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Research Article

Rooted in Risk: Genetic Predisposition for Low-Density Lipoprotein Cholesterol Level Associates with Diminished Low-Density Lipoprotein Cholesterol Response to Statin Treatment

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Pages 1621-1628 | Received 20 May 2016, Accepted 28 Jul 2016, Published online: 20 Sep 2016

References

  • Cholesterol Treatment Trialist’ (CTT) Collaborators , MihaylovaB , EmbersonJet al.The effects of lowering LDL cholesterol with statin therapy in people at low risk of vascular disease: meta-analysis of individual data from 27 randomised trials . Lancet380 ( 9841 ), 581 – 590 ( 2012 ).
  • Cholesterol Treatment Trialists’ (CTT) Collaboration , BaigentC , BlackwellLet al.Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170,000 participants in 26 randomised trials . Lancet376 ( 9753 ), 1670 – 1681 ( 2010 ).
  • Davidson MH , TothPP . Comparative effects of lipid-lowering therapies . Prog. Cardiovasc. Dis.47 ( 2 ), 73 – 104 ( 2004 ).
  • Postmus I , TrompetS , DeshmukhHAet al. Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins . Nat. Commun.5 , 5068 ( 2014 ).
  • Global Lipids Genetics Consortium , WillerCJ , SchmidtEMet al.Discovery and refinement of loci associated with lipid levels . Nat. Genet.45 ( 11 ), 1274 – 1283 ( 2013 ).
  • Center for Statistical Genetics, University of Michigan . http://csg.sph.umich.edu//abecasis/public/lipids2013/ .
  • Johnson T . Efficient calculation for multi-SNP genetic risk scores . The Comprehensive R Archive Network ( 2012 ). https://cran.r-project.org/web/packages/gtx/vignettes/ashg2012.pdf .
  • Burgess S , ButterworthA , ThompsonSG . Mendelian randomization analysis with multiple genetic variants using summarized data . Genet. Epidemiol.37 ( 7 ), 658 – 665 ( 2013 ).
  • Greenland S . An introduction to instrumental variables for epidemiologists . Int. J. Epidemiol.29 ( 4 ), 722 – 729 ( 2000 ).
  • Bowden J , Davey SmithG , HaycockPCet al. Consistent estimation in Mendelian randomization with some invalid instruments using a weighted median estimator . Genet. Epidemiol.40 ( 4 ), 304 – 314 ( 2016 ).
  • Bowden J , Davey SmithG , BurgessS . Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression . Int. J. Epidemiol.44 ( 2 ), 512 – 525 ( 2015 ).
  • Egger M , Davey SmithG , SchneiderMet al. Bias in meta-analysis detected by a simple, graphical test . BMJ315 ( 7109 ), 629 – 634 ( 1997 ).
  • R Core Team . R: A language and environment for statistical computing . R Foundation for Statistical Computing , Vienna, Austria ( 2016 ). www.r-project.org/ .
  • Jia L , BettersJL , YuL . Niemann-pick C1-like 1 (NPC1L1) protein in intestinal and hepatic cholesterol transport . Annu. Rev. Physiol.73 , 239 – 259 ( 2011 ).
  • Garcia-Calvo M , LisnockJ , BullHGet al. The target of ezetimibe is Niemann-Pick C1-Like 1 (NPC1L1) . Proc. Natl Acad. Sci. USA102 ( 23 ), 8132 – 8137 ( 2005 ).
  • Hegele RA , GuyJ , BanMRet al. NPC1L1 haplotype is associated with inter-individual variation in plasma low-density lipoprotein response to ezetimibe . Lipids Health Dis.4 , 16 ( 2005 ).
  • Simon JS , KarnoubMC , DevlinDJet al. Sequence variation in NPC1L1 and association with improved LDL-cholesterol lowering in response to ezetimibe treatment . Genomics86 ( 6 ), 648 – 656 ( 2005 ).
  • Chan DC , WattsGF , WangJet al. Variation in Niemann-Pick C1-like 1 gene as a determinant of apolipoprotein B-100 kinetics and response to statin therapy in centrally obese men . Clin. Endocrinol. (Oxf.)69 ( 1 ), 45 – 51 ( 2008 ).
  • Polisecki E , PeterI , SimonJSet al. Genetic variation at the NPC1L1 gene locus, plasma lipoproteins, and heart disease risk in the elderly . J. Lipid. Res.51 ( 5 ), 1201 – 1207 ( 2010 ).
  • Qi Y , LiuJ , MaCet al. Association between cholesterol synthesis/absorption markers and effects of cholesterol lowering by atorvastatin among patients with high risk of coronary heart disease . J. Lipid. Res.54 ( 11 ), 3189 – 3197 ( 2013 ).
  • Tremblay AJ , LamarcheB , LemelinVet al. Atorvastatin increases intestinal expression of NPC1L1 in hyperlipidemic men . J. Lipid Res.52 ( 3 ), 558 – 565 ( 2011 ).
  • Davey Smith G , HemaniG . Mendelian randomization: genetic anchors for causal inference in epidemiological studies . Hum. Mol. Genet.23 ( R1 ), R89 – R98 ( 2014 ).
  • Holmes MV , AsselbergsFW , PalmerTMet al. Mendelian randomization of blood lipids for coronary heart disease . Eur. Heart J.36 ( 9 ), 539 – 550 ( 2014 ).
  • Pierce BL , BurgessS . Efficient design for Mendelian randomization studies: subsample and 2-sample instrumental variable estimators . Am. J. Epidemiol.178 ( 7 ), 1177 – 1184 ( 2013 ).
  • Stock JH , YogoM . Testing for weak instruments in linear IV regression . In : Identification and Inference for Econometric Models . AndrewsDWK , StockJH ( Eds ). Cambridge University Press , NY, USA , 80 – 108 ( 2005 ).
  • Leusink M , Maitland-van der ZeeAH , DingBet al. A genetic risk score is associated with statin-induced low-density lipoprotein cholesterol lowering . Pharmacogenomics17 ( 6 ), 583 – 591 ( 2016 ).
  • Cannon CP , BlazingMA , GiuglianoRPet al. Ezetimibe added to statin therapy after acute coronary syndromes . N. Engl. J. Med.372 ( 25 ), 2387 – 2397 ( 2015 ).

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