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Special Report

Pharmacogenetics and the Treatment of Asthma

, , , , &
Pages 1271-1280 | Received 30 Jan 2017, Accepted 07 May 2017, Published online: 04 Aug 2017

References

  • Moore WC , MeyersDA , WenzelSEet al. Identification of asthma phenotypes using cluster analysis in the severe asthma research program . Am. J. Respir. Crit. Care Med.181 ( 4 ), 315 – 323 ( 2010 ).
  • Miranda C , BusackerA , BalzarS , TrudeauJ , WenzelSE . Distinguishing severe asthma phenotypes: role of age at onset and eosinophilic inflammation . J. Allergy Clin. Immunol.113 ( 1 ), 101 – 108 ( 2004 ).
  • Nelson HS , WeissST , BleeckerER , YanceySW , DorinskyPM , SMART Study Group . The salmeterol multicenter asthma research trial: a comparison of usual pharmacotherapy for asthma or usual pharmacotherapy plus salmeterol . Chest129 ( 1 ), 15 – 26 ( 2006 ).
  • Fajt ML , WenzelSE . Asthma phenotypes and the use of biologic medications in asthma and allergic disease: the next steps toward personalized care . J. Allergy Clin. Immunol.135 ( 2 ), 299 – 310 ; quiz 311 ( 2015 ).
  • Hekking P-PW , BelEH . Developing and emerging clinical asthma phenotypes . J. Allergy Clin. Immunol. Pract.2 ( 6 ), 671 – 680 ( 2014 ).
  • Ray A , OrissTB , WenzelSE . Emerging molecular phenotypes of asthma . Am. J. Physiol. Lung Cell. Mol. Physiol.308 ( 2 ), L130 – 140 ( 2015 ).
  • Skloot GS . Asthma phenotypes and endotypes: a personalized approach to treatment . Curr. Opin. Pulm. Med.22 ( 1 ), 3 – 9 ( 2016 ).
  • Wang L , McLeodHL , WeinshilboumRM . Genomics and drug response . N. Engl. J. Med.364 ( 12 ), 1144 – 1153 ( 2011 ).
  • Davis JS , WeissST , TantisiraKG . Asthma pharmacogenomics: 2015 Update . Curr. Allergy Asthma Rep.15 ( 7 ), 42 ( 2015 ).
  • Kersten ETG , KoppelmanGH . Pharmacogenetics of asthma: toward precision medicine . Curr. Opin. Pulm. Med.23 ( 1 ), 12 – 20 ( 2017 ).
  • Himes BE , JiangX , WagnerPet al. RNA-Seq transcriptome profiling identifies CRISPLD2 as a glucocorticoid responsive gene that modulates cytokine function in airway smooth muscle cells . PloS ONE.9 ( 6 ), e99625 ( 2014 ).
  • Nadeau JH , DudleyAM . Genetics. Systems genetics . Science331 ( 6020 ), 1015 – 1016 ( 2011 ).
  • Tantisira KG , LakeS , SilvermanESet al. Corticosteroid pharmacogenetics: association of sequence variants in CRHR1 with improved lung function in asthmatics treated with inhaled corticosteroids . Hum. Mol. Genet.13 ( 13 ), 1353 – 1359 ( 2004 ).
  • Tantisira KG , SilvermanES , MarianiTJet al. FCER2: a pharmacogenetic basis for severe exacerbations in children with asthma . J. Allergy Clin. Immunol.120 ( 6 ), 1285 – 1291 ( 2007 ).
  • Tse SM , TantisiraK , WeissST . The pharmacogenetics and pharmacogenomics of asthma therapy . Pharmacogenomics J.11 ( 6 ), 383 – 392 ( 2011 ).
  • Maitland-van der Zee AH , RaaijmakersJA . Variation at GLCCI1 and FCER2: one step closer to personalized asthma treatment . Pharmacogenomics13 ( 3 ), 243 – 245 ( 2012 ).
  • Tantisira KG , Lasky-SuJ , HaradaMet al. Genomewide association between GLCCI1 and response to glucocorticoid therapy in asthma . N. Engl. J. Med.365 ( 13 ), 1173 – 1183 ( 2011 ).
  • Hosking L , BleeckerE , GhoshSet al. GLCCI1 rs37973 does not influence treatment response to inhaled corticosteroids in white asthma subjects . J. Allergy Clin. Immunol.133 ( 2 ), 587 – 589 ( 2014 ).
