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Short Communication

Association of 63/91 Length Polymorphism in the DHFR Gene Major Promoter with Toxicity of Methotrexate in Patients with c arthritis

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Pages 1687-1691 | Received 20 May 2016, Accepted 01 Jul 2016, Published online: 16 Sep 2016

References

  • Saag KG , TengGG , PatkarNet al. American College of Rheumatology 2008 recommendations for the use of non biologic and biologic disease-modifying antirheumaticdrugs in rheumatoid arthritis . Arhritis Rheum.59 , 762 – 784 ( 2008 ).
  • Stamp L , RobertsR , KennedyMet al. The use of low dose methotrexate in rheumatoid arthritis – are we entering a new era of therapeutic drug monitoring and pharmacogenomics? Biomed. Pharmacother. 60 , 678 – 687 ( 2006 ).
  • Blume SW , MengZ , ShresthaKet al. The 5′-untranslated RNA of the human DHFR minor transcript alters transcription pre-initiation complex assembly at the major (core) promoter . J. Cell. Biochem.88 , 165 – 180 ( 2003 ).
  • Martianov I , RamadassA , Serra BarrosAet al. Repression of the human dihydrofolate reductase gene by a non-coding interfering transcript . Nature445 , 666 – 670 ( 2007 ).
  • Al-Shakfa F , DulucqS , Ivan BruknerIet al. DNA variants in region for noncoding interfering transcript of dihydrofolate reductase gene and outcome in childhood acute lymphoblastic leukemia . Clin. Cancer Res.15 ( 22 ), 6931 – 6938 ( 2009 ).
  • Arnett FC , EdworthySM , BlochDAet al. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis . Arthritis Rheum.31 , 315 – 324 ( 1988 ).
  • Milic V , JekicB , LukovicLet al. Association of dihydrofolate reductase (DHFR) -317AA genotype with poor response to methotrexate in patients with rheumatoid arthritis . Clin. Exp. Rheumatol.30 ( 2 ), 178 – 183 ( 2012 ).
  • Matherly LH , TaubJW , RavindranathYet al. Elevated dihydrofolate reductase and impaired methotrexate transport as elements in methotrexate resistance in childhood acute lymphoblastic leukemia . Blood85 ( 2 ), 500 – 509 ( 1995 ).
  • Göker E , WalthamM , KheradpourAet al. Amplification of the dihydrofolate reductase gene is a mechanism of acquired resistance to methotrexate in patients with acute lymphoblastic leukemia and is correlated with p53 gene mutations . Blood86 ( 2 ), 677 – 684 ( 1995 ).
  • Salazar J , MoyaP , AltésAet al. Polymorphisms in genes involved in the mechanism of action of methotrexate: are they associated with outcome in rheumatoid arthritis patients? Pharmacogenomics 15 ( 8 ), 1079 – 1090 ( 2014 ).
  • Owen SA , HiderSL , MartinPet al. Genetic polymorphisms in key methotrexate pathway genes are associated with response to treatment in rheumatoid arthritis patients . Pharmacogenomics J.13 ( 3 ), 227 – 234 ( 2013 ).
  • Bekki N , BaeSK , YoshizawaSet al. A case of primary biliary cirrhosis in a patient with rheumatoid arthritis . Clin. Case Rep.4 ( 1 ), 90 – 94 ( 2016 ).

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