Advanced search
Publication Cover
Nanomedicine Volume 8, 2013 - Issue 3
Submit an article Journal homepage
346
Views
0
CrossRef citations to date
0
Altmetric
Research Article

Bioactive Macro/Micro Porous Silk Fibroin/Nano-Sized Calcium Phosphate Scaffolds with Potential for Bone-Tissue-Engineering Applications

Le-Ping Yan1 Biomaterials, Biodegradables & Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering & Regenerative Medicine, AvePark, S. Cláudio de Barco, 4806-909 Taipas, Guimarães, Portugal;2 ICVS/3B‘s – PT Government Associate Laboratory, Braga/Guimarães, PortugalView further author information
,
Joana Silva-Correia1 Biomaterials, Biodegradables & Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering & Regenerative Medicine, AvePark, S. Cláudio de Barco, 4806-909 Taipas, Guimarães, Portugal;2 ICVS/3B‘s – PT Government Associate Laboratory, Braga/Guimarães, PortugalView further author information
,
Cristina Correia1 Biomaterials, Biodegradables & Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering & Regenerative Medicine, AvePark, S. Cláudio de Barco, 4806-909 Taipas, Guimarães, Portugal;2 ICVS/3B‘s – PT Government Associate Laboratory, Braga/Guimarães, PortugalView further author information
,
Sofia G Caridade1 Biomaterials, Biodegradables & Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering & Regenerative Medicine, AvePark, S. Cláudio de Barco, 4806-909 Taipas, Guimarães, Portugal;2 ICVS/3B‘s – PT Government Associate Laboratory, Braga/Guimarães, PortugalView further author information
,
Emanuel M Fernandes1 Biomaterials, Biodegradables & Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering & Regenerative Medicine, AvePark, S. Cláudio de Barco, 4806-909 Taipas, Guimarães, Portugal;2 ICVS/3B‘s – PT Government Associate Laboratory, Braga/Guimarães, PortugalView further author information
,
Rui A Sousa1 Biomaterials, Biodegradables & Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering & Regenerative Medicine, AvePark, S. Cláudio de Barco, 4806-909 Taipas, Guimarães, Portugal;2 ICVS/3B‘s – PT Government Associate Laboratory, Braga/Guimarães, PortugalView further author information
,
João F Mano1 Biomaterials, Biodegradables & Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering & Regenerative Medicine, AvePark, S. Cláudio de Barco, 4806-909 Taipas, Guimarães, Portugal;2 ICVS/3B‘s – PT Government Associate Laboratory, Braga/Guimarães, PortugalView further author information
,
Joaquim M Oliveira1 Biomaterials, Biodegradables & Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering & Regenerative Medicine, AvePark, S. Cláudio de Barco, 4806-909 Taipas, Guimarães, Portugal;2 ICVS/3B‘s – PT Government Associate Laboratory, Braga/Guimarães, PortugalView further author information
,
Ana L Oliveira1 Biomaterials, Biodegradables & Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering & Regenerative Medicine, AvePark, S. Cláudio de Barco, 4806-909 Taipas, Guimarães, Portugal;2 ICVS/3B‘s – PT Government Associate Laboratory, Braga/Guimarães, Portugal;3 Department of Health Sciences, Portuguese Catholic University, 3504-505Viseu, PortugalView further author information
&
Rui L Reis1 Biomaterials, Biodegradables & Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering & Regenerative Medicine, AvePark, S. Cláudio de Barco, 4806-909 Taipas, Guimarães, Portugal;2 ICVS/3B‘s – PT Government Associate Laboratory, Braga/Guimarães, PortugalCorrespondence[email protected]
View further author information
 show all
Pages 359-378 | Received 21 Dec 2011, Published online: 11 Mar 2013

