225
Views
0
CrossRef citations to date
0
Altmetric
Research Article

Antiarthritic and Chondroprotective Activity of Lakshadi Guggul in Novel Alginate-Enclosed Chitosan Calcium Phosphate Nanocarriers

, , &
Pages 819-837 | Received 10 Oct 2012, Published online: 01 Jul 2014

References

  • Antoni C , BraunJ. Side effects of anti-TNF therapy: current knowledge. Clin. Exp. Rheumatol.20(6 Suppl. 28), S152–S157 (2002).
  • Little CV , ParsonsT. Herbal therapy for treating osteoarthritis. Cochrane Database Syst. Rev.1, CD002947 (2001).
  • Rao JK , MihaliakK, KroenkeK, BradleyJ, TierneyWM, WeinbergerM. Use of complementary therapies for arthritis among patients of rheumatologists. Ann. Intern. Med.131(6), 409–416 (1999).
  • Mishra G , SrivastavaS, NagoriBP. Pharmacological and therapeutic activity of Cissus quadrangularis: an overview. Int. J. Pharm. Tech. Res.2(2), 1298–1310 (2010).
  • Unnati S . Pharmacognostical investigation on cissus quadrangularis linn. Int. J. Pharma. Bio. Sci.1(3), 1–5 (2010).
  • Ichikawa H , TakadaY, ShishodiaS, JayaprakasamB, NairMG, AggarwalBB. Withanolides potentiate apoptosis, inhibit invasion, and abolish osteoclastogenesis through suppression of nuclear factor-kappaB (NF-kappaB) activation and NF-kappaB-regulated gene expression. Mol. Cancer Ther.5(6), 1434–1445 (2006).
  • Begum VH , SadiqueJ. Long term effect of herbal drug Withania somnifera on adjuvant induced arthritis in rats. Indian J. Exp. Biol.26(11), 877–882 (1988).
  • Sivakumar G , RaoGC, ShravanN, SomasekharP, Sindhu Priya ES. A study on the antiarthritic activity of Terminalia arjuna bark. Int. J. Adv. Pharm. Biol. Sci.1(2), 79–81 (2011).
  • Park J , ErnstE. Ayurvedic medicine for rheumatoid arthritis: a systematic review. Semin. Arthritis Rheum.34(5), 705–713 (2005).
  • Sharma VD , SharmaA, KushwahHK. An indigenous approach to manage the osteoarthritis of knee joint with lakshadi guggulu, kalka-patra bandhan and knee traction. Anc. Sci. Life26(3), 23–29 (2007).
  • Rasoanaivo P , WrightCW, WillcoxML, GilbertB. Whole plant extracts versus single compounds for the treatment of malaria: synergy and positive interactions. Malar. J.10(Suppl. 1), S4 (2011).
  • Wagner H . Synergy research: approaching a new generation of phytopharmaceuticals. Fitoterapia82(1), 34–37 (2011).
  • Kanwar JR , MahidharaG, KanwarRK. Novel alginate-enclosed chitosan–calcium phosphate-loaded iron-saturated bovine lactoferrin nanocarriers for oral delivery in colon cancer therapy. Nanomedicine (Lond.)7(10), 1521–1550 (2012).
  • Mahidhara G , KanwarRK, KanwarJR. Novel nanoplatform for oral delivery of anti-cancer biomacromolecules. Int. J. Nanotechnol.9, 942–960 (2012).
  • Mahidhara VNLG . Orally Administered Anti-Cancer Nanocarriers Loaded with Therapeutic Proteins [PhD thesis]. School of Life and Environmental Science, Deakin University, Geelong, Australia (2012).
  • Haque E , MandalI, PalS, BaralR. Prophylactic dose of neem (Azadirachta indica) leaf preparation restricting murine tumor growth is nontoxic, hematostimulatory and immunostimulatory. Immunopharmacol. Immunotoxicol.28(1), 33–50 (2006).
  • Dubois M , GillesKA, HamiltonJK, RubersP, SmithF. Colorometric method for determination of sugars and related substances. Anal. Chem.28, 350–356 (1956).
  • Kanwar JR , KanwarRK. Gut health immunomodulatory and anti-inflammatory functions of gut enzyme digested high protein micro-nutrient dietary supplement – enprocal. BMC Immunol.10, 7 (2009).
