SLCO1A2, SLCO1B1 and SLCO2B1 Polymorphisms Influences Chloroquine and Primaquine Treatment in Plasmodium vivax Malaria

References

• WHO . World Malaria Report 2016 . www.who.int/malaria/publications/world-malaria-report-2016/report/en/ .
   Google Scholar
• Howes RE , BattleKE , MendisKNet al. Global epidemiology of Plasmodium vivax . Am. J. Trop. Med. Hyg.95 ( Suppl. 6 ), 5 – 34 ( 2016 ).
   PubMed Web of Science ®Google Scholar
• Mueller I , GalinskiMR , BairdJKet al. Key gaps in the knowledge of Plasmodium vivax, a neglected human malaria parasite . Lancet Infect. Dis.9 ( 9 ), 555 – 566 ( 2009 ).
   PubMed Web of Science ®Google Scholar
• Ferreira MU , CastroMC . Challenges for malaria elimination in Brazil . Malar. J.15 ( 1 ), 284 ( 2016 ).
   PubMedGoogle Scholar
• WHO . Guidelines for the Treatment of Malaria (3rd Edition) . www.who.int/malaria/publications/atoz/9789241549127/en/ .
   Google Scholar
• Thomé R , LopesSC , CostaFT , VerinaudL . Chloroquine: modes of action of an undervalued drug . Immunol. Lett.153 ( 1–2 ), 50 – 57 ( 2013 ).
   PubMed Web of Science ®Google Scholar
• Vale N , MoreiraR , GomesP . Primaquine revisited six decades after its discovery . Eur. J. Med. Chem.44 ( 3 ), 937 – 953 ( 2009 ).
   PubMed Web of Science ®Google Scholar
• Baird JK . Resistance to therapies for infection by Plasmodium vivax . Clin. Microbiol. Rev.22 ( 3 ), 508 – 534 ( 2009 ).
   PubMed Web of Science ®Google Scholar
• Hellgren U , AlvánG , JerlingM . On the question of interindividual variations in chloroquine concentrations . Eur. J. Clin. Pharmacol.45 ( 4 ), 383 – 385 ( 1993 ).
   PubMed Web of Science ®Google Scholar
• Walker O , DawoduAH , AdeyokunnuAA , SalakoLA , AlvanG . Plasma chloroquine and desethylchloroquine concentrations in children during and after chloroquine treatment for malaria . Br. J. Clin. Pharmacol.16 ( 6 ), 701 – 705 ( 1983 ).
   PubMed Web of Science ®Google Scholar
• Dua VK , GuptaNC , KarPKet al. Chloroquine and desethylchloroquine concentrations in blood cells and plasma from Indian patients infected with sensitive or resistant Plasmodium falciparum . Ann. Trop. Med. Parasitol.94 ( 6 ), 565 – 570 ( 2000 ).
   PubMed Web of Science ®Google Scholar
• Kim YR , KuhHJ , KimMYet al. Pharmacokinetics of primaquine and carboxyprimaquine in Korean patients with vivax malaria . Arch. Pharm. Res.27 ( 5 ), 576 – 580 ( 2004 ).
   PubMed Web of Science ®Google Scholar
• Fletcher KA , EvansDA , GillesHM , GreavesJ , BunnagD , HarinasutaT . Studies on the pharmacokinetics of primaquine . Bull. World Health Organ.59 ( 3 ), 407 – 412 ( 1981 ).
   PubMed Web of Science ®Google Scholar
• Goller JL , JolleyD , RingwaldP , BiggsBA . Regional differences in the response of Plasmodium vivax malaria to primaquine as anti-relapse therapy . Am. J. Trop. Med. Hyg.76 ( 2 ), 203 – 207 ( 2007 ).
   PubMed Web of Science ®Google Scholar
• Pukrittayakamee S , TarningJ , JittamalaPet al. Pharmacokinetic interactions between primaquine and chloroquine . Antimicrob. Agents Chemother.58 ( 6 ), 3354 – 3359 ( 2014 ).
   PubMed Web of Science ®Google Scholar
• Höglund R , MoussaviY , RuengweerayutR , CheomungA , ÄbelöA , Na-BangchangK . Population pharmacokinetics of a three-day chloroquine treatment in patients with Plasmodium vivax infection on the Thai-Myanmar border . Malar. J.29 ( 15 ), 129 ( 2016 ).