  • Huizenga NA , KoperJW , De LangePet al. A polymorphism in the glucocorticoid receptor gene may be associated with and increased sensitivity to glucocorticoids in vivo . J. Clin. Endocrinol. Metab.83 ( 1 ), 144 – 151 ( 1998 ).
  • Hawkins GA , LazarusR , SmithRSet al. The glucocorticoid receptor heterocomplex gene STIP1 is associated with improved lung function in asthmatic subjects treated with inhaled corticosteroids . J. Allergy Clin. Immunol.123 ( 6 ), 1376 – 1383.e7 ( 2009 ).
  • Tantisira KG , HwangES , RabyBAet al. TBX21: a functional variant predicts improvement in asthma with the use of inhaled corticosteroids . Proc. Natl. Acad. Sci. USA101 ( 52 ), 18099 – 18104 ( 2004 ).
  • Ye Y-M , LeeH-Y , KimS-Het al. Pharmacogenetic study of the effects of NK2R G231E G>A and TBX21 H33Q C>G polymorphisms on asthma control with inhaled corticosteroid treatment . J. Clin. Pharm. Ther.34 ( 6 ), 693 – 701 ( 2009 ).
  • Perin P , PotočnikU . Polymorphisms in recent GWA identified asthma genes CA10, SGK493, and CTNNA3 are associated with disease severity and treatment response in childhood asthma . Immunogenetics66 ( 3 ), 143 – 151 ( 2014 ).
  • Wang Y , TongC , WangZet al. Pharmacodynamic genome-wide association study identifies new responsive loci for glucocorticoid intervention in asthma . Pharmacogenomics J.15 ( 5 ), 422 – 429 ( 2015 ).
  • Qiu W , RogersAJ , DamaskAet al. Pharmacogenomics: novel loci identification via integrating gene differential analysis and eQTL analysis . Hum. Mol. Genet.23 ( 18 ), 5017 – 5024 ( 2014 ).
  • Tantisira KG , DamaskA , SzeflerSJet al. Genome-wide association identifies the T gene as a novel asthma pharmacogenetic locus . Am. J. Respir. Crit. Care Med.185 ( 12 ), 1286 – 1291 ( 2012 ).
  • Litonjua AA , GongL , DuanQLet al. Very important pharmacogene summary ADRB2 . Pharmacogenet. Genomics20 ( 1 ), 64 – 69 ( 2010 ).
  • Tantisira KG , SmallKM , LitonjuaAA , WeissST , LiggettSB . Molecular properties and pharmacogenetics of a polymorphism of adenylyl cyclase type 9 in asthma: interaction between beta-agonist and corticosteroid pathways . Hum. Mol. Genet.14 ( 12 ), 1671 – 1677 ( 2005 ).
  • Kim SH , YeYM , LeeHY , SinHJ , ParkHS . Combined pharmacogenetic effect of ADCY9 and ADRB2 gene polymorphisms on the bronchodilator response to inhaled combination therapy . J. Clin. Pharm. Ther.36 ( 3 ), 399 – 405 ( 2011 ).
  • Drake KA , TorgersonDG , GignouxCRet al. A genome-wide association study of bronchodilator response in Latinos implicates rare variants . J. Allergy Clin. Immunol.133 ( 2 ), 370 – 378 ( 2014 ).
  • Israel E , DrazenJM , LiggettSBet al. The effect of polymorphisms of the beta(2)-adrenergic receptor on the response to regular use of albuterol in asthma . Am. J. Respir. Crit. Care Med.162 ( 1 ), 75 – 80 ( 2000 ).
  • Israel E , ChinchilliVM , FordJGet al. Use of regularly scheduled albuterol treatment in asthma: genotype-stratified, randomised, placebo-controlled cross-over trial . Lancet Lond. Engl.364 ( 9444 ), 1505 – 1512 ( 2004 ).
  • Ortega VE , MeyersDA , BleeckerER . Asthma pharmacogenetics and the development of genetic profiles for personalized medicine . Pharmacogenomics Pers. Med.8 , 9 – 22 ( 2015 ).
  • Choudhry S , UngN , AvilaPCet al. Pharmacogenetic differences in response to albuterol between Puerto Ricans and Mexicans with asthma . Am. J. Respir. Crit. Care Med.171 ( 6 ), 563 – 570 ( 2005 ).
  • Lima JJ , ThomasonDB , MohamedMH , EberleLV , SelfTH , JohnsonJA . Impact of genetic polymorphisms of the beta2-adrenergic receptor on albuterol bronchodilator pharmacodynamics . Clin. Pharmacol. Ther.65 ( 5 ), 519 – 525 ( 1999 ).
