedicine Volume 4, 2009 - Issue 3
Submit an article Journal homepage
255
Views
1
CrossRef citations to date
0
Altmetric
Research Article

Probing and Preventing Quantum Dot-Induced Cytotoxicity with Multimodal α-Lipoic Acid in Multiple Dimensions of The Peripheral Nervous System

Manasi P Jain1 Department of Pharmacology & Therapeutics, McGill University, 3655 Promenade Sir-William-Osler, McIntyre Medical Sciences Building, Room 1314, Montreal, QCH3G 1Y6, CanadaView further author information
,
Angela O Choi1 Department of Pharmacology & Therapeutics, McGill University, 3655 Promenade Sir-William-Osler, McIntyre Medical Sciences Building, Room 1314, Montreal, QCH3G 1Y6, CanadaView further author information
,
Kevin D Neibert1 Department of Pharmacology & Therapeutics, McGill University, 3655 Promenade Sir-William-Osler, McIntyre Medical Sciences Building, Room 1314, Montreal, QCH3G 1Y6, CanadaView further author information
&
Dusica Maysinger1 Department of Pharmacology & Therapeutics, McGill University, 3655 Promenade Sir-William-Osler, McIntyre Medical Sciences Building, Room 1314, Montreal, QCH3G 1Y6, CanadaCorrespondence[email protected]
View further author information
Pages 277-290 | Published online: 30 Mar 2009