   Google Scholar
• Sortica VA , LindenauJD , CunhaMGet al. The effect of SNPs in CYP450 in chloroquine/primaquine Plasmodium vivax malaria treatment . Pharmacogenomics17 ( 17 ), 1903 – 1911 ( 2016 ).
   PubMed Web of Science ®Google Scholar
• Silvino AC , CostaGL , AraújoFCet al. Variation in human cytochrome P-450 drug-metabolism genes: a gateway to the understanding of Plasmodium vivax relapses . PLoS ONE11 ( 7 ), e0160172 ( 2016 ).
   PubMed Web of Science ®Google Scholar
• Kerb R , FuxR , MörikeKet al. Pharmacogenetics of antimalarial drugs: effect on metabolism and transport . Lancet Infect. Dis.9 ( 12 ), 760 – 774 ( 2009 ).
   PubMed Web of Science ®Google Scholar
• Chen Z , ShiT , ZhangLet al. Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: a review of the past decade . Cancer Lett.370 ( 1 ), 153 – 164 ( 2016 ).
   PubMed Web of Science ®Google Scholar
• Hong M . Biochemical studies on the structure-function relationship of major drug transporters in the ATP-binding cassette family and solute carrier family . Adv. Drug Deliv. Rev. doi:10.1016/j.addr.2016.06.003 ( 2016 ) ( Epub ahead of print ).
   PubMed Web of Science ®Google Scholar
• Zhou F , ZhuL , WangK , MurrayM . Recent advance in the pharmacogenomics of human solute carrier transporters (SLCs) in drug disposition . Adv. Drug Deliv. Rev. doi:10.1016/j.addr.2016.06.004 ( 2016 ) ( Epub ahead of print ).
   Web of Science ®Google Scholar
• Vezmar M , GeorgesE . Direct binding of chloroquine to the multidrug resistance protein (MRP): possible role for MRP in chloroquine drug transport and resistance in tumor cells . Biochem. Pharmacol.56 ( 6 ), 733 – 742 ( 1998 ).
   PubMed Web of Science ®Google Scholar
• Oerlemans R , van der HeijdenJ , VinkJet al. Acquired resistance to chloroquine in human CEM T cells is mediated by multidrug resistance-associated protein 1 and provokes high levels of crossresistance to glucocorticoids . Arthritis Rheum.54 ( 2 ), 557 – 568 ( 2006 ).
   PubMedGoogle Scholar
• Crowe A , IlettKF , KarunajeewaHA , BattyKT , DavisTME . Role of P glycoprotein in absorption of novel antimalarial drugs . Antimicrob. Agents Chemother.50 ( 10 ), 3504 – 3506 ( 2006 ).
   PubMed Web of Science ®Google Scholar
• Hayeshi R , MasimirembwaC , MukanganyamaS , UngellAL . The potential inhibitory effect of antiparasitic drugs and natural products on P-glycoprotein mediated efflux . Eur. J. Pharm. Sci.29 ( 1 ), 70 – 81 ( 2006 ).
   PubMed Web of Science ®Google Scholar
• Alam K , PahwaS , WangXet al. Downregulation of organic anion transporting polypeptide (OATP) 1b1 transport function by lysosomotropic drug chloroquine: implication in OATP-mediated drug–drug interactions . Mol. Pharm.13 ( 3 ), 839 – 851 ( 2016 ).
   PubMed Web of Science ®Google Scholar
• Hubeny A , KeiserM , OswaldSet al. Expression of organic anion transporting polypeptide 1A2 in red blood cells and its potential impact on antimalarial therapy . Drug Metab. Dispos.44 ( 10 ), 1562 – 1568 ( 2016 ).
   PubMed Web of Science ®Google Scholar
• Brazilian Ministry of Health . Epidemiological bulletin n43 ( 2015 ). http://portalsaude.saude.gov.br/ .
   Google Scholar
• Brazilian Ministry of Health . Manual of Malaria laboratory diagnosis ( 2009 ). http://bvsms.saude.gov.br/bvs/publicacoes/manual_diagnostico_laboratorial_malaria_2ed.pdf .
   Google Scholar
• Sambrook J , FritschEF , ManiatisT . Molecular Cloning: A Laboratory Manual (2nd Edition) . Cold Spring Harbor Laboratory Press , NY, USA ( 1989 ).
   Google Scholar
• Stephens M , DonnellyP . A comparison of Bayesian methods for haplotype reconstruction from population genotype data . Am. J. Hum. Genet.73 ( 5 ), 1162 – 1169 ( 2003 ).