References

  • Hutmacher DW , SchantzJT, LamCXF, TanKC, LimTC. State of the art and future directions of scaffold-based bone engineering from a biomaterials perspective. J. Tissue Eng. Regen. M.1(4), 245–260 (2007).
  • Oliveira JM , KotobukiN, TadokoroMet al.: Ex vivo culturing of stromal cells with dexamethasone-loaded carboxymethylchitosan/poly(amidoamine) dendrimer nanoparticles promotes ectopic bone formation. Bone46(5), 1424–1435 (2010).
  • Oliveira JM , SousaRA, KotobukiNet al. The osteogenic differentiation of rat bone marrow stromal cells cultured with dexamethasone-loaded carboxymethylchitosan/poly(amidoamine) dendrimer nanoperticles. Biomaterials 30(5), 804–813 (2009).
  • Rezwan K , ChenQZ, BlakerJJ, BoccacciniAR. Biodegradable and bioactive porous polymer/inorganic composite scaffolds for bone tissue engineering. Biomaterials27(18), 3413–3431 (2006).
  • Oliveira AL , SunL, KimHJet al. Aligned silk-based 3-D architectures for contact guidance in tissue engineering. Acta Biomater. 8(4), 1530–1542 (2012).
  • Fuchs S , JiangX, SchmidtHet al. Dynamic process involved in the pre-vascularization of silk fibroin constructs for bone regeneration using outgrowth endothelial cells. Biomaterials 30(7), 1329–1338 (2009).
  • Makaya K , TeradaS, OhgoK, AsakuraT. Comparative study of silk fibroin porous scaffolds derived from salt/water and sucrose/hexafluoroisopropanol in cartilage formation. J. Biosci. Bioeng.108(1), 68–75 (2009).
  • Vepari C , KaplanDL. Silk as a biomaterial. Prog. Polym. Sci.32(8–9), 991–1007 (2007).
  • Kundu B , KunduSC. Osteogenesis of human stem cells in silk biomaterial for regenerative therapy. Prog. Polym. Sci.35(9), 1116–1127 (2010).
  • Bessa PC , BalmayorER, AzevedoHSet al. Silk fibroin microparticles as carriers for delivery of human recombinant BMPs. Physical characterization and drug release. J. Tissue Eng. Regen. M. 4(5), 349–355 (2010).
  • Mandal BB , KunduSC. Cell proliferation and migration in silk fibroin 3D scaffolds. Biomaterials30(15), 2956–2965 (2009).
  • Kim UJ , ParkJ, KimHJ, WadaM, KaplanDL. Three-dimensional aqueous-derived biomaterial scaffolds from silk fibroin. Biomaterials26(15), 2775–2785 (2005).
  • Mathur AB , GuptaV. Silk fibroin-derived nanoparticles for biomedical applications. Nanomedicine5(5), 807–820 (2010).
  • Oliveira AL , SampaioSC, SousaRA, ReisRL. Controlled mineralization of nature-inspired silk fibroin/hydroxyapatite hybrid bioactive scaffolds for bone tissue engineering applications. Presented at: 20th European Conference on Biomaterials. Nantes, France, 27 September–1 October 2006.
  • Kim HJ , KimUJ, KimHSet al. Bone tissue engineering with premineralized silk scaffolds. Bone 42(6), 1226–1234 (2008).
  • Collins AM , SkaerNJV, GheysensTet al. Bone-like resorbable silk-based scaffolds for load-bearing osteoregenerative applications. Adv. Mater. 21(1), 75–78 (2009).
  • Zhang Y , WuC, FriisT, XiaoY. The osteogenic properties of CaP/silk composite scaffolds. Biomaterials31(10), 2848–2856 (2010).
  • Yan LP , OliveiraJM, OliveiraAL, CaridadeSG, ManoJF, ReisRL. Macro/micro porous silk fibroin scaffolds with potential for articular cartilage and meniscus tissue engineering applications. Acta Biomater.8(1), 289–301 (2012).
  • Jin H , KaplanDL. Mechanism of silk processing in insects and spiders. Nature424(6952), 1057–1061 (2003).
  • Kokubo T , TakadamaH. How useful is SBF in predicting in vivo bone bioactivity? Biomaterials27(15), 2907–2915 (2006).
  • Oliveira JM , SilvaSS, MalafayaPB, et al. Macroporous hydroxyapatite scaffolds for bone tissue engineering applications: physicochemical characterization and assessment of rat bone marrow stromal cell viability. J. Biomed. Mater. Res. A.91A(1), 175–186 (2009).
  • Dorozhkin SV . Amorphous calcium (ortho)phosphates. Acta Biomater.6(12), 4457–4475 (2010).
  • Lu Q , HuX, WangXQet al. Water-insoluble silk films with silk-I structure. Acta Biomater. 6(4), 1380–1387 (2010).
  • Chen X , ShaoZZ, KnightDP, VollrathF. Conformation transition kinetics of Bombyx mori silk protein. Proteins68(1), 223–231 (2007).
  • Oliveira JM , RodriguesMT, SilvaSSet al. Novel hydroxyapatite/chitosan bilayered scaffold for osteochondral tissue-engineering applications: scaffold design and its performance when seeded with goat bone marrow stromal cells. Biomaterials 27(36), 6123–6137 (2006).
  • Oliveira AL , ReisRL. Bone-like apatite coatings nucleated on biodegradable polymers as a way to induce bone mineralization: current developments and future trends. In: Biodegradable Systems in Medical Functions: Design, Processing, Testing and Applications. Reis RL, San Roman J (Eds). CRC Press, Boca Raton, FL, USA, 205–221 (2004).
  • Bhumiratana S , GraysonWL, CastanedaAet al. Nucleation and growth of mineralized bone matrix on silk-hydroxyapatite composite scaffolds. Biomaterials 32(11), 2812–2820 (2011).
  • Kong XD , CuiFZ, WangXM, ZhangM, ZhangW. Silk fibroin regulated mineralization of hydroxyapatite nanocrystals. J. Crystal. Growth270(1–2), 197–202 (2004).
  • Karageorgiou V , KaplanD. Porosity of 3D biomaterial scaffolds and osteogenesis. Biomaterials26(27), 5474–5491 (2005).
  • Oliveira AL , MalafayaPB, CostaSA, SousaRA, ReisRL. Micro-computed tomography (µ-CT) as a potential tool to assess the effect of dynamic coating routes on the formation of biomimetic apatite layers on 3D-plotted biodegradable polymeric scaffolds. J. Mater. Sci. Mater. M.18(2), 211–223 (2007).
  • Liu L , LiuJY, WangMQet al. Preparation and characterization of nano-hydroxyapatite/silk fibroin porous scaffolds. J. Biomater. Sci. Polym. Ed. 19(3), 325–338 (2008).
  • Rajkhowa R , GilES, KlugeJet al. Reinforcing silk scaffolds with silk particles. Macromol. Biosci. 10(6), 599–611 (2010).
  • Yan LP , WangYJ, RenLet al. Genipin-cross-linked collagen/chitosan biomimetic scaffolds for articular cartilage tissue engineering applications. J. Biomed. Mater. Res. A. 95A(2), 465–475 (2010).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.