  • Szomor Z , ShimizuK, FujimoriY, YamamotoS, YamamuroT. Appearance of calpain correlates with arthritis and cartilage destruction in collagen induced arthritic knee joints of mice. Ann. Rheum. Dis.54(6), 477–483 (1995).
  • Pierer M , WagnerU, RossolM, IbrahimS. Toll-like receptor 4 is involved in inflammatory and joint destructive pathways in collagen-induced arthritis in DBA1J mice. PLoS ONE6(8), e23539 (2011).
  • Mankin HJ , DorfmanH, LippielloL, ZarinsA. Biochemical and metabolic abnormalities in articular cartilage from osteo-arthritic human hips. II. Correlation of morphology with biochemical and metabolic data. J. Bone Joint Surg. Am.53(3), 523–537 (1971).
  • Rossomacha E , HoemannCD, ShiveMS. Simple methods for staining chitosan in biotechnological applications. J. Histotechnol.1(6), 31–36 (2004).
  • Blanco FJ , RegoI, Ruiz-RomeroC. The role of mitochondria in osteoarthritis. Nat. Rev. Rheumatol.7(3), 161–169 (2011).
  • Kapoor M , Martel-PelletierJ, LajeunesseD, PelletierJP, FahmiH. Role of proinflammatory cytokines in the pathophysiology of osteoarthritis. Nat. Rev. Rheumatol.7(1), 33–42 (2011).
  • Leventhal LJ , BoyceEG, ZurierRB. Treatment of rheumatoid arthritis with gammalinolenic acid. Ann. Intern. Med.119(9), 867–873 (1993).
  • Deodhar SD , SethiR, SrimalRC. Preliminary study on antirheumatic activity of curcumin (diferuloyl methane). Indian J. Med. Res.71, 632–634 (1980).
  • Deal CL , SchnitzerTJ, Lipstein E et al. Treatment of arthritis with topical capsaicin: a double-blind trial. Clin. Ther.13(3), 383–395 (1991).
  • Tao X , YoungerJ, FanFZ, WangB, LipskyPE. Benefit of an extract of Tripterygium Wilfordii Hook F in patients with rheumatoid arthritis: a double-blind, placebo-controlled study. Arthritis Rheum.46(7), 1735–1743 (2002).
  • Goggs R , CarterSD, Schulze-TanzilG, ShakibaeiM, MobasheriA. Apoptosis and the loss of chondrocyte survival signals contribute to articular cartilage degradation in osteoarthritis. Vet. J.166(2), 140–158 (2003).
  • Kim J , XuM, Xo R et al. Mitochondrial DNA damage is involved in apoptosis caused by pro-inflammatory cytokines in human OA chondrocytes. Osteoarthritis Cartilage18(3), 424–432 (2010).
  • Muthusami S , SenthilkumarK, Vignesh C et al. Effects of Cissus quadrangularis on the proliferation, differentiation and matrix mineralization of human osteoblast like SaOS-2 cells. J. Cell Biochem.112(4), 1035–1045 (2011).
  • Schwartz ER , AdamyL. Effect of ascorbic acid on arylsulfatase activities and sulfated proteoglycan metabolism in chondrocyte cultures. J. Clin. Invest.60(1), 96–106 (1977).
  • Sowers M , LachanceL. Vitamins and arthritis. The roles of vitamins A, C, D, and E. Rheum. Dis. Clin. North Am.25(2), 315–332 (1999).
  • Rasool M , VaralakshmiP. Protective effect of Withania somnifera root powder in relation to lipid peroxidation, antioxidant status, glycoproteins and bone collagen on adjuvant-induced arthritis in rats. Fundam. Clin. Pharmacol.21(2), 157–164 (2007).
  • Kumar P , KumarA. Possible neuroprotective effect of Withania somnifera root extract against 3-nitropropionic acid-induced behavioral, biochemical, and mitochondrial dysfunction in an animal model of Huntington‘s disease. J. Med. Food12(3), 591–600 (2009).
  • Verma N , VinayakM. Effect of Terminalia arjuna on antioxidant defense system in cancer. Mol. Biol. Rep.36(1), 159–164 (2009).
  • Karthikeyan K , BaiBR, GauthamanK, SathishKS, DevarajSN. Cardioprotective effect of the alcoholic extract of Terminalia arjuna bark in an in vivo model of myocardial ischemic reperfusion injury. Life Sci.73(21), 2727–2739 (2003).