   PubMed Web of Science ®Google Scholar
• Sortica VA , CunhaMG , OhnishiMDet al. IL1B, IL4R, IL12RB1 and TNF gene polymorphisms are associated with Plasmodium vivax malaria in Brazil . Malar. J.11 , 409 ( 2012 ).
   PubMed Web of Science ®Google Scholar
• Liang K-Y , ZegerSL . Longitudinal data analysis using generalized linear models . Biometrika73 ( 1 ), 13 – 22 ( 1986 ).
   Web of Science ®Google Scholar
• Fritz CO , MorrisPE , RichlerJJ . Effect size estimates: current use, calculations, and interpretation . J. Exp. Psychol. Gen.141 ( 1 ), 2 – 18 ( 2012 ).
   PubMed Web of Science ®Google Scholar
• Sortica Vde A , OjopiEB , GenroJPet al. Influence of genomic ancestry on the distribution of SLCO1B1, SLCO1B3 and ABCB1 gene polymorphisms among Brazilians . Basic Clin. Pharmacol. Toxicol.110 ( 5 ), 460 – 468 ( 2012 ).
   PubMed Web of Science ®Google Scholar
• Cohen J , CohenP , WestSG , AikenLS . Applied Multiple Regression/Correlation Analysis for the Behavioral Science . Erlbaum , NJ, USA ( 2002 ).
   Google Scholar
• Wirjanata G , SebayangBF , ChalfeinFet al. Contrasting ex vivo efficacies of “reversed chloroquine” compounds in chloroquine-resistant Plasmodium falciparum and P. vivax isolates . J. Antimicrob. Agents Chemother.59 ( 9 ), 5721 – 5726 ( 2015 ).
   PubMed Web of Science ®Google Scholar
• Sharrock WW , SuwanaruskR , Lek-UthaiUet al. Plasmodium vivax trophozoites insensitive to chloroquine . Malar. J.7 , 94 ( 2008 ).
   PubMed Web of Science ®Google Scholar
• Siqueira AM , AlencarAC , MeloGCet al. Fixed-dose artesunate–amodiaquine combination vs chloroquine for treatment of uncomplicated blood stage P. vivax infection in the Brazilian Amazon: an open-label randomized, controlled trial . Clin. Infect. Dis.64 ( 2 ), 166 – 174 ( 2017 ).
   PubMed Web of Science ®Google Scholar
• Price RN , AuburnS , MarfurtJ , ChengQ . Phenotypic and genotypic characterization of drug-resistant Plasmodium vivax . Trends Parasitol.28 , 522 – 529 ( 2012 ).
   PubMed Web of Science ®Google Scholar
• Gonçalves LA , CravoP , FerreiraMU . Emerging Plasmodium vivax resistance to chloroquine in South America: an overview . Mem. Inst. Oswaldo Cruz109 ( 5 ), 534 – 539 ( 2014 ).
   PubMed Web of Science ®Google Scholar
• Hagenbuch B , MeierPJ . Organic anion transporting polypeptides of the OATP/SLC21 family: phylogenetic classification asOATP/SLCO superfamily, new nomenclature and molecular/functional properties . Pflugers Arch.447 ( 5 ), 653 – 665 ( 2004 ).
   PubMed Web of Science ®Google Scholar
• Kalliokoski A , NiemiM . Impact of OATP transporters on pharmacokinetics . Br. J. Pharmacol.158 ( 3 ), 693 – 705 ( 2009 ).
   PubMed Web of Science ®Google Scholar
• Kullak-Ublick GA , IsmairMG , StiegerBet al. Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver . Gastroenterology120 ( 2 ), 525 – 533 ( 2001 ).
   PubMed Web of Science ®Google Scholar
• Kobayashi D , NozawaT , ImaiK , NezuJ , TsujiA , TamaiI . Involvement of human organic anion transporting polypeptide OATP-B (SLC21A9) in pH-dependent transport across intestinal apical membrane . J. Pharmacol. Exp. Ther.306 ( 2 ), 703 – 708 ( 2003 ).
   PubMed Web of Science ®Google Scholar
• Ho RH , TironaRG , LeakeBFet al. Drug and bile acid transporters in rosuvastatin hepatic uptake: function, expression, and pharmacogenetics . Gastroenterology130 ( 6 ), 1793 – 1806 ( 2006 ).