  • Taylor DR , DrazenJM , HerbisonGP , YandavaCN , HancoxRJ , TownGI . Asthma exacerbations during long term beta agonist use: influence of beta(2) adrenoceptor polymorphism . Thorax55 ( 9 ), 762 – 767 ( 2000 ).
  • Wechsler ME , KunselmanSJ , ChinchilliVMet al. Effect of beta2-adrenergic receptor polymorphism on response to longacting beta2 agonist in asthma (LARGE trial): a genotype-stratified, randomised, placebo-controlled, crossover trial . Lancet Lond. Engl.374 ( 9703 ), 1754 – 1764 ( 2009 ).
  • Bleecker ER , NelsonHS , KraftMet al. Beta2-receptor polymorphisms in patients receiving salmeterol with or without fluticasone propionate . Am. J. Respir. Crit. Care Med.181 ( 7 ), 676 – 687 ( 2010 ).
  • Lipworth BJ , BasuK , DonaldHPet al. Tailored second-line therapy in asthmatic children with the Arg(16) genotype . Clin. Sci. Lond. Engl. 1979.124 ( 8 ), 521 – 528 ( 2013 ).
  • Zuurhout MJL , VijverbergSJH , RaaijmakersJAMet al. Arg16 ADRB2 genotype increases the risk of asthma exacerbation in children with a reported use of long-acting β2-agonists: results of the PACMAN cohort . Pharmacogenomics14 ( 16 ), 1965 – 1971 ( 2013 ).
  • Green SA , ColeG , JacintoM , InnisM , LiggettSB . A polymorphism of the human beta 2-adrenergic receptor within the fourth transmembrane domain alters ligand binding and functional properties of the receptor . J. Biol. Chem.268 ( 31 ), 23116 – 23121 ( 1993 ).
  • Ortega VE , HawkinsGA , MooreWCet al. Effect of rare variants in ADRB2 on risk of severe exacerbations and symptom control during longacting β agonist treatment in a multiethnic asthma population: a genetic study . Lancet Respir. Med.2 ( 3 ), 204 – 213 ( 2014 ).
  • Litonjua AA , Lasky-SuJ , SchneiterKet al. ARG1 is a novel bronchodilator response gene: screening and replication in four asthma cohorts . Am. J. Respir. Crit. Care Med.178 ( 7 ), 688 – 694 ( 2008 ).
  • Duan QL , GaumeBR , HawkinsGAet al. Regulatory haplotypes in ARG1 are associated with altered bronchodilator response . Am. J. Respir. Crit. Care Med.183 ( 4 ), 449 – 454 ( 2011 ).
  • Vonk JM , PostmaDS , MaarsinghH , BruinenbergM , KoppelmanGH , MeursH . Arginase 1 and arginase 2 variations associate with asthma, asthma severity and beta2 agonist and steroid response . Pharmacogenet. Genomics20 ( 3 ), 179 – 186 ( 2010 ).
  • Que LG , YangZ , StamlerJS , LugogoNL , KraftM . S-nitrosoglutathione reductase: an important regulator in human asthma . Am. J. Respir. Crit. Care Med.180 ( 3 ), 226 – 231 ( 2009 ).
  • Choudhry S , QueLG , YangZet al. GSNO reductase and beta2-adrenergic receptor gene–gene interaction: bronchodilator responsiveness to albuterol . Pharmacogenet. Genomics20 ( 6 ), 351 – 358 ( 2010 ).
  • Iordanidou M , ParaskakisE , TavridouA , PaschouP , ChatzimichaelA , ManolopoulosVG . G894T polymorphism of eNOS gene is a predictor of response to combination of inhaled corticosteroids with long-lasting β2-agonists in asthmatic children . Pharmacogenomics13 ( 12 ), 1363 – 1372 ( 2012 ).
  • Himes BE , JiangX , HuRet al. Genome-wide association analysis in asthma subjects identifies SPATS2L as a novel bronchodilator response gene . PLoS Genet.8 ( 7 ), e1002824 ( 2012 ).
  • Israel E , Lasky-SuJ , MarkezichAet al. Genome-wide association study of short-acting β2-agonists. A novel genome-wide significant locus on chromosome 2 near ASB3 . Am. J. Respir. Crit. Care Med.191 ( 5 ), 530 – 537 ( 2015 ).
