Advanced search
Publication Cover
Pharmacogenomics Volume 17, 2016 - Issue 11
Submit an article Journal homepage
1,819
Views
0
CrossRef citations to date
0
Altmetric
Editorial

Genetic Variation and the D2 Dopamine Receptor: Implications for the Treatment of Neuropsychiatric Disease

Brian J Mickey1 Department of Psychiatry, University of Utah School of Medicine, Salt Lake City, UT, USA;2 Department of Psychiatry, University of Michigan Medical School, Ann Arbor, MI, USACorrespondence[email protected]
Pages 1207-1210 | Received 16 May 2016, Accepted 17 May 2016, Published online: 05 Jul 2016

References

  • Noble EP , BlumK , RitchieT , MontgomeryA , SheridanPJ . Allelic association of the D2 dopamine receptor gene with receptor-binding characteristics in alcoholism . Arch. Gen. Psychiatry48 ( 7 ), 648 – 654 ( 1991 ).
  • Thompson J , ThomasN , SingletonAet al. D2 dopamine receptor gene (DRD2) Taq1 A polymorphism: reduced dopamine D2 receptor binding in the human striatum associated with the A1 allele . Pharmacogenetics7 ( 6 ), 479 – 484 ( 1997 ).
  • Farde L , HallH , PauliS , HalldinC . Variability in D2-dopamine receptor density and affinity: a PET study with [11C]raclopride in man . Synapse20 ( 3 ), 200 – 208 ( 1995 ).
  • Volkow ND , WangGJ , FowlerJS , TomasiD . Addiction circuitry in the human brain . Annu. Rev. Pharmacol. Toxicol.52 , 321 – 336 ( 2012 ).
  • Borg J , CervenkaS , Kuja-HalkolaRet al. Contribution of non-genetic factors to dopamine and serotonin receptor availability in the adult human brain . Mol. Psychiatry doi:10.1038/mp.2015.147 ( 2015 ) ( Epub ahead of print ).
  • Gluskin BS , MickeyBJ . Genetic variation and dopamine D2 receptor availability: a systematic review and meta-analysis of human in vivo molecular imaging studies . Transl. Psychiatry6 , e747 ( 2016 ).
  • Neville MJ , JohnstoneEC , WaltonRT . Identification and characterization of ANKK1: a novel kinase gene closely linked to DRD2 on chromosome band 11q23.1 . Hum Mutat23 ( 6 ), 540 – 545 ( 2004 ).
  • Allen Brain Atlas . http://human.brain-map.org .
  • Hawrylycz MJ , LeinES , Guillozet-BongaartsALet al. An anatomically comprehensive atlas of the adult human brain transcriptome . Nature489 ( 7416 ), 391 – 399 ( 2012 ).
  • Garrido E , PalomoT , PonceG , Garcia-ConsuegraI , Jimenez-ArrieroMA , HoenickaJ . The ANKK1 protein associated with addictions has nuclear and cytoplasmic localization and shows a differential response of Ala239Thr to apomorphine . Neurotox. Res.20 ( 1 ), 32 – 39 ( 2011 ).
  • Hoenicka J , Quinones-LombranaA , Espana-SerranoLet al. The ANKK1 gene associated with addictions is expressed in astroglial cells and upregulated by apomorphine . Biological Psychiatry67 ( 1 ), 3 – 11 ( 2010 ).
  • Zhang Y , BertolinoA , FazioLet al. Polymorphisms in human dopamine D2 receptor gene affect gene expression, splicing, and neuronal activity during working memory . Proc. Natl Acad. Sci. USA104 ( 51 ), 20552 – 20557 ( 2007 ).
  • Brody AL , MandelkernMA , OlmsteadREet al. Gene variants of brain dopamine pathways and smoking-induced dopamine release in the ventral caudate/nucleus accumbens . Arch. Gen. Psychiatry63 ( 7 ), 808 – 816 ( 2006 ).
  • Pecina M , MickeyBJ , LoveTet al. DRD2 polymorphisms modulate reward and emotion processing, dopamine neurotransmission and openness to experience . Cortex49 ( 3 ), 877 – 890 ( 2013 ).
  • Savitz J , HodgkinsonCA , Martin-SoelchCet al. The functional DRD3 Ser9Gly polymorphism (rs6280) is pleiotropic, affecting reward as well as movement . PLoS ONE8 ( 1 ), e54108 ( 2013 ).
  • Mickey BJ , SanfordBJ , LoveTMet al. Striatal dopamine release and genetic variation of the serotonin 2C receptor in humans . J. Neurosci.32 ( 27 ), 9344 – 9350 ( 2012 ).
  • Domino EF , EvansCL , NiL , GuthrieSK , KoeppeRA , ZubietaJK . Tobacco smoking produces greater striatal dopamine release in G-allele carriers with mu opioid receptor A118G polymorphism . Prog. Neuropsychopharmacol. Biol. Psychiatry38 ( 2 ), 236 – 240 ( 2012 ).
  • Pecina M , LoveT , StohlerCS , GoldmanD , ZubietaJK . Effects of the Mu opioid receptor polymorphism (OPRM1 A118G) on pain regulation, placebo effects and associated personality trait measures . Neuropsychopharmacology40 ( 4 ), 957 – 965 ( 2015 ).
  • Schellekens AF , FrankeB , EllenbroekBet al. Reduced dopamine receptor sensitivity as an intermediate phenotype in alcohol dependence and the role of the COMT Val158Met and DRD2 Taq1A genotypes . Arch. Gen. Psychiatry69 ( 4 ), 339 – 348 ( 2012 ).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.