   PubMed Web of Science ®Google Scholar
• Niemi M . Role of OATP transporters in the disposition of drugs . Pharmacogenomics8 ( 7 ), 787 – 802 ( 2007 ).
   PubMed Web of Science ®Google Scholar
• Pasanen MK , NeuvonenM , NeuvonenPJ , NiemiM . SLCO1B1 polymorphism markedly affects the pharmacokinetics of simvastatin acid . Pharmacogenet. Genomics16 ( 12 ), 873 – 979 ( 2006 ).
   PubMed Web of Science ®Google Scholar
• Couvert P , GiralP , DejagerSet al. Association between a frequent allele of the gene encoding OATP1B1 and enhanced LDL-lowering response to fluvastatin therapy . Pharmacogenomics9 ( 9 ), 1217 – 1227 ( 2008 ).
   PubMed Web of Science ®Google Scholar
• Romaine SP , BaileyKM , HallAS , BalmforthAJ . The influence of SLCO1B1 (OATP1B1) gene polymorphisms on response to statin therapy . Pharmacogenomics J.10 ( 1 ), 1 – 11 ( 2010 ).
   PubMed Web of Science ®Google Scholar
• Sortica VA , FiegenbaumM , LimaLOet al. SLCO1B1 gene variability influences lipid-lowering efficacy on simvastatin therapy in Southern Brazilians . Clin. Chem. Lab. Med.50 ( 3 ), 441 – 448 ( 2012 ).
   PubMed Web of Science ®Google Scholar
• Michalski C , CuiY , NiesATet al. A naturally occurring mutation in the SLC21A6 gene causing impaired membrane localisation of the hepatocyte uptake transporter . J. Biol. Chem.277 ( 45 ), 43058 – 43063 ( 2002 ).
   PubMed Web of Science ®Google Scholar
• Kullak-Ublick GA , FischT , OswaldMet al. Dehydroepiandrosterone sulfate (DHEAS): identification of a carrier protein in human liver and brain . FEBS Lett.424 ( 3 ), 173 – 176 ( 1998 ).
   PubMed Web of Science ®Google Scholar
• Lee W , GlaeserH , SmithLHet al. Polymorphisms in human organic aniontransporting polypeptide 1A2 (OATP1A2): implications for altered drug disposition and central nervous system drug entry . J. Biol. Chem.280 ( 10 ), 9610 – 9617 ( 2005 ).
   PubMed Web of Science ®Google Scholar
• Franke RM , ScherkenbachLA , SparreboomA . Pharmacogenetics of the organic anion transporting polypeptide 1A2 . Pharmacogenomics10 ( 3 ), 339 – 344 ( 2009 ).
   PubMed Web of Science ®Google Scholar
• Gong IY , KimRB . Impact of genetic variation in OATP transporters to drug disposition and response . Drug Metab. Pharmacokinet.28 ( 1 ), 4 – 18 ( 2013 ).
   PubMed Web of Science ®Google Scholar
• Zhou Y1 , YuanJ , LiZet al. Genetic polymorphisms and function of the organic anion-transporting polypeptide 1A2 and its clinical relevance in drug disposition . Pharmacology95 ( 3–4 ), 201 – 208 ( 2015 ).
   PubMed Web of Science ®Google Scholar
• Badagnani I , CastroRA , TaylorTRet al. Interaction of methotrexate with organic-anion transporting polypeptide 1A2 and its genetic variants . J. Pharmacol. Exp. Ther.318 ( 2 ), 521 – 529 ( 2006 ).
   PubMed Web of Science ®Google Scholar
• Deeley RG , WestlakeC , ColeSP . Transmembrane transport of endo- and xenobiotics by mammalian ATP-binding cassette multidrug resistance proteins . Physiol. Rev.86 ( 3 ), 849 – 899 ( 2006 ).
   PubMed Web of Science ®Google Scholar
• Fung KL , GottesmanMM . A synonymous polymorphism in a common MDR1 (ABCB1) haplotype shapes protein function . Biochim. Biophys. Acta.1794 ( 5 ), 860 – 871 ( 2009 ).
   PubMed Web of Science ®Google Scholar
• de Santana Filho FS , ArcanjoAR , ChehuanYMet al. Chloroquine-resistant Plasmodium vivax, Brazilian Amazon . Emerg. Infect. Dis.13 ( 7 ), 1125 – 1126 ( 2007 ).
   PubMed Web of Science ®Google Scholar