  • Duan QL , Lasky-SuJ , HimesBEet al. A genome-wide association study of bronchodilator response in asthmatics . Pharmacogenomics J.14 ( 1 ), 41 – 47 ( 2014 ).
  • Padhukasahasram B , YangJJ , LevinAMet al. Gene-based association identifies SPATA13-AS1 as a pharmacogenomic predictor of inhaled short-acting beta-agonist response in multiple population groups . Pharmacogenomics J.14 ( 4 ), 365 – 371 ( 2014 ).
  • Szefler SJ , PhillipsBR , MartinezFDet al. Characterization of within-subject responses to fluticasone and montelukast in childhood asthma . J. Allergy Clin. Immunol.115 ( 2 ), 233 – 242 ( 2005 ).
  • Lima JJ , ZhangS , GrantAet al. Influence of leukotriene pathway polymorphisms on response to montelukast in asthma . Am. J. Respir. Crit. Care Med.173 ( 4 ), 379 – 385 ( 2006 ).
  • Asano K , ShiomiT , HasegawaNet al. Leukotriene C4 synthase gene A(-444)C polymorphism and clinical response to a CYS-LT(1) antagonist, pranlukast, in Japanese patients with moderate asthma . Pharmacogenetics12 ( 7 ), 565 – 570 ( 2002 ).
  • Telleria JJ , Blanco-QuirosA , VarillasDet al. ALOX5 promoter genotype and response to montelukast in moderate persistent asthma . Respir. Med.102 ( 6 ), 857 – 861 ( 2008 ).
  • Klotsman M , YorkTP , PillaiSGet al. Pharmacogenetics of the 5-lipoxygenase biosynthetic pathway and variable clinical response to montelukast . Pharmacogenet. Genomics17 ( 3 ), 189 – 196 ( 2007 ).
  • Tantisira KG , LimaJ , SylviaJ , KlandermanB , WeissST . 5-lipoxygenase pharmacogenetics in asthma: overlap with Cys-leukotriene receptor antagonist loci . Pharmacogenet. Genomics19 ( 3 ), 244 – 247 ( 2009 ).
  • Tapaninen T , KaronenT , BackmanJT , NeuvonenPJ , NiemiM . SLCO2B1 c.935G>A single nucleotide polymorphism has no effect on the pharmacokinetics of montelukast and aliskiren . Pharmacogenet. Genomics23 ( 1 ), 19 – 24 ( 2013 ).
  • Kim K-A , LeeH-M , JooH-J , ParkI-B , ParkJ-Y . Effects of polymorphisms of the SLCO2B1 transporter gene on the pharmacokinetics of montelukast in humans . J. Clin. Pharmacol.53 ( 11 ), 1186 – 1193 ( 2013 ).
  • Dahlin A , LitonjuaA , IrvinCGet al. Genome-wide association study of leukotriene modifier response in asthma . Pharmacogenomics J.16 ( 2 ), 151 – 157 ( 2016 ).
  • Dahlin A , LitonjuaA , LimaJJet al. Genome-wide association study identifies novel pharmacogenomic loci for therapeutic response to montelukast in asthma . PloS ONE.10 ( 6 ), e0129385 ( 2015 ).
  • McGhee SA . How the practice of allergy shows the promise and challenge of personalized medicine . Mol. Genet. Metab.104 ( 1–2 ), 3 – 6 ( 2011 ).
  • Poland GA , OvsyannikovaIG , JacobsonRM . Personalized vaccines: the emerging field of vaccinomics . Expert Opin. Biol. Ther.8 ( 11 ), 1659 – 1667 ( 2008 ).
  • Poland GA , OvsyannikovaIG , JacobsonRM . Application of pharmacogenomics to vaccines . Pharmacogenomics10 ( 5 ), 837 – 852 ( 2009 ).
  • Haralambieva IH , PolandGA . Vaccinomics, predictive vaccinology and the future of vaccine development . Future Microbiol.5 ( 12 ), 1757 – 1760 ( 2010 ).
  • Fujisawa T , NagaoM , HiraguchiYet al. Biomarkers for allergen immunotherapy in cedar pollinosis . Allergol. Int. Off. J. Jpn. Soc. Allergol.58 ( 2 ), 163 – 170 ( 2009 ).
  • Karakis GP , SinB , TutkakH , KoseK , MisirligilZ . Genetic aspect of venom allergy: association with HLA class I and class II antigens . Ann. Agric. Environ. Med. AAEM.17 ( 1 ), 119 – 123 ( 2010 ).