  • Devi RS , NarayanS, VaniG, Shyamala Devi CS. Gastroprotective effect of Terminalia arjuna bark on diclofenac sodium induced gastric ulcer. Chem. Biol. Interact.167(1), 71–83 (2007).
  • Manna P , SinhaM, SilPC. Aqueous extract of Terminalia arjuna prevents carbon tetrachloride induced hepatic and renal disorders. BMC Complement. Altern. Med.6, 33 (2006).
  • Kanwar JR , KanwarRK, Sun X et al. Molecular and biotechnological advances in milk proteins in relation to human health. Curr. Protein Pept. Sci.10(4), 308–338 (2009).
  • Kanwar JR , PalmanoKP, Sun X et al. ‘Iron-saturated’ lactoferrin is a potent natural adjuvant for augmenting cancer chemotherapy. Immun. Cell Bio86, 277–288 (2008).
  • Kanwar JR , SamarasingheRM, KanwarRK. Nano-lactoferrin in diagnostic, imaging and targeted delivery for cancer and infectious diseases. J. Cancer Sci. Ther.4(3), 31–42 (2012).
  • Sumantran VN , KulkarniA, Boddul S et al. Chondroprotective potential of root extracts of Withania somnifera in osteoarthritis. J. Biosci.32(2), 299–307 (2007).
  • Ganesan K , SehgalPK, MandalAB, SayeedS. Protective effect of Withania somnifera and Cardiospermum halicacabum extracts against collagenolytic degradation of collagen. Appl. Biochem. Biotechnol.165(3–4), 1075–1091 (2011).
  • Huh JE , JungIT, Choi J et al. The natural flavonoid galangin inhibits osteoclastic bone destruction and osteoclastogenesis by suppressing NF-kappaB in collagen-induced arthritis and bone marrow-derived macrophages. Eur. J. Pharmacol.698(1–3), 57–66 (2013).
  • Sehgal N , GuptaA, Valli RK et al.Withania somnifera reverses Alzheimer‘s disease pathology by enhancing low-density lipoprotein receptor-related protein in liver. Proc. Natl Acad. Sci. USA109(9), 3510–3515 (2012).
  • Mehta KD , MillerL. Inhibition of stress-activated p38 mitogen-activated protein kinase induces low-density lipoprotein receptor expression. Trends Cardiovasc. Med.9(7), 201–205 (1999).
  • Singh D , AggarwalA, MauryaR, NaikS. Withania somnifera inhibits NF-kappaB and AP-1 transcription factors in human peripheral blood and synovial fluid mononuclear cells. Phytother. Res.21(10), 905–913 (2007).
  • Parisuthiman D , SinghatanadgitW, DechatiwongseT, KoontongkaewS. Cissus quadrangularis extract enhances biomineralization through up-regulation of MAPK-dependent alkaline phosphatase activity in osteoblasts. In Vitro Cell Dev. Biol. Anim.45(3–4), 194–200 (2009).
  • Yousef M , PichyangkuraR, SoodvilaiS, ChatsudthipongV, MuanprasatC. Chitosan oligosaccharide as potential therapy of inflammatory bowel disease: therapeutic efficacy and possible mechanisms of action. Pharmacol. Res.66(1), 66–79 (2012).
  • Kanwar JR , MahidharaG, KanwarRK. Antiangiogenic therapy using nanotechnological-based delivery system. Drug Discov. Today16(5–6), 188–202 (2011).
  • Koch AE . Angiogenesis as a target in rheumatoid arthritis. Ann. Rheum. Dis.62(Suppl. 2), ii60–ii67 (2003).
  • Stokes DG , LiuG, DharmavaramR, HawkinsD, Piera-VelazquezS, JimenezSA. Regulation of type-II collagen gene expression during human chondrocyte de-differentiation and recovery of chondrocyte-specific phenotype in culture involves Sry-type high-mobility-group box (SOX) transcription factors. Biochem. J.360(Pt 2), 461–470 (2001).
  • Yang S , KimJ, Ryu JH et al. Hypoxia-inducible factor-2alpha is a catabolic regulator of osteoarthritic cartilage destruction. Nat. Med.16(6), 687–693 (2010).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.