Bibliography

  • Lewinski N , ColvinV, DrezekR: Cytotoxicity of nanoparticles.Small4(1), 26–49 (2007).
  • Nel A , XiaT, MadlerL, LiN: Toxic potential of materials at the nanolevel.Science311, 622–627 (2006).
  • Mortensen LJ , OberdorsterG, PentlandAP, DelouiseLA: In vivo skin penetration of quantum dot nanoparticles in the murine model: the effect of UVR.Nano Lett.8, 2779–2787 (2008).
  • Fischer HC , LiuL, PangKS, ChanWC: Pharmacokinetics of nanoscale quantum dots: in vivo distribution, sequestration, and clearance in the rat.Adv. Funct. Mater.16, 1299–1305 (2006).
  • Maysinger D , BehrendtM, Lalancette-HebertM, KrizJ: Real-time imaging of astrocyte response to quantum dots: in vivo screening model system for biocompatibility of nanoparticles.Nano Lett.7, 2513–2520 (2007).
  • Ballou B , LagerholmBC, ErnstLA, BruchezMP, WaggonerAS: Noninvasive imaging of quantum dots in mice.Bioconjug. Chem.15, 79–86 (2004).
  • Li RH , SliwkowskiMX, LoJ, MatherJP: Establishment of Schwann cell lines from normal adult and embryonic rat dorsal root ganglia.J. Neurosci. Methods67, 57–69 (1996).
  • Fraher JP : The transitional zone and CNS regeneration.J. Anat.194(Pt 2), 161–182 (1999).
  • Goldberg JL , BarresBA: Neuronal regeneration: extending axons from bench to brain.Curr. Biol.8, R310–R312 (1998).
  • Alivisatos AP , GuW, LarabellC: Quantum dots as cellular probes.Annu. Rev. Biomed. Eng.7, 55–76 (2005).
  • Nie S , XingY, KimGJ, SimonsJW: Nanotechnology applications in cancer.Annu. Rev. Biomed. Eng.9, 257–288 (2007).
  • Maysinger D : Nanoparticles and cells: good companions and doomed partnerships.Org. Biomol. Chem.5, 2335–2342 (2007).
  • Maysinger D , LovricJ, EisenbergA, SavicR: Fate of micelles and quantum dots in cells.Eur. J. Pharm. Biopharm.65, 270–281 (2007).
  • Lovric J , ChoSJ, WinnikFM, MaysingerD: Unmodified cadmium telluride quantum dots induce reactive oxygen species formation leading to multiple organelle damage and cell death.Chem. Biol.12, 1227–1234 (2005).
  • Cho SJ , MaysingerD, JainM, RoderB, HackbarthS, WinnikFM: Long-term exposure to CdTe quantum dots causes functional impairments in live cells.Langmuir23, 1974–80 (2007).
  • Choi AO , ChoSJ, DesbaratsJ, LovricJ, MaysingerD: Quantum dot-induced cell death involves Fas upregulation and lipid peroxidation in human neuroblastoma cells.J. Nanobiotechnol.5, 1 (2007).
  • Choi AO , BrownSE, SzyfM, MaysingerD: Quantum dot-induced epigenetic and genotoxic changes in human breast cancer cells.J. Mol. Med.86(3), 291–302 (2008).
  • Bhattacharya R , MukherjeeP: Biological properties of ‘naked’ metal nanoparticles.Adv. Drug Deliv. Rev.60, 1289–1306 (2008).
  • Susumu K , UyedaHT, MedintzIL, PonsT, DelehantyJB, MattoussiH: Enhancing the stability and biological functionalities of quantum dots via compact multifunctional ligands.J. Am. Chem. Soc.129, 13987–13996 (2007).
  • Packer L , WittEH, TritschlerHJ: α-lipoic acid as a biological antioxidant.Free Radic. Biol. Med.19, 227–250 (1995).
  • Biewenga GP , HaenenGR, BastA: The pharmacology of the antioxidant lipoic acid.Gen. Pharmacol.29, 315–331 (1997).
  • Gaponik N , TalapinDV, RogachALet al.: Thiol-capping of CdTe nanocrystals: an alternative to organometallic synthetic routes.J. Phys. Chem. B106, 7177–85 (2002).
  • Tam J , RosenbergL, MaysingerD: Islet-neogenesis-associated protein enhances neurite outgrowth from DRG neurons.Biochem. Biophys. Res. Commun.291, 649–654 (2002).
  • Gregor MF , HotamisligilGS: Thematic review series: adipocyte biology. Adipocyte stress: the endoplasmic reticulum and metabolic disease.J. Lipid Res.48, 1905–1914 (2007).
  • Harry GJ , GoodrumJF, BouldinTW, Wagner-RecioM, ToewsAD, MorellP: Tellurium-induced neuropathy: metabolic alterations associated with demyelination and remyelination in rat sciatic nerve.J. Neurochem.52, 938–945 (1989).
  • Cui B , WuC, ChenLet al.: One at a time, live tracking of NGF axonal transport using quantum dots.Proc. Natl Acad. Sci. USA104, 13666–13671 (2007).
  • Jin HY , JoungSJ, ParkJH, BaekHS, ParkTS: The effect of α-lipoic acid on symptoms and skin blood flow in diabetic neuropathy.Diabet. Med.24, 1034–1038 (2007).
  • Jia Z , HallurS, ZhuH, LiY, MisraHP: Potent upregulation of glutathione and NAD(P)H:quinone oxidoreductase 1 by α-lipoic acid in human neuroblastoma SH-SY5Y cells: protection against neurotoxicant-elicited cytotoxicity.Neurochem. Res.33, 790–800 (2008).
  • Berciano MT , FernandezR, PenaE, CalleE, VillagraNT, LafargaM: Necrosis of schwann cells during tellurium-induced primary demyelination: DNA fragmentation, reorganization of splicing machinery, and formation of intranuclear rods of actin.J. Neuropathol. Exp. Neurol.58, 1234–1243 (1999).
  • Calle E , BercianoMT, FernandezR, LafargaM: Activation of the autophagy, c-FOS and ubiquitin expression, and nucleolar alterations in Schwann cells precede demyelination in tellurium-induced neuropathy.Acta Neuropathol.97, 143–155 (1999).
  • Goodrum JF , EarnhardtTS, GoinesND, BouldinTW: Lipid droplets in Schwann cells during tellurium neuropathy are derived from newly synthesized lipid.J. Neurochem.55, 1928–1932 (1990).
  • Yiin SJ , SheuJY, LinTH: Lipid peroxidation in rat adrenal glands after administration cadmium and role of essential metals.J. Toxicol. Environ. Health A62, 47–56 (2001).
  • Schomburg L , KohrleJ: On the importance of selenium and iodine metabolism for thyroid hormone biosynthesis and human health.Mol. Nutr. Food Res.52(11), 1235–1246 (2008).
  • Liu Y , ZhangSP, CaiYQ: Cytoprotective effects of selenium on cadmium-induced LLC-PK1 cells apoptosis by activating JNK pathway.Toxicol. In Vitro21, 677–684 (2007).
  • Stern ST , ZolnikBS, McLelandCB, ClogstonJ, ZhengJ, McNeilSE: Induction of autophagy in porcine kidney cells by quantum dots: a common cellular response to nanomaterials?Toxicol. Sci.106, 140–152 (2008).
  • Maysinger D , LovricJ: Quantum dots and other fluorescent nanoparticles: quo vadis in the cell?Adv. Exp. Med. Biol.620, 156–167 (2007).
  • Winnik FM , MaysingerD: Assessment of the issues related to the toxicity of quantum dots. In: Nanomedicine. Mattoussi H (Ed.). Stanford Publishing Pte, Ltd, Hackensack, NJ, USA (2008)
  • Fraher J : Axons and glial interfaces: ultrastructural studies.J. Anat.200, 415–430 (2002).
  • Wood PM , WilliamsAK: Oligodendrocyte proliferation and CNS myelination in cultures containing dissociated embryonic neuroglia and dorsal root ganglion neurons.Brain Res.314, 225–241 (1984).
  • Holzer P , MaggiCA: Dissociation of dorsal root ganglion neurons into afferent and efferent-like neurons.Neuroscience86, 389–398 (1998).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.