  • Simms E , SyedI , RudulierC , LarchéM . Peptide immunotherapy; short but long lasting?Curr. Treat. Options Allergy2 ( 1 ), 64 – 71 ( 2015 ).
  • McDonnell AM , DangCH . Basic review of the cytochrome p450 system . J. Adv. Pract. Oncol.4 ( 4 ), 263 – 268 ( 2013 ).
  • Isidoro-García M , Sánchez-MartínA , García-BerrocalB , Román-CurtoC . Primun non nocere, polypharmacy and pharmacogenetics . Pharmacogenomics16 ( 17 ), 1903 – 1905 ( 2015 ).
  • Isidoro-Garcia M , Sanchez-MartinA , Garcia-BerrocalB . impact of new technologies on pharmacogenomics . Curr. Pharmacogenomics Pers. Med.14 ( 2 ), 74 – 85 ( 2016 ).
  • Meyers DA , BleeckerER , HollowayJW , HolgateST . Asthma genetics and personalised medicine . Lancet Respir. Med.2 ( 5 ), 405 – 415 ( 2014 ).
  • Ortega VE , MeyersDA . Pharmacogenetics: implications of race and ethnicity on defining genetic profiles for personalized medicine . J. Allergy Clin. Immunol.133 ( 1 ), 16 – 26 ( 2014 ).
  • Tabatabaian F , LedfordDK , CasaleTB . Biologic and new therapies in asthma . Immunol. Allergy Clin. North Am.37 ( 2 ), 329 – 343 ( 2017 ).
  • Pascual M , RoaS , García-SánchezAet al. Genome-wide expression profiling of B lymphocytes reveals IL4R increase in allergic asthma . J. Allergy Clin. Immunol.134 ( 4 ), 972 – 975 ( 2014 ).
  • Slager RE , OtulanaBA , HawkinsGAet al. IL-4 receptor polymorphisms predict reduction in asthma exacerbations during response to an anti-IL-4 receptor α antagonist . J. Allergy Clin. Immunol.130 ( 2 ), 516 – 522.e4 ( 2012 ).
  • Wenzel S , FordL , PearlmanDet al. Dupilumab in persistent asthma with elevated eosinophil levels . N. Engl. J. Med.368 ( 26 ), 2455 – 2466 ( 2013 ).
  • Wenzel S , CastroM , CorrenJet al. Dupilumab efficacy and safety in adults with uncontrolled persistent asthma despite use of medium-to-high-dose inhaled corticosteroids plus a long-acting β2 agonist: a randomised double-blind placebo-controlled pivotal Phase 2b dose-ranging trial . Lancet Lond. Engl.388 ( 10039 ), 31 – 44 ( 2016 ).
  • Isidoro-García M , Dávila-GonzálezI , Pascual de PedroM , Sanz-LozanoC , Lorente-ToledanoF . Interactions between genes and the environment. Epigenetics in allergy . Allergol. Immunopathol. (Madr.).35 ( 6 ), 254 – 258 ( 2007 ).
  • Pascual M , SuzukiM , Isidoro-GarciaMet al. Epigenetic changes in B lymphocytes associated with house dust mite allergic asthma . Epigenetics6 ( 9 ), 1131 – 1137 ( 2011 ).
  • Booton R , LindsayMA . Emerging role of MicroRNAs and long noncoding RNAs in respiratory disease . Chest146 ( 1 ), 193 – 204 ( 2014 ).
  • Elbehidy RM , YoussefDM , El-ShalASet al. MicroRNA-21 as a novel biomarker in diagnosis and response to therapy in asthmatic children . Mol. Immunol.71 , 107 – 114 ( 2016 ).
  • Dahlin A , TantisiraKG . Integrative systems biology approaches in asthma pharmacogenomics . Pharmacogenomics13 ( 12 ), 1387 – 1404 ( 2012 ).
  • Park H-W , TantisiraKG , WeissST . Pharmacogenomics in asthma therapy: where are we and where do we go?Annu. Rev. Pharmacol. Toxicol.55 , 129 – 147 ( 2015 ).
  • Bunyavanich S , SchadtEE . Systems biology of asthma and allergic diseases: a multiscale approach . J. Allergy Clin. Immunol.135 ( 1 ), 31 – 42 ( 2015 ).
  • Sanchez-Martín A , García-SánchezA , Isidoro-GarcíaM . Review on pharmacogenetic and pharmacogenomics applied to the study of asthma . Methods Mol. Biol.1434 , 255 – 272 ( 2016